{"id":"https://openalex.org/W2139213296","doi":"https://doi.org/10.1534/g3.111.001230","title":"Modulation of the Activity of a Polycomb-Group Response Element in Drosophila by a Mutation in the Transcriptional Activator Woc","display_name":"Modulation of the Activity of a Polycomb-Group Response Element in Drosophila by a Mutation in the Transcriptional Activator Woc","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2139213296","doi":"https://doi.org/10.1534/g3.111.001230","mag":"2139213296","pmid":"https://pubmed.ncbi.nlm.nih.gov/22384357","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3276158"},"language":"en","primary_location":{"id":"doi:10.1534/g3.111.001230","doi":"https://doi.org/10.1534/g3.111.001230","is_oa":true,"landing_page_url":"https://doi.org/10.1534/g3.111.001230","pdf_url":"https://academic.oup.com/g3journal/article-pdf/1/6/471/38165014/g3journal0471.pdf","source":{"id":"https://openalex.org/S109822313","display_name":"G3 Genes Genomes Genetics","issn_l":"2160-1836","issn":["2160-1836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319844","host_organization_name":"Genetics Society of America","host_organization_lineage":["https://openalex.org/P4310319844"],"host_organization_lineage_names":["Genetics Society of America"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 Genes|Genomes|Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/g3journal/article-pdf/1/6/471/38165014/g3journal0471.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066283652","display_name":"Amanda Noyes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Noyes","raw_affiliation_strings":["Program on Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program on Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086699196","display_name":"Catherine M. Stefaniuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Stefaniuk","raw_affiliation_strings":["Program on Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program on Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029468472","display_name":"Yuzhong Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuzhong Cheng","raw_affiliation_strings":["Program on Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program on Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045284198","display_name":"James A. Kennison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A Kennison","raw_affiliation_strings":["Program on Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program on Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088694477","display_name":"Judith A. Kassis","orcid":"https://orcid.org/0000-0001-9268-3213","observed_orcids":["https://orcid.org/0000-0001-9268-3213"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Judith A Kassis","raw_affiliation_strings":["Program on Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program on Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088694477"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"],"apc_list":{"value":2709,"currency":"USD","value_usd":2709},"apc_paid":{"value":2709,"currency":"USD","value_usd":2709},"fwci":0.4279,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.55856705,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1","issue":"6","first_page":"471","last_page":"478"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.093299999833107,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/engrailed","display_name":"engrailed","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cis-regulatory-elements","display_name":"cis-regulatory elements","score":0.7549999952316284},{"id":"https://openalex.org/keywords/polycomb-group-proteins","display_name":"Polycomb group proteins","score":0.746999979019165},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.6890000104904175},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.6990000009536743},{"id":"https://openalex.org/keywords/gain-of-function-mutations","display_name":"gain-of-function mutations","score":0.9100000262260437},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.8030604124069214},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7259905934333801},{"id":"https://openalex.org/C2777116130","wikidata":"https://www.wikidata.org/wiki/Q4082046","display_name":"Polycomb-group proteins","level":5,"score":0.7114397287368774},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.6764953136444092},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6437323093414307},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.6371610760688782},{"id":"https://openalex.org/C70883133","wikidata":"https://www.wikidata.org/wiki/Q7318316","display_name":"Reversion","level":4,"score":0.5733973383903503},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5695984959602356},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5508768558502197},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4640113115310669},{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.4406387209892273},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4161180555820465},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3885210454463959},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26097893714904785},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.21002119779586792}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1534/g3.111.001230","doi":"https://doi.org/10.1534/g3.111.001230","is_oa":true,"landing_page_url":"https://doi.org/10.1534/g3.111.001230","pdf_url":"https://academic.oup.com/g3journal/article-pdf/1/6/471/38165014/g3journal0471.pdf","source":{"id":"https://openalex.org/S109822313","display_name":"G3 Genes Genomes Genetics","issn_l":"2160-1836","issn":["2160-1836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319844","host_organization_name":"Genetics Society of America","host_organization_lineage":["https://openalex.org/P4310319844"],"host_organization_lineage_names":["Genetics Society of America"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 Genes|Genomes|Genetics","raw_type":"journal-article"},{"id":"pmid:22384357","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22384357","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 (Bethesda, Md.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3276158","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3276158/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 (Bethesda)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1534/g3.111.001230","doi":"https://doi.org/10.1534/g3.111.001230","is_oa":true,"landing_page_url":"https://doi.org/10.1534/g3.111.001230","pdf_url":"https://academic.oup.com/g3journal/article-pdf/1/6/471/38165014/g3journal0471.pdf","source":{"id":"https://openalex.org/S109822313","display_name":"G3 Genes Genomes Genetics","issn_l":"2160-1836","issn":["2160-1836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319844","host_organization_name":"Genetics Society of America","host_organization_lineage":["https://openalex.org/P4310319844"],"host_organization_lineage_names":["Genetics Society of America"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G3 Genes|Genomes|Genetics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139213296.pdf","grobid_xml":"https://content.openalex.org/works/W2139213296.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W295681533","https://openalex.org/W1550369932","https://openalex.org/W1895544505","https://openalex.org/W1910936647","https://openalex.org/W1956344811","https://openalex.org/W1969341584","https://openalex.org/W1970709003","https://openalex.org/W1973279069","https://openalex.org/W1977275028","https://openalex.org/W1978139037","https://openalex.org/W2003523972","https://openalex.org/W2026290399","https://openalex.org/W2037589637","https://openalex.org/W2053317015","https://openalex.org/W2066170392","https://openalex.org/W2073177834","https://openalex.org/W2073869073","https://openalex.org/W2075794898","https://openalex.org/W2076468459","https://openalex.org/W2080933801","https://openalex.org/W2090017665","https://openalex.org/W2092476087","https://openalex.org/W2097150818","https://openalex.org/W2106719240","https://openalex.org/W2108720726","https://openalex.org/W2109134285","https://openalex.org/W2115060340","https://openalex.org/W2120176673","https://openalex.org/W2123404816","https://openalex.org/W2126788527","https://openalex.org/W2126815931","https://openalex.org/W2127614175","https://openalex.org/W2132621604","https://openalex.org/W2138739367","https://openalex.org/W2163965551","https://openalex.org/W2174739588","https://openalex.org/W2182131804"],"related_works":["https://openalex.org/W2080933801","https://openalex.org/W2108720726","https://openalex.org/W2124473740","https://openalex.org/W2152452846","https://openalex.org/W1522340243","https://openalex.org/W2160172277","https://openalex.org/W2109134285","https://openalex.org/W296753606","https://openalex.org/W2106719240","https://openalex.org/W2001681640"],"abstract_inverted_index":{"Polycomb":[0,10,140],"group":[1,11,141],"response":[2],"elements":[3,7],"(PRE)":[4],"are":[5,14,95,116],"cis-regulatory":[6],"that":[8,35,55,114,124],"bind":[9],"proteins.":[12],"We":[13,122],"studying":[15],"a":[16],"181-bp":[17,37,61],"PRE":[18,24,38],"from":[19],"the":[20,36,50,57,60,91,98,105,129,132],"Drosophilaengrailed":[21],"gene.":[22],"This":[23],"causes":[25],"pairing-sensitive":[26],"silencing":[27],"of":[28,49,59,68,74,85,90,131],"mini-white":[29,41,70,75],"in":[30,43,104,120],"transgenes.":[31],"Here":[32],"we":[33,63,79],"show":[34,113],"also":[39],"represses":[40],"expression":[42],"flies":[44],"with":[45,128],"only":[46,81],"one":[47],"copy":[48],"transgene.":[51],"To":[52],"isolate":[53],"mutations":[54,83,93,119],"alter":[56],"activity":[58,130],"PRE,":[62],"screened":[64],"for":[65,138],"dominant":[66,117],"suppressors":[67,73],"PRE-mediated":[69],"repression.":[71],"Dominant":[72],"repression":[76],"were":[77],"rare;":[78],"recovered":[80],"nine":[82,92],"out":[84],"68,274":[86],"progeny":[87],"screened.":[88],"Two":[89],"isolated":[94],"due":[96],"to":[97,144],"same":[99],"single":[100],"amino":[101],"acid":[102],"change":[103],"transcriptional":[106],"activator":[107],"Woc":[108,125],"(without":[109],"children).":[110],"Reversion":[111],"experiments":[112],"these":[115],"gain-of-function":[118],"woc.":[121],"suggest":[123],"can":[126],"interfere":[127],"PRE.":[133],"Our":[134],"data":[135],"have":[136],"implications":[137],"how":[139],"proteins":[142],"act":[143],"either":[145],"partially":[146],"repress":[147],"or":[148],"completely":[149],"silence":[150],"their":[151],"target":[152],"genes.":[153]},"counts_by_year":[{"year":2021,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
