{"id":"https://openalex.org/W2139206468","doi":"https://doi.org/10.1634/theoncologist.12-8-999","title":"Gemcitabine and Docetaxel in Metastatic Sarcoma: Past, Present, and Future","display_name":"Gemcitabine and Docetaxel in Metastatic Sarcoma: Past, Present, and Future","publication_year":2007,"publication_date":"2007-08-01","ids":{"openalex":"https://openalex.org/W2139206468","doi":"https://doi.org/10.1634/theoncologist.12-8-999","mag":"2139206468","pmid":"https://pubmed.ncbi.nlm.nih.gov/17766660"},"language":"en","primary_location":{"id":"doi:10.1634/theoncologist.12-8-999","doi":"https://doi.org/10.1634/theoncologist.12-8-999","is_oa":true,"landing_page_url":"https://doi.org/10.1634/theoncologist.12-8-999","pdf_url":"https://academic.oup.com/oncolo/article-pdf/12/8/999/41835356/oncolo_12_8_999.pdf","source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/oncolo/article-pdf/12/8/999/41835356/oncolo_12_8_999.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068677359","display_name":"Robert G. Maki","orcid":"https://orcid.org/0000-0002-9853-2528","observed_orcids":["https://orcid.org/0000-0002-9853-2528"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert G. Maki","raw_affiliation_strings":["Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5068677359"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":{"value":3852,"currency":"USD","value_usd":3852},"apc_paid":null,"fwci":1.1562,"has_fulltext":true,"cited_by_count":102,"citation_normalized_percentile":{"value":0.75428571,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"12","issue":"8","first_page":"999","last_page":"1006"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.9909999966621399},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":1.0},{"id":"https://openalex.org/keywords/metastatic-sarcoma","display_name":"metastatic sarcoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/leiomyosarcoma","display_name":"leiomyosarcoma","score":0.8939999938011169},{"id":"https://openalex.org/keywords/liposarcoma","display_name":"liposarcoma","score":0.9599999785423279},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.765999972820282},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.6679999828338623},{"id":"https://openalex.org/keywords/conventional-chemotherapy","display_name":"cytotoxic chemotherapy","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9483796954154968},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.9346680641174316},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.7353094816207886},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5750033855438232},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47814998030662537},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.4704774022102356},{"id":"https://openalex.org/C2994587330","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Metastatic melanoma","level":3,"score":0.46659019589424133},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.34397029876708984},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22108319401741028},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15876370668411255}],"mesh":[{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1634/theoncologist.12-8-999","doi":"https://doi.org/10.1634/theoncologist.12-8-999","is_oa":true,"landing_page_url":"https://doi.org/10.1634/theoncologist.12-8-999","pdf_url":"https://academic.oup.com/oncolo/article-pdf/12/8/999/41835356/oncolo_12_8_999.pdf","source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},{"id":"pmid:17766660","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17766660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The oncologist","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.572.811","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.572.811","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://theoncologist.alphamedpress.org/content/12/8/999.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1634/theoncologist.12-8-999","doi":"https://doi.org/10.1634/theoncologist.12-8-999","is_oa":true,"landing_page_url":"https://doi.org/10.1634/theoncologist.12-8-999","pdf_url":"https://academic.oup.com/oncolo/article-pdf/12/8/999/41835356/oncolo_12_8_999.pdf","source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6730169073","display_name":"Soft Tissue Sarcoma Program Project","funder_award_id":"P01CA047179","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139206468.pdf","grobid_xml":"https://content.openalex.org/works/W2139206468.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W26253050","https://openalex.org/W35855642","https://openalex.org/W1496021054","https://openalex.org/W1882650898","https://openalex.org/W1890647543","https://openalex.org/W1908664989","https://openalex.org/W1919221066","https://openalex.org/W1939916640","https://openalex.org/W1965734230","https://openalex.org/W1966107654","https://openalex.org/W1974029074","https://openalex.org/W1975828433","https://openalex.org/W1981483088","https://openalex.org/W1985169709","https://openalex.org/W1996262472","https://openalex.org/W1999532427","https://openalex.org/W2004869577","https://openalex.org/W2006204358","https://openalex.org/W2015247425","https://openalex.org/W2045371413","https://openalex.org/W2051482515","https://openalex.org/W2061358986","https://openalex.org/W2065519386","https://openalex.org/W2067299834","https://openalex.org/W2070871717","https://openalex.org/W2077295631","https://openalex.org/W2080325319","https://openalex.org/W2087581153","https://openalex.org/W2094532843","https://openalex.org/W2107078868","https://openalex.org/W2114862111","https://openalex.org/W2116025938","https://openalex.org/W2119464734","https://openalex.org/W2132574756","https://openalex.org/W2138550636","https://openalex.org/W2149636226","https://openalex.org/W2151804484","https://openalex.org/W2159885083","https://openalex.org/W2161170571","https://openalex.org/W2164208194","https://openalex.org/W2168555194","https://openalex.org/W2268003579","https://openalex.org/W2300371971","https://openalex.org/W2339287929","https://openalex.org/W2414325906","https://openalex.org/W6680566781","https://openalex.org/W6682372540","https://openalex.org/W6684451969"],"related_works":["https://openalex.org/W2159885083","https://openalex.org/W2753570202","https://openalex.org/W2009220618","https://openalex.org/W2146371741","https://openalex.org/W2602174495","https://openalex.org/W2751640999","https://openalex.org/W2804030303","https://openalex.org/W2113795742","https://openalex.org/W2348230945","https://openalex.org/W2155537485"],"abstract_inverted_index":{"Objective.":[0],"In":[1],"the":[2,17,50,69,75,97,105,142,194,197,208,228,239],"era":[3],"of":[4,19,52,63,77,96,107,123,141,161,180,205,227,231,234,241],"oral":[5],"molecular":[6],"kinase":[7],"inhibitors,":[8],"cytotoxic":[9],"chemotherapy":[10],"agents":[11],"are":[12,170],"somewhat":[13],"overlooked,":[14],"but":[15],"remain":[16],"backbone":[18,51],"treatment":[20,54],"for":[21,55,85,174,188,196],"most":[22],"cancers.":[23],"Patients":[24],"with":[25,87,114,118,155,190],"non-gastrointestinal":[26],"stromal":[27],"tumor":[28],"sarcomas,":[29,89],"such":[30],"as":[31,49,81,214],"leiomyosarcoma,":[32],"liposarcoma,":[33],"and":[34,47,79,90,100,125,131,159,163,182],"undifferentiated":[35,132],"high-grade":[36,133],"pleomorphic":[37,134],"sarcoma":[38],"(formerly":[39],"called":[40],"malignant":[41],"fibrous":[42],"histiocytoma),":[43],"have":[44,72],"received":[45],"doxorubicin":[46],"ifosfamide":[48],"their":[53],"over":[56],"15":[57],"years":[58],"or":[59,110],"more.":[60],"The":[61,102,157,178],"goal":[62],"this":[64,202,242],"article":[65],"is":[66,112,127,137,148,184,219,223,236],"to":[67,74,91,212],"review":[68],"data":[70],"that":[71,221],"led":[73],"use":[76,106],"gemcitabine":[78,124,162,181],"docetaxel":[80,126,164,183,213],"a":[82,215],"useful":[83],"combination":[84,143,179],"patients":[86,117,154,189],"metastatic":[88,119,191],"comment":[92],"on":[93,116],"possible":[94],"synergy":[95,226],"combination.":[98,229],"Methods":[99],"results.":[101],"literature":[103],"regarding":[104],"gemcitabine,":[108],"docetaxel,":[109],"both,":[111],"reviewed,":[113],"emphasis":[115],"sarcoma.":[120,135],"Results.":[121],"Activity":[122],"observed":[128],"in":[129,144,153,166,200],"leiomyosarcoma":[130],"There":[136],"apparent":[138],"schedule":[139,151,160],"dependence":[140],"other":[145],"cancers;":[146],"it":[147,218],"unclear":[149],"if":[150],"matters":[152],"sarcomas.":[156],"dose":[158],"examined":[165],"phase":[167],"II":[168],"studies":[169],"probably":[171],"too":[172],"high":[173],"routine":[175],"practice.":[176],"Conclusions.":[177],"an":[185],"effective":[186],"option":[187],"sarcoma,":[192],"increasing":[193],"armamentarium":[195],"practicing":[198],"oncologist":[199],"treating":[201],"heterogeneous":[203],"group":[204],"diseases.":[206],"Given":[207],"low":[209],"response":[210],"rate":[211],"single":[216],"agent,":[217],"likely":[220],"there":[222],"true":[224],"clinical":[225],"Disclosure":[230],"potential":[232],"conflicts":[233],"interest":[235],"found":[237],"at":[238],"end":[240],"article.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
