{"id":"https://openalex.org/W2139192561","doi":"https://doi.org/10.1254/jphs.93.265","title":"cGMP Inhibits GTP Cyclohydrolase I Activity and Biosynthesis of Tetrahydrobiopterin in Human Umbilical Vein Endothelial Cells","display_name":"cGMP Inhibits GTP Cyclohydrolase I Activity and Biosynthesis of Tetrahydrobiopterin in Human Umbilical Vein Endothelial Cells","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2139192561","doi":"https://doi.org/10.1254/jphs.93.265","mag":"2139192561","pmid":"https://pubmed.ncbi.nlm.nih.gov/14646243"},"language":"en","primary_location":{"id":"doi:10.1254/jphs.93.265","doi":"https://doi.org/10.1254/jphs.93.265","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jphs.93.265","pdf_url":"https://www.jstage.jst.go.jp/article/jphs/93/3/93_3_265/_pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jphs/93/3/93_3_265/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064255737","display_name":"Hiroaki Shiraishi","orcid":"https://orcid.org/0009-0006-0016-631X","observed_orcids":["https://orcid.org/0009-0006-0016-631X"]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Shiraishi","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan","Department of Pharmacology, School of Medicine, Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan","institution_ids":["https://openalex.org/I145673806"]},{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, Fujita Health University","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110140847","display_name":"Taiya Kato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taiya Kato","raw_affiliation_strings":["Department of Internal Medicine, School of Medicine, Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, School of Medicine, Fujita Health University","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078718507","display_name":"Koji Atsuta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Atsuta","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, Fujita Health University","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045052745","display_name":"Chiho Sumi\u2010Ichinose","orcid":"https://orcid.org/0000-0001-5261-0853","observed_orcids":["https://orcid.org/0000-0001-5261-0853"]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chiho Sumi-Ichinose","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, Fujita Health University","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013230217","display_name":"Masatsugu Ohtsuki","orcid":"https://orcid.org/0009-0002-9583-2469","observed_orcids":["https://orcid.org/0009-0002-9583-2469"]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masatsugu Ohtsuki","raw_affiliation_strings":["Department of Internal Medicine, School of Medicine, Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, School of Medicine, Fujita Health University","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109967081","display_name":"Mitsuyasu Itoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuyasu Itoh","raw_affiliation_strings":["Department of Internal Medicine, School of Medicine, Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, School of Medicine, Fujita Health University","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108127462","display_name":"Hitoshi Hishida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitoshi Hishida","raw_affiliation_strings":["Department of Internal Medicine, School of Medicine, Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, School of Medicine, Fujita Health University","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112998704","display_name":"Shin Tada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin Tada","raw_affiliation_strings":["Department of Obstetrics and Gynecology, School of Medicine, Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, School of Medicine, Fujita Health University","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087051417","display_name":"Yasuhiro Udagawa","orcid":"https://orcid.org/0000-0002-0474-9276","observed_orcids":["https://orcid.org/0000-0002-0474-9276"]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Udagawa","raw_affiliation_strings":["Department of Obstetrics and Gynecology, School of Medicine, Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, School of Medicine, Fujita Health University","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004939550","display_name":"Toshiharu Nagatsu","orcid":"https://orcid.org/0000-0002-9216-6029","observed_orcids":["https://orcid.org/0000-0002-9216-6029"]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]},{"id":"https://openalex.org/I4405287432","display_name":"Center for Medical Science, Fujita Health University","ror":"https://ror.org/054he0258","country_code":"JP","type":"facility","lineage":["https://openalex.org/I145673806","https://openalex.org/I4405287432"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiharu Nagatsu","raw_affiliation_strings":["Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University","institution_ids":["https://openalex.org/I145673806","https://openalex.org/I4405287432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108729382","display_name":"Yasumichi Hagino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasumichi Hagino","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, Fujita Health University","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007531407","display_name":"Hiroshi Ichinose","orcid":"https://orcid.org/0000-0001-6008-6860","observed_orcids":["https://orcid.org/0000-0001-6008-6860"]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]},{"id":"https://openalex.org/I4405287432","display_name":"Center for Medical Science, Fujita Health University","ror":"https://ror.org/054he0258","country_code":"JP","type":"facility","lineage":["https://openalex.org/I145673806","https://openalex.org/I4405287432"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Ichinose","raw_affiliation_strings":["Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University","institution_ids":["https://openalex.org/I145673806","https://openalex.org/I4405287432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102172683","display_name":"Takahide Nomura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahide Nomura","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, Fujita Health University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, Fujita Health University","institution_ids":["https://openalex.org/I145673806"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2070,"currency":"USD","value_usd":2070},"apc_paid":null,"fwci":0.9572,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.75734603,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"93","issue":"3","first_page":"265","last_page":"271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.7592999935150146,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.7592999935150146,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.1979999989271164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.8569999933242798},{"id":"https://openalex.org/keywords/gtp-cyclohydrolase-i","display_name":"GTP cyclohydrolase I","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tetrahydrobiopterin-biosynthesis","display_name":"tetrahydrobiopterin biosynthesis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-cofactor","display_name":"nitric oxide synthase cofactor","score":0.8180000185966492},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.765999972820282},{"id":"https://openalex.org/keywords/nitric-oxide-donors","display_name":"nitric oxide donors","score":0.8040000200271606},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8679999709129333},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5630000233650208},{"id":"https://openalex.org/keywords/8-bromo-cgmp","display_name":"8-bromo-cGMP","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cptio","display_name":"cPTIO","score":0.800000011920929},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C2776145790","wikidata":"https://www.wikidata.org/wiki/Q419808","display_name":"Tetrahydrobiopterin","level":4,"score":0.8667941689491272},{"id":"https://openalex.org/C2775956414","wikidata":"https://www.wikidata.org/wiki/Q1487359","display_name":"GTP cyclohydrolase I","level":5,"score":0.8373159766197205},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.5906646251678467},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5801274180412292},{"id":"https://openalex.org/C2779610285","wikidata":"https://www.wikidata.org/wiki/Q27108300","display_name":"Sodium nitroprusside","level":3,"score":0.5628430247306824},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5522397756576538},{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.4824300706386566},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45257845520973206},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.45053455233573914},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.4314592480659485},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.41077545285224915},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.41006237268447876},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.1957833468914032},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.150623619556427},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001708","descriptor_name":"Biopterins","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D001708","descriptor_name":"Biopterins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006136","descriptor_name":"GTP Cyclohydrolase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D006136","descriptor_name":"GTP Cyclohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1254/jphs.93.265","doi":"https://doi.org/10.1254/jphs.93.265","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jphs.93.265","pdf_url":"https://www.jstage.jst.go.jp/article/jphs/93/3/93_3_265/_pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},{"id":"pmid:14646243","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14646243","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmacological sciences","raw_type":"Comparative Study"},{"id":"pmh:oai:doaj.org/article:65a0a2ec34a74d11950d7056fb8babfb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/65a0a2ec34a74d11950d7056fb8babfb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pharmacological Sciences, Vol 93, Iss 3, Pp 265-271 (2003)","raw_type":"article"},{"id":"pmh:oai:irdb.nii.ac.jp:00897:0003960860","doi":null,"is_oa":false,"landing_page_url":"http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100706848","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal article"},{"id":"pmh:oai:t2r2.star.titech.ac.jp:50309596","doi":null,"is_oa":false,"landing_page_url":"http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100706848","pdf_url":null,"source":{"id":"https://openalex.org/S4377196385","display_name":"Tokyo Tech Research Repository (Tokyo Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114531698","host_organization_name":"Tokyo Institute of Technology","host_organization_lineage":["https://openalex.org/I114531698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1254/jphs.93.265","doi":"https://doi.org/10.1254/jphs.93.265","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jphs.93.265","pdf_url":"https://www.jstage.jst.go.jp/article/jphs/93/3/93_3_265/_pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324750","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139192561.pdf","grobid_xml":"https://content.openalex.org/works/W2139192561.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W133994298","https://openalex.org/W623570351","https://openalex.org/W1493899800","https://openalex.org/W1496789829","https://openalex.org/W1573614933","https://openalex.org/W1675755394","https://openalex.org/W1849664627","https://openalex.org/W1967950800","https://openalex.org/W1971377175","https://openalex.org/W1972668150","https://openalex.org/W1980766453","https://openalex.org/W1982581996","https://openalex.org/W1986330406","https://openalex.org/W1993069143","https://openalex.org/W1994911436","https://openalex.org/W1995658147","https://openalex.org/W1997201100","https://openalex.org/W2022699060","https://openalex.org/W2023947131","https://openalex.org/W2028289811","https://openalex.org/W2029137272","https://openalex.org/W2032359335","https://openalex.org/W2044941841","https://openalex.org/W2060152496","https://openalex.org/W2060717747","https://openalex.org/W2071186420","https://openalex.org/W2078538542","https://openalex.org/W2079182225","https://openalex.org/W2093774938","https://openalex.org/W2094309129","https://openalex.org/W2095080894","https://openalex.org/W2105713194","https://openalex.org/W2107947903","https://openalex.org/W2128399345","https://openalex.org/W2128635872","https://openalex.org/W2157603347","https://openalex.org/W2213248838","https://openalex.org/W2416247742"],"related_works":["https://openalex.org/W1496789829","https://openalex.org/W2157301630","https://openalex.org/W2141653095","https://openalex.org/W2112129182","https://openalex.org/W1972816103","https://openalex.org/W1994135664","https://openalex.org/W2417305702","https://openalex.org/W2117314504","https://openalex.org/W1001919356","https://openalex.org/W44005688"],"abstract_inverted_index":{"Tetrahydrobiopterin":[0],"(BH4)":[1],"acts":[2],"as":[3],"an":[4,82,128],"essential":[5],"cofactor":[6,19],"for":[7],"the":[8,18,38,48,68,78,93,103,113,125,143,151,166,179],"enzymatic":[9,27],"activity":[10,55,76,91,111,121,173],"of":[11,17,37,50,67,118,127,156,165,178],"nitric":[12],"oxide":[13],"(NO)":[14],"synthases.":[15],"Biosynthesis":[16],"BH4":[20],"starts":[21],"from":[22],"GTP":[23,31],"and":[24,40,99,107],"requires":[25],"3":[26],"steps,":[28],"which":[29],"include":[30],"cyclohydrolase":[32],"I":[33,54,75,90,110,120,139,158,172,181],"(GCH":[34],"I)":[35],"catalysis":[36],"first":[39],"rate-limiting":[41],"step.":[42],"In":[43],"this":[44],"study":[45],"we":[46],"examined":[47],"effects":[49],"cGMP":[51,69,105,167],"on":[52,88,137],"GCH":[53,74,89,109,119,138,157,171,180],"in":[56,77,112,124,142],"human":[57],"umbilical":[58],"vein":[59],"endothelial":[60],"cells":[61],"under":[62,92],"inflammatory":[63],"conditions.":[64],"Exogenous":[65],"application":[66],"analogue":[70,84],"8-bromo-cGMP":[71],"markedly":[72],"inhibited":[73],"short":[79,114,144],"term,":[80],"whereas":[81],"cAMP":[83],"had":[85,134],"no":[86,135],"effect":[87,136],"same":[94],"condition.":[95],"NO":[96,129,132,154],"donors,":[97],"NOR3":[98],"sodium":[100],"nitroprusside,":[101],"elevated":[102],"intracellular":[104],"level":[106],"reduced":[108],"term.":[115,145],"This":[116],"inhibition":[117,152],"was":[122],"obliterated":[123],"presence":[126],"trapper":[130],"carboxy-PTIO.":[131],"donors":[133,155],"mRNA":[140],"expression":[141],"Moreover,":[146],"cycloheximide":[147],"did":[148],"not":[149],"alter":[150],"by":[153],"activity.":[159],"These":[160],"findings":[161],"suggest":[162],"that":[163],"stimulation":[164],"signaling":[168],"cascade":[169],"down-regulates":[170],"through":[174],"post":[175],"translational":[176],"modification":[177],"enzyme.":[182]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}