{"id":"https://openalex.org/W2139191414","doi":"https://doi.org/10.1530/eje.0.1410035","title":"Protective effect of dehydroepiandrosterone against lipid peroxidation in a human liver cell line","display_name":"Protective effect of dehydroepiandrosterone against lipid peroxidation in a human liver cell line","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W2139191414","doi":"https://doi.org/10.1530/eje.0.1410035","mag":"2139191414","pmid":"https://pubmed.ncbi.nlm.nih.gov/10407220"},"language":"en","primary_location":{"id":"doi:10.1530/eje.0.1410035","doi":"https://doi.org/10.1530/eje.0.1410035","is_oa":false,"landing_page_url":"https://doi.org/10.1530/eje.0.1410035","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026404310","display_name":"Marco Gallo","orcid":"https://orcid.org/0000-0001-7166-0848","observed_orcids":["https://orcid.org/0000-0001-7166-0848","https://orcid.org/0009-0003-3129-3176"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Gallo","raw_affiliation_strings":["Department of Clinical Pathophysiology, University of Turin, Via Genova 3, 10126 Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathophysiology, University of Turin, Via Genova 3, 10126 Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014865083","display_name":"Manuela Aragno","orcid":"https://orcid.org/0000-0002-0453-5235","observed_orcids":["https://orcid.org/0000-0002-0453-5235"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Aragno","raw_affiliation_strings":["Department of Clinical Pathophysiology, University of Turin, Via Genova 3, 10126 Turin, Italy","Department of Experimental Medicine and Oncology, General Pathology Section, University of Turin, C.so Raffaello 30, 10125 Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathophysiology, University of Turin, Via Genova 3, 10126 Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Department of Experimental Medicine and Oncology, General Pathology Section, University of Turin, C.so Raffaello 30, 10125 Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026288588","display_name":"Valentina Gatto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"V Gatto","raw_affiliation_strings":["Department of Clinical Pathophysiology, University of Turin, Via Genova 3, 10126 Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathophysiology, University of Turin, Via Genova 3, 10126 Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020038037","display_name":"Elena Tamagno","orcid":"https://orcid.org/0000-0003-2817-2835","observed_orcids":["https://orcid.org/0000-0003-2817-2835"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E Tamagno","raw_affiliation_strings":["Department of Clinical Pathophysiology, University of Turin, Via Genova 3, 10126 Turin, Italy","Department of Experimental Medicine and Oncology, General Pathology Section, University of Turin, C.so Raffaello 30, 10125 Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathophysiology, University of Turin, Via Genova 3, 10126 Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Department of Experimental Medicine and Oncology, General Pathology Section, University of Turin, C.so Raffaello 30, 10125 Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090812795","display_name":"Enrico Brignardello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E Brignardello","raw_affiliation_strings":["Department of Clinical Pathophysiology, University of Turin, Via Genova 3, 10126 Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathophysiology, University of Turin, Via Genova 3, 10126 Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001050579","display_name":"Roberta Manti","orcid":"https://orcid.org/0009-0005-3443-8603","observed_orcids":["https://orcid.org/0009-0005-3443-8603"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R Manti","raw_affiliation_strings":["Department of Clinical Pathophysiology, University of Turin, Via Genova 3, 10126 Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathophysiology, University of Turin, Via Genova 3, 10126 Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018676412","display_name":"Oliviero Danni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"O Danni","raw_affiliation_strings":["Department of Clinical Pathophysiology, University of Turin, Via Genova 3, 10126 Turin, Italy","Department of Experimental Medicine and Oncology, General Pathology Section, University of Turin, C.so Raffaello 30, 10125 Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathophysiology, University of Turin, Via Genova 3, 10126 Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Department of Experimental Medicine and Oncology, General Pathology Section, University of Turin, C.so Raffaello 30, 10125 Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111946673","display_name":"Giuseppe Boccuzzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"G Boccuzzi","raw_affiliation_strings":["Department of Clinical Pathophysiology, University of Turin, Via Genova 3, 10126 Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathophysiology, University of Turin, Via Genova 3, 10126 Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111946673"],"corresponding_institution_ids":["https://openalex.org/I55143463"],"apc_list":{"value":3798,"currency":"EUR","value_usd":4292},"apc_paid":null,"fwci":0.9475,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.68637654,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"141","issue":"1","first_page":"35","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dehydroepiandrosterone","display_name":"dehydroepiandrosterone","score":1.0},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.996999979019165},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.6660000085830688},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cumene","display_name":"cumene","score":0.699999988079071},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.6639999747276306},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.6980000138282776},{"id":"https://openalex.org/keywords/chang-liver-cells","display_name":"Chang liver cells","score":0.7099999785423279},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.5809999704360962},{"id":"https://openalex.org/keywords/thiobarbituric-acid-reactive-substances","display_name":"TBARS","score":0.8119999766349792},{"id":"https://openalex.org/keywords/steroid-hormones","display_name":"steroid hormones","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.8672105073928833},{"id":"https://openalex.org/C2777352226","wikidata":"https://www.wikidata.org/wiki/Q7669516","display_name":"TBARS","level":4,"score":0.7869406938552856},{"id":"https://openalex.org/C2776992908","wikidata":"https://www.wikidata.org/wiki/Q408376","display_name":"Dehydroepiandrosterone","level":4,"score":0.774219274520874},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7446220517158508},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7157297134399414},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6515138149261475},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.564595103263855},{"id":"https://openalex.org/C2777504301","wikidata":"https://www.wikidata.org/wiki/Q418230","display_name":"Thiobarbituric acid","level":4,"score":0.5594517588615417},{"id":"https://openalex.org/C2778113725","wikidata":"https://www.wikidata.org/wiki/Q414439","display_name":"Cumene hydroperoxide","level":3,"score":0.5227301716804504},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.47674262523651123},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.46971243619918823},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4101272225379944},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3543979525566101},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.21820127964019775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17205524444580078},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.14753657579421997},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10635802149772644},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0924949049949646},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003687","descriptor_name":"Dehydroepiandrosterone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003687","descriptor_name":"Dehydroepiandrosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014343","descriptor_name":"Trypan Blue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017392","descriptor_name":"Thiobarbituric Acid Reactive Substances","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1530/eje.0.1410035","doi":"https://doi.org/10.1530/eje.0.1410035","is_oa":false,"landing_page_url":"https://doi.org/10.1530/eje.0.1410035","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:10407220","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10407220","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.507.4076","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.507.4076","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.eje.org/content/141/1/35.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.883.9216","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.883.9216","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Manuela_Aragno/publication/12892624_Protective_effect_of_dehydroepiandrosterone_against_lipid_peroxidation_in_a_human_liver_cell_line/links/0c960515c035592d9f000000.pdf","raw_type":"text"},{"id":"pmh:oai:iris.unito.it:2318/38118","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/38118","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W94681228","https://openalex.org/W137236905","https://openalex.org/W173619687","https://openalex.org/W1487270545","https://openalex.org/W1491664534","https://openalex.org/W1576830910","https://openalex.org/W1828279030","https://openalex.org/W1969216468","https://openalex.org/W1980629930","https://openalex.org/W1984770458","https://openalex.org/W1986480120","https://openalex.org/W1986597145","https://openalex.org/W1992796056","https://openalex.org/W1995385187","https://openalex.org/W1997847266","https://openalex.org/W1998106197","https://openalex.org/W1998235342","https://openalex.org/W2005951019","https://openalex.org/W2010980830","https://openalex.org/W2015424714","https://openalex.org/W2029673044","https://openalex.org/W2030434244","https://openalex.org/W2032442742","https://openalex.org/W2034566257","https://openalex.org/W2049634154","https://openalex.org/W2059683712","https://openalex.org/W2060693165","https://openalex.org/W2062088318","https://openalex.org/W2063767993","https://openalex.org/W2082218696","https://openalex.org/W2083374585","https://openalex.org/W2094493191","https://openalex.org/W2106378155","https://openalex.org/W2117610041","https://openalex.org/W2128981238","https://openalex.org/W2130095506","https://openalex.org/W2130267710","https://openalex.org/W2131117148","https://openalex.org/W2169422711","https://openalex.org/W2335537724","https://openalex.org/W2399629054","https://openalex.org/W2956440974"],"related_works":["https://openalex.org/W7098694720","https://openalex.org/W7098476906","https://openalex.org/W2005951019","https://openalex.org/W2060693165","https://openalex.org/W2064418467","https://openalex.org/W2588738454","https://openalex.org/W2053347111","https://openalex.org/W2322129270","https://openalex.org/W2055116762","https://openalex.org/W2047350902"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Dehydroepiandrosterone":[1],"(DHEA)":[2],"is":[3,169,219,237],"a":[4,72,108,179,241],"widely":[5],"studied":[6],"steroid":[7],"hormone":[8],"with":[9],"multi-functional":[10],"properties.":[11],"Reports":[12],"suggest":[13],"that":[14,225],"some":[15],"of":[16,20,35,41,182,216,224,232],"the":[17,32,39,58,167,213],"many":[18],"activities":[19],"DHEA":[21,36,89,150,183,186,217,233],"are":[22,37],"due":[23],"to":[24,46,96,147,171,201,204],"its":[25,49,196],"protective":[26],"effect":[27,164,181,231],"against":[28,155],"lipid":[29,54,156,192,235],"peroxidation.":[30],"Nevertheless,":[31],"antioxidant":[33,228],"properties":[34],"still":[38],"subject":[40],"debate.":[42],"The":[43,208],"aim":[44],"was":[45],"evaluate":[47],"whether":[48],"two":[50,188],"opposed":[51,189],"effects":[52,190],"on":[53,63,191,195,234],"peroxidation":[55,157,236],"reported":[56],"in":[57,81,222],"literature":[59],"may":[60],"be":[61],"dependent":[62],"schedule":[64],"and":[65,105,124,129],"doses":[66],"used.":[67],"METHODS:":[68],"Chang":[69,152],"liver":[70,153],"cells,":[71],"line":[73],"derived":[74],"from":[75,93,144],"normal":[76],"human":[77],"liver,":[78],"were":[79,103,138],"grown":[80],"media":[82],"containing":[83],"either":[84,200],"no":[85],"steroids":[86],"(control)":[87],"or":[88,203],"at":[90,115,174,211],"concentrations":[91,142,176],"ranging":[92,143],"0.1":[94,145],"micromol/l":[95,146],"50":[97],"micromol/l.":[98],"At":[99,141],"specific":[100],"times,":[101],"cultures":[102],"halted":[104],"cells":[106,154],"received":[107],"pro-oxidant":[109,214],"stimulus":[110],"(cumene":[111],"(CuOOH)":[112],"0.5":[113],"mmol/l),":[114],"which":[116,212],"time":[117],"cell":[118],"viability":[119],"(by":[120],"trypan":[121],"blue":[122],"staining":[123],"lactate":[125],"dehydrogenase":[126],"(LDH)":[127],"release)":[128],"thiobarbituric":[130],"acid":[131],"reactive":[132],"substances":[133],"(TBARS)":[134],"concentration":[135,168,197,210],"(spectrophotometrical":[136],"assay)":[137],"evaluated.":[139],"RESULTS:":[140],"1":[148],"micromol/l,":[149],"protects":[151],"and/or":[158],"death":[159],"induced":[160],"by":[161],"cumene.":[162],"This":[163],"disappears":[165],"if":[166],"increased":[170],"10":[172],"micromol/l;":[173],"higher":[175],"(50":[177],"micromol/l)":[178],"pro-oxidant/cytotoxic":[180],"appears.":[184],"CONCLUSIONS:":[185],"exhibits":[187],"peroxidation;":[193],"depending":[194],"it":[198],"acts":[199],"limit":[202],"induce":[205],"oxidative":[206],"stress.":[207],"threshold":[209],"activity":[215],"prevails":[218],"not":[220],"far":[221],"excess":[223],"having":[226],"an":[227],"effect.":[229],"Either":[230],"only":[238],"evident":[239],"after":[240],"'lag-phase'.":[242]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
