{"id":"https://openalex.org/W2139186150","doi":"https://doi.org/10.1002/(sici)1521-1878(199803)20:3<200::aid-bies3>3.0.co;2-v","title":"Conditional genome alteration in mice","display_name":"Conditional genome alteration in mice","publication_year":1998,"publication_date":"1998-12-06","ids":{"openalex":"https://openalex.org/W2139186150","doi":"https://doi.org/10.1002/(sici)1521-1878(199803)20:3<200::aid-bies3>3.0.co;2-v","mag":"2139186150","pmid":"https://pubmed.ncbi.nlm.nih.gov/9631647"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1521-1878(199803)20:3<200::aid-bies3>3.0.co;2-v","doi":"https://doi.org/10.1002/(sici)1521-1878(199803)20:3<200::aid-bies3>3.0.co;2-v","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1521-1878(199803)20:3<200::aid-bies3>3.0.co;2-v","pdf_url":null,"source":{"id":"https://openalex.org/S27819959","display_name":"BioEssays","issn_l":"0265-9247","issn":["0265-9247","1521-1878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112865921","display_name":"Corrinne G. Lobe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Corrinne G. Lobe","raw_affiliation_strings":["Division of Cancer Biology Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada","Department of Medical Biophysics, University of Toronto, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Biology Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1323843004"]},{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011105258","display_name":"Andr\u00e1s Nagy","orcid":"https://orcid.org/0000-0003-4311-0413","observed_orcids":["https://orcid.org/0000-0003-4311-0413"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Andras Nagy","raw_affiliation_strings":["Department of Molecular and Medical Genetics, University of Toronto, Toronto, Canada","Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada","Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Genetics, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]},{"raw_affiliation_string":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5011105258"],"corresponding_institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I185261750","https://openalex.org/I210557978"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":1.3451,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.77137871,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"3","first_page":"200","last_page":"208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.10499999672174454,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/conditional-knockout","display_name":"conditional knockout","score":0.7950000166893005},{"id":"https://openalex.org/keywords/spatial-and-temporal-gene-regulation","display_name":"spatial and temporal gene regulation","score":0.6000000238418579},{"id":"https://openalex.org/keywords/genetic-redundancy","display_name":"gene redundancy","score":0.6460000276565552},{"id":"https://openalex.org/keywords/functional-redundancy","display_name":"functional redundancy","score":0.5230000019073486},{"id":"https://openalex.org/keywords/gene-inactivation","display_name":"gene inactivation","score":0.4830000102519989},{"id":"https://openalex.org/keywords/chimeric-mice","display_name":"chimeric mice","score":0.6209999918937683},{"id":"https://openalex.org/keywords/complementation-tests","display_name":"complementation assay","score":0.7559999823570251},{"id":"https://openalex.org/keywords/dominant-negative-mutant","display_name":"dominant-negative mutant","score":0.984000027179718},{"id":"https://openalex.org/keywords/mouse-genetics","display_name":"mouse genetics","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7808502316474915},{"id":"https://openalex.org/C77957584","wikidata":"https://www.wikidata.org/wiki/Q1133550","display_name":"Gene knockout","level":3,"score":0.6828457713127136},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6706265807151794},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5834029316902161},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.5808522701263428},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5640928745269775},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5629758238792419},{"id":"https://openalex.org/C30278631","wikidata":"https://www.wikidata.org/wiki/Q281721","display_name":"Chimera (genetics)","level":3,"score":0.4792454242706299},{"id":"https://openalex.org/C164659718","wikidata":"https://www.wikidata.org/wiki/Q5159266","display_name":"Conditional gene knockout","level":4,"score":0.4101075828075409},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.32433366775512695},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.11916515231132507}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002678","descriptor_name":"Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005821","descriptor_name":"Genetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030342","descriptor_name":"Genetic Diseases, Inborn","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1521-1878(199803)20:3<200::aid-bies3>3.0.co;2-v","doi":"https://doi.org/10.1002/(sici)1521-1878(199803)20:3<200::aid-bies3>3.0.co;2-v","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1521-1878(199803)20:3<200::aid-bies3>3.0.co;2-v","pdf_url":null,"source":{"id":"https://openalex.org/S27819959","display_name":"BioEssays","issn_l":"0265-9247","issn":["0265-9247","1521-1878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays","raw_type":"journal-article"},{"id":"pmid:9631647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9631647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays : news and reviews in molecular, cellular and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.600.4365","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.600.4365","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://biolog-e.ls.biu.ac.il/faculty/wides/80-855/lobeandnagy.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W16534552","https://openalex.org/W221180449","https://openalex.org/W330935414","https://openalex.org/W1041182074","https://openalex.org/W1204884779","https://openalex.org/W1538796191","https://openalex.org/W1545372895","https://openalex.org/W1840467085","https://openalex.org/W1856781683","https://openalex.org/W1922337323","https://openalex.org/W1965131212","https://openalex.org/W1966697925","https://openalex.org/W1966897395","https://openalex.org/W1967071065","https://openalex.org/W1967287827","https://openalex.org/W1972249453","https://openalex.org/W1980110416","https://openalex.org/W1984684498","https://openalex.org/W2001675603","https://openalex.org/W2002316686","https://openalex.org/W2006853643","https://openalex.org/W2007414034","https://openalex.org/W2010778459","https://openalex.org/W2012160343","https://openalex.org/W2017599618","https://openalex.org/W2019156031","https://openalex.org/W2036314272","https://openalex.org/W2038970416","https://openalex.org/W2041799836","https://openalex.org/W2045247659","https://openalex.org/W2048139403","https://openalex.org/W2054210423","https://openalex.org/W2054323447","https://openalex.org/W2055568103","https://openalex.org/W2056388065","https://openalex.org/W2058528119","https://openalex.org/W2061116292","https://openalex.org/W2063367127","https://openalex.org/W2067194336","https://openalex.org/W2069022895","https://openalex.org/W2072984471","https://openalex.org/W2074249987","https://openalex.org/W2077452186","https://openalex.org/W2079749432","https://openalex.org/W2081978633","https://openalex.org/W2082557203","https://openalex.org/W2084033631","https://openalex.org/W2085033687","https://openalex.org/W2086176700","https://openalex.org/W2086764321","https://openalex.org/W2092543937","https://openalex.org/W2096386031","https://openalex.org/W2104526708","https://openalex.org/W2111399322","https://openalex.org/W2126464081","https://openalex.org/W2133659563","https://openalex.org/W2137742613","https://openalex.org/W2146150145","https://openalex.org/W2160446640","https://openalex.org/W2163307259","https://openalex.org/W2166694150","https://openalex.org/W2166697185","https://openalex.org/W2169466938","https://openalex.org/W2404894647","https://openalex.org/W4299999786","https://openalex.org/W6632136564"],"related_works":["https://openalex.org/W2009603525","https://openalex.org/W2099823282","https://openalex.org/W2914325411","https://openalex.org/W2050049123","https://openalex.org/W4388386554","https://openalex.org/W2114622743","https://openalex.org/W3151628216","https://openalex.org/W203211499","https://openalex.org/W2434320056","https://openalex.org/W4244132810"],"abstract_inverted_index":{"The":[0],"recent":[1],"ability":[2,28],"to":[3,93,133,143],"inactivate":[4],"specific":[5],"genes":[6,43],"in":[7,38,40,44],"mice":[8],"has":[9,29,60,126,139],"significantly":[10],"accelerated":[11],"our":[12],"understanding":[13],"of":[14,21,35,65,75,87],"molecular,":[15],"cellular,":[16],"and":[17,23,54,84,96,107,120],"even":[18],"behavioral":[19],"aspects":[20],"normal":[22],"disease":[24],"processes.":[25],"However,":[26],"this":[27,79,127],"also":[30],"demonstrated":[31],"the":[32,45,100,141],"extreme":[33],"complexity":[34],"genetic":[36,150],"determination":[37],"mammals,":[39],"particular,":[41],"that":[42,55],"same":[46],"family":[47],"or":[48],"pathway":[49],"can":[50],"be":[51],"functionally":[52],"redundant":[53],"a":[56,66],"given":[57],"gene":[58,67,118,122],"often":[59,68],"multiple":[61],"roles.":[62],"Thus,":[63],"inactivation":[64],"does":[69],"not":[70],"indicate":[71],"its":[72],"complete":[73],"spectrum":[74],"functions.":[76],"To":[77],"circumvent":[78],"problem,":[80],"many":[81],"new":[82],"tools":[83],"novel":[85],"applications":[86],"classic":[88],"techniques":[89],"have":[90],"been":[91],"developed":[92],"place":[94],"spatial":[95],"temporal":[97],"restrictions":[98],"on":[99],"genomic":[101,135],"alterations.":[102],"These":[103],"approaches":[104],"include":[105],"chimera":[106],"mosaic":[108],"studies,":[109],"organ":[110],"transplantation,":[111],"complementation":[112],"assays,":[113],"dominant":[114],"negative":[115],"mutants,":[116],"conditional":[117],"knockouts,":[119],"lineage-specific":[121],"rescue.":[123],"Not":[124],"only":[125],"opened":[128],"up":[129],"more":[130],"sophisticated":[131],"ways":[132],"make":[134],"alterations,":[136],"but":[137],"it":[138],"provided":[140],"opportunity":[142],"create":[144],"animal":[145],"models":[146],"for":[147],"sporadic":[148],"human":[149],"diseases.":[151]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
