{"id":"https://openalex.org/W2139183922","doi":"https://doi.org/10.1542/peds.106.2.311","title":"High-Dose Albuterol by Metered-Dose Inhaler Plus a Spacer Device Versus Nebulization in Preschool Children With Recurrent Wheezing: A Double-Blind, Randomized Equivalence Trial","display_name":"High-Dose Albuterol by Metered-Dose Inhaler Plus a Spacer Device Versus Nebulization in Preschool Children With Recurrent Wheezing: A Double-Blind, Randomized Equivalence Trial","publication_year":2000,"publication_date":"2000-08-01","ids":{"openalex":"https://openalex.org/W2139183922","doi":"https://doi.org/10.1542/peds.106.2.311","mag":"2139183922","pmid":"https://pubmed.ncbi.nlm.nih.gov/10920157"},"language":"en","primary_location":{"id":"doi:10.1542/peds.106.2.311","doi":"https://doi.org/10.1542/peds.106.2.311","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.106.2.311","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086090481","display_name":"Dominique Ploin","orcid":"https://orcid.org/0000-0002-9668-7606","observed_orcids":["https://orcid.org/0000-0002-9668-7606"]},"institutions":[{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210119578","display_name":"H\u00f4pital Debrousse","ror":"https://ror.org/02cc58y38","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210119578"]},{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dominique Ploin","raw_affiliation_strings":["From the Service d'Urgence et de Re\u0301animation Pe\u0301diatrique, Ho\u0302pital Edouard Herriot, Hospices Civils, Lyon, France;","Unite\u0301 d'Accueil des Urgences Pe\u0301diatriques, Ho\u0302pital Debrousse, Hospices Civils, Lyon, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Service d'Urgence et de Re\u0301animation Pe\u0301diatrique, Ho\u0302pital Edouard Herriot, Hospices Civils, Lyon, France;","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]},{"raw_affiliation_string":"Unite\u0301 d'Accueil des Urgences Pe\u0301diatriques, Ho\u0302pital Debrousse, Hospices Civils, Lyon, France;","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210119578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108832705","display_name":"Fran\u00e7ois R. Chapuis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Franc\u0327ois R. Chapuis","raw_affiliation_strings":["Unite\u0301 de Recherche Clinique, De\u0301partement d'Information Me\u0301dicale, Hospices Civils, Lyon, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite\u0301 de Recherche Clinique, De\u0301partement d'Information Me\u0301dicale, Hospices Civils, Lyon, France;","institution_ids":["https://openalex.org/I4210100596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113502339","display_name":"Didier Stamm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Didier Stamm","raw_affiliation_strings":["From the Service d'Urgence et de Re\u0301animation Pe\u0301diatrique, Ho\u0302pital Edouard Herriot, Hospices Civils, Lyon, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Service d'Urgence et de Re\u0301animation Pe\u0301diatrique, Ho\u0302pital Edouard Herriot, Hospices Civils, Lyon, France;","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010913328","display_name":"Jacques Robert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jacques Robert","raw_affiliation_strings":["63 Bis rue de la Re\u0301publique, F-69150 De\u0301cines Charpieu, France;","De\u0301partement de Pe\u0301diatrie, Ho\u0302pital Edouard Herriot, Hospices Civils, Lyon, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"63 Bis rue de la Re\u0301publique, F-69150 De\u0301cines Charpieu, France;","institution_ids":[]},{"raw_affiliation_string":"De\u0301partement de Pe\u0301diatrie, Ho\u0302pital Edouard Herriot, Hospices Civils, Lyon, France; and","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107446606","display_name":"Louis David","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Louis David","raw_affiliation_strings":["De\u0301partement de Pe\u0301diatrie, Ho\u0302pital Edouard Herriot, Hospices Civils, Lyon, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"De\u0301partement de Pe\u0301diatrie, Ho\u0302pital Edouard Herriot, Hospices Civils, Lyon, France; and","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pierre G. Chatelain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210119578","display_name":"H\u00f4pital Debrousse","ror":"https://ror.org/02cc58y38","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210119578"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre G. Chatelain","raw_affiliation_strings":["Unite\u0301 d'Accueil des Urgences Pe\u0301diatriques, Ho\u0302pital Debrousse, Hospices Civils, Lyon, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite\u0301 d'Accueil des Urgences Pe\u0301diatriques, Ho\u0302pital Debrousse, Hospices Civils, Lyon, France;","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210119578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057626811","display_name":"Guy Dutau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146666","display_name":"H\u00f4pital des Enfants","ror":"https://ror.org/044hb6b32","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210146666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guy Dutau","raw_affiliation_strings":["Service de Pneumologie-Allergologie Pe\u0301diatrique, Ho\u0302pital des Enfants, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Pneumologie-Allergologie Pe\u0301diatrique, Ho\u0302pital des Enfants, Toulouse, France","institution_ids":["https://openalex.org/I4210146666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113603452","display_name":"Daniel Floret","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daniel Floret","raw_affiliation_strings":["From the Service d'Urgence et de Re\u0301animation Pe\u0301diatrique, Ho\u0302pital Edouard Herriot, Hospices Civils, Lyon, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Service d'Urgence et de Re\u0301animation Pe\u0301diatrique, Ho\u0302pital Edouard Herriot, Hospices Civils, Lyon, France;","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.199,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.93939394,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"106","issue":"2","first_page":"311","last_page":"317"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.36469998955726624,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13770","display_name":"Pediatric health and respiratory diseases","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salbutamol","display_name":"salbutamol","score":0.9629999995231628},{"id":"https://openalex.org/keywords/spacers","display_name":"spacers","score":0.8349999785423279},{"id":"https://openalex.org/keywords/metered-dose-inhaler","display_name":"MDI","score":0.9430000185966492},{"id":"https://openalex.org/keywords/nebulization","display_name":"nebulization","score":0.9760000109672546},{"id":"https://openalex.org/keywords/recurrent-wheezing","display_name":"recurrent wheezing","score":0.8610000014305115},{"id":"https://openalex.org/keywords/preschool-children","display_name":"preschool children","score":0.7639999985694885},{"id":"https://openalex.org/keywords/bronchodilator-delivery","display_name":"bronchodilator delivery","score":0.8410000205039978},{"id":"https://openalex.org/keywords/treatment-acceptability","display_name":"treatment acceptability","score":0.6690000295639038},{"id":"https://openalex.org/keywords/pediatric-emergency-care","display_name":"pediatric emergency care","score":0.7480000257492065},{"id":"https://openalex.org/keywords/treatment-equivalence","display_name":"treatment equivalence","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9418742656707764},{"id":"https://openalex.org/C2780667556","wikidata":"https://www.wikidata.org/wiki/Q16897784","display_name":"Metered-dose inhaler","level":4,"score":0.8711216449737549},{"id":"https://openalex.org/C2780352487","wikidata":"https://www.wikidata.org/wiki/Q2281580","display_name":"Nebulizer","level":2,"score":0.8319596648216248},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.7485408186912537},{"id":"https://openalex.org/C2780261241","wikidata":"https://www.wikidata.org/wiki/Q1394363","display_name":"Inhaler","level":3,"score":0.7415370941162109},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6364749073982239},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5323868989944458},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.49508562684059143},{"id":"https://openalex.org/C2777394947","wikidata":"https://www.wikidata.org/wiki/Q410358","display_name":"Salbutamol","level":3,"score":0.4941597282886505},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.47831180691719055},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.39420005679130554},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.34158530831336975},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.16297456622123718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1388419270515442}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009330","descriptor_name":"Nebulizers and Vaporizers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012135","descriptor_name":"Respiratory Sounds","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013810","descriptor_name":"Therapeutic Equivalency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1542/peds.106.2.311","doi":"https://doi.org/10.1542/peds.106.2.311","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.106.2.311","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},{"id":"pmid:10920157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10920157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W103650626","https://openalex.org/W387031605","https://openalex.org/W1873740596","https://openalex.org/W1973417040","https://openalex.org/W1980923839","https://openalex.org/W1998698913","https://openalex.org/W2020580216","https://openalex.org/W2047417898","https://openalex.org/W2054805201","https://openalex.org/W2064182390","https://openalex.org/W2067871119","https://openalex.org/W2093272023","https://openalex.org/W2113480650","https://openalex.org/W2129327022","https://openalex.org/W2136594758","https://openalex.org/W2153086068","https://openalex.org/W2169489631","https://openalex.org/W4243182330"],"related_works":["https://openalex.org/W2165272918","https://openalex.org/W7095580319","https://openalex.org/W1973769036","https://openalex.org/W2019147895","https://openalex.org/W2169489631","https://openalex.org/W2074256742","https://openalex.org/W2012245125","https://openalex.org/W2028163296","https://openalex.org/W3085328663","https://openalex.org/W2074134800"],"abstract_inverted_index":{"UNLABELLED:":[0],"Inhaled":[1],"albuterol":[2,57,193,211,232],"is":[3,14],"the":[4,15,39,93,100,134,140,159,173,195,214,222,235],"most":[5],"frequently":[6],"used":[7],"bronchodilator":[8],"for":[9,56,139,248],"acute":[10,82],"wheezing,":[11],"and":[12,34,37,53,104,124,150,155,200],"nebulization":[13],"standard":[16],"mode":[17],"of":[18,121,133,172,192,210,221,231],"delivery":[19],"in":[20,144,158,176,182,241],"hospital":[21,242],"setting.":[22],"However,":[23],"recent":[24],"guidelines":[25],"consider":[26],"spacer":[27,51,94,196,215,236],"devices":[28],"as":[29,245],"an":[30],"easier":[31,198],"to":[32,78,186,219],"use,":[33,122],"cost-saving":[35],"alternative":[36],"recommend":[38],"high-dose":[40],"metered-dose":[41],"inhaler":[42],"bronchodilator.":[43],"OBJECTIVE:":[44],"To":[45],"demonstrate":[46],"clinical":[47],"equivalence":[48,64,160],"between":[49,136,148],"a":[50,54,113],"device":[52,95,197,216,237],"nebulizer":[55,101],"administration.":[58],"DESIGN:":[59],"Randomized,":[60],"double-blind,":[61],"parallel":[62],"group":[63,184],"trial.":[65],"SETTING:":[66],"Pediatric":[67],"emergency":[68,243],"wards":[69],"at":[70,108],"2":[71],"tertiary":[72],"teaching":[73],"hospitals.":[74],"PATIENTS:":[75],"Sixty-four":[76],"12-":[77],"60-month-old":[79],"children":[80,174,205],"with":[81,167],"recurrent":[83],"wheezing":[84],"(32":[85],"per":[86],"group).":[87],"INTERVENTIONS:":[88],"Albuterol":[89],"was":[90,152,156,217],"administered":[91,212,233],"through":[92,99,234],"(50":[96],"microg/kg)":[97,103],"or":[98],"(150":[102],"repeated":[105,228],"3":[106],"times":[107],"20-minute":[109],"intervals.":[110],"Parents":[111,189],"completed":[112],"questionnaire.":[114],"OUTCOME":[115],"MEASURES:":[116],"Pulmonary":[117],"index,":[118],"hospitalization,":[119],"ease":[120],"acceptability,":[123],"pulse":[125],"oximetry":[126],"saturation.":[127],"RESULTS:":[128],"The":[129,208],"90%":[130],"confidence":[131],"interval":[132,161],"difference":[135],"treatment":[137,187],"groups":[138],"median":[141],"absolute":[142],"changes":[143],"pulmonary":[145],"index":[146],"values":[147],"T0":[149],"T60":[151],"[-1;":[153],"+1]":[154],"included":[157],"[-1.5;":[162],"+1.5].":[163],"Clinical":[164],"improvement":[165],"increased":[166],"time.":[168],"Less":[169],"than":[170],"10%":[171],"(3":[175],"each":[177,183],"group)":[178],"required":[179],"hospitalization":[180],"(2":[181],"attributable":[185],"failure).":[188],"considered":[190,240],"administration":[191],"using":[194,213],"(94%)":[199],"better":[201],"accepted":[202],"by":[203],"their":[204],"(62%).":[206],"CONCLUSIONS:":[207],"efficacy":[209],"equivalent":[218],"that":[220],"nebulizer.":[223],"Given":[224],"its":[225],"high":[226],"tolerance,":[227],"50-microg/kg":[229],"doses":[230],"should":[238],"be":[239],"departments":[244],"first-line":[246],"therapy":[247],"wheezing.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
