{"id":"https://openalex.org/W2139183289","doi":"https://doi.org/10.1161/01.res.87.1.66","title":"FK409, a Spontaneous Nitric Oxide Releaser, Attenuates Allograft Vasculopathy in a Rat Aortic Transplant Model","display_name":"FK409, a Spontaneous Nitric Oxide Releaser, Attenuates Allograft Vasculopathy in a Rat Aortic Transplant Model","publication_year":2000,"publication_date":"2000-07-07","ids":{"openalex":"https://openalex.org/W2139183289","doi":"https://doi.org/10.1161/01.res.87.1.66","mag":"2139183289","pmid":"https://pubmed.ncbi.nlm.nih.gov/10884374"},"language":"en","primary_location":{"id":"doi:10.1161/01.res.87.1.66","doi":"https://doi.org/10.1161/01.res.87.1.66","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.res.87.1.66","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104015978","display_name":"Johji Fukada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]},{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Johji Fukada","raw_affiliation_strings":["From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310","https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021110463","display_name":"Stefano Schena","orcid":"https://orcid.org/0000-0002-8392-0528","observed_orcids":["https://orcid.org/0000-0002-8392-0528"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]},{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Stefano Schena","raw_affiliation_strings":["From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310","https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011117707","display_name":"Ivan Tack","orcid":"https://orcid.org/0000-0001-7557-8737","observed_orcids":["https://orcid.org/0000-0001-7557-8737"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]},{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Ivan Tack","raw_affiliation_strings":["From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310","https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016888338","display_name":"Phillip Ruiz","orcid":"https://orcid.org/0000-0003-2291-4594","observed_orcids":["https://orcid.org/0000-0003-2291-4594"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]},{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Phillip Ruiz","raw_affiliation_strings":["From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310","https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067094560","display_name":"Yoshihiko Kurimoto","orcid":"https://orcid.org/0000-0001-8596-6813","observed_orcids":["https://orcid.org/0000-0001-8596-6813"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]},{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Yoshihiko Kurimoto","raw_affiliation_strings":["From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310","https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108450254","display_name":"Manhui Pang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]},{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Manhui Pang","raw_affiliation_strings":["From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310","https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110091613","display_name":"Abdelouahab A\u0131\u0308touche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]},{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Abdelouahab Aitouche","raw_affiliation_strings":["From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310","https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110781851","display_name":"Tomio Abe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]},{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Tomio Abe","raw_affiliation_strings":["From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310","https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111548231","display_name":"Liliane J. Striker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]},{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Liliane J. Striker","raw_affiliation_strings":["From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310","https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034119339","display_name":"Si M. Pham","orcid":"https://orcid.org/0000-0001-7396-8344","observed_orcids":["https://orcid.org/0000-0001-7396-8344"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]},{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Si M. Pham","raw_affiliation_strings":["From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery (J.F., S.S., M.P., A.A., S.M.P.), Medicine (I.T., L.J.S.), and Pathology (P.R.), University of Miami School of Medicine, Miami, Fla, and the Department of Thoracic and Cardiovascular Surgery (Y.K., T.A.), Sapporo Medical University, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310","https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0803,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.80354545,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"87","issue":"1","first_page":"66","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.14319999516010284,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fk409","display_name":"FK409","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nitric-oxide-donors","display_name":"nitric oxide donors","score":0.843999981880188},{"id":"https://openalex.org/keywords/allograft-vasculopathy","display_name":"allograft vasculopathy","score":0.9710000157356262},{"id":"https://openalex.org/keywords/neointimal-hyperplasia","display_name":"intimal hyperplasia","score":0.9700000286102295},{"id":"https://openalex.org/keywords/aortic-transplantation","display_name":"aortic transplantation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9409999847412109},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/fas-expression","display_name":"Fas expression","score":0.8489999771118164},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/neointimal-thickness","display_name":"neointimal thickness","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2778095995","wikidata":"https://www.wikidata.org/wiki/Q17147174","display_name":"Neointimal hyperplasia","level":4,"score":0.8888957500457764},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7075961232185364},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6638698577880859},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5295394659042358},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.518193781375885},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.4594070017337799},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.44800904393196106},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.4129559397697449},{"id":"https://openalex.org/C2777921159","wikidata":"https://www.wikidata.org/wiki/Q32089","display_name":"Sirolimus","level":2,"score":0.4122140109539032},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.37809282541275024},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3364626169204712},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.330759733915329},{"id":"https://openalex.org/C2778283817","wikidata":"https://www.wikidata.org/wiki/Q6590597","display_name":"Restenosis","level":3,"score":0.31827324628829956},{"id":"https://openalex.org/C2778583881","wikidata":"https://www.wikidata.org/wiki/Q1325542","display_name":"Stent","level":2,"score":0.2580867409706116},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.22539862990379333}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D001973","descriptor_name":"Bromodeoxyuridine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009574","descriptor_name":"Nitro Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011912","descriptor_name":"Rats, Inbred ACI","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011920","descriptor_name":"Rats, Inbred WF","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020030","descriptor_name":"Nitric Oxide Donors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.res.87.1.66","doi":"https://doi.org/10.1161/01.res.87.1.66","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.res.87.1.66","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.506.1264","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.506.1264","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"http://circres.ahajournals.org/content/87/1/66.full.pdf","raw_type":"text"},{"id":"pmid:10884374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10884374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1366213748","display_name":null,"funder_award_id":"R01 HL63426-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5092626128","display_name":"NITRIC OXIDE IN ALLOGRAFT VASCULOPATHY","funder_award_id":"5r01hl063426-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1490576088","https://openalex.org/W1517477388","https://openalex.org/W1796908871","https://openalex.org/W1929009802","https://openalex.org/W1970693099","https://openalex.org/W1975889968","https://openalex.org/W1979230311","https://openalex.org/W1983270784","https://openalex.org/W1984728211","https://openalex.org/W1985253103","https://openalex.org/W1990534992","https://openalex.org/W1994911436","https://openalex.org/W2007737411","https://openalex.org/W2022463563","https://openalex.org/W2029491963","https://openalex.org/W2041466047","https://openalex.org/W2041765744","https://openalex.org/W2068611368","https://openalex.org/W2073304956","https://openalex.org/W2074887912","https://openalex.org/W2077525790","https://openalex.org/W2079796572","https://openalex.org/W2080480505","https://openalex.org/W2083646691","https://openalex.org/W2085663049","https://openalex.org/W2089967550","https://openalex.org/W2090711586","https://openalex.org/W2091389334","https://openalex.org/W2092715957","https://openalex.org/W2106649681","https://openalex.org/W2107429652","https://openalex.org/W2111787291","https://openalex.org/W2122009720","https://openalex.org/W2135709443","https://openalex.org/W2138302361","https://openalex.org/W2143293940","https://openalex.org/W2286338204","https://openalex.org/W2400940908","https://openalex.org/W2402002188","https://openalex.org/W2764862291","https://openalex.org/W4247832651"],"related_works":["https://openalex.org/W2074887912","https://openalex.org/W2017351966","https://openalex.org/W2519060012","https://openalex.org/W2077889384","https://openalex.org/W2313831595","https://openalex.org/W2896530362","https://openalex.org/W2085663049","https://openalex.org/W1963893070","https://openalex.org/W2095458607","https://openalex.org/W7095658358"],"abstract_inverted_index":{"Although":[0],"systemic":[1],"administration":[2],"of":[3,13,30,40,49,70,84,89,114,195],"NO":[4,44],"donors":[5],"has":[6,23],"been":[7,25],"shown":[8],"to":[9,86,143],"attenuate":[10],"the":[11,17,38,47,67,82,87,98,131,134,138,156,199,211],"development":[12,48],"neointimal":[14,109,135,157,200],"hyperplasia":[15],"in":[16,27,133,155,176,184,198,214],"balloon":[18],"injury":[19],"model,":[20],"this":[21,34],"strategy":[22],"not":[24],"tested":[26],"a":[28,42,53,124,173,215],"model":[29],"allograft":[31,50,212],"vasculopathy.":[32],"In":[33],"study,":[35],"we":[36],"investigated":[37],"effect":[39],"FK409,":[41],"spontaneous":[43],"releaser,":[45],"on":[46,97],"vasculopathy,":[51],"using":[52],"rat":[54,216],"aortic":[55,99,217],"transplant":[56,218],"model.":[57,219],"Thoracic":[58],"aortas":[59],"from":[60,81,141],"ACI":[61],"rats":[62],"were":[63,95],"transplanted":[64],"heterotopically":[65],"into":[66],"abdominal":[68],"aorta":[69],"Wistar-Furth":[71],"rats.":[72],"Postoperatively,":[73],"recipients":[74],"received":[75],"FK409":[76,168,209],"orally":[77],"every":[78],"8":[79,101],"hours":[80],"day":[83],"transplantation":[85],"time":[88],"euthanization.":[90],"Morphometric":[91],"and":[92,164,193],"immunohistochemical":[93],"analyses":[94],"performed":[96],"grafts":[100],"weeks":[102],"after":[103],"transplantation.":[104],"Control":[105],"allografts":[106,122],"showed":[107,123],"severe":[108],"hyperplasia,":[110],"which":[111],"consists":[112],"mainly":[113],"alpha-actin-containing":[115],"vascular":[116,201],"smooth":[117,202],"muscle":[118,203],"cells.":[119,204],"The":[120],"FK409-treated":[121],"dose-dependent":[125],"reduction":[126],"(statistically":[127],"significant":[128,153,174],"compared":[129],"with":[130,162,165],"control)":[132],"thickness":[136,158],"as":[137],"dose":[139],"increased":[140],"1":[142],"10":[144,163],"mg/kg":[145],"(thrice":[146],"per":[147],"day).":[148],"However,":[149],"there":[150],"was":[151],"no":[152],"difference":[154],"between":[159],"groups":[160],"treated":[161],"20":[166],"mg/kg.":[167],"treatment":[169],"(10":[170],"mg/kg)":[171],"caused":[172],"decrease":[175],"DNA":[177,185],"synthesis":[178],"(5-bromo-2-deoxyuridine":[179],"[BrdU]":[180],"uptake),":[181],"an":[182],"increase":[183],"fragmentation":[186],"(terminal":[187],"deoxynucleotidyltransferase-mediated":[188],"uridine":[189],"nick-end":[190],"labeling":[191],"[TUNEL]),":[192],"upregulation":[194],"Fas":[196],"expression,":[197],"These":[205],"data":[206],"suggest":[207],"that":[208],"attenuates":[210],"vasculopathy":[213]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}