{"id":"https://openalex.org/W2139181583","doi":"https://doi.org/10.1073/pnas.96.20.11470","title":"Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells","display_name":"Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells","publication_year":1999,"publication_date":"1999-09-28","ids":{"openalex":"https://openalex.org/W2139181583","doi":"https://doi.org/10.1073/pnas.96.20.11470","mag":"2139181583","pmid":"https://pubmed.ncbi.nlm.nih.gov/10500200"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.96.20.11470","doi":"https://doi.org/10.1073/pnas.96.20.11470","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.96.20.11470","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/18057","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090336430","display_name":"Jens Zerrahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Jens Zerrahn","raw_affiliation_strings":["Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720; and Unit\u00e9 d\u2019Immunit\u00e9 Cellulaire Antivirale, Institut Pasteur, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720; and Unit\u00e9 d\u2019Immunit\u00e9 Cellulaire Antivirale, Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573","https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007037072","display_name":"Ariane Volkmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Ariane Volkmann","raw_affiliation_strings":["Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720; and Unit\u00e9 d\u2019Immunit\u00e9 Cellulaire Antivirale, Institut Pasteur, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720; and Unit\u00e9 d\u2019Immunit\u00e9 Cellulaire Antivirale, Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573","https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048352835","display_name":"Mark Christopher Coles","orcid":"https://orcid.org/0000-0001-8079-9358","observed_orcids":["https://orcid.org/0000-0001-8079-9358"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Mark C. Coles","raw_affiliation_strings":["Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720; and Unit\u00e9 d\u2019Immunit\u00e9 Cellulaire Antivirale, Institut Pasteur, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720; and Unit\u00e9 d\u2019Immunit\u00e9 Cellulaire Antivirale, Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573","https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040071446","display_name":"Werner Held","orcid":"https://orcid.org/0000-0003-3292-1536","observed_orcids":["https://orcid.org/0000-0003-3292-1536"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Werner Held","raw_affiliation_strings":["Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720; and Unit\u00e9 d\u2019Immunit\u00e9 Cellulaire Antivirale, Institut Pasteur, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720; and Unit\u00e9 d\u2019Immunit\u00e9 Cellulaire Antivirale, Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573","https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028371625","display_name":"Fran\u00e7ois A. Lemonnier","orcid":"https://orcid.org/0000-0002-6741-2742","observed_orcids":["https://orcid.org/0000-0002-6741-2742"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Francois A. Lemonnier","raw_affiliation_strings":["Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720; and Unit\u00e9 d\u2019Immunit\u00e9 Cellulaire Antivirale, Institut Pasteur, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720; and Unit\u00e9 d\u2019Immunit\u00e9 Cellulaire Antivirale, Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573","https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058734512","display_name":"David H. Raulet","orcid":"https://orcid.org/0000-0002-1257-8649","observed_orcids":["https://orcid.org/0000-0002-1257-8649"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"David H. Raulet","raw_affiliation_strings":["Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720; and Unit\u00e9 d\u2019Immunit\u00e9 Cellulaire Antivirale, Institut Pasteur, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720; and Unit\u00e9 d\u2019Immunit\u00e9 Cellulaire Antivirale, Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573","https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3886,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.81156303,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"96","issue":"20","first_page":"11470","last_page":"11475"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mhc-class-i","display_name":"MHC class I","score":0.8709999918937683},{"id":"https://openalex.org/keywords/positive-selection","display_name":"positive selection","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8870000243186951},{"id":"https://openalex.org/keywords/t-cell-receptor-transgenic-mice","display_name":"T cell receptor transgenic mice","score":0.8240000009536743},{"id":"https://openalex.org/keywords/beta2-microglobulin","display_name":"beta2-microglobulin","score":0.7519999742507935},{"id":"https://openalex.org/keywords/chimeric-mice","display_name":"chimeric mice","score":0.6949999928474426},{"id":"https://openalex.org/keywords/tcr-avidity","display_name":"TCR avidity","score":0.6710000038146973},{"id":"https://openalex.org/keywords/thymocyte-selection","display_name":"thymic selection","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7339473366737366},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.6646499633789062},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6535964608192444},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6193982362747192},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5330295562744141},{"id":"https://openalex.org/C7386963","wikidata":"https://www.wikidata.org/wiki/Q3954859","display_name":"Negative selection","level":4,"score":0.5228543877601624},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5207512378692627},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4861904978752136},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4841664433479309},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.482599139213562},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.47926971316337585},{"id":"https://openalex.org/C30278631","wikidata":"https://www.wikidata.org/wiki/Q281721","display_name":"Chimera (genetics)","level":3,"score":0.47121232748031616},{"id":"https://openalex.org/C37386791","wikidata":"https://www.wikidata.org/wiki/Q2248081","display_name":"CD1","level":5,"score":0.42819371819496155},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3944476246833801},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3944273591041565},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.34836041927337646},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.32519254088401794},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3180762827396393},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2262304425239563},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12530428171157837},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12218502163887024},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11842212080955505},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002678","descriptor_name":"Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002678","descriptor_name":"Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002678","descriptor_name":"Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.96.20.11470","doi":"https://doi.org/10.1073/pnas.96.20.11470","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.96.20.11470","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:10500200","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10500200","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:1235010","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/18057","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:18057","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/18057","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:18057","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/18057","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1799621566","display_name":"H-2 GENES AND T CELL SELECTION","funder_award_id":"5r01ai030171-11","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5123562147","display_name":null,"funder_award_id":"AI-30171","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306271","display_name":"Damon Runyon Cancer Research Foundation","ror":"https://ror.org/01gd7b947"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1518511714","https://openalex.org/W1539572779","https://openalex.org/W1596533977","https://openalex.org/W1597257637","https://openalex.org/W1964161140","https://openalex.org/W1975806042","https://openalex.org/W1978757502","https://openalex.org/W1994001202","https://openalex.org/W1994183260","https://openalex.org/W1996350333","https://openalex.org/W2006914141","https://openalex.org/W2007969716","https://openalex.org/W2008523533","https://openalex.org/W2013436886","https://openalex.org/W2028159810","https://openalex.org/W2030085696","https://openalex.org/W2066023902","https://openalex.org/W2068401310","https://openalex.org/W2072179705","https://openalex.org/W2073726842","https://openalex.org/W2090295166","https://openalex.org/W2090832869","https://openalex.org/W2094227488","https://openalex.org/W2098157239","https://openalex.org/W2139229993","https://openalex.org/W2139980032","https://openalex.org/W2142256483","https://openalex.org/W2156375958","https://openalex.org/W2160071211","https://openalex.org/W2174800991","https://openalex.org/W2179494586","https://openalex.org/W2345623715"],"related_works":["https://openalex.org/W2065430316","https://openalex.org/W1982121321","https://openalex.org/W1999440367","https://openalex.org/W2022847127","https://openalex.org/W2139478235","https://openalex.org/W2093116728","https://openalex.org/W2032441316","https://openalex.org/W2094264237","https://openalex.org/W2148615757","https://openalex.org/W1982805017"],"abstract_inverted_index":{"The":[0,163],"identity":[1],"of":[2,8,52,65,112,125,156],"cells":[3,11,42,60,80,107,115,131,151],"that":[4,104,144,165,174],"mediate":[5],"positive":[6,110,146,168],"selection":[7,111,147,169],"CD8(+)":[9,58,78,113,129],"T":[10,16,59,79,114,130],"was":[12,132],"investigated":[13],"in":[14,30,62,69,72,134,183],"two":[15],"cell":[17,97],"receptor":[18],"(TCR)":[19],"transgenic":[20,47],"systems.":[21],"Irradiated":[22],"beta(2)-microglobulin":[23],"mutant":[24],"mice":[25,27],"or":[26,159],"with":[28,39,172,180],"mutations":[29],"both":[31],"the":[32,50,53,63,66,73,157,184],"K(b)":[33],"and":[34,68,88],"D(b)":[35],"genes":[36],"were":[37,81,89],"repopulated":[38],"fetal":[40],"liver":[41],"from":[43],"class":[44,98,135,138],"I(+)":[45,136],"TCR":[46,158],"mice.":[48],"In":[49,120],"case":[51],"2C":[54],"TCR,":[55],"mature":[56],"transgene-expressing":[57],"appeared":[61],"thymuses":[64],"chimeras":[67],"larger":[70],"numbers":[71],"peripheral":[74],"lymphoid":[75],"organs.":[76],"These":[77,101,141],"functional,":[82],"exhibited":[83],"a":[84,117],"naive,":[85],"resting":[86],"phenotype,":[87],"mostly":[90],"thymus-dependent.":[91],"Their":[92],"development":[93,124],"depended":[94],"on":[95,153],"donor":[96],"I":[99],"expression.":[100],"results":[102],"establish":[103],"thymic":[105,161],"hematopoietic":[106,150,166],"can":[108],"direct":[109],"expressing":[116],"conventional":[118],"TCR.":[119],"contrast,":[121],"no":[122],"significant":[123],"HY":[126],"(male":[127],"antigen)-TCR(+)":[128],"observed":[133],"into":[137],"I-deficient":[139],"chimeras.":[140],"data":[142],"suggest":[143],"successful":[145],"directed":[148],"by":[149],"depends":[152],"specific":[154],"properties":[155],"its":[160],"ligands.":[162],"possibility":[164],"cell-induced,":[167],"occurs":[170],"only":[171],"TCRs":[173],"exhibit":[175],"relatively":[176],"high":[177],"avidity":[178],"interactions":[179],"selecting":[181],"ligands":[182],"thymus":[185],"is":[186],"discussed.":[187]},"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}