{"id":"https://openalex.org/W2139181115","doi":"https://doi.org/10.4049/jimmunol.1201168","title":"SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation","display_name":"SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation","publication_year":2012,"publication_date":"2012-08-27","ids":{"openalex":"https://openalex.org/W2139181115","doi":"https://doi.org/10.4049/jimmunol.1201168","mag":"2139181115","pmid":"https://pubmed.ncbi.nlm.nih.gov/22925925","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4184888"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.1201168","doi":"https://doi.org/10.4049/jimmunol.1201168","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.1201168","pdf_url":"https://www.jimmunol.org/content/jimmunol/189/7/3439.full.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jimmunol.org/content/jimmunol/189/7/3439.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062642187","display_name":"Hongwei Qin","orcid":"https://orcid.org/0000-0002-7511-5078","observed_orcids":["https://orcid.org/0000-0002-7511-5078"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongwei Qin","raw_affiliation_strings":["Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham , Birmingham, AL 35294","Department of Cell, Developmental & Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham , Birmingham, AL 35294","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Department of Cell, Developmental & Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063694861","display_name":"Andrew T. Holdbrooks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew T Holdbrooks","raw_affiliation_strings":["Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079115940","display_name":"Yudong Liu","orcid":"https://orcid.org/0000-0002-5153-3400","observed_orcids":["https://orcid.org/0000-0002-5153-3400","https://orcid.org/0000-0002-8183-1732"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yudong Liu","raw_affiliation_strings":["Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032623839","display_name":"Stephanie L. Reynolds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie L Reynolds","raw_affiliation_strings":["Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031770645","display_name":"Lora L. Yanagisawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lora L Yanagisawa","raw_affiliation_strings":["Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032782967","display_name":"Etty N. Benveniste","orcid":"https://orcid.org/0000-0003-4120-5750","observed_orcids":["https://orcid.org/0000-0003-4120-5750"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Etty N Benveniste","raw_affiliation_strings":["Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":10.5249,"has_fulltext":true,"cited_by_count":458,"citation_normalized_percentile":{"value":0.99010812,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"189","issue":"7","first_page":"3439","last_page":"3448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.06340000033378601,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/socs3","display_name":"SOCS3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.8809999823570251},{"id":"https://openalex.org/keywords/m1-macrophages","display_name":"M1 macrophages","score":0.9160000085830688},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.8569999933242798},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/lps-induced-sepsis","display_name":"LPS-induced sepsis","score":0.8730000257492065},{"id":"https://openalex.org/keywords/th1-cell-differentiation","display_name":"Th1 differentiation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/th17-differentiation","display_name":"Th17 cell differentiation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7670000195503235},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8510000109672546},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.902999997138977},{"id":"https://openalex.org/keywords/chromatin-modification","display_name":"chromatin modification","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C126042315","wikidata":"https://www.wikidata.org/wiki/Q18033763","display_name":"SOCS3","level":4,"score":0.839577317237854},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.7872573137283325},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.7743755578994751},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6141974329948425},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5685683488845825},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5569145083427429},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4956260919570923},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.47724008560180664},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4409126043319702},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42969810962677},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4110254645347595},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.33470839262008667},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.1400737762451172},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10995689034461975},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08838331699371338}],"mesh":[{"descriptor_ui":"D000071223","descriptor_name":"Suppressor of Cytokine Signaling 3 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4049/jimmunol.1201168","doi":"https://doi.org/10.4049/jimmunol.1201168","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.1201168","pdf_url":"https://www.jimmunol.org/content/jimmunol/189/7/3439.full.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:22925925","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22925925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3157383","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4184888","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4184888","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4184888","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.1201168","doi":"https://doi.org/10.4049/jimmunol.1201168","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.1201168","pdf_url":"https://www.jimmunol.org/content/jimmunol/189/7/3439.full.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1658563393","display_name":"CD40 Expression and Function in Microglia","funder_award_id":"R01NS045290","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2194436067","display_name":"Therapeutic Intervention of the JAK/STAT Pathway for Neuroinflammation","funder_award_id":"R01NS057563","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3230356866","display_name":null,"funder_award_id":"CA1059-A-13","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7820584853","display_name":"Rheumatic Diseases Core Centers (P30)","funder_award_id":"P30AR048311","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8534364389","display_name":"NCI CLINICAL INVESTIGATOR AWARD PROGRAM","funder_award_id":"K08CA001059","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000921343","display_name":"UAB Center for AIDS Research (CFAR)","funder_award_id":"P30AI027767","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320320084","display_name":"Multiple Sclerosis Society","ror":"https://ror.org/043fwdk81"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332582","display_name":"Center for AIDS Research, University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139181115.pdf","grobid_xml":"https://content.openalex.org/works/W2139181115.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1645591373","https://openalex.org/W1900874324","https://openalex.org/W1904816508","https://openalex.org/W1947901393","https://openalex.org/W1962869168","https://openalex.org/W1967369695","https://openalex.org/W1972685619","https://openalex.org/W1979161827","https://openalex.org/W1982871919","https://openalex.org/W1985859986","https://openalex.org/W2016313989","https://openalex.org/W2025067737","https://openalex.org/W2026778930","https://openalex.org/W2027768860","https://openalex.org/W2034916295","https://openalex.org/W2035817205","https://openalex.org/W2037010452","https://openalex.org/W2037368492","https://openalex.org/W2043184804","https://openalex.org/W2051515172","https://openalex.org/W2064212960","https://openalex.org/W2065210647","https://openalex.org/W2065743466","https://openalex.org/W2066984888","https://openalex.org/W2068793888","https://openalex.org/W2069456851","https://openalex.org/W2070791475","https://openalex.org/W2071117491","https://openalex.org/W2073387289","https://openalex.org/W2074891744","https://openalex.org/W2081810806","https://openalex.org/W2083829960","https://openalex.org/W2091311019","https://openalex.org/W2093442991","https://openalex.org/W2094958168","https://openalex.org/W2103031848","https://openalex.org/W2105564248","https://openalex.org/W2106797333","https://openalex.org/W2108014241","https://openalex.org/W2115116869","https://openalex.org/W2117382612","https://openalex.org/W2121438383","https://openalex.org/W2122224565","https://openalex.org/W2124112561","https://openalex.org/W2129942863","https://openalex.org/W2131227412","https://openalex.org/W2133536768","https://openalex.org/W2138722443","https://openalex.org/W2141421205","https://openalex.org/W2143364214","https://openalex.org/W2146448366","https://openalex.org/W2147495692","https://openalex.org/W2163601934","https://openalex.org/W2164967233","https://openalex.org/W2171878279","https://openalex.org/W2172089049","https://openalex.org/W6666935314","https://openalex.org/W6678569993"],"related_works":["https://openalex.org/W3177462711","https://openalex.org/W317277006","https://openalex.org/W2124881273","https://openalex.org/W4313365848","https://openalex.org/W2152127772","https://openalex.org/W1986668504","https://openalex.org/W7071397720","https://openalex.org/W2105564248","https://openalex.org/W2140913323","https://openalex.org/W3167522056"],"abstract_inverted_index":{"Macrophages":[0,102],"participate":[1],"in":[2,110,181,215,225],"both":[3],"the":[4,9,16,74,93,120,136,217],"amplification":[5],"of":[6,11,15,27,40,64,73,95,119,135,195],"inflammation":[7],"at":[8],"time":[10],"injury":[12],"and":[13,52,54,57,78,83,100,116,143,152,166,184,191,205],"downregulation":[14],"inflammatory":[17,223],"response":[18],"to":[19,148,163],"avoid":[20],"excess":[21],"tissue":[22],"damage.":[23],"These":[24,207],"divergent":[25],"functions":[26],"macrophages":[28,125,131,157,172],"are":[29],"dictated":[30],"by":[31,49],"their":[32],"microenvironment,":[33],"especially":[34],"cytokines,":[35],"which":[36,107],"promote":[37],"a":[38,160],"spectrum":[39],"macrophage":[41,98],"phenotypes.":[42],"The":[43],"M1":[44,137,156,171,196,218],"proinflammatory":[45,219],"phenotype":[46],"is":[47,179,185,213],"induced":[48],"LPS,":[50],"IFN-\u03b3,":[51],"GM-CSF,":[53],"IL-4,":[55],"IL-13,":[56],"M-CSF":[58],"induce":[59,164],"anti-inflammatory":[60],"M2":[61],"macrophages.":[62,226],"Suppressors":[63],"cytokine":[65],"signaling":[66,76],"(SOCS)":[67],"proteins":[68],"function":[69],"as":[70,199],"feedback":[71],"inhibitors":[72],"JAK/STAT":[75,121],"pathway,":[77],"they":[79],"can":[80],"terminate":[81],"innate":[82],"adaptive":[84],"immune":[85],"responses.":[86],"In":[87],"this":[88],"study,":[89],"we":[90],"have":[91,132,159],"evaluated":[92],"influence":[94],"SOCS3":[96,109,212],"on":[97],"polarization":[99],"function.":[101],"obtained":[103],"from":[104,126,173],"LysMCre-SOCS3(fl/fl)":[105,182],"mice,":[106],"lack":[108],"myeloid":[111],"lineage":[112],"cells,":[113],"exhibit":[114],"enhanced":[115,149,188],"prolonged":[117],"activation":[118,151,190],"pathway":[122],"compared":[123],"with":[124,187],"SOCS3(fl/fl)":[127,174],"mice.":[128,175],"Furthermore,":[129],"SOCS3-deficient":[130,155],"higher":[133],"levels":[134,194],"genes":[138],"IL-1\u03b2,":[139,200],"IL-6,":[140,202],"IL-12,":[141],"IL-23,":[142],"inducible":[144],"NO":[145],"synthase":[146],"owing":[147],"transcriptional":[150],"chromatin":[153],"modifications.":[154],"also":[158],"stronger":[161],"capacity":[162],"Th1":[165],"Th17":[167],"cell":[168],"differentiation":[169],"than":[170],"Lastly,":[176],"LPS-induced":[177],"sepsis":[178],"exacerbated":[180],"mice":[183],"associated":[186],"STAT1/3":[189],"increased":[192],"plasma":[193],"cytokines/chemokines":[197],"such":[198],"TNF-\u03b1,":[201],"CCL3,":[203],"CCL4,":[204],"CXCL11.":[206],"findings":[208],"collectively":[209],"indicate":[210],"that":[211],"involved":[214],"repressing":[216],"phenotype,":[220],"thereby":[221],"deactivating":[222],"responses":[224]},"counts_by_year":[{"year":2026,"cited_by_count":22},{"year":2025,"cited_by_count":40},{"year":2024,"cited_by_count":36},{"year":2023,"cited_by_count":51},{"year":2022,"cited_by_count":42},{"year":2021,"cited_by_count":36},{"year":2020,"cited_by_count":34},{"year":2019,"cited_by_count":32},{"year":2018,"cited_by_count":27},{"year":2017,"cited_by_count":26},{"year":2016,"cited_by_count":30},{"year":2015,"cited_by_count":30},{"year":2014,"cited_by_count":34},{"year":2013,"cited_by_count":17}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}