{"id":"https://openalex.org/W2139179966","doi":"https://doi.org/10.1152/ajpendo.00241.2013","title":"Agouti-related peptide plays a critical role in leptin's effects on female puberty and reproduction","display_name":"Agouti-related peptide plays a critical role in leptin's effects on female puberty and reproduction","publication_year":2013,"publication_date":"2013-10-30","ids":{"openalex":"https://openalex.org/W2139179966","doi":"https://doi.org/10.1152/ajpendo.00241.2013","mag":"2139179966","pmid":"https://pubmed.ncbi.nlm.nih.gov/24169048","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3882375"},"language":"en","primary_location":{"id":"doi:10.1152/ajpendo.00241.2013","doi":"https://doi.org/10.1152/ajpendo.00241.2013","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00241.2013","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3882375","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002466884","display_name":"Sharone Sheffer-Babila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharone Sheffer-Babila","raw_affiliation_strings":["Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York;","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yan Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Sun","raw_affiliation_strings":["Department of Obstetrics/Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, New York; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics/Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, New York; and","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050883143","display_name":"Davelene Davinah Israel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Davelene D. Israel","raw_affiliation_strings":["Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York;","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shun-Mei Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shun-Mei Liu","raw_affiliation_strings":["Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York;","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113571436","display_name":"Genevieve Scott Neal-Perry","orcid":"https://orcid.org/0000-0002-1065-4898","observed_orcids":["https://orcid.org/0000-0002-1065-4898"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Genevieve Neal-Perry","raw_affiliation_strings":["Department of Obstetrics/Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, New York; and","Dominick Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics/Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, New York; and","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Dominick Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066893639","display_name":"Streamson C. Chua","orcid":"https://orcid.org/0000-0002-9437-9925","observed_orcids":["https://orcid.org/0000-0002-9437-9925"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Streamson C. Chua","raw_affiliation_strings":["Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York;","Dominick Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York;","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Dominick Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066893639"],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":null,"apc_paid":null,"fwci":10.5319,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.98750756,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"305","issue":"12","first_page":"E1512","last_page":"E1520"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/agouti-related-protein","display_name":"agouti-related protein","score":0.9520000219345093},{"id":"https://openalex.org/keywords/leptin-signaling","display_name":"leptin signaling","score":0.8679999709129333},{"id":"https://openalex.org/keywords/female-puberty","display_name":"female puberty","score":0.8960000276565552},{"id":"https://openalex.org/keywords/gnrh-neurons","display_name":"GnRH neurons","score":0.8889999985694885},{"id":"https://openalex.org/keywords/hypothalamic-arcuate-nucleus","display_name":"hypothalamic arcuate nucleus","score":0.8949999809265137},{"id":"https://openalex.org/keywords/neuropeptide-y","display_name":"neuropeptide Y","score":0.8130000233650208},{"id":"https://openalex.org/keywords/melanocortin-4-receptor","display_name":"melanocortin-4 receptor","score":0.8510000109672546},{"id":"https://openalex.org/keywords/leptin-receptor-deficiency","display_name":"leptin receptor deficiency","score":0.652999997138977},{"id":"https://openalex.org/keywords/db-db-mice","display_name":"db/db mice","score":0.7760000228881836},{"id":"https://openalex.org/keywords/fertility","display_name":"fertility","score":0.527999997138977},{"id":"https://openalex.org/keywords/vaginal-opening","display_name":"vaginal opening","score":0.7440000176429749},{"id":"https://openalex.org/keywords/estrous-cycle","display_name":"estrous cycle","score":0.8090000152587891},{"id":"https://openalex.org/keywords/lactation","display_name":"lactation","score":0.7139999866485596},{"id":"https://openalex.org/keywords/mammary-gland-development","display_name":"mammary gland development","score":0.7129999995231628},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.8702688217163086},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8547277450561523},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.847137451171875},{"id":"https://openalex.org/C14372207","wikidata":"https://www.wikidata.org/wiki/Q7072306","display_name":"Leptin receptor","level":4,"score":0.7113127708435059},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6291375160217285},{"id":"https://openalex.org/C2778458369","wikidata":"https://www.wikidata.org/wiki/Q253246","display_name":"Arcuate nucleus","level":3,"score":0.5486122965812683},{"id":"https://openalex.org/C2776354409","wikidata":"https://www.wikidata.org/wiki/Q1516012","display_name":"Delayed puberty","level":3,"score":0.5242509841918945},{"id":"https://openalex.org/C2776808119","wikidata":"https://www.wikidata.org/wiki/Q909371","display_name":"Kisspeptin","level":3,"score":0.5069825649261475},{"id":"https://openalex.org/C1998276","wikidata":"https://www.wikidata.org/wiki/Q388121","display_name":"Estrous cycle","level":2,"score":0.4639342427253723},{"id":"https://openalex.org/C2776659692","wikidata":"https://www.wikidata.org/wiki/Q719426","display_name":"Lactation","level":3,"score":0.4504200518131256},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.4303184747695923},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4268847405910492},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.3919588029384613},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3713069260120392},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.27500423789024353},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2093583643436432},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20492348074913025},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012098","descriptor_name":"Reproduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012098","descriptor_name":"Reproduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012741","descriptor_name":"Sexual Maturation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012741","descriptor_name":"Sexual Maturation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D030762","descriptor_name":"Estrous Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D030762","descriptor_name":"Estrous Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054369","descriptor_name":"Agouti-Related Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1152/ajpendo.00241.2013","doi":"https://doi.org/10.1152/ajpendo.00241.2013","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00241.2013","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3233358","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3882375","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3882375","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3882375","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Endocrinol Metab","raw_type":"Text"},{"id":"pmid:24169048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24169048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3233358","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3882375","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6386923705","display_name":null,"funder_award_id":"P01-DK-026687","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G788956770","display_name":"Diabetes Research and Training Center","funder_award_id":"P60DK020541","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8744593747","display_name":"Center for the Study of Reproductive Biology and Women's Health","funder_award_id":"U54HD058155","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1507740248","https://openalex.org/W1512733937","https://openalex.org/W1967578015","https://openalex.org/W1967710144","https://openalex.org/W1987711524","https://openalex.org/W1989917638","https://openalex.org/W1994545264","https://openalex.org/W2000858697","https://openalex.org/W2005121205","https://openalex.org/W2007013969","https://openalex.org/W2013780942","https://openalex.org/W2014215341","https://openalex.org/W2020053653","https://openalex.org/W2022586856","https://openalex.org/W2025295789","https://openalex.org/W2030183538","https://openalex.org/W2048438803","https://openalex.org/W2051192888","https://openalex.org/W2053608443","https://openalex.org/W2061076565","https://openalex.org/W2066904572","https://openalex.org/W2069137752","https://openalex.org/W2080508995","https://openalex.org/W2082925844","https://openalex.org/W2090113277","https://openalex.org/W2092103308","https://openalex.org/W2095692745","https://openalex.org/W2103925135","https://openalex.org/W2105470099","https://openalex.org/W2107277218","https://openalex.org/W2108743642","https://openalex.org/W2110983908","https://openalex.org/W2125312207","https://openalex.org/W2128193301","https://openalex.org/W2129281059","https://openalex.org/W2130828561","https://openalex.org/W2134794678","https://openalex.org/W2144690367","https://openalex.org/W2167528859","https://openalex.org/W2170438345","https://openalex.org/W2319361543","https://openalex.org/W7075730780"],"related_works":["https://openalex.org/W2594039714","https://openalex.org/W2480412843","https://openalex.org/W2048438803","https://openalex.org/W2087331049","https://openalex.org/W2030183538","https://openalex.org/W2077674418","https://openalex.org/W2750582226","https://openalex.org/W4383998403","https://openalex.org/W2322909744","https://openalex.org/W2944004154"],"abstract_inverted_index":{"Deficient":[0],"leptin":[1,26,56,74,122],"signaling":[2,123,128],"causes":[3],"infertility":[4],"via":[5],"reduced":[6],"activity":[7],"of":[8,58,67,71,82,89,107,110,116,121,144,179,206,259,262,284],"GnRH":[9,21,31,59,117,285],"neurons,":[10,255],"causing":[11],"a":[12,130],"hypogonadal":[13],"state":[14],"in":[15,55,73,80,97,119,132,153,173,216,220,227,234,242,253],"both":[16],"rodents":[17],"and":[18,45,69,84,91,135,165,182,189,202,276],"humans.":[19],"Because":[20],"neurons":[22,32,53,112,152,279],"do":[23],"not":[24,232],"express":[25],"receptors,":[27],"leptin's":[28,108,161],"effect":[29,273],"on":[30,163,274],"must":[33],"be":[34,50],"indirect.":[35],"Neurons":[36],"within":[37],"the":[38,65,87,98,103,141,257],"hypothalamic":[39,228],"arcuate":[40],"nucleus":[41],"that":[42,64,102,170,268,277],"coexpress":[43],"AGRP":[44,68,171,213,238,269],"NPY":[46],"are":[47,193,200],"considered":[48],"to":[49,114,148,210],"important":[51],"intermediate":[52],"involved":[54],"regulation":[57,261],"neurons.":[60,264,286],"Previously,":[61],"we":[62],"reported":[63],"absence":[66,104],"haploinsufficiency":[70],"MC4R":[72,246],"receptor":[75],"mutant":[76],"(Lepr(db/db))":[77],"females":[78,175,199],"result":[79],"restoration":[81],"fertility":[83],"lactation":[85,209],"despite":[86],"persistence":[88],"obesity":[90],"insulin":[92],"resistance.":[93],"The":[94,224],"overarching":[95],"hypothesis":[96],"present":[99],"study":[100,146],"is":[101,136,147],"or":[105],"reduction":[106],"inhibition":[109,283],"AGRP/NPY":[111],"leads":[113],"suppression":[115],"release":[118],"cases":[120],"deficiency.":[124],"Since":[125],"TAC2":[126,229,254,263,278],"(NKB)-TAC3R":[127],"plays":[129],"role":[131],"puberty":[133,164,275],"maturation":[134],"modulated":[137],"by":[138,156],"metabolic":[139],"status,":[140],"other":[142],"aim":[143],"this":[145],"test":[149],"whether":[150],"TAC2/NKB":[151],"ARC":[154],"regulated":[155],"melanocortinergic":[157,260,282],"signals":[158],"herein":[159],"affect":[160],"action":[162],"reproduction.":[166],"Our":[167],"data":[168],"showed":[169],"deficiency":[172,214,239],"Lepr(db/db)":[174,198,235,243],"restores":[176],"normal":[177],"timing":[178],"vaginal":[180,218],"opening":[181,219],"estrous":[183],"cycling,":[184],"although":[185],"uterine":[186],"weight":[187],"gain":[188],"mammary":[190],"gland":[191],"development":[192],"morphologically":[194],"delayed.":[195],"Nonetheless,":[196],"Agrp(-/-)":[197],"fertile":[201],"sustain":[203],"adequate":[204],"nutrition":[205],"pups":[207],"with":[208,248],"weaning":[211],"age.":[212],"results":[215],"advanced":[217],"wild-type":[221],"female":[222],"mice.":[223],"postpubertal":[225],"increase":[226],"mRNA":[230],"was":[231],"observed":[233],"females,":[236],"whereas":[237],"restored":[240],"it":[241],"females.":[244],"Additionally,":[245],"activation":[247],"MTII":[249],"induced":[250],"FOS":[251],"expression":[252],"supporting":[256],"concept":[258],"These":[265],"studies":[266],"suggest":[267],"imposes":[270],"an":[271],"inhibitory":[272],"may":[280],"transmit":[281]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
