{"id":"https://openalex.org/W2139169990","doi":"https://doi.org/10.1002/(sici)1097-4636(199721)38:1<35::aid-jbm5>3.0.co;2-i","title":"Adhesion of staphylococci to polymers with and without immobilized heparin in cerebrospinal fluid","display_name":"Adhesion of staphylococci to polymers with and without immobilized heparin in cerebrospinal fluid","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2139169990","doi":"https://doi.org/10.1002/(sici)1097-4636(199721)38:1<35::aid-jbm5>3.0.co;2-i","mag":"2139169990","pmid":"https://pubmed.ncbi.nlm.nih.gov/9086415"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-4636(199721)38:1<35::aid-jbm5>3.0.co;2-i","doi":"https://doi.org/10.1002/(sici)1097-4636(199721)38:1<35::aid-jbm5>3.0.co;2-i","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4636(199721)38:1<35::aid-jbm5>3.0.co;2-i","pdf_url":null,"source":{"id":"https://openalex.org/S34814058","display_name":"Journal of Biomedical Materials Research","issn_l":"0021-9304","issn":["0021-9304","1097-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101170702","display_name":"Sadahiro Nomura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sadahiro Nomura","raw_affiliation_strings":["Department of Medical Microbiology, Lund University, Sweden","Department of Medical Microbiology, Lund University, Lund, Sweden,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, Lund University, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Department of Medical Microbiology, Lund University, Lund, Sweden,","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072782775","display_name":"Fredrik Lundberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Fredrik Lundberg","raw_affiliation_strings":["Department of Medical Microbiology, Lund University, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036411314","display_name":"Maria M. Stollenwerk","orcid":"https://orcid.org/0000-0001-9718-1175","observed_orcids":["https://orcid.org/0000-0001-9718-1175"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Maria Stollenwerk","raw_affiliation_strings":["Department of Medical Microbiology, Lund University, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000876079","display_name":"Kazuyuki Nakamura","orcid":"https://orcid.org/0000-0002-9128-5229","observed_orcids":["https://orcid.org/0000-0002-9128-5229"]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuyuki Nakamura","raw_affiliation_strings":["The First Department of Biochemistry, Yamaguchi University School of Medicine, Ube, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Department of Biochemistry, Yamaguchi University School of Medicine, Ube, Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110235229","display_name":"\ufffdsa Ljungh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"\ufffdsa Ljungh","raw_affiliation_strings":["Department of Medical Microbiology, Lund University, Lund, Sweden,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, Lund University, Lund, Sweden,","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3037,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.80139901,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"38","issue":"1","first_page":"35","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.3334999978542328,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.03359999880194664,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacterial-adhesion","display_name":"bacterial adhesion","score":0.9330000281333923},{"id":"https://openalex.org/keywords/coagulase-negative-staphylococci","display_name":"coagulase-negative staphylococci","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-shunt-infection","display_name":"cerebrospinal fluid shunt infection","score":0.8299999833106995},{"id":"https://openalex.org/keywords/heparin-anticoagulation","display_name":"heparin anticoagulation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/polyvinyl-chloride","display_name":"polyvinyl chloride","score":0.9559999704360962},{"id":"https://openalex.org/keywords/silicone","display_name":"silicone","score":0.9300000071525574},{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.9169999957084656},{"id":"https://openalex.org/keywords/suramin","display_name":"suramin","score":0.7609999775886536},{"id":"https://openalex.org/keywords/chondroitin-sulfate","display_name":"chondroitin sulfate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fucoidan","display_name":"fucoidan","score":1.0},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-protein","display_name":"cerebrospinal fluid protein","score":0.6600000262260437},{"id":"https://openalex.org/keywords/neurosurgical-implants","display_name":"neurosurgical implants","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.6779418587684631},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.6391936540603638},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.6310644745826721},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6130146384239197},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.5268339514732361},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.47913476824760437},{"id":"https://openalex.org/C2778414984","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biomaterial","level":2,"score":0.47397154569625854},{"id":"https://openalex.org/C126348684","wikidata":"https://www.wikidata.org/wiki/Q3456979","display_name":"Polymer science","level":1,"score":0.3927081823348999},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2961822748184204},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.23385855555534363},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2037644386291504},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.16373813152313232},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13105839490890503}],"mesh":[{"descriptor_ui":"D001422","descriptor_name":"Bacterial Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011143","descriptor_name":"Polyvinyl Chloride","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012828","descriptor_name":"Silicones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013210","descriptor_name":"Staphylococcus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1097-4636(199721)38:1<35::aid-jbm5>3.0.co;2-i","doi":"https://doi.org/10.1002/(sici)1097-4636(199721)38:1<35::aid-jbm5>3.0.co;2-i","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4636(199721)38:1<35::aid-jbm5>3.0.co;2-i","pdf_url":null,"source":{"id":"https://openalex.org/S34814058","display_name":"Journal of Biomedical Materials Research","issn_l":"0021-9304","issn":["0021-9304","1097-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1097-4636(199721)38:1<35::aid-jbm5>3.3.co;2-p","doi":"https://doi.org/10.1002/(sici)1097-4636(199721)38:1<35::aid-jbm5>3.3.co;2-p","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4636(199721)38:1<35::aid-jbm5>3.3.co;2-p","pdf_url":null,"source":{"id":"https://openalex.org/S34814058","display_name":"Journal of Biomedical Materials Research","issn_l":"0021-9304","issn":["0021-9304","1097-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research","raw_type":"journal-article"},{"id":"pmid:9086415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9086415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical materials research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W11260006","https://openalex.org/W1530734265","https://openalex.org/W1571981529","https://openalex.org/W1581129475","https://openalex.org/W1967642037","https://openalex.org/W1968361518","https://openalex.org/W1989212864","https://openalex.org/W1995498884","https://openalex.org/W2001939636","https://openalex.org/W2005768741","https://openalex.org/W2009445658","https://openalex.org/W2011642047","https://openalex.org/W2015531372","https://openalex.org/W2023852225","https://openalex.org/W2024424463","https://openalex.org/W2035891866","https://openalex.org/W2036229335","https://openalex.org/W2044514252","https://openalex.org/W2064983807","https://openalex.org/W2077136017","https://openalex.org/W2081400514","https://openalex.org/W2085378543","https://openalex.org/W2089511414","https://openalex.org/W2090310213","https://openalex.org/W2093801055","https://openalex.org/W2109541938","https://openalex.org/W2127285624","https://openalex.org/W2137854143","https://openalex.org/W2138141525","https://openalex.org/W2142076308","https://openalex.org/W2152379670","https://openalex.org/W2161299549","https://openalex.org/W2886317133","https://openalex.org/W4211032636","https://openalex.org/W6903112552"],"related_works":["https://openalex.org/W1980929889","https://openalex.org/W2070099730","https://openalex.org/W2133909702","https://openalex.org/W2242111513","https://openalex.org/W2035435875","https://openalex.org/W2094107621","https://openalex.org/W2003165935","https://openalex.org/W2090310213","https://openalex.org/W2081070298","https://openalex.org/W2055975400"],"abstract_inverted_index":{"Infections":[0],"of":[1,13,68,93,125,136,150,157],"cerebrospinal":[2],"fluid":[3],"(CSF)":[4],"shunts":[5],"constitute":[6],"a":[7,90],"serious":[8],"clinical":[9],"problem.":[10],"The":[11,58,86],"role":[12],"adhesion":[14,53,60,111,122,145,182],"by":[15,56,160],"coagulase":[16],"negative":[17,76],"staphylococci,":[18],"the":[19,94,126,134,142,155,208,227],"most":[20],"common":[21],"etiological":[22],"agent,":[23],"was":[24,54],"examined":[25],"in":[26,49,109,123,131],"vitro":[27],"to":[28,34,61,112,129,162,166,169,183,215,230],"polyvinyl":[29],"chloride":[30],"(PVC),":[31],"silicone,":[32],"and":[33,36,84,152,164,179,190,205],"PVC":[35,153],"silicone":[37,151],"with":[38,65,115,222],"end-point":[39],"attached":[40],"(EPA)":[41],"heparin.":[42],"These":[43,195],"are":[44,107],"flexible":[45],"materials":[46],"commonly":[47],"used":[48],"neurosurgical":[50],"implants.":[51],"Bacterial":[52],"quantitated":[55],"bioluminescence.":[57],"bacterial":[59,69,110,121,144,217],"biomaterial":[62,83,209],"surfaces":[63],"increased":[64],"increasing":[66],"concentrations":[67],"cells.":[70],"Scatchard":[71],"plot":[72],"analysis":[73],"showed":[74,89],"continuous":[75],"(concave)":[77],"slopes,":[78],"indicating":[79],"multiple":[80],"interactions":[81,106,200],"between":[82],"bacteria.":[85],"thermodynamic":[87],"studies":[88],"positive":[91],"value":[92],"standard":[95],"entropy":[96],"change":[97],"at":[98],"37":[99],"degrees":[100],"C,":[101],"which":[102],"indicates":[103],"that":[104,198],"hydrophobic":[105,199],"important":[108,203],"polymers.":[113],"Incubation":[114],"CSF":[116,137],"for":[117,141],"1":[118],"h":[119],"decreased":[120,154],"75%":[124],"samples":[127],"compared":[128,168],"incubation":[130],"buffer.":[132],"Thus,":[133],"contribution":[135],"proteins,":[138],"like":[139],"fibronectin,":[140],"initial":[143],"might":[146],"be":[147,226],"small.":[148],"Heparinization":[149],"numbers":[156],"adhered":[158],"bacteria":[159],"23":[161],"54%":[163],"0":[165],"43%":[167],"unheparinized":[170],"surfaces.":[171],"Among":[172],"putative":[173,223],"inhibitors":[174,224],"tested,":[175],"suramin,":[176],"chondroitin":[177],"sulfate,":[178],"fucoidan":[180],"inhibited":[181],"81":[184],"+/-":[185,188,192],"19,":[186],"78":[187],"22,":[189],"64":[191],"7%,":[193],"respectively.":[194],"findings":[196],"indicate":[197],"play":[201],"an":[202],"role,":[204],"heparinization":[206],"rendering":[207],"surface":[210],"hydrophilic":[211],"is":[212],"therefore":[213],"effective":[214],"reduce":[216],"adhesion.":[218],"Heparinized":[219],"polymers":[220],"incubated":[221],"may":[225],"optimal":[228],"way":[229],"prevent":[231],"shunt":[232],"infections.":[233]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}