{"id":"https://openalex.org/W2139168208","doi":"https://doi.org/10.1128/mcb.01478-07","title":"Complex Formation of Yeast Rev1 with DNA Polymerase \u03b7","display_name":"Complex Formation of Yeast Rev1 with DNA Polymerase \u03b7","publication_year":2007,"publication_date":"2007-09-17","ids":{"openalex":"https://openalex.org/W2139168208","doi":"https://doi.org/10.1128/mcb.01478-07","mag":"2139168208","pmid":"https://pubmed.ncbi.nlm.nih.gov/17875922","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2169172"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.01478-07","doi":"https://doi.org/10.1128/mcb.01478-07","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.01478-07","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2169172","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073212909","display_name":"Narottam Acharya","orcid":"https://orcid.org/0000-0001-8858-5418","observed_orcids":["https://orcid.org/0000-0001-8858-5418"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Narottam Acharya","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555-1061"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555-1061","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017776028","display_name":"Lajos Haracska","orcid":"https://orcid.org/0000-0003-3608-5897","observed_orcids":["https://orcid.org/0000-0003-3608-5897"]},"institutions":[{"id":"https://openalex.org/I2800351701","display_name":"HUN-REN Szegedi Biol\u00f3giai Kutat\u00f3k\u00f6zpont","ror":"https://ror.org/016gb1631","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I7597260"]},{"id":"https://openalex.org/I4210155639","display_name":"Institute of Genetics","ror":"https://ror.org/04tjemt46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I4210155639","https://openalex.org/I7597260"]},{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Lajos Haracska","raw_affiliation_strings":["Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary","institution_ids":["https://openalex.org/I2800351701","https://openalex.org/I4210155639","https://openalex.org/I7597260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015003542","display_name":"Satya Prakash","orcid":"https://orcid.org/0000-0001-7228-1444","observed_orcids":["https://orcid.org/0000-0001-7228-1444"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satya Prakash","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555-1061"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555-1061","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011484270","display_name":"Louise Prakash","orcid":"https://orcid.org/0000-0001-9143-6261","observed_orcids":["https://orcid.org/0000-0001-9143-6261"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louise Prakash","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555-1061"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555-1061","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8531,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.84882782,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"27","issue":"23","first_page":"8401","last_page":"8408"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rev1","display_name":"Rev1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/dna-polymerase-eta","display_name":"DNA polymerase eta","score":0.972000002861023},{"id":"https://openalex.org/keywords/translesion-synthesis","display_name":"translesion synthesis","score":0.7310000061988831},{"id":"https://openalex.org/keywords/y-family-dna-polymerases","display_name":"Y-family DNA polymerases","score":0.6869999766349792},{"id":"https://openalex.org/keywords/protein-complex-assembly","display_name":"protein complex formation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8919488191604614},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.6046091318130493},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.5898067951202393},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5830304026603699},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.49706175923347473},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49212831258773804},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4150979518890381},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3358346223831177},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3206411898136139}],"mesh":[{"descriptor_ui":"D000099270","descriptor_name":"Y-Family DNA Polymerases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009713","descriptor_name":"Nucleotidyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/mcb.01478-07","doi":"https://doi.org/10.1128/mcb.01478-07","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.01478-07","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2169172","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2169172","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:17875922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17875922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2169172","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2169172","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2887760609","display_name":"Bypass of DNA lesions by translesion synthesis in yeast","funder_award_id":"R01CA107650","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8471237781","display_name":null,"funder_award_id":"CA107650","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1492057161","https://openalex.org/W1531823089","https://openalex.org/W1904872562","https://openalex.org/W1967625467","https://openalex.org/W1982453626","https://openalex.org/W1994386041","https://openalex.org/W1997803780","https://openalex.org/W2006803834","https://openalex.org/W2011580988","https://openalex.org/W2018179063","https://openalex.org/W2024703739","https://openalex.org/W2025841293","https://openalex.org/W2032124996","https://openalex.org/W2050857231","https://openalex.org/W2052965880","https://openalex.org/W2062487397","https://openalex.org/W2063240589","https://openalex.org/W2065286203","https://openalex.org/W2081059444","https://openalex.org/W2096030977","https://openalex.org/W2098002585","https://openalex.org/W2101101375","https://openalex.org/W2102091313","https://openalex.org/W2109247109","https://openalex.org/W2121671527","https://openalex.org/W2123758041","https://openalex.org/W2126628078","https://openalex.org/W2134678790","https://openalex.org/W2139137226","https://openalex.org/W2142513901","https://openalex.org/W2143064529","https://openalex.org/W2154518311","https://openalex.org/W2169950973","https://openalex.org/W2470508052","https://openalex.org/W4234412137"],"related_works":["https://openalex.org/W2102091313","https://openalex.org/W2121671527","https://openalex.org/W1996368299","https://openalex.org/W2024703739","https://openalex.org/W2064614219","https://openalex.org/W2217879408","https://openalex.org/W2032124996","https://openalex.org/W1621604326","https://openalex.org/W2072438120","https://openalex.org/W2296938981"],"abstract_inverted_index":{"In":[0,57],"Saccharomyces":[1],"cerevisiae,":[2],"Rev1":[3,25,60,80,100,124,154,158,173],"functions":[4],"in":[5,31,46,55,94,120,136,162,176],"translesion":[6],"DNA":[7,169],"synthesis":[8,170],"(TLS)":[9],"together":[10],"with":[11,49,67],"polymerase":[12],"zeta":[13,34,53,107],"(Pol":[14],"zeta),":[15],"comprised":[16],"of":[17,38,99,153,172,183,192],"the":[18,39,68,79,88,97,117,150,157,168,181,189],"Rev3":[19,50],"catalytic":[20],"and":[21,36,75,78,91,108,129,155,185,198],"Rev7":[22],"accessory":[23],"subunits.":[24],"plays":[26],"an":[27],"indispensable":[28],"structural":[29,103,122,194],"role":[30,195],"promoting":[32],"Pol":[33,52,71,73,76,106,111],"function,":[35],"deletion":[37],"Rev1-C":[40],"terminal":[41],"region":[42],"that":[43,119,134,167],"is":[44,174],"involved":[45],"physical":[47],"interactions":[48],"inactivates":[51],"function":[54],"TLS.":[56],"humans,":[58],"however,":[59],"has":[61,125],"been":[62],"shown":[63],"to":[64],"physically":[65],"interact":[66],"Y-family":[69],"polymerases":[70],"eta,":[72,112],"iota,":[74],"kappa,":[77],"C":[81,159],"terminus":[82,160],"mediates":[83],"these":[84,113,184],"interactions.":[85],"Since":[86],"all":[87],"available":[89],"genetic":[90],"biochemical":[92],"evidence":[93],"yeast":[95,128,137,197],"support":[96],"requirement":[98],"as":[101,161],"a":[102,138],"element":[104],"for":[105,110,188],"not":[109,156],"observations":[114,187],"have":[115],"raised":[116],"possibility":[118],"its":[121],"role,":[123],"diverged":[126],"between":[127,196],"humans.":[130,163,199],"Here":[131],"we":[132],"show":[133],"although":[135],"stable":[139],"Rev1-Pol":[140],"eta":[141],"complex":[142,147],"can":[143],"be":[144],"formed,":[145],"this":[146,177],"formation":[148],"involves":[149],"polymerase-associated":[151],"domain":[152],"We":[164,179],"also":[165],"found":[166],"activity":[171],"enhanced":[175],"complex.":[178],"discuss":[180],"implications":[182],"other":[186],"possible":[190],"divergence":[191],"Rev1's":[193]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}