{"id":"https://openalex.org/W2139165027","doi":"https://doi.org/10.1001/archneur.63.6.895","title":"Efficacy of Surgical Treatment of De Novo, Adult-Onset, Cryptogenic, Refractory Focal Status Epilepticus","display_name":"Efficacy of Surgical Treatment of De Novo, Adult-Onset, Cryptogenic, Refractory Focal Status Epilepticus","publication_year":2006,"publication_date":"2006-06-01","ids":{"openalex":"https://openalex.org/W2139165027","doi":"https://doi.org/10.1001/archneur.63.6.895","mag":"2139165027","pmid":"https://pubmed.ncbi.nlm.nih.gov/16769873"},"language":"en","primary_location":{"id":"doi:10.1001/archneur.63.6.895","doi":"https://doi.org/10.1001/archneur.63.6.895","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archneur.63.6.895","pdf_url":null,"source":{"id":"https://openalex.org/S4210230857","display_name":"Archives of Neurology","issn_l":"0003-9942","issn":["0003-9942","1538-3687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079261381","display_name":"Daniel J. Costello","orcid":"https://orcid.org/0000-0001-6023-8246","observed_orcids":["https://orcid.org/0000-0001-6023-8246"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Costello","raw_affiliation_strings":["Epilepsy Service, Department of Neurology, Massachusetts General Hospital, Boston 02114, USA. djcostello@partners.org","Epilepsy Service, Department of Neurology, Massachusetts General Hospital, Boston 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epilepsy Service, Department of Neurology, Massachusetts General Hospital, Boston 02114, USA. djcostello@partners.org","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Epilepsy Service, Department of Neurology, Massachusetts General Hospital, Boston 02114, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063623431","display_name":"Mirela V. Simon","orcid":"https://orcid.org/0009-0004-7516-5253","observed_orcids":["https://orcid.org/0009-0004-7516-5253"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mirela V. Simon","raw_affiliation_strings":["Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047068032","display_name":"Emad N. Eskandar","orcid":"https://orcid.org/0000-0002-0682-2625","observed_orcids":["https://orcid.org/0000-0002-0682-2625","https://orcid.org/0000-0003-4743-2938"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emad N. Eskandar","raw_affiliation_strings":["Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005004760","display_name":"Matthew P. Frosch","orcid":"https://orcid.org/0000-0002-3940-9861","observed_orcids":["https://orcid.org/0000-0002-3940-9861"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew P. Frosch","raw_affiliation_strings":["Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002680481","display_name":"Heidi L. Henninger","orcid":"https://orcid.org/0000-0002-5616-2194","observed_orcids":["https://orcid.org/0000-0002-5616-2194"]},"institutions":[{"id":"https://openalex.org/I1334536514","display_name":"Maine Medical Center","ror":"https://ror.org/03g5f5777","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334536514"]},{"id":"https://openalex.org/I4210123774","display_name":"Maine Medical Center","ror":"https://ror.org/034c1gc25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heidi L. Henninger","raw_affiliation_strings":["Maine Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maine Medical Center","institution_ids":["https://openalex.org/I1334536514","https://openalex.org/I4210123774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051181005","display_name":"Keith H. Chiappa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith H. Chiappa","raw_affiliation_strings":["Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077601092","display_name":"Andrew J. Cole","orcid":"https://orcid.org/0000-0002-0828-826X","observed_orcids":["https://orcid.org/0000-0002-0828-826X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Cole","raw_affiliation_strings":["Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7569,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.890866,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"63","issue":"6","first_page":"895","last_page":"895"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/focal-status-epilepticus","display_name":"focal status epilepticus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cryptogenic-epilepsy","display_name":"cryptogenic epilepsy","score":0.9290000200271606},{"id":"https://openalex.org/keywords/drug-resistant-epilepsy","display_name":"drug-resistant epilepsy","score":0.7179999947547913},{"id":"https://openalex.org/keywords/epilepsy-surgery","display_name":"epilepsy surgery","score":0.7799999713897705},{"id":"https://openalex.org/keywords/frontal-lobe-resection","display_name":"frontal lobe resection","score":0.7960000038146973},{"id":"https://openalex.org/keywords/subpial-transection","display_name":"subpial transection","score":0.9739999771118164},{"id":"https://openalex.org/keywords/epileptogenic-zone","display_name":"epileptogenic zone","score":0.7540000081062317},{"id":"https://openalex.org/keywords/continuous-eeg-monitoring","display_name":"continuous EEG monitoring","score":0.5360000133514404},{"id":"https://openalex.org/keywords/anticonvulsant-therapy","display_name":"anticonvulsant therapy","score":0.7879999876022339},{"id":"https://openalex.org/keywords/neuropathology","display_name":"neuropathology","score":0.5950000286102295},{"id":"https://openalex.org/keywords/adult-onset-epilepsy","display_name":"adult-onset epilepsy","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8464944362640381},{"id":"https://openalex.org/C2777341932","wikidata":"https://www.wikidata.org/wiki/Q980709","display_name":"Status epilepticus","level":3,"score":0.8063904047012329},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.552756130695343},{"id":"https://openalex.org/C2777060296","wikidata":"https://www.wikidata.org/wiki/Q1316942","display_name":"Cortical dysplasia","level":3,"score":0.5416910648345947},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.44448375701904297},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.37096816301345825},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.36094188690185547},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.21038928627967834},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.20077583193778992},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013226","descriptor_name":"Status Epilepticus","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D013226","descriptor_name":"Status Epilepticus","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013226","descriptor_name":"Status Epilepticus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013226","descriptor_name":"Status Epilepticus","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019635","descriptor_name":"Neurosurgical Procedures","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1001/archneur.63.6.895","doi":"https://doi.org/10.1001/archneur.63.6.895","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archneur.63.6.895","pdf_url":null,"source":{"id":"https://openalex.org/S4210230857","display_name":"Archives of Neurology","issn_l":"0003-9942","issn":["0003-9942","1538-3687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Neurology","raw_type":"journal-article"},{"id":"pmid:16769873","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16769873","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of neurology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1528465726","https://openalex.org/W1590649988","https://openalex.org/W2000312174","https://openalex.org/W2000512308","https://openalex.org/W2008452090","https://openalex.org/W2012318617","https://openalex.org/W2013047628","https://openalex.org/W2014144878","https://openalex.org/W2024400128","https://openalex.org/W2027148076","https://openalex.org/W2030183746","https://openalex.org/W2056215110","https://openalex.org/W2060933426","https://openalex.org/W2065299306","https://openalex.org/W2068305426","https://openalex.org/W2137403824"],"related_works":["https://openalex.org/W7097976805","https://openalex.org/W2030183746","https://openalex.org/W2087072894","https://openalex.org/W2070850426","https://openalex.org/W2103529856","https://openalex.org/W2096871605","https://openalex.org/W2060933426","https://openalex.org/W2088064100","https://openalex.org/W2056215110","https://openalex.org/W2409381938"],"abstract_inverted_index":{"BACKGROUND:":[0],"There":[1],"have":[2,25],"been":[3,26],"few":[4,176],"published":[5],"reports":[6],"of":[7,11,33,52,57,67,74,81,84,88,99,108,128,135,145,166,184,228],"successful":[8,85],"surgical":[9,86,154],"treatment":[10,87],"focal":[12,46,90,194,205],"status":[13,47,91,206],"epilepticus.":[14,92],"Surgical":[15],"intervention":[16,201],"is":[17,214],"considered":[18,221],"a":[19,31,82,132,175],"last":[20],"resort":[21],"after":[22,122],"medical":[23],"strategies":[24],"exhausted.":[27],"OBJECTIVE:":[28],"To":[29],"report":[30],"case":[32,83],"an":[34,53,95,116,199,210,223],"adult":[35],"who":[36],"was":[37,149,187],"initially":[38],"seen":[39],"with":[40,63,141],"de":[41],"novo,":[42],"medically":[43,203],"refractory,":[44],"cryptogenic":[45,89],"epilepticus":[48,207],"and":[49,104,121,125,156,174,218],"underwent":[50],"resection":[51,134,155,196],"electrographically":[54],"defined":[55],"portion":[56],"the":[58,68,75,129,136,146,161,167,226],"left":[59,137],"middle":[60,138],"frontal":[61,139],"gyrus":[62,140],"multiple":[64,142,157],"subpial":[65,143,158],"transections":[66,144,159],"adjacent":[69],"cortex":[70,148],"resulting":[71],"in":[72,115,202],"termination":[73],"electroclinical":[76],"seizure":[77,162],"activity.":[78,163],"DESIGN:":[79],"Report":[80],"INTERVENTION:":[93],"After":[94],"initial":[96],"35":[97],"days":[98,107],"oral":[100],"antiepileptic":[101,112],"drug":[102,113],"therapy":[103,114],"subsequent":[105],"16":[106],"continuous":[109],"electroencephalography-guided":[110],"intravenous":[111],"intensive":[117],"care":[118],"unit":[119],"setting,":[120],"extensive":[123],"preoperative":[124],"intraoperative":[126],"characterization":[127],"epileptogenic":[130],"zone,":[131],"tailored":[133],"surrounding":[147],"performed.":[150],"RESULTS:":[151],"The":[152],"restricted":[153],"terminated":[160],"Neuropathological":[164],"examination":[165],"resected":[168],"tissue":[169],"revealed":[170],"moderate":[171],"inflammatory":[172],"changes":[173],"abnormally":[177],"located":[178],"neurons":[179],"without":[180],"any":[181],"definitive":[182],"evidence":[183],"dysplasia,":[185],"which":[186],"suspected":[188],"preoperatively.":[189],"CONCLUSIONS:":[190],"We":[191],"suggest":[192],"that":[193],"cortical":[195],"may":[197],"be":[198,220],"appropriate":[200],"refractory":[204],"even":[208],"when":[209],"overt":[211],"structural":[212],"etiology":[213],"not":[215],"evident":[216],"preoperatively":[217],"should":[219],"as":[222],"option":[224],"at":[225],"onset":[227],"intractability.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}