{"id":"https://openalex.org/W2139160364","doi":null,"title":"Myocardial clearance kinetics of technetium-99m-SQ30217: a marker of regional myocardial blood flow.","display_name":"Myocardial clearance kinetics of technetium-99m-SQ30217: a marker of regional myocardial blood flow.","publication_year":1990,"publication_date":"1990-07-01","ids":{"openalex":"https://openalex.org/W2139160364","mag":"2139160364","pmid":"https://pubmed.ncbi.nlm.nih.gov/2362197"},"language":"en","primary_location":{"id":"pmid:2362197","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2362197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"R E Stewart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R E Stewart","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000481071","display_name":"Markus Schwaiger","orcid":"https://orcid.org/0000-0002-2305-7144","observed_orcids":["https://orcid.org/0000-0002-2305-7144"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Schwaiger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060374102","display_name":"Gary D. Hutchins","orcid":"https://orcid.org/0000-0002-9243-3211","observed_orcids":["https://orcid.org/0000-0002-9243-3211"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G D Hutchins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108499428","display_name":"Ping-Chun Chiao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P C Chiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112937609","display_name":"K P Gallagher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K P Gallagher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"N Nguyen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Nguyen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039817140","display_name":"Neil A. Petry","orcid":"https://orcid.org/0000-0001-5255-1654","observed_orcids":["https://orcid.org/0000-0001-5255-1654"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N A Petry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022008404","display_name":"W.L. Rogers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W L Rogers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":11.8302,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.98905034,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"31","issue":"7","first_page":"1183","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-perfusion-imaging","display_name":"myocardial perfusion imaging","score":0.8859999775886536},{"id":"https://openalex.org/keywords/myocardial-blood-flow","display_name":"myocardial blood flow","score":0.8389999866485596},{"id":"https://openalex.org/keywords/dipyridamole","display_name":"dipyridamole","score":0.890999972820282},{"id":"https://openalex.org/keywords/regional-myocardial-perfusion","display_name":"regional myocardial blood flow","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2776890861","wikidata":"https://www.wikidata.org/wiki/Q419374","display_name":"Dipyridamole","level":2,"score":0.8371320366859436},{"id":"https://openalex.org/C4375535","wikidata":"https://www.wikidata.org/wiki/Q2373354","display_name":"Technetium-99m","level":3,"score":0.7344215512275696},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.6805463433265686},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.6534237265586853},{"id":"https://openalex.org/C138944611","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Clearance","level":2,"score":0.6086176633834839},{"id":"https://openalex.org/C522557706","wikidata":"https://www.wikidata.org/wiki/Q1054","display_name":"Technetium","level":2,"score":0.5899434089660645},{"id":"https://openalex.org/C18206936","wikidata":"https://www.wikidata.org/wiki/Q378749","display_name":"Clearance rate","level":2,"score":0.5797712802886963},{"id":"https://openalex.org/C2778405248","wikidata":"https://www.wikidata.org/wiki/Q1956679","display_name":"Myocardial perfusion imaging","level":3,"score":0.5743390321731567},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5470231771469116},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4912523627281189},{"id":"https://openalex.org/C2778863792","wikidata":"https://www.wikidata.org/wiki/Q16909918","display_name":"TRACER","level":2,"score":0.48883718252182007},{"id":"https://openalex.org/C2910541568","wikidata":"https://www.wikidata.org/wiki/Q1956679","display_name":"Myocardial imaging","level":2,"score":0.4773316979408264},{"id":"https://openalex.org/C2780723685","wikidata":"https://www.wikidata.org/wiki/Q1961418","display_name":"Technetium-99","level":2,"score":0.47199228405952454},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3168884515762329},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.31075119972229004},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2796061933040619},{"id":"https://openalex.org/C2779902710","wikidata":"https://www.wikidata.org/wiki/Q1130465","display_name":"Scintigraphy","level":2,"score":0.23486220836639404},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010091","descriptor_name":"Oximes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015609","descriptor_name":"Organotechnetium Compounds","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2362197","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2362197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"mag:2139160364","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2362197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6399999856948853,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G294318035","display_name":"RADIONUCLIDES--RADIATION DETECTION AND QUANTIFICATION","funder_award_id":"5r01ca032846-30","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2182993953","https://openalex.org/W2435936051","https://openalex.org/W2409228367","https://openalex.org/W2065996993","https://openalex.org/W4233924186","https://openalex.org/W2047216875","https://openalex.org/W2436543260","https://openalex.org/W1999477893","https://openalex.org/W2104421517","https://openalex.org/W2412262732"],"abstract_inverted_index":{"SQ30217":[0,93],"is":[1,123],"a":[2,49,59,124],"new,":[3],"technetium-99m-(99mTc)":[4],"labeled":[5],"perfusion":[6],"agent":[7],"introduced":[8],"for":[9],"cardiac":[10],"imaging.":[11],"To":[12],"evaluate":[13],"the":[14,45,67,77],"myocardial":[15,82,131],"tracer":[16,46,127],"kinetics,":[17],"99mTc-SQ30217,":[18],"was":[19],"injected":[20],"intracoronarily":[21],"in":[22,48],"open-chested":[23],"dogs":[24],"under":[25],"baseline":[26],"conditions":[27],"and":[28,112,133],"after":[29],"administration":[30],"of":[31,44,54,61,76],"intravenous":[32],"(i.v.)":[33],"dipyridamole.":[34,120],"Myocardial":[35,92],"first-pass":[36],"retention":[37,132],"fraction":[38],"averaged":[39,107],"0.90":[40],"+/-":[41,63,109,116],"0.04.":[42],"Clearance":[43],"occurred":[47],"biexponential":[50],"manner.":[51],"Sixty-seven":[52],"percent":[53],"retained":[55],"activity":[56,69],"cleared":[57],"with":[58,81,104,128],"half-time":[60],"2.3":[62],"0.6":[64],"min,":[65],"while":[66],"residual":[68],"demonstrated":[70],"slow":[71],"clearance.":[72],"The":[73],"clearance":[74,94],"rate":[75,95],"rapid":[78,134],"phase":[79],"correlated":[80],"blood":[83],"flow":[84,126,140],"(r":[85],"=":[86],"0.72,":[87],"p":[88],"less":[89],"than":[90],"0.001).":[91],"following":[96,119],"i.v.":[97],"injection":[98],"as":[99],"determined":[100],"by":[101],"dynamic":[102],"imaging":[103],"tomography":[105],"(SPRINT)":[106],"21":[108],"4":[110,117],"min":[111,118],"increased":[113],"to":[114],"13":[115],"Thus,":[121],"99mTc-SQ30217":[122],"promising":[125],"high":[129],"initial":[130],"tissue":[135],"clearance,":[136],"which":[137],"allow":[138],"repeated":[139],"determinations":[141],"within":[142],"short":[143],"time":[144],"intervals":[145],"using":[146],"advanced":[147],"SPECT":[148],"technology.":[149]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}