{"id":"https://openalex.org/W2139154967","doi":"https://doi.org/10.1101/gad.13.10.1240","title":"Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53","display_name":"Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53","publication_year":1999,"publication_date":"1999-05-15","ids":{"openalex":"https://openalex.org/W2139154967","doi":"https://doi.org/10.1101/gad.13.10.1240","mag":"2139154967","pmid":"https://pubmed.ncbi.nlm.nih.gov/10346812","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/316726"},"language":"en","primary_location":{"id":"doi:10.1101/gad.13.10.1240","doi":"https://doi.org/10.1101/gad.13.10.1240","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.13.10.1240","pdf_url":"http://genesdev.cshlp.org/content/13/10/1240.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & Development","raw_type":"journal-article"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://genesdev.cshlp.org/content/13/10/1240.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089842877","display_name":"Hiroaki Nozawa","orcid":"https://orcid.org/0000-0002-7891-5986","observed_orcids":["https://orcid.org/0000-0002-7891-5986"]},"institutions":[{"id":"https://openalex.org/I20783137","display_name":"Central Institute for Experimental Animals","ror":"https://ror.org/05eagc649","country_code":"JP","type":"facility","lineage":["https://openalex.org/I20783137"]},{"id":"https://openalex.org/I4405286258","display_name":"Institute of Molecular Embryology and Genetics, Kumamoto University","ror":"https://ror.org/01mrmn149","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Nozawa","raw_affiliation_strings":["Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan","Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","institution_ids":["https://openalex.org/I20783137"]},{"raw_affiliation_string":"Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":null,"display_name":"E. Oda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20783137","display_name":"Central Institute for Experimental Animals","ror":"https://ror.org/05eagc649","country_code":"JP","type":"facility","lineage":["https://openalex.org/I20783137"]},{"id":"https://openalex.org/I4405286258","display_name":"Institute of Molecular Embryology and Genetics, Kumamoto University","ror":"https://ror.org/01mrmn149","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"E. Oda","raw_affiliation_strings":["Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I20783137","https://openalex.org/I4405286258","https://openalex.org/I4405286826","https://openalex.org/I74801974","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","institution_ids":["https://openalex.org/I20783137"]},{"raw_affiliation_string":"Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113627059","display_name":"Kazuki Nakao","orcid":"https://orcid.org/0009-0001-5407-0819","observed_orcids":["https://orcid.org/0009-0001-5407-0819"]},"institutions":[{"id":"https://openalex.org/I20783137","display_name":"Central Institute for Experimental Animals","ror":"https://ror.org/05eagc649","country_code":"JP","type":"facility","lineage":["https://openalex.org/I20783137"]},{"id":"https://openalex.org/I4405286258","display_name":"Institute of Molecular Embryology and Genetics, Kumamoto University","ror":"https://ror.org/01mrmn149","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Nakao","raw_affiliation_strings":["Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I20783137","https://openalex.org/I4405286258","https://openalex.org/I4405286826","https://openalex.org/I74801974","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","institution_ids":["https://openalex.org/I20783137"]},{"raw_affiliation_string":"Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103076283","display_name":"Masayuki Ishihara","orcid":"https://orcid.org/0000-0003-2930-7973","observed_orcids":["https://orcid.org/0000-0003-2930-7973"]},"institutions":[{"id":"https://openalex.org/I20783137","display_name":"Central Institute for Experimental Animals","ror":"https://ror.org/05eagc649","country_code":"JP","type":"facility","lineage":["https://openalex.org/I20783137"]},{"id":"https://openalex.org/I4405286258","display_name":"Institute of Molecular Embryology and Genetics, Kumamoto University","ror":"https://ror.org/01mrmn149","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Ishihara","raw_affiliation_strings":["Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I20783137","https://openalex.org/I4405286258","https://openalex.org/I4405286826","https://openalex.org/I74801974","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","institution_ids":["https://openalex.org/I20783137"]},{"raw_affiliation_string":"Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Ueda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20783137","display_name":"Central Institute for Experimental Animals","ror":"https://ror.org/05eagc649","country_code":"JP","type":"facility","lineage":["https://openalex.org/I20783137"]},{"id":"https://openalex.org/I4405286258","display_name":"Institute of Molecular Embryology and Genetics, Kumamoto University","ror":"https://ror.org/01mrmn149","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Ueda","raw_affiliation_strings":["Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I20783137","https://openalex.org/I4405286258","https://openalex.org/I4405286826","https://openalex.org/I74801974","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","institution_ids":["https://openalex.org/I20783137"]},{"raw_affiliation_string":"Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016777111","display_name":"Taeko Yokochi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20783137","display_name":"Central Institute for Experimental Animals","ror":"https://ror.org/05eagc649","country_code":"JP","type":"facility","lineage":["https://openalex.org/I20783137"]},{"id":"https://openalex.org/I4405286258","display_name":"Institute of Molecular Embryology and Genetics, Kumamoto University","ror":"https://ror.org/01mrmn149","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Yokochi","raw_affiliation_strings":["Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I20783137","https://openalex.org/I4405286258","https://openalex.org/I4405286826","https://openalex.org/I74801974","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","institution_ids":["https://openalex.org/I20783137"]},{"raw_affiliation_string":"Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059141673","display_name":"Ken Ogasawara","orcid":"https://orcid.org/0000-0002-4264-8927","observed_orcids":["https://orcid.org/0000-0002-4264-8927"]},"institutions":[{"id":"https://openalex.org/I20783137","display_name":"Central Institute for Experimental Animals","ror":"https://ror.org/05eagc649","country_code":"JP","type":"facility","lineage":["https://openalex.org/I20783137"]},{"id":"https://openalex.org/I4405286258","display_name":"Institute of Molecular Embryology and Genetics, Kumamoto University","ror":"https://ror.org/01mrmn149","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Ogasawara","raw_affiliation_strings":["Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I20783137","https://openalex.org/I4405286258","https://openalex.org/I4405286826","https://openalex.org/I74801974","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","institution_ids":["https://openalex.org/I20783137"]},{"raw_affiliation_string":"Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056960216","display_name":"Yoko Nakatsuru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20783137","display_name":"Central Institute for Experimental Animals","ror":"https://ror.org/05eagc649","country_code":"JP","type":"facility","lineage":["https://openalex.org/I20783137"]},{"id":"https://openalex.org/I4405286258","display_name":"Institute of Molecular Embryology and Genetics, Kumamoto University","ror":"https://ror.org/01mrmn149","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Nakatsuru","raw_affiliation_strings":["Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I20783137","https://openalex.org/I4405286258","https://openalex.org/I4405286826","https://openalex.org/I74801974","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","institution_ids":["https://openalex.org/I20783137"]},{"raw_affiliation_string":"Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003305480","display_name":"Sumera SHIMIZU","orcid":"https://orcid.org/0000-0001-5330-4575","observed_orcids":["https://orcid.org/0000-0001-5330-4575"]},"institutions":[{"id":"https://openalex.org/I20783137","display_name":"Central Institute for Experimental Animals","ror":"https://ror.org/05eagc649","country_code":"JP","type":"facility","lineage":["https://openalex.org/I20783137"]},{"id":"https://openalex.org/I4405286258","display_name":"Institute of Molecular Embryology and Genetics, Kumamoto University","ror":"https://ror.org/01mrmn149","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Shimizu","raw_affiliation_strings":["Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I20783137","https://openalex.org/I4405286258","https://openalex.org/I4405286826","https://openalex.org/I74801974","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","institution_ids":["https://openalex.org/I20783137"]},{"raw_affiliation_string":"Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y. Ohira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20783137","display_name":"Central Institute for Experimental Animals","ror":"https://ror.org/05eagc649","country_code":"JP","type":"facility","lineage":["https://openalex.org/I20783137"]},{"id":"https://openalex.org/I4405286258","display_name":"Institute of Molecular Embryology and Genetics, Kumamoto University","ror":"https://ror.org/01mrmn149","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Ohira","raw_affiliation_strings":["Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I20783137","https://openalex.org/I4405286258","https://openalex.org/I4405286826","https://openalex.org/I74801974","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","institution_ids":["https://openalex.org/I20783137"]},{"raw_affiliation_string":"Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Hioki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20783137","display_name":"Central Institute for Experimental Animals","ror":"https://ror.org/05eagc649","country_code":"JP","type":"facility","lineage":["https://openalex.org/I20783137"]},{"id":"https://openalex.org/I4405286258","display_name":"Institute of Molecular Embryology and Genetics, Kumamoto University","ror":"https://ror.org/01mrmn149","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Hioki","raw_affiliation_strings":["Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I20783137","https://openalex.org/I4405286258","https://openalex.org/I4405286826","https://openalex.org/I74801974","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","institution_ids":["https://openalex.org/I20783137"]},{"raw_affiliation_string":"Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Aizawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20783137","display_name":"Central Institute for Experimental Animals","ror":"https://ror.org/05eagc649","country_code":"JP","type":"facility","lineage":["https://openalex.org/I20783137"]},{"id":"https://openalex.org/I4405286258","display_name":"Institute of Molecular Embryology and Genetics, Kumamoto University","ror":"https://ror.org/01mrmn149","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Aizawa","raw_affiliation_strings":["Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I20783137","https://openalex.org/I4405286258","https://openalex.org/I4405286826","https://openalex.org/I74801974","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","institution_ids":["https://openalex.org/I20783137"]},{"raw_affiliation_string":"Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T. Ishikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20783137","display_name":"Central Institute for Experimental Animals","ror":"https://ror.org/05eagc649","country_code":"JP","type":"facility","lineage":["https://openalex.org/I20783137"]},{"id":"https://openalex.org/I4405286258","display_name":"Institute of Molecular Embryology and Genetics, Kumamoto University","ror":"https://ror.org/01mrmn149","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Ishikawa","raw_affiliation_strings":["Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I20783137","https://openalex.org/I4405286258","https://openalex.org/I4405286826","https://openalex.org/I74801974","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","institution_ids":["https://openalex.org/I20783137"]},{"raw_affiliation_string":"Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040582134","display_name":"Motoya Katsuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20783137","display_name":"Central Institute for Experimental Animals","ror":"https://ror.org/05eagc649","country_code":"JP","type":"facility","lineage":["https://openalex.org/I20783137"]},{"id":"https://openalex.org/I4405286258","display_name":"Institute of Molecular Embryology and Genetics, Kumamoto University","ror":"https://ror.org/01mrmn149","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Katsuki","raw_affiliation_strings":["Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I20783137","https://openalex.org/I4405286258","https://openalex.org/I4405286826","https://openalex.org/I74801974","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","institution_ids":["https://openalex.org/I20783137"]},{"raw_affiliation_string":"Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066926591","display_name":"Tetsuichiro Muto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20783137","display_name":"Central Institute for Experimental Animals","ror":"https://ror.org/05eagc649","country_code":"JP","type":"facility","lineage":["https://openalex.org/I20783137"]},{"id":"https://openalex.org/I4405286258","display_name":"Institute of Molecular Embryology and Genetics, Kumamoto University","ror":"https://ror.org/01mrmn149","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Muto","raw_affiliation_strings":["Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I20783137","https://openalex.org/I4405286258","https://openalex.org/I4405286826","https://openalex.org/I74801974","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","institution_ids":["https://openalex.org/I20783137"]},{"raw_affiliation_string":"Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101896608","display_name":"Tadatsugu Taniguchi","orcid":"https://orcid.org/0000-0001-5212-090X","observed_orcids":["https://orcid.org/0000-0001-5212-090X"]},"institutions":[{"id":"https://openalex.org/I20783137","display_name":"Central Institute for Experimental Animals","ror":"https://ror.org/05eagc649","country_code":"JP","type":"facility","lineage":["https://openalex.org/I20783137"]},{"id":"https://openalex.org/I4405286258","display_name":"Institute of Molecular Embryology and Genetics, Kumamoto University","ror":"https://ror.org/01mrmn149","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Taniguchi","raw_affiliation_strings":["Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I20783137","https://openalex.org/I4405286258","https://openalex.org/I4405286826","https://openalex.org/I74801974","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","institution_ids":["https://openalex.org/I20783137"]},{"raw_affiliation_string":"Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029014038","display_name":"Nobuyuki Tanaka","orcid":"https://orcid.org/0000-0002-6373-2220","observed_orcids":["https://orcid.org/0000-0002-6373-2220"]},"institutions":[{"id":"https://openalex.org/I20783137","display_name":"Central Institute for Experimental Animals","ror":"https://ror.org/05eagc649","country_code":"JP","type":"facility","lineage":["https://openalex.org/I20783137"]},{"id":"https://openalex.org/I4405286258","display_name":"Institute of Molecular Embryology and Genetics, Kumamoto University","ror":"https://ror.org/01mrmn149","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Tanaka","raw_affiliation_strings":["Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan; \n Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan; \n Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan; \n Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I20783137","https://openalex.org/I4405286258","https://openalex.org/I4405286826","https://openalex.org/I74801974","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan","institution_ids":["https://openalex.org/I20783137"]},{"raw_affiliation_string":"Department of DNA Biology and Embryo Engineering, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,\n Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Immunology, \n Department of Surgical Oncology, and \n Department of Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033,\n Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Institute of Molecular Embryology and Genetics, Faculty of Medicine, Kumamoto University, Kumamoto 860-0811, Japan","institution_ids":["https://openalex.org/I4405286258","https://openalex.org/I96036126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":121,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"10","first_page":"1240","last_page":"1245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irf-1","display_name":"IRF1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.9079999923706055},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7789999842643738},{"id":"https://openalex.org/keywords/spontaneous-tumorigenesis","display_name":"spontaneous tumor development","score":0.890999972820282},{"id":"https://openalex.org/keywords/mutation-rate","display_name":"mutation rate","score":0.7519999742507935},{"id":"https://openalex.org/keywords/tumor-spectrum","display_name":"tumor spectrum","score":0.6309999823570251},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4490000009536743},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8930277228355408},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.7579691410064697},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6160953044891357},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5335080623626709},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.519347071647644},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.509545624256134},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4737185835838318},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.44501200318336487},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4433099925518036},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.43575310707092285},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41994550824165344},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3362516760826111},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24603945016860962},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008769","descriptor_name":"Methylnitronitrosoguanidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050856","descriptor_name":"Interferon Regulatory Factor-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1101/gad.13.10.1240","doi":"https://doi.org/10.1101/gad.13.10.1240","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.13.10.1240","pdf_url":"http://genesdev.cshlp.org/content/13/10/1240.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & Development","raw_type":"journal-article"},{"id":"pmid:10346812","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10346812","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & development","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:316726","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC316726/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes Dev","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/gad.13.10.1240","doi":"https://doi.org/10.1101/gad.13.10.1240","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.13.10.1240","pdf_url":"http://genesdev.cshlp.org/content/13/10/1240.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & Development","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325456","display_name":"Princess Takamatsu Cancer Research Fund","ror":"https://ror.org/00q3q5393"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139154967.pdf","grobid_xml":"https://content.openalex.org/works/W2139154967.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W9749486","https://openalex.org/W62620914","https://openalex.org/W69362276","https://openalex.org/W1041182074","https://openalex.org/W1493803609","https://openalex.org/W1517689414","https://openalex.org/W1650984530","https://openalex.org/W1674283941","https://openalex.org/W1937941822","https://openalex.org/W1973812603","https://openalex.org/W1977795184","https://openalex.org/W1985929162","https://openalex.org/W1990017150","https://openalex.org/W1999104040","https://openalex.org/W2019065162","https://openalex.org/W2021951044","https://openalex.org/W2028297274","https://openalex.org/W2029080338","https://openalex.org/W2032770280","https://openalex.org/W2033417996","https://openalex.org/W2034890422","https://openalex.org/W2046589688","https://openalex.org/W2048949968","https://openalex.org/W2049883910","https://openalex.org/W2055952888","https://openalex.org/W2063367127","https://openalex.org/W2067283352","https://openalex.org/W2069678419","https://openalex.org/W2073166594","https://openalex.org/W2079360957","https://openalex.org/W2106253081","https://openalex.org/W2106315019","https://openalex.org/W2107415177","https://openalex.org/W2126679757","https://openalex.org/W2156896745","https://openalex.org/W2163853656","https://openalex.org/W2165257757","https://openalex.org/W2315794330","https://openalex.org/W2338410536","https://openalex.org/W2463057371","https://openalex.org/W6607901207","https://openalex.org/W6643811563"],"related_works":["https://openalex.org/W2033417996","https://openalex.org/W2154507328","https://openalex.org/W2080993588","https://openalex.org/W2079360957","https://openalex.org/W2056218982","https://openalex.org/W2028297274","https://openalex.org/W1991586667","https://openalex.org/W2015141576","https://openalex.org/W1953337176","https://openalex.org/W2125128986"],"abstract_inverted_index":{"The":[0],"transcription":[1],"factor":[2],"IRF-1":[3,10,26,72,89],"has":[4,30],"been":[5],"implicated":[6],"in":[7,17,37,68],"tumor":[8,35,44,58,96],"suppression:":[9],"suppresses":[11],"cell":[12],"transformation":[13],"and":[14,73,75],"mediates":[15],"apoptosis":[16],"vitro.":[18],"Here":[19],"we":[20],"show":[21,80],"that":[22,88],"the":[23,38,48,95],"loss":[24],"of":[25,94],"alleles":[27],"per":[28],"se":[29],"no":[31],"effect":[32],"on":[33],"spontaneous":[34],"development":[36],"mouse":[39],"but":[40],"dramatically":[41],"exacerbates":[42],"previous":[43],"predispositions":[45],"caused":[46],"by":[47,52],"c-Ha-ras":[49],"transgene":[50],"or":[51],"nullizygosity":[53],"for":[54],"p53.":[55],"Grossly":[56],"altered":[57],"spectrum,":[59],"as":[60],"compared":[61],"to":[62],"p53-null":[63],"mice,":[64],"was":[65],"also":[66],"observed":[67],"mice":[69,79],"lacking":[70],"both":[71],"p53,":[74],"cells":[76],"from":[77],"these":[78],"significantly":[81],"higher":[82],"mutation":[83],"rate.":[84],"Our":[85],"results":[86],"suggest":[87],"is":[90],"a":[91],"new":[92],"member":[93],"susceptibility":[97],"genes.":[98]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}