{"id":"https://openalex.org/W2139144434","doi":"https://doi.org/10.1084/jem.186.5.683","title":"Impaired Bone Marrow Microenvironment and Immune Function in T Cell Protein Tyrosine Phosphatase\u2013deficient Mice","display_name":"Impaired Bone Marrow Microenvironment and Immune Function in T Cell Protein Tyrosine Phosphatase\u2013deficient Mice","publication_year":1997,"publication_date":"1997-08-29","ids":{"openalex":"https://openalex.org/W2139144434","doi":"https://doi.org/10.1084/jem.186.5.683","mag":"2139144434","pmid":"https://pubmed.ncbi.nlm.nih.gov/9271584","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2199020"},"language":"en","primary_location":{"id":"doi:10.1084/jem.186.5.683","doi":"https://doi.org/10.1084/jem.186.5.683","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.186.5.683","pdf_url":"https://rupress.org/jem/article-pdf/186/5/683/1685856/97-0656.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jem/article-pdf/186/5/683/1685856/97-0656.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004825092","display_name":"Kong Eric You-Ten","orcid":"https://orcid.org/0000-0003-4371-0259","observed_orcids":["https://orcid.org/0000-0003-4371-0259"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kong E. You-Ten","raw_affiliation_strings":["From the *Department of Biochemistry, \u2021Department of Pathology, and \u00a7Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Department of Biochemistry, \u2021Department of Pathology, and \u00a7Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026798889","display_name":"Eric S. Muise","orcid":"https://orcid.org/0000-0002-1238-5118","observed_orcids":["https://orcid.org/0000-0002-1238-5118"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Eric S. Muise","raw_affiliation_strings":["From the *Department of Biochemistry, \u2021Department of Pathology, and \u00a7Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Department of Biochemistry, \u2021Department of Pathology, and \u00a7Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042256262","display_name":"Annick Iti\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Annick Iti\u00e9","raw_affiliation_strings":["From the *Department of Biochemistry, \u2021Department of Pathology, and \u00a7Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Department of Biochemistry, \u2021Department of Pathology, and \u00a7Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068124048","display_name":"Eva Michaliszyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Eva Michaliszyn","raw_affiliation_strings":["From the *Department of Biochemistry, \u2021Department of Pathology, and \u00a7Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Department of Biochemistry, \u2021Department of Pathology, and \u00a7Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002299684","display_name":"John Wagner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John Wagner","raw_affiliation_strings":["From the *Department of Biochemistry, \u2021Department of Pathology, and \u00a7Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Department of Biochemistry, \u2021Department of Pathology, and \u00a7Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110029133","display_name":"Serge Jothy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Serge Jothy","raw_affiliation_strings":["From the *Department of Biochemistry, \u2021Department of Pathology, and \u00a7Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Department of Biochemistry, \u2021Department of Pathology, and \u00a7Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084510190","display_name":"Wayne S. Lapp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Wayne S. Lapp","raw_affiliation_strings":["From the *Department of Biochemistry, \u2021Department of Pathology, and \u00a7Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Department of Biochemistry, \u2021Department of Pathology, and \u00a7Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007653418","display_name":"Michel L. Tremblay","orcid":"https://orcid.org/0000-0002-0281-541X","observed_orcids":["https://orcid.org/0000-0002-0281-541X"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michel L. Tremblay","raw_affiliation_strings":["From the *Department of Biochemistry, \u2021Department of Pathology, and \u00a7Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Department of Biochemistry, \u2021Department of Pathology, and \u00a7Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6","institution_ids":["https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I5023651"],"apc_list":null,"apc_paid":null,"fwci":2.2466,"has_fulltext":true,"cited_by_count":362,"citation_normalized_percentile":{"value":0.88873045,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"186","issue":"5","first_page":"683","last_page":"693"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tcptp","display_name":"TCPTP","score":0.9829999804496765},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/b-cell-lymphopoiesis","display_name":"B cell lymphopoiesis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/t-cell-function","display_name":"T cell function","score":0.7070000171661377},{"id":"https://openalex.org/keywords/b-cell-function","display_name":"B cell function","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hematopoietic-stromal-cells","display_name":"hematopoietic stromal cells","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hematopoietic-failure","display_name":"hematopoietic failure","score":0.6940000057220459},{"id":"https://openalex.org/keywords/thymic-t-cell-development","display_name":"thymic T cell development","score":0.6600000262260437},{"id":"https://openalex.org/keywords/immune-function","display_name":"immune function","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C79904392","wikidata":"https://www.wikidata.org/wiki/Q5976738","display_name":"Lymphopoiesis","level":4,"score":0.6741311550140381},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.654999852180481},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6373533010482788},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6143949031829834},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5977259874343872},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.5902739763259888},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5542850494384766},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5527191162109375},{"id":"https://openalex.org/C2779703530","wikidata":"https://www.wikidata.org/wiki/Q837174","display_name":"Erythropoiesis","level":3,"score":0.5088265538215637},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.49298879504203796},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.47847601771354675},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4536629319190979},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41677114367485046},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3766965866088867},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3295094966888428},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.29876163601875305},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2941189706325531},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1441875398159027},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12284600734710693},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.11072677373886108},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.10570499300956726}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005720","descriptor_name":"Gamma Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054578","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1084/jem.186.5.683","doi":"https://doi.org/10.1084/jem.186.5.683","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.186.5.683","pdf_url":"https://rupress.org/jem/article-pdf/186/5/683/1685856/97-0656.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2199020","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2199020","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:9271584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9271584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1084/jem.186.5.683","doi":"https://doi.org/10.1084/jem.186.5.683","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.186.5.683","pdf_url":"https://rupress.org/jem/article-pdf/186/5/683/1685856/97-0656.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9539999961853027,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3759270703","display_name":null,"funder_award_id":"MT12466","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G6087740471","display_name":null,"funder_award_id":"MT3526","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G8832659798","display_name":null,"funder_award_id":"MT10315","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320310638","display_name":"McGill University","ror":"https://ror.org/01pxwe438"},{"id":"https://openalex.org/F4320311169","display_name":"Cancer Research Society","ror":"https://ror.org/00t38a349"},{"id":"https://openalex.org/F4320324195","display_name":"Medical Research Council Canada","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139144434.pdf","grobid_xml":"https://content.openalex.org/works/W2139144434.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W37545008","https://openalex.org/W197781038","https://openalex.org/W275936519","https://openalex.org/W1522665065","https://openalex.org/W1524755897","https://openalex.org/W1582172850","https://openalex.org/W1968546256","https://openalex.org/W1973930641","https://openalex.org/W1990563378","https://openalex.org/W1993948601","https://openalex.org/W1996026499","https://openalex.org/W2002390354","https://openalex.org/W2003044215","https://openalex.org/W2011874994","https://openalex.org/W2012116939","https://openalex.org/W2015003193","https://openalex.org/W2018826402","https://openalex.org/W2019032255","https://openalex.org/W2019386067","https://openalex.org/W2019396874","https://openalex.org/W2023602283","https://openalex.org/W2027480790","https://openalex.org/W2027683989","https://openalex.org/W2034296167","https://openalex.org/W2037951817","https://openalex.org/W2041844597","https://openalex.org/W2044725781","https://openalex.org/W2046241907","https://openalex.org/W2053335836","https://openalex.org/W2058860422","https://openalex.org/W2077236851","https://openalex.org/W2093778225","https://openalex.org/W2093835397","https://openalex.org/W2094290237","https://openalex.org/W2094601206","https://openalex.org/W2098008339","https://openalex.org/W2106018231","https://openalex.org/W2114417847","https://openalex.org/W2114943013","https://openalex.org/W2120494772","https://openalex.org/W2124642640","https://openalex.org/W2130708019","https://openalex.org/W2134143263","https://openalex.org/W2144634347","https://openalex.org/W2145040425","https://openalex.org/W2157131553","https://openalex.org/W2162743131","https://openalex.org/W2163995402","https://openalex.org/W2173291795","https://openalex.org/W2177231732","https://openalex.org/W2181131337","https://openalex.org/W2310647335","https://openalex.org/W2411808662","https://openalex.org/W2414478220","https://openalex.org/W2576734941","https://openalex.org/W4233277218","https://openalex.org/W6698152837"],"related_works":["https://openalex.org/W7095336335","https://openalex.org/W6996928878","https://openalex.org/W4389244011","https://openalex.org/W2008193652","https://openalex.org/W2062853747","https://openalex.org/W7099158147","https://openalex.org/W2589362794","https://openalex.org/W2020329417","https://openalex.org/W4283398526","https://openalex.org/W7006395384"],"abstract_inverted_index":{"The":[0,43],"T":[1,100,114],"cell":[2,24,92,103,115,141,148],"protein":[3],"tyrosine":[4,14],"phosphatase":[5],"(TC-PTP)":[6],"is":[7],"one":[8],"of":[9,36,59,75],"the":[10,33,57,111,118],"most":[11],"abundant":[12],"mammalian":[13],"phosphatases":[15],"in":[16,22,64,87,110,117,131,159],"hematopoietic":[17,23,129],"cells;":[18],"however,":[19],"its":[20],"role":[21,158],"function":[25],"remains":[26],"unknown.":[27],"In":[28],"this":[29],"report,":[30],"we":[31],"investigated":[32],"physiological":[34],"function(s)":[35],"TC-PTP":[37,60,132,154],"by":[38,72],"generating":[39],"TC-PTP-deficient":[40],"mutant":[41,69],"mice.":[42],"three":[44],"genotypes":[45],"(+/+,":[46],"+/-,":[47],"-/-)":[48],"showed":[49,127],"mendelian":[50],"segregation":[51],"at":[52],"birth":[53],"(1:2:1)":[54],"demonstrating":[55],"that":[56,128,153],"absence":[58],"was":[61,135],"not":[62,121,136],"lethal":[63],"utero,":[65],"but":[66,143],"all":[67],"homozygous":[68],"mice":[70,83],"died":[71],"3-5":[73],"wk":[74],"age,":[76],"displaying":[77],"runting,":[78],"splenomegaly,":[79],"and":[80,94,101,107,113,162],"lymphadenopathy.":[81],"Homozygous":[82],"exhibited":[84],"specific":[85],"defects":[86],"bone":[88],"marrow":[89],"(BM),":[90],"B":[91,102],"lymphopoiesis,":[93],"erythropoiesis,":[95],"as":[96,98],"well":[97],"impaired":[99],"functions.":[104],"However,":[105],"myeloid":[106],"macrophage":[108],"development":[109,116],"BM":[112,124],"thymus":[119],"were":[120],"significantly":[122],"affected.":[123],"transplantation":[125],"experiments":[126],"failure":[130],"-/-":[133],"animals":[134],"due":[137],"to":[138,145],"a":[139,146,156],"stem":[140],"defect,":[142],"rather":[144],"stromal":[147],"deficiency.":[149],"This":[150],"study":[151],"demonstrates":[152],"plays":[155],"significant":[157],"both":[160],"hematopoiesis":[161],"immune":[163],"function.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}