{"id":"https://openalex.org/W2139143168","doi":null,"title":"Visualisation of tumour regression after local chemotherapy with magnetic nanoparticles - a pilot study.","display_name":"Visualisation of tumour regression after local chemotherapy with magnetic nanoparticles - a pilot study.","publication_year":2010,"publication_date":"2010-05-01","ids":{"openalex":"https://openalex.org/W2139143168","mag":"2139143168","pmid":"https://pubmed.ncbi.nlm.nih.gov/20592340"},"language":"en","primary_location":{"id":"pmid:20592340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20592340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039200412","display_name":"Stefan Lyer","orcid":"https://orcid.org/0000-0003-2338-1136","observed_orcids":["https://orcid.org/0000-0003-2338-1136"]},"institutions":[{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Lyer","raw_affiliation_strings":["Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital Erlangen, Section for Experimental Oncology and Nanomedicine (Else Kr\u00f6ner-Fresenius Foundation Professorship), Gl\u00fcckstrasse 10, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital Erlangen, Section for Experimental Oncology and Nanomedicine (Else Kr\u00f6ner-Fresenius Foundation Professorship), Gl\u00fcckstrasse 10, Erlangen, Germany","institution_ids":["https://openalex.org/I4210088053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072070951","display_name":"Rainer Tietze","orcid":"https://orcid.org/0000-0001-9306-633X","observed_orcids":["https://orcid.org/0000-0001-9306-633X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rainer Tietze","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051953266","display_name":"Roland Jurgons","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roland Jurgons","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051424274","display_name":"Tobias Struffert","orcid":"https://orcid.org/0000-0002-8708-597X","observed_orcids":["https://orcid.org/0000-0002-8708-597X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tobias Struffert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053400883","display_name":"Tobias Engelhorn","orcid":"https://orcid.org/0000-0001-7341-3584","observed_orcids":["https://orcid.org/0000-0001-7341-3584"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tobias Engelhorn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090820233","display_name":"Eveline Schreiber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eveline Schreiber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110328756","display_name":"Arnd D\u00f6rfler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arnd D\u00f6rfler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012400250","display_name":"Christoph Alexiou","orcid":"https://orcid.org/0000-0003-2220-6790","observed_orcids":["https://orcid.org/0000-0003-2220-6790"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christoph Alexiou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1574,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.73584373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"30","issue":"5","first_page":"1553","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.6973000168800354,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.6973000168800354,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12405","display_name":"Characterization and Applications of Magnetic Nanoparticles","score":0.13089999556541443,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.047200001776218414,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/magnetic-drug-targeting","display_name":"magnetic drug delivery","score":0.9959999918937683},{"id":"https://openalex.org/keywords/superparamagnetic-iron-oxide-nanoparticles","display_name":"superparamagnetic iron oxide nanoparticles","score":0.9020000100135803},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.6840000152587891},{"id":"https://openalex.org/keywords/tumor-vascularity","display_name":"tumor vascularity","score":0.9399999976158142},{"id":"https://openalex.org/keywords/mitoxantrone","display_name":"mitoxantrone","score":0.878000020980835},{"id":"https://openalex.org/keywords/fe3o4-nanoparticles","display_name":"Fe3O4 nanoparticles","score":0.8370000123977661},{"id":"https://openalex.org/keywords/angiography","display_name":"angiography","score":0.7739999890327454},{"id":"https://openalex.org/keywords/locoregional-chemotherapy","display_name":"locoregional chemotherapy","score":0.9210000038146973}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6998196840286255},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5586580634117126},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5219911336898804},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4958437383174896},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.19284334778785706}],"mesh":[{"descriptor_ui":"D000792","descriptor_name":"Angiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005263","descriptor_name":"Femoral Artery","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008280","descriptor_name":"Magnetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:20592340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20592340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2139143168","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20592340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W6982722","https://openalex.org/W35825319","https://openalex.org/W1971456299","https://openalex.org/W1974344113","https://openalex.org/W1982576185","https://openalex.org/W1990765972","https://openalex.org/W1992166069","https://openalex.org/W2006046782","https://openalex.org/W2031791697","https://openalex.org/W2047922626","https://openalex.org/W2054341667","https://openalex.org/W2059619902","https://openalex.org/W2104251127","https://openalex.org/W2111443510","https://openalex.org/W2122285281","https://openalex.org/W2131311685","https://openalex.org/W2144197242","https://openalex.org/W2149507906","https://openalex.org/W2152793262","https://openalex.org/W2167397010","https://openalex.org/W2183078339"],"related_works":["https://openalex.org/W121345056","https://openalex.org/W2061384988","https://openalex.org/W2037984983","https://openalex.org/W2068394284","https://openalex.org/W2000366683","https://openalex.org/W1980264362","https://openalex.org/W1963801939","https://openalex.org/W6927631353","https://openalex.org/W2025490093","https://openalex.org/W2002969676"],"abstract_inverted_index":{"UNLABELLED:":[0],"Magnetic":[1],"drug":[2,14],"targeting":[3],"(MDT)":[4],"is":[5,54],"a":[6,80,113,127,181,203],"new":[7,140],"locoregional":[8],"chemotherapy":[9],"method":[10],"that":[11],"increases":[12],"the":[13,17,23,27,42,55,58,65,68,92,97,139,155,170,178,185,219,222,225],"dose":[15,25],"in":[16,49],"tumour":[18,83,104,186,196],"region,":[19],"while":[20],"simultaneously":[21],"reducing":[22],"overall":[24],"through":[26,91],"application":[28],"of":[29,52,57,67,101,142,169,184,206,224],"chemotherapeutic-bound":[30],"superparamagnetic":[31],"nanoparticles,":[32],"which":[33],"are":[34],"focused":[35],"by":[36,161],"an":[37,214],"external":[38],"magnetic":[39],"field":[40],"to":[41,87,96,121,194,217],"desired":[43],"body":[44],"compartment.":[45],"An":[46],"important":[47],"factor":[48],"this":[50,62,209],"kind":[51],"therapy":[53],"vascularisation":[56,102,220],"targeted":[59],"tumour.":[60,98],"In":[61,79,132,208],"pilot":[63,210],"study,":[64,211],"visualisation":[66,100],"tumour-vascularisation":[69],"before":[70,106,163,227],"and":[71,103,107,154,164,177,221,228],"after":[72,108,165,202,229],"MDT":[73,109,192],"was":[74,89,110],"investigated.":[75],"MATERIALS":[76],"AND":[77],"METHODS:":[78],"rabbit":[81],"VX-2":[82],"model,":[84],"mitoxantrone":[85],"bound":[86],"Fe(3)O(4)-nanoparticles":[88],"applied":[90],"femoral":[93],"artery":[94],"close":[95],"The":[99,152,167],"size":[105,175,197,223],"performed":[111],"using":[112],"biplane":[114],"angiographic":[115,124],"system":[116],"(Siemens":[117],"Axiom":[118],"Artis":[119],"dBA)":[120],"obtain":[122],"conventional":[123],"series":[125],"with":[126,138],"standard":[128],"iodine":[129],"contrast":[130],"agent.":[131],"addition,":[133],"cross-sectional":[134],"images":[135],"were":[136,158],"obtained":[137],"technique":[141],"flat":[143],"panel":[144],"detector":[145],"computed":[146],"tomography":[147],"(FD-CT)":[148],"called":[149],"DYNA-CT.":[150],"RESULTS:":[151],"tumours":[153,168,226],"supplying":[156],"vessels":[157,188],"clearly":[159],"displayed":[160],"FD-CT":[162,212],"MDT.":[166,190,230],"study":[171],"group":[172],"showed":[173,180],"considerable":[174],"reductions":[176,198],"angiography":[179],"drastic":[182],"reduction":[183],"supporting":[187],"following":[189],"CONCLUSION:":[191],"leads":[193],"significant":[195],"within":[199],"several":[200],"weeks":[201],"single":[204],"administration":[205],"chemotherapy.":[207],"offered":[213],"excellent":[215],"possibility":[216],"monitor":[218]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}