{"id":"https://openalex.org/W2139139966","doi":"https://doi.org/10.1084/jem.191.5.859","title":"Deficiency of the Stress Kinase P38\u03b1 Results in Embryonic Lethality","display_name":"Deficiency of the Stress Kinase P38\u03b1 Results in Embryonic Lethality","publication_year":2000,"publication_date":"2000-03-06","ids":{"openalex":"https://openalex.org/W2139139966","doi":"https://doi.org/10.1084/jem.191.5.859","mag":"2139139966","pmid":"https://pubmed.ncbi.nlm.nih.gov/10704466","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2195860"},"language":"en","primary_location":{"id":"doi:10.1084/jem.191.5.859","doi":"https://doi.org/10.1084/jem.191.5.859","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.191.5.859","pdf_url":"https://rupress.org/jem/article-pdf/191/5/859/1126398/991557.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2139139966"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jem/article-pdf/191/5/859/1126398/991557.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113848043","display_name":"Melanie R. Allen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie Allen","raw_affiliation_strings":["bDepartment of Genetic Technologies, Pfizer Central Research, Groton, Connecticut 06340","Department of Respiratory, Allergy, Immunology, Inflammation, and Infectious Diseases, Central Research, Pfizer, Inc., Groton, CT 06340, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"bDepartment of Genetic Technologies, Pfizer Central Research, Groton, Connecticut 06340","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Department of Respiratory, Allergy, Immunology, Inflammation, and Infectious Diseases, Central Research, Pfizer, Inc., Groton, CT 06340, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069572113","display_name":"Linne Svensson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Linne Svensson","raw_affiliation_strings":["aDepartment of Respiratory, Allergy, Immunology, Inflammation, and Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDepartment of Respiratory, Allergy, Immunology, Inflammation, and Infectious Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024227275","display_name":"Marsha L. Roach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marsha Roach","raw_affiliation_strings":["bDepartment of Genetic Technologies, Pfizer Central Research, Groton, Connecticut 06340"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"bDepartment of Genetic Technologies, Pfizer Central Research, Groton, Connecticut 06340","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040475295","display_name":"John Hambor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Hambor","raw_affiliation_strings":["bDepartment of Genetic Technologies, Pfizer Central Research, Groton, Connecticut 06340"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"bDepartment of Genetic Technologies, Pfizer Central Research, Groton, Connecticut 06340","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103622606","display_name":"John D. McNeish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John McNeish","raw_affiliation_strings":["bDepartment of Genetic Technologies, Pfizer Central Research, Groton, Connecticut 06340"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"bDepartment of Genetic Technologies, Pfizer Central Research, Groton, Connecticut 06340","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064863646","display_name":"Christopher A. Gabel","orcid":"https://orcid.org/0009-0008-0569-9574","observed_orcids":["https://orcid.org/0009-0008-0569-9574"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher A. Gabel","raw_affiliation_strings":["aDepartment of Respiratory, Allergy, Immunology, Inflammation, and Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDepartment of Respiratory, Allergy, Immunology, Inflammation, and Infectious Diseases","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.3795,"has_fulltext":true,"cited_by_count":267,"citation_normalized_percentile":{"value":0.9576013,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"191","issue":"5","first_page":"859","last_page":"870"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6449999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6449999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.21559999883174896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0414000004529953,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.7919999957084656},{"id":"https://openalex.org/keywords/p38alpha","display_name":"p38\u03b1","score":0.8610000014305115},{"id":"https://openalex.org/keywords/embryonic-lethality","display_name":"embryonic lethality","score":0.9200000166893005},{"id":"https://openalex.org/keywords/mapkapk2","display_name":"MAPKAPK2","score":0.9750000238418579},{"id":"https://openalex.org/keywords/il-1-signaling","display_name":"IL-1 signaling","score":0.921999990940094},{"id":"https://openalex.org/keywords/interleukin-1-receptor","display_name":"interleukin-1 receptor","score":0.8960000276565552},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8840000033378601},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.5699999928474426},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.578000009059906},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/gene-targeting","display_name":"gene targeting","score":0.33500000834465027}],"concepts":[{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.625203013420105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6094648838043213},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5982220768928528},{"id":"https://openalex.org/C124160383","wikidata":"https://www.wikidata.org/wiki/Q14914383","display_name":"ASK1","level":5,"score":0.46868282556533813},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.4561828672885895},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44680866599082947},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4137621223926544},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.41195616126060486},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.29621630907058716},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17711469531059265},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08949139714241028}],"mesh":[{"descriptor_ui":"D000099190","descriptor_name":"MAP-Kinase-Activated Kinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000841","descriptor_name":"Anisomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005804","descriptor_name":"Genes, Lethal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017670","descriptor_name":"Sodium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018053","descriptor_name":"Arsenites","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1084/jem.191.5.859","doi":"https://doi.org/10.1084/jem.191.5.859","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.191.5.859","pdf_url":"https://rupress.org/jem/article-pdf/191/5/859/1126398/991557.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmid:10704466","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10704466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2195860","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2195860/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.282.6180","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.282.6180","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/f1/af/J_Exp_Med_2000_Mar_6_191(5)_859-870.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1084/jem.191.5.859","doi":"https://doi.org/10.1084/jem.191.5.859","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.191.5.859","pdf_url":"https://rupress.org/jem/article-pdf/191/5/859/1126398/991557.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139139966.pdf","grobid_xml":"https://content.openalex.org/works/W2139139966.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1484163259","https://openalex.org/W1545327957","https://openalex.org/W1549679997","https://openalex.org/W1566502635","https://openalex.org/W1587892340","https://openalex.org/W1830781212","https://openalex.org/W1906605547","https://openalex.org/W1925667723","https://openalex.org/W1964994259","https://openalex.org/W1969436183","https://openalex.org/W1972366604","https://openalex.org/W1973769612","https://openalex.org/W1974353473","https://openalex.org/W1976384844","https://openalex.org/W1976385326","https://openalex.org/W1976462601","https://openalex.org/W1980831535","https://openalex.org/W1983237714","https://openalex.org/W1984026719","https://openalex.org/W1985888026","https://openalex.org/W1997065297","https://openalex.org/W1998487776","https://openalex.org/W2001333805","https://openalex.org/W2001399809","https://openalex.org/W2002022970","https://openalex.org/W2007986629","https://openalex.org/W2011936496","https://openalex.org/W2012766600","https://openalex.org/W2018289835","https://openalex.org/W2018936093","https://openalex.org/W2022914311","https://openalex.org/W2026692684","https://openalex.org/W2026951979","https://openalex.org/W2030900078","https://openalex.org/W2032731042","https://openalex.org/W2047263793","https://openalex.org/W2050690958","https://openalex.org/W2054116154","https://openalex.org/W2059844384","https://openalex.org/W2062892166","https://openalex.org/W2064510514","https://openalex.org/W2068502127","https://openalex.org/W2072410510","https://openalex.org/W2075084906","https://openalex.org/W2076276305","https://openalex.org/W2076810768","https://openalex.org/W2078065785","https://openalex.org/W2078532650","https://openalex.org/W2082355820","https://openalex.org/W2086525709","https://openalex.org/W2088764696","https://openalex.org/W2094179447","https://openalex.org/W2097066538","https://openalex.org/W2099729324","https://openalex.org/W2100837269","https://openalex.org/W2101710059","https://openalex.org/W2112146951","https://openalex.org/W2118188078","https://openalex.org/W2124962639","https://openalex.org/W2142638534","https://openalex.org/W2142848667","https://openalex.org/W2150792239","https://openalex.org/W2166103492","https://openalex.org/W2341881834","https://openalex.org/W4313343327"],"related_works":["https://openalex.org/W1964842427","https://openalex.org/W2168215091","https://openalex.org/W2025198517","https://openalex.org/W2152824905","https://openalex.org/W2074771170","https://openalex.org/W4231073711","https://openalex.org/W4306405230","https://openalex.org/W7100137481","https://openalex.org/W2002022970"],"abstract_inverted_index":{"The":[0],"mitogen-activated":[1],"protein":[2,74,81],"(MAP)":[3],"kinase":[4,83,110,173],"p38":[5,33],"is":[6,166],"a":[7,66,167,176],"key":[8,177],"component":[9,178],"of":[10,17,55,61,145,171,179],"stress":[11,89,102],"response":[12,86],"pathways":[13],"and":[14,75,96,104,107,118,156,175],"the":[15,29,39,53,62,126,154,180],"target":[16],"cytokine-suppressing":[18],"antiinflammatory":[19],"drugs":[20],"(CSAIDs).":[21],"A":[22],"genetic":[23],"approach":[24],"was":[25],"employed":[26],"to":[27,65,77,87,101,138,141],"inactivate":[28],"gene":[30],"encoding":[31],"one":[32],"isoform,":[34],"p38alpha.":[35],"Mice":[36],"null":[37],"for":[38],"p38alpha":[40,73,165,185],"allele":[41,64],"die":[42],"during":[43],"embryonic":[44,47,98],"development.":[45],"p38alpha(1/)-":[46],"stem":[48],"(ES)":[49],"cells":[50,71,95,121,123,136],"grown":[51],"in":[52,85,113,192],"presence":[54],"high":[56],"neomycin":[57],"concentrations":[58],"demonstrated":[59],"conversion":[60],"wild-type":[63,117],"targeted":[67],"allele.":[68],"p38alpha(-/)-":[69,119,134,157],"ES":[70,94,120,158],"lacked":[72],"failed":[76],"activate":[78],"MAP":[79],"kinase-activated":[80],"(MAPKAP)":[82],"2":[84,174],"chemical":[88],"inducers.":[90],"In":[91],"contrast,":[92],"p38alpha(1/+)":[93,131,155],"primary":[97],"fibroblasts":[99],"responded":[100,137],"stimuli":[103],"phosphorylated":[105],"p38alpha,":[106],"activated":[108],"MAPKAP":[109,172],"2.":[111],"After":[112],"vitro":[114],"differentiation,":[115],"both":[116],"yielded":[122],"that":[124,164],"expressed":[125],"interleukin":[127],"1":[128],"receptor":[129],"(IL-1R).":[130],"but":[132],"not":[133,187],"IL-1R-positive":[135],"IL-1":[139,181],"activation":[140],"produce":[142],"IL-6.":[143],"Comparison":[144],"chemical-induced":[146],"apoptosis":[147],"processes":[148],"revealed":[149],"no":[150],"significant":[151],"difference":[152],"between":[153],"cells.":[159],"Therefore,":[160],"these":[161],"studies":[162],"demonstrate":[163],"major":[168],"upstream":[169],"activator":[170],"signaling":[182],"pathway.":[183],"However,":[184],"does":[186],"serve":[188],"an":[189],"indispensable":[190],"role":[191],"apoptosis.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}