{"id":"https://openalex.org/W2139137006","doi":"https://doi.org/10.1128/jvi.80.9.4570-4579.2006","title":"Hexamethylbisacetamide Remodels the Human Immunodeficiency Virus Type 1 (HIV-1) Promoter and Induces Tat-Independent HIV-1 Expression but Blunts Cell Activation","display_name":"Hexamethylbisacetamide Remodels the Human Immunodeficiency Virus Type 1 (HIV-1) Promoter and Induces Tat-Independent HIV-1 Expression but Blunts Cell Activation","publication_year":2006,"publication_date":"2006-04-12","ids":{"openalex":"https://openalex.org/W2139137006","doi":"https://doi.org/10.1128/jvi.80.9.4570-4579.2006","mag":"2139137006","pmid":"https://pubmed.ncbi.nlm.nih.gov/16611917","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1472000"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.80.9.4570-4579.2006","doi":"https://doi.org/10.1128/jvi.80.9.4570-4579.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.80.9.4570-4579.2006","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://cdr.lib.unc.edu/downloads/0c483r97f","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012141938","display_name":"Vladimir I. Klichko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104138","display_name":"VA North Texas Health Care System","ror":"https://ror.org/01nzxq896","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210104138","https://openalex.org/I4210144023"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladimir Klichko","raw_affiliation_strings":["North Texas Veterans Health Care Systems, Dallas, Texas 75216","University of Texas Southwestern Medical Center at Dallas, Texas 75390"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Texas Veterans Health Care Systems, Dallas, Texas 75216","institution_ids":["https://openalex.org/I4210104138"]},{"raw_affiliation_string":"University of Texas Southwestern Medical Center at Dallas, Texas 75390","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055961426","display_name":"Nancy M. Archin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Archin","raw_affiliation_strings":["University of North Carolina at Chapel Hill, North Carolina 27599-7435"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill, North Carolina 27599-7435","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rupinderjeet Kaur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rupinderjeet Kaur","raw_affiliation_strings":["University of Texas Southwestern Medical Center at Dallas, Texas 75390"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center at Dallas, Texas 75390","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051525928","display_name":"Ginger K. Lehrman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ginger Lehrman","raw_affiliation_strings":["University of Texas Southwestern Medical Center at Dallas, Texas 75390"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center at Dallas, Texas 75390","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008716404","display_name":"David M. Margolis","orcid":"https://orcid.org/0000-0001-5714-0002","observed_orcids":["https://orcid.org/0000-0001-5714-0002"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Margolis","raw_affiliation_strings":["University of North Carolina at Chapel Hill, North Carolina 27599-7435"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill, North Carolina 27599-7435","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008716404"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":1.9652,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.8546943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"80","issue":"9","first_page":"4570","last_page":"4579"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-latency","display_name":"HIV-1 latency","score":0.7839999794960022},{"id":"https://openalex.org/keywords/hiv-1-promoter","display_name":"HIV-1 promoter","score":0.7269999980926514},{"id":"https://openalex.org/keywords/long-terminal-repeat","display_name":"long terminal repeat","score":0.8939999938011169},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.9269999861717224},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hiv-reactivation","display_name":"HIV reactivation","score":0.5619999766349792},{"id":"https://openalex.org/keywords/cd4-downregulation","display_name":"CD4 downregulation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5230000019073486},{"id":"https://openalex.org/keywords/cell-activation","display_name":"cell activation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/chronic-hiv-infection","display_name":"chronic HIV infection","score":0.7649999856948853},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8640767335891724},{"id":"https://openalex.org/C2910020833","wikidata":"https://www.wikidata.org/wiki/Q1869477","display_name":"HIV Long Terminal Repeat","level":5,"score":0.6899755001068115},{"id":"https://openalex.org/C199491388","wikidata":"https://www.wikidata.org/wiki/Q1869477","display_name":"Long terminal repeat","level":4,"score":0.6170678734779358},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5573863387107849},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5502502918243408},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.546399712562561},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5386403203010559},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4311392605304718},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4310634732246399},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.42490923404693604},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.35616758465766907},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33685600757598877},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.25023382902145386},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2416786253452301},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12050610780715942}],"mesh":[{"descriptor_ui":"D000081","descriptor_name":"Acetamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004706","descriptor_name":"Endodeoxyribonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011991","descriptor_name":"Receptors, Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015375","descriptor_name":"Receptors, Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015696","descriptor_name":"Gene Products, tat","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016325","descriptor_name":"HIV Long Terminal Repeat","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054322","descriptor_name":"tat Gene Products, Human Immunodeficiency Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.80.9.4570-4579.2006","doi":"https://doi.org/10.1128/jvi.80.9.4570-4579.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.80.9.4570-4579.2006","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmid:16611917","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16611917","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:h128nn488","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/0bmq-hc48","pdf_url":"https://cdr.lib.unc.edu/downloads/0c483r97f","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Virology, 80(9)","raw_type":"Article"},{"id":"doi:10.17615/0bmq-hc48","doi":"https://doi.org/10.17615/0bmq-hc48","is_oa":true,"landing_page_url":"https://doi.org/10.17615/0bmq-hc48","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:cdr.lib.unc.edu:h128nn488","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/0bmq-hc48","pdf_url":"https://cdr.lib.unc.edu/downloads/0c483r97f","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Virology, 80(9)","raw_type":"Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8600000143051147}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4449209241","display_name":"Repression of HIV Transcription-A Pathway to Quiescence","funder_award_id":"R01AI045297","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139137006.pdf","grobid_xml":"https://content.openalex.org/works/W2139137006.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W172814412","https://openalex.org/W266859766","https://openalex.org/W1491954563","https://openalex.org/W1497870368","https://openalex.org/W1514219739","https://openalex.org/W1519029260","https://openalex.org/W1527634862","https://openalex.org/W1541385864","https://openalex.org/W1558864286","https://openalex.org/W1590436404","https://openalex.org/W1598902601","https://openalex.org/W1646901593","https://openalex.org/W1928725833","https://openalex.org/W1968177936","https://openalex.org/W1968550320","https://openalex.org/W1969482587","https://openalex.org/W1978664410","https://openalex.org/W1980160768","https://openalex.org/W1981262353","https://openalex.org/W1982206175","https://openalex.org/W1982619775","https://openalex.org/W1985393916","https://openalex.org/W1989600543","https://openalex.org/W1996270170","https://openalex.org/W1996604523","https://openalex.org/W2000337153","https://openalex.org/W2000576198","https://openalex.org/W2002033226","https://openalex.org/W2002698073","https://openalex.org/W2004246558","https://openalex.org/W2009227393","https://openalex.org/W2011626958","https://openalex.org/W2015110425","https://openalex.org/W2020994321","https://openalex.org/W2024713471","https://openalex.org/W2026368142","https://openalex.org/W2030844138","https://openalex.org/W2032025865","https://openalex.org/W2035915355","https://openalex.org/W2036890038","https://openalex.org/W2037662479","https://openalex.org/W2039703359","https://openalex.org/W2046648601","https://openalex.org/W2059180250","https://openalex.org/W2060829964","https://openalex.org/W2068170981","https://openalex.org/W2069933653","https://openalex.org/W2070837282","https://openalex.org/W2071960376","https://openalex.org/W2072916562","https://openalex.org/W2076610142","https://openalex.org/W2081091627","https://openalex.org/W2081550246","https://openalex.org/W2085910360","https://openalex.org/W2090646713","https://openalex.org/W2092340900","https://openalex.org/W2093012266","https://openalex.org/W2101516953","https://openalex.org/W2107662340","https://openalex.org/W2107815011","https://openalex.org/W2118798209","https://openalex.org/W2121571483","https://openalex.org/W2124221188","https://openalex.org/W2125284130","https://openalex.org/W2125593632","https://openalex.org/W2126183658","https://openalex.org/W2126824096","https://openalex.org/W2132062260","https://openalex.org/W2132456440","https://openalex.org/W2135547889","https://openalex.org/W2139250164","https://openalex.org/W2139996002","https://openalex.org/W2143658931","https://openalex.org/W2147701937","https://openalex.org/W2149941627","https://openalex.org/W2154643608","https://openalex.org/W2162714011","https://openalex.org/W2163921097","https://openalex.org/W2166861522","https://openalex.org/W2171248671","https://openalex.org/W2413745988"],"related_works":["https://openalex.org/W2101066888","https://openalex.org/W7100062689","https://openalex.org/W1989600543","https://openalex.org/W2070837282","https://openalex.org/W1976928187","https://openalex.org/W1587232660","https://openalex.org/W7098484053","https://openalex.org/W1994203761","https://openalex.org/W1590436404","https://openalex.org/W2153810373"],"abstract_inverted_index":{"Hexamethylbisacetamide":[0],"(HMBA)":[1],"induces":[2,51],"human":[3],"immunodeficiency":[4],"virus":[5],"type":[6],"1":[7,56],"(HIV-1)":[8],"gene":[9],"expression":[10,26,103,126],"in":[11,90,111,132,142],"latently":[12],"infected":[13],"T-cell":[14],"and":[15,109,122,129,131,160],"monocytoid":[16],"cell":[17,94,120],"lines.":[18],"We":[19],"find":[20],"that":[21,167],"HMBA":[22,50,84,99,117,138],"activation":[23],"of":[24,36,38,62,104,127,156,173],"viral":[25],"is":[27],"Tat":[28],"independent":[29],"but,":[30],"like":[31],"Tat,":[32],"increases":[33],"the":[34,39,59,105,169],"efficiency":[35],"elongation":[37],"HIV-1":[40],"promoter":[41,158],"(long":[42],"terminal":[43],"repeat":[44],"[LTR])":[45],"transcripts.":[46],"Further,":[47],"exposure":[48],"to":[49,135],"chromatin":[52],"remodeling":[53],"at":[54],"nucleosome":[55],"(Nuc-1)":[57],"near":[58,76],"start":[60],"site":[61],"LTR":[63],"transcription":[64],"but":[65,113],"does":[66],"so":[67],"without":[68],"increasing":[69],"histone":[70,74],"acetylation":[71],"or":[72],"altering":[73],"methylation":[75],"Nuc-1.":[77],"Of":[78],"note,":[79],"despite":[80],"enhanced":[81],"proviral":[82,171],"expression,":[83],"suppressed":[85,125],"HIV":[86,106,157,175],"infection":[87],"ex":[88],"vivo":[89],"primary":[91],"blood":[92],"mononuclear":[93],"(PBMC)":[95],"cultures.":[96],"Treatment":[97],"with":[98,119],"did":[100],"not":[101],"alter":[102],"coreceptors,":[107],"CCR5":[108],"CXCR4,":[110],"PBMCs":[112,133],"down-regulated":[114],"CD4.":[115],"Finally,":[116],"interferes":[118],"proliferation":[121],"activation;":[123],"it":[124,149],"Ki67":[128],"CD25":[130],"exposed":[134],"mitogen.":[136],"As":[137],"has":[139],"been":[140],"tested":[141],"oncology":[143],"trials,":[144],"its":[145],"unusual":[146],"properties":[147],"make":[148],"a":[150,161],"useful":[151],"reagent":[152],"for":[153,165],"future":[154],"studies":[155],"regulation":[159],"novel":[162],"prototype":[163],"molecule":[164],"therapeutics":[166],"abort":[168],"latent":[170],"state":[172],"chronic":[174],"infection.":[176]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
