{"id":"https://openalex.org/W2139126323","doi":"https://doi.org/10.1111/j.1440-1746.2006.04630.x","title":"Lamivudine resistance in patients with chronic hepatitis B: Role of clinical and virological factors","display_name":"Lamivudine resistance in patients with chronic hepatitis B: Role of clinical and virological factors","publication_year":2006,"publication_date":"2006-08-16","ids":{"openalex":"https://openalex.org/W2139126323","doi":"https://doi.org/10.1111/j.1440-1746.2006.04630.x","mag":"2139126323","pmid":"https://pubmed.ncbi.nlm.nih.gov/17608854"},"language":"en","primary_location":{"id":"doi:10.1111/j.1440-1746.2006.04630.x","doi":"https://doi.org/10.1111/j.1440-1746.2006.04630.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1746.2006.04630.x","pdf_url":null,"source":{"id":"https://openalex.org/S131037608","display_name":"Journal of Gastroenterology and Hepatology","issn_l":"0815-9319","issn":["0815-9319","1440-1746"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology and Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111793890","display_name":"Alexander J. V. Thompson","orcid":"https://orcid.org/0000-0001-9882-0071","observed_orcids":["https://orcid.org/0000-0001-9882-0071"]},"institutions":[{"id":"https://openalex.org/I4210087110","display_name":"St Vincent's Hospital Melbourne","ror":"https://ror.org/001kjn539","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087110","https://openalex.org/I4210098850"]},{"id":"https://openalex.org/I4210088630","display_name":"Victorian Infectious Diseases Reference Laboratory","ror":"https://ror.org/005ynf375","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210088630"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Alexander J V Thompson","raw_affiliation_strings":["St Vincent's Hospital, Melbourne, Victoria, Australia","St Vincent's Hospital and","Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Vincent's Hospital, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I4210087110"]},{"raw_affiliation_string":"St Vincent's Hospital and","institution_ids":["https://openalex.org/I4210087110"]},{"raw_affiliation_string":"Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I4210088630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111673677","display_name":"Anna Ayres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088630","display_name":"Victorian Infectious Diseases Reference Laboratory","ror":"https://ror.org/005ynf375","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210088630"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Anna Ayres","raw_affiliation_strings":["Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I4210088630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002122776","display_name":"Lilly K. W. Yuen","orcid":"https://orcid.org/0000-0003-2934-0167","observed_orcids":["https://orcid.org/0000-0003-2934-0167"]},"institutions":[{"id":"https://openalex.org/I4210088630","display_name":"Victorian Infectious Diseases Reference Laboratory","ror":"https://ror.org/005ynf375","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210088630"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lilly Yuen","raw_affiliation_strings":["Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I4210088630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032963402","display_name":"Angeline Bartholomeusz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088630","display_name":"Victorian Infectious Diseases Reference Laboratory","ror":"https://ror.org/005ynf375","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210088630"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Angeline Bartholomeusz","raw_affiliation_strings":["Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I4210088630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111505366","display_name":"D. Scott Bowden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088630","display_name":"Victorian Infectious Diseases Reference Laboratory","ror":"https://ror.org/005ynf375","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210088630"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"D Scott Bowden","raw_affiliation_strings":["Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I4210088630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049020371","display_name":"David M. Iser","orcid":"https://orcid.org/0000-0003-4437-0591","observed_orcids":["https://orcid.org/0000-0003-4437-0591"]},"institutions":[{"id":"https://openalex.org/I4210087110","display_name":"St Vincent's Hospital Melbourne","ror":"https://ror.org/001kjn539","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087110","https://openalex.org/I4210098850"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David M Iser","raw_affiliation_strings":["St Vincent\u2019s Hospital and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Vincent\u2019s Hospital and","institution_ids":["https://openalex.org/I4210087110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082060802","display_name":"Robert Y. M. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087110","display_name":"St Vincent's Hospital Melbourne","ror":"https://ror.org/001kjn539","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087110","https://openalex.org/I4210098850"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Robert Y M Chen","raw_affiliation_strings":["St Vincent\u2019s Hospital and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Vincent\u2019s Hospital and","institution_ids":["https://openalex.org/I4210087110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087226208","display_name":"Barbara Demediuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087110","display_name":"St Vincent's Hospital Melbourne","ror":"https://ror.org/001kjn539","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087110","https://openalex.org/I4210098850"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Barbara Demediuk","raw_affiliation_strings":["St Vincent\u2019s Hospital and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Vincent\u2019s Hospital and","institution_ids":["https://openalex.org/I4210087110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071002271","display_name":"Gideon Shaw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087110","display_name":"St Vincent's Hospital Melbourne","ror":"https://ror.org/001kjn539","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087110","https://openalex.org/I4210098850"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gideon Shaw","raw_affiliation_strings":["St Vincent\u2019s Hospital and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Vincent\u2019s Hospital and","institution_ids":["https://openalex.org/I4210087110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086869055","display_name":"Sally Bell","orcid":"https://orcid.org/0000-0002-7002-453X","observed_orcids":["https://orcid.org/0000-0002-7002-453X"]},"institutions":[{"id":"https://openalex.org/I4210087110","display_name":"St Vincent's Hospital Melbourne","ror":"https://ror.org/001kjn539","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087110","https://openalex.org/I4210098850"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sally J Bell","raw_affiliation_strings":["St Vincent\u2019s Hospital and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Vincent\u2019s Hospital and","institution_ids":["https://openalex.org/I4210087110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111961926","display_name":"Katrina J R Watson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087110","display_name":"St Vincent's Hospital Melbourne","ror":"https://ror.org/001kjn539","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087110","https://openalex.org/I4210098850"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Katrina J R Watson","raw_affiliation_strings":["St Vincent\u2019s Hospital and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Vincent\u2019s Hospital and","institution_ids":["https://openalex.org/I4210087110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085621586","display_name":"STEPHEN A LOCARNINI","orcid":"https://orcid.org/0000-0001-7253-8932","observed_orcids":["https://orcid.org/0000-0001-7253-8932"]},"institutions":[{"id":"https://openalex.org/I4210088630","display_name":"Victorian Infectious Diseases Reference Laboratory","ror":"https://ror.org/005ynf375","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210088630"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Stephen A Locarnini","raw_affiliation_strings":["Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I4210088630"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110096232","display_name":"Paul V Desmond","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087110","display_name":"St Vincent's Hospital Melbourne","ror":"https://ror.org/001kjn539","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087110","https://openalex.org/I4210098850"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Paul V Desmond","raw_affiliation_strings":["St Vincent\u2019s Hospital and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Vincent\u2019s Hospital and","institution_ids":["https://openalex.org/I4210087110"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110096232"],"corresponding_institution_ids":["https://openalex.org/I4210087110"],"apc_list":{"value":4620,"currency":"USD","value_usd":4620},"apc_paid":null,"fwci":3.9038,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.93305891,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"22","issue":"7","first_page":"1078","last_page":"1085"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lamivudine-resistance","display_name":"lamivudine resistance","score":0.9940000176429749},{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.996999979019165},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.8529999852180481},{"id":"https://openalex.org/keywords/persistent-viremia","display_name":"persistent viremia","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hbv-genotypes","display_name":"HBV genotypes","score":0.609000027179718},{"id":"https://openalex.org/keywords/hbv-polymerase-gene","display_name":"HBV polymerase gene","score":0.5839999914169312},{"id":"https://openalex.org/keywords/monotherapy","display_name":"monotherapy","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C2777869810","wikidata":"https://www.wikidata.org/wiki/Q422631","display_name":"Lamivudine","level":4,"score":0.9631285667419434},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8016862273216248},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.654068112373352},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.6478140950202942},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5932818651199341},{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.5311962962150574},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5030583739280701},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4414724111557007},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.4162943959236145},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.41510143876075745},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3534312844276428},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34636056423187256},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3118610084056854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10797402262687683},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0768352746963501}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019259","descriptor_name":"Lamivudine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1440-1746.2006.04630.x","doi":"https://doi.org/10.1111/j.1440-1746.2006.04630.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1746.2006.04630.x","pdf_url":null,"source":{"id":"https://openalex.org/S131037608","display_name":"Journal of Gastroenterology and Hepatology","issn_l":"0815-9319","issn":["0815-9319","1440-1746"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology and Hepatology","raw_type":"journal-article"},{"id":"pmid:17608854","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17608854","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastroenterology and hepatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1498132922","https://openalex.org/W1639652471","https://openalex.org/W1937171440","https://openalex.org/W1991359390","https://openalex.org/W1999864391","https://openalex.org/W2002548940","https://openalex.org/W2004054613","https://openalex.org/W2009944703","https://openalex.org/W2014837723","https://openalex.org/W2019144721","https://openalex.org/W2052006933","https://openalex.org/W2052966995","https://openalex.org/W2066329245","https://openalex.org/W2067333579","https://openalex.org/W2079105578","https://openalex.org/W2087416757","https://openalex.org/W2094174828","https://openalex.org/W2098008728","https://openalex.org/W2102271923","https://openalex.org/W2104621393","https://openalex.org/W2134970942","https://openalex.org/W2144297979","https://openalex.org/W2146003334","https://openalex.org/W2148572944","https://openalex.org/W2157857312","https://openalex.org/W2158440429","https://openalex.org/W2160648249","https://openalex.org/W2167185739","https://openalex.org/W2293495463","https://openalex.org/W2338794667","https://openalex.org/W2440995936","https://openalex.org/W3152231134"],"related_works":["https://openalex.org/W2136680766","https://openalex.org/W1992023944","https://openalex.org/W2046397049","https://openalex.org/W2099287729","https://openalex.org/W2916563119","https://openalex.org/W1967668205","https://openalex.org/W2355502534","https://openalex.org/W2066469842","https://openalex.org/W2979237013","https://openalex.org/W2062564818"],"abstract_inverted_index":{"BACKGROUND:":[0],"Lamivudine":[1],"resistance":[2,100,134,199,240],"is":[3],"associated":[4],"with":[5,48,93,174,229],"long-term":[6],"monotherapy":[7],"for":[8,122,246],"chronic":[9],"hepatitis":[10,27,66,232],"B":[11,28,67,233],"and":[12,57,138,143,158,187,242],"can":[13],"lead":[14],"to":[15,41,117,223,237],"potentially":[16],"serious":[17],"clinical":[18],"consequences.":[19],"Scant":[20],"information":[21],"exists":[22],"regarding":[23],"the":[24,32,53,63,123,150,168,251,258],"influence":[25,218],"of":[26,34,45,55,65,126,132,167,171,177,225,260],"virus":[29,234],"variants":[30,61],"in":[31,62,90],"development":[33,170,259],"resistance.":[35,128,226,261],"The":[36,110,130],"present":[37],"study":[38],"was":[39,85,105,115,135],"designed":[40],"identify":[42],"factors":[43],"predictive":[44],"lamivudine":[46,82,99,127,133,172,239],"resistance,":[47,173],"a":[49,98],"particular":[50],"focus":[51],"on":[52,81],"role":[54],"precore":[56,151,230],"basal":[58],"core":[59],"promoter":[60],"setting":[64],"e":[68],"antigen-negative":[69],"disease.":[70],"METHODS:":[71],"Eighty-five":[72],"patients,":[73],"representing":[74],"four":[75],"major":[76],"genotypes,":[77],"were":[78,210],"followed":[79],"prospectively":[80],"therapy.":[83],"Resistance":[84],"defined":[86],"as":[87,164],"an":[88],"increase":[89],"viral":[91],"load,":[92],"polymerase":[94],"gene":[95],"sequencing":[96],"confirming":[97],"mutation.":[101],"Median":[102],"follow":[103],"up":[104],"19":[106],"months":[107],"(6-54":[108],"months).":[109],"Cox":[111],"proportional":[112],"hazards":[113],"model":[114],"used":[116],"determine":[118],"variables":[119],"independently":[120],"predicting":[121],"early":[124,169,198,241],"onset":[125,224],"RESULTS:":[129],"rate":[131,175],"6%,":[136],"31%":[137],"51%":[139],"at":[140],"12,":[141],"24":[142],"48":[144],"months,":[145],"respectively.":[146],"Multivariate":[147],"analysis":[148],"identified":[149],"variant,":[152],"high":[153],"baseline":[154],"alanine":[155],"aminotransferase":[156],"(ALT),":[157],"persistent":[159],"viremia":[160],"(at":[161],"6":[162],"months)":[163],"independent":[165],"predictors":[166],"ratios":[176],"4.93":[178],"(95%":[179],"confidence":[180],"interval":[181],"[CI]:":[182],"1.32-18.5),":[183],"1.22":[184],"(95%CI:":[185,189],"1.08-1.49),":[186],"4.73":[188],"1.49-15.0),":[190],"respectively":[191],"(P":[192],"<":[193,206],"0.05).":[194],"Female":[195],"sex":[196],"predicted":[197],"(rate":[200],"ratio":[201],"5.27":[202],"[95%CI:":[203],"1.23-22.5,":[204],"P":[205],"0.05])":[207],"although":[208],"numbers":[209],"small":[211],"(n":[212],"=":[213],"12).":[214],"Genotype":[215],"did":[216],"not":[217],"treatment":[219],"response":[220],"nor":[221],"time":[222],"CONCLUSION:":[227],"Patients":[228],"variant":[231],"are":[235],"likely":[236],"develop":[238],"should":[243],"be":[244],"considered":[245],"alternate":[247],"first-line":[248],"monotherapy.":[249],"In":[250],"future,":[252],"combination":[253],"antiviral":[254],"therapy":[255],"may":[256],"limit":[257]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
