{"id":"https://openalex.org/W2139117716","doi":"https://doi.org/10.1111/acer.12904","title":"Acute and Chronic Ethanol Administration Differentially Modulate Hepatic Autophagy and Transcription Factor EB","display_name":"Acute and Chronic Ethanol Administration Differentially Modulate Hepatic Autophagy and Transcription Factor EB","publication_year":2015,"publication_date":"2015-11-11","ids":{"openalex":"https://openalex.org/W2139117716","doi":"https://doi.org/10.1111/acer.12904","mag":"2139117716","pmid":"https://pubmed.ncbi.nlm.nih.gov/26556759"},"language":"en","primary_location":{"id":"doi:10.1111/acer.12904","doi":"https://doi.org/10.1111/acer.12904","is_oa":false,"landing_page_url":"https://doi.org/10.1111/acer.12904","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088616838","display_name":"Paul G. Thomes","orcid":"https://orcid.org/0000-0003-2158-7077","observed_orcids":["https://orcid.org/0000-0003-2158-7077"]},"institutions":[{"id":"https://openalex.org/I4210094650","display_name":"Omaha VA Medical Center","ror":"https://ror.org/00nsz0a92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094650","https://openalex.org/I4210117924","https://openalex.org/I4210155874"]},{"id":"https://openalex.org/I4210155874","display_name":"VA Nebraska Western Iowa Health Care System","ror":"https://ror.org/0594ske86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117924","https://openalex.org/I4210155874"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul G. Thomes","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska","Liver Study Unit, Department of Veterans Affairs, VA Nebraska-Western Iowa Health Care System (NWIHCS), Omaha, Nebraska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Liver Study Unit, Department of Veterans Affairs, VA Nebraska-Western Iowa Health Care System (NWIHCS), Omaha, Nebraska","institution_ids":["https://openalex.org/I4210094650","https://openalex.org/I4210155874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076890129","display_name":"Casey S. Trambly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094650","display_name":"Omaha VA Medical Center","ror":"https://ror.org/00nsz0a92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094650","https://openalex.org/I4210117924","https://openalex.org/I4210155874"]},{"id":"https://openalex.org/I4210155874","display_name":"VA Nebraska Western Iowa Health Care System","ror":"https://ror.org/0594ske86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117924","https://openalex.org/I4210155874"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Casey S. Trambly","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska","Liver Study Unit, Department of Veterans Affairs, VA Nebraska-Western Iowa Health Care System (NWIHCS), Omaha, Nebraska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Liver Study Unit, Department of Veterans Affairs, VA Nebraska-Western Iowa Health Care System (NWIHCS), Omaha, Nebraska","institution_ids":["https://openalex.org/I4210094650","https://openalex.org/I4210155874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061418721","display_name":"Howard S. Fox","orcid":"https://orcid.org/0000-0003-2032-374X","observed_orcids":["https://orcid.org/0000-0003-2032-374X","https://orcid.org/0000-0003-1141-6725"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard S. Fox","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061970794","display_name":"Dean J. Tuma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094650","display_name":"Omaha VA Medical Center","ror":"https://ror.org/00nsz0a92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094650","https://openalex.org/I4210117924","https://openalex.org/I4210155874"]},{"id":"https://openalex.org/I4210155874","display_name":"VA Nebraska Western Iowa Health Care System","ror":"https://ror.org/0594ske86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117924","https://openalex.org/I4210155874"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean J. Tuma","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska","Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska","Liver Study Unit, Department of Veterans Affairs, VA Nebraska-Western Iowa Health Care System (NWIHCS), Omaha, Nebraska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Liver Study Unit, Department of Veterans Affairs, VA Nebraska-Western Iowa Health Care System (NWIHCS), Omaha, Nebraska","institution_ids":["https://openalex.org/I4210094650","https://openalex.org/I4210155874"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010327408","display_name":"Terrence M. Donohue","orcid":"https://orcid.org/0000-0002-5185-9910","observed_orcids":["https://orcid.org/0000-0002-5185-9910"]},"institutions":[{"id":"https://openalex.org/I4210094650","display_name":"Omaha VA Medical Center","ror":"https://ror.org/00nsz0a92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094650","https://openalex.org/I4210117924","https://openalex.org/I4210155874"]},{"id":"https://openalex.org/I4210155874","display_name":"VA Nebraska Western Iowa Health Care System","ror":"https://ror.org/0594ske86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117924","https://openalex.org/I4210155874"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Terrence M. Donohue","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska","Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska","Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska","Liver Study Unit, Department of Veterans Affairs, VA Nebraska-Western Iowa Health Care System (NWIHCS), Omaha, Nebraska","The Center for Environmental Health and Toxicology, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Liver Study Unit, Department of Veterans Affairs, VA Nebraska-Western Iowa Health Care System (NWIHCS), Omaha, Nebraska","institution_ids":["https://openalex.org/I4210094650","https://openalex.org/I4210155874"]},{"raw_affiliation_string":"The Center for Environmental Health and Toxicology, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010327408"],"corresponding_institution_ids":["https://openalex.org/I4210094650","https://openalex.org/I4210155874","https://openalex.org/I59130452"],"apc_list":{"value":4110,"currency":"USD","value_usd":4110},"apc_paid":null,"fwci":2.9441,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.91640644,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"39","issue":"12","first_page":"2354","last_page":"2363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hepatic-autophagy","display_name":"hepatic autophagy","score":0.9470000267028809},{"id":"https://openalex.org/keywords/tfeb","display_name":"TFEB","score":0.9139999747276306},{"id":"https://openalex.org/keywords/lysosomal-biogenesis","display_name":"lysosomal biogenesis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/acute-ethanol-administration","display_name":"acute ethanol administration","score":0.6610000133514404},{"id":"https://openalex.org/keywords/chronic-ethanol-feeding","display_name":"chronic ethanol feeding","score":0.9649999737739563},{"id":"https://openalex.org/keywords/autophagosomes","display_name":"autophagosomes","score":0.8500000238418579},{"id":"https://openalex.org/keywords/p62","display_name":"p62","score":0.8960000276565552},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.4090000092983246},{"id":"https://openalex.org/keywords/lysosomal-catabolism","display_name":"lysosomal catabolism","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C132647116","wikidata":"https://www.wikidata.org/wiki/Q18032677","display_name":"TFEB","level":4,"score":0.9927641153335571},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9357323050498962},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.7000227570533752},{"id":"https://openalex.org/C168296220","wikidata":"https://www.wikidata.org/wiki/Q14882441","display_name":"Autophagosome","level":4,"score":0.628865122795105},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49127334356307983},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.4533001482486725},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.43835124373435974},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4321020245552063},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42895978689193726},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40883421897888184},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3984018862247467},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3128097951412201},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.17072364687919617},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16832679510116577},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1317690908908844},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09994891285896301},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.05801284313201904}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051778","descriptor_name":"Basic Helix-Loop-Helix Leucine Zipper Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/acer.12904","doi":"https://doi.org/10.1111/acer.12904","is_oa":false,"landing_page_url":"https://doi.org/10.1111/acer.12904","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},{"id":"pmid:26556759","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26556759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism, clinical and experimental research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309137","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1538648309","https://openalex.org/W1920985532","https://openalex.org/W1964320224","https://openalex.org/W1975200363","https://openalex.org/W1976434856","https://openalex.org/W1978955254","https://openalex.org/W1979952830","https://openalex.org/W1985409997","https://openalex.org/W1986047025","https://openalex.org/W1988658486","https://openalex.org/W1995966034","https://openalex.org/W1996716971","https://openalex.org/W2000913561","https://openalex.org/W2007505836","https://openalex.org/W2011191028","https://openalex.org/W2014023780","https://openalex.org/W2017379742","https://openalex.org/W2019822900","https://openalex.org/W2022884184","https://openalex.org/W2024087913","https://openalex.org/W2028351193","https://openalex.org/W2032189193","https://openalex.org/W2033212418","https://openalex.org/W2035299223","https://openalex.org/W2038162199","https://openalex.org/W2046074477","https://openalex.org/W2050043099","https://openalex.org/W2067207099","https://openalex.org/W2072885549","https://openalex.org/W2074187955","https://openalex.org/W2077499130","https://openalex.org/W2079569342","https://openalex.org/W2095360215","https://openalex.org/W2098649404","https://openalex.org/W2106283724","https://openalex.org/W2113068155","https://openalex.org/W2117212522","https://openalex.org/W2118519973","https://openalex.org/W2130846480","https://openalex.org/W2135574023","https://openalex.org/W2144468748","https://openalex.org/W2154846778","https://openalex.org/W2160935294","https://openalex.org/W2168526937","https://openalex.org/W2169530207","https://openalex.org/W2413734118"],"related_works":["https://openalex.org/W2811264456","https://openalex.org/W2804184608","https://openalex.org/W7155754480","https://openalex.org/W7125508231","https://openalex.org/W2060474525","https://openalex.org/W3209785898","https://openalex.org/W1915514552","https://openalex.org/W2000913561","https://openalex.org/W2803979225","https://openalex.org/W3170249225"],"abstract_inverted_index":{"BACKGROUND:":[0],"Chronic":[1],"ethanol":[2],"(EtOH)":[3],"consumption":[4],"decelerates":[5],"the":[6,39,228],"catabolism":[7],"of":[8,56,66,82,96,122,133,139,153,160,230],"long-lived":[9],"proteins,":[10],"indicating":[11,143],"that":[12,227,240],"it":[13],"slows":[14],"hepatic":[15,214,235,255],"macroautophagy":[16],"(hereafter":[17],"called":[18],"autophagy)":[19],"a":[20,53,93,130,149,204,218],"crucial":[21],"lysosomal":[22],"catabolic":[23],"pathway":[24],"in":[25,64,192,252],"most":[26],"eukaryotic":[27],"cells.":[28],"Autophagy":[29],"and":[30,71,136,178,257],"lysosome":[31,170,258],"biogenesis":[32],"are":[33,36],"linked.":[34],"Both":[35],"regulated":[37],"by":[38,59,108],"transcription":[40],"factor":[41],"EB":[42],"(TFEB).":[43],"Here,":[44],"we":[45,88],"tested":[46],"whether":[47],"TFEB":[48,78,190,207,221,249],"can":[49],"be":[50],"used":[51],"as":[52],"singular":[54],"indicator":[55],"autophagic":[57],"activity,":[58],"quantifying":[60],"its":[61],"nuclear":[62,77,151,189,206,220],"content":[63,152],"livers":[65,121,159],"mice":[67,91,106,124,162],"subjected":[68],"to":[69,79],"acute":[70,86,199,231],"chronic":[72,210,242],"EtOH":[73,97,113,200,211,232,243],"administration.":[74],"We":[75,104],"correlated":[76,147,186,202],"specific":[80],"indices":[81],"autophagy.":[83],"METHODS:":[84],"In":[85],"experiments,":[87],"gavaged":[89],"GFP-LC3(tg)":[90],"with":[92,99,118,148,156,187,203,217],"single":[94],"dose":[95],"or":[98,112],"phosphate":[100],"buffered":[101],"saline":[102],"(PBS).":[103],"fed":[105],"chronically":[107],"feeding":[109,212],"them":[110],"control":[111],"liquid":[114],"diets.":[115],"RESULTS:":[116],"Compared":[117,155],"PBS-gavaged":[119],"controls,":[120,158],"EtOH-gavaged":[123],"exhibited":[125,163],"greater":[126],"autophagosome":[127],"(AV)":[128],"numbers,":[129,166,171],"higher":[131,150,164,175,205],"incidence":[132],"AV-lysosome":[134,173],"co-localization,":[135,174],"elevated":[137],"levels":[138,191],"free":[140,180],"GFP,":[141],"all":[142],"enhanced":[144,196],"autophagy,":[145,215],"which":[146,251],"TFEB.":[154],"pair-fed":[157],"EtOH-fed":[161,193],"AV":[165],"but":[167],"had":[168],"lower":[169,172,179,188,219],"P62/SQSTM1":[176],"levels,":[177],"GFP":[181],"levels.":[182],"The":[183],"latter":[184],"findings":[185,225],"mice.":[194],"Thus,":[195],"autophagy":[197,236,256],"after":[198,241],"gavage":[201,233],"content.":[208,222],"Conversely,":[209],"inhibited":[213],"associated":[216],"CONCLUSIONS:":[223],"Our":[224],"suggest":[226],"effect":[229],"on":[234],"differs":[237],"significantly":[238],"from":[239],"feeding.":[244],"Each":[245],"regimen":[246],"distinctly":[247],"affects":[248],"localization,":[250],"turn,":[253],"regulates":[254],"biogenesis.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}