{"id":"https://openalex.org/W2139116340","doi":"https://doi.org/10.1016/j.yrtph.2004.09.001","title":"A thirteen week dietary toxicity study with 7-hydroxymatairesinol potassium acetate (HMRlignan) in rats","display_name":"A thirteen week dietary toxicity study with 7-hydroxymatairesinol potassium acetate (HMRlignan) in rats","publication_year":2004,"publication_date":"2004-12-13","ids":{"openalex":"https://openalex.org/W2139116340","doi":"https://doi.org/10.1016/j.yrtph.2004.09.001","mag":"2139116340","pmid":"https://pubmed.ncbi.nlm.nih.gov/15649825"},"language":"en","primary_location":{"id":"doi:10.1016/j.yrtph.2004.09.001","doi":"https://doi.org/10.1016/j.yrtph.2004.09.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.yrtph.2004.09.001","pdf_url":null,"source":{"id":"https://openalex.org/S87719511","display_name":"Regulatory Toxicology and Pharmacology","issn_l":"0273-2300","issn":["0273-2300","1096-0295"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regulatory Toxicology and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111463278","display_name":"Ben A.R. Lina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Lina","raw_affiliation_strings":["TNO Nutrition and Food Research, Department of Toxicology and Applied Pharmacology, Zeist, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TNO Nutrition and Food Research, Department of Toxicology and Applied Pharmacology, Zeist, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085385957","display_name":"H Korte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Korte","raw_affiliation_strings":["Hormos Medical Corp., Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hormos Medical Corp., Turku, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. Nyman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Nyman","raw_affiliation_strings":["Hormos Medical Corp., Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hormos Medical Corp., Turku, Finland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080092755","display_name":"Mikko Unkila","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"M. Unkila","raw_affiliation_strings":["Hormos Medical Corp., Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hormos Medical Corp., Turku, Finland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5080092755"],"corresponding_institution_ids":[],"apc_list":{"value":4210,"currency":"USD","value_usd":4210},"apc_paid":null,"fwci":0.3904,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.52533507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"41","issue":"1","first_page":"28","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12360","display_name":"Plant-derived Lignans Synthesis and Bioactivity","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12360","display_name":"Plant-derived Lignans Synthesis and Bioactivity","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11208","display_name":"Lignin and Wood Chemistry","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1508","display_name":"Process Chemistry and Technology"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-toxicity","display_name":"dietary toxicity","score":0.6520000100135803},{"id":"https://openalex.org/keywords/plant-lignans","display_name":"plant lignans","score":0.8019999861717224},{"id":"https://openalex.org/keywords/enterolactone","display_name":"enterolactone","score":0.9539999961853027},{"id":"https://openalex.org/keywords/matairesinol","display_name":"matairesinol","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cecum","display_name":"cecum","score":0.6930000185966492},{"id":"https://openalex.org/keywords/ovary","display_name":"ovary","score":0.8330000042915344},{"id":"https://openalex.org/keywords/estrous-cycle","display_name":"estrous cycle","score":0.7860000133514404},{"id":"https://openalex.org/keywords/plasma-lipids","display_name":"plasma lipids","score":0.5849999785423279},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.32100000977516174},{"id":"https://openalex.org/keywords/flaxseed","display_name":"flaxseed","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2777927066","wikidata":"https://www.wikidata.org/wiki/Q3055376","display_name":"Enterolactone","level":4,"score":0.9799814820289612},{"id":"https://openalex.org/C2781264555","wikidata":"https://www.wikidata.org/wiki/Q424634","display_name":"Lignan","level":2,"score":0.7146091461181641},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6162921786308289},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.593378484249115},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.517969012260437},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5148445963859558},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.50044846534729},{"id":"https://openalex.org/C172873279","wikidata":"https://www.wikidata.org/wiki/Q3361262","display_name":"Palatability","level":2,"score":0.4508143365383148},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.43831580877304077},{"id":"https://openalex.org/C79410662","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Dose\u2013response relationship","level":2,"score":0.4113718271255493},{"id":"https://openalex.org/C2778270713","wikidata":"https://www.wikidata.org/wiki/Q414496","display_name":"Phytoestrogens","level":3,"score":0.39351797103881836},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.39278051257133484},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2616368532180786},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.24906301498413086},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.216770738363266},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.11025109887123108},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015107","descriptor_name":"4-Butyrolactone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015107","descriptor_name":"4-Butyrolactone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017705","descriptor_name":"Lignans","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017705","descriptor_name":"Lignans","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017705","descriptor_name":"Lignans","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D019055","descriptor_name":"No-Observed-Adverse-Effect Level","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019347","descriptor_name":"Potassium Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.yrtph.2004.09.001","doi":"https://doi.org/10.1016/j.yrtph.2004.09.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.yrtph.2004.09.001","pdf_url":null,"source":{"id":"https://openalex.org/S87719511","display_name":"Regulatory Toxicology and Pharmacology","issn_l":"0273-2300","issn":["0273-2300","1096-0295"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regulatory Toxicology and Pharmacology","raw_type":"journal-article"},{"id":"pmid:15649825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15649825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regulatory toxicology and pharmacology : RTP","raw_type":"Journal Article"},{"id":"pmh:oai:oai-pmh.tno.nl:21450","doi":null,"is_oa":false,"landing_page_url":"https://resolver.tno.nl/uuid:e16f2f06-8fd0-44ba-9d6f-87eb65bc1085","pdf_url":null,"source":{"id":"https://openalex.org/S7407055233","display_name":"TNO Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Regulatory Toxicology and Pharmacology, 41(1), pp. 28-38.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:tudelft.nl:uuid:e16f2f06-8fd0-44ba-9d6f-87eb65bc1085","doi":null,"is_oa":false,"landing_page_url":"http://resolver.tudelft.nl/uuid:e16f2f06-8fd0-44ba-9d6f-87eb65bc1085","pdf_url":null,"source":{"id":"https://openalex.org/S4306402238","display_name":"Repository hosted by TU Delft Library (TU Delft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98358874","host_organization_name":"Delft University of Technology","host_organization_lineage":["https://openalex.org/I98358874"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Regulatory Toxicology and Pharmacology, 1, 41, 28-38","raw_type":"article"},{"id":"pmh:tno:oai:tudelft.nl:uuid:e16f2f06-8fd0-44ba-9d6f-87eb65bc1085","doi":null,"is_oa":false,"landing_page_url":"http://resolver.tudelft.nl/uuid:e16f2f06-8fd0-44ba-9d6f-87eb65bc1085","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1557404598","https://openalex.org/W1893803214","https://openalex.org/W1913746350","https://openalex.org/W1930279371","https://openalex.org/W1969788453","https://openalex.org/W1970840105","https://openalex.org/W1977741921","https://openalex.org/W1979078001","https://openalex.org/W1987838099","https://openalex.org/W1988688882","https://openalex.org/W1991425311","https://openalex.org/W2011529790","https://openalex.org/W2018510674","https://openalex.org/W2038348020","https://openalex.org/W2043919519","https://openalex.org/W2045734870","https://openalex.org/W2048324577","https://openalex.org/W2051078491","https://openalex.org/W2056599488","https://openalex.org/W2068963312","https://openalex.org/W2077827094","https://openalex.org/W2079425133","https://openalex.org/W2082343007","https://openalex.org/W2085956026","https://openalex.org/W2087880867","https://openalex.org/W2090905087","https://openalex.org/W2092115612","https://openalex.org/W2094037781","https://openalex.org/W2117098665","https://openalex.org/W2118141905","https://openalex.org/W2120278489","https://openalex.org/W2130999184","https://openalex.org/W2137673317","https://openalex.org/W2145819863","https://openalex.org/W2170196292","https://openalex.org/W2735491585","https://openalex.org/W4234316972","https://openalex.org/W4250560834"],"related_works":["https://openalex.org/W25937096","https://openalex.org/W2885555916","https://openalex.org/W2090914301","https://openalex.org/W2060457085","https://openalex.org/W4233273455","https://openalex.org/W1991801326","https://openalex.org/W2076575976","https://openalex.org/W2073962291","https://openalex.org/W4400179002","https://openalex.org/W2035436236"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}