{"id":"https://openalex.org/W2139104231","doi":"https://doi.org/10.2174/187152009788451860","title":"The Intermediate Enzymes of Isoprenoid Metabolism as Anticancer Targets","display_name":"The Intermediate Enzymes of Isoprenoid Metabolism as Anticancer Targets","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W2139104231","doi":"https://doi.org/10.2174/187152009788451860","mag":"2139104231","pmid":"https://pubmed.ncbi.nlm.nih.gov/19519294"},"language":"en","primary_location":{"id":"doi:10.2174/187152009788451860","doi":"https://doi.org/10.2174/187152009788451860","is_oa":false,"landing_page_url":"https://doi.org/10.2174/187152009788451860","pdf_url":null,"source":{"id":"https://openalex.org/S159246083","display_name":"Anti-Cancer Agents in Medicinal Chemistry","issn_l":"1568-0118","issn":["1568-0118","1871-5206","1875-5968","1875-5992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Cancer Agents in Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088029990","display_name":"Andrew J. Wiemer","orcid":"https://orcid.org/0000-0002-3029-1780","observed_orcids":["https://orcid.org/0000-0002-3029-1780"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Wiemer","raw_affiliation_strings":["Department of Internal Medicine, University of Iowa, 5219 MERF, 375 Newton Road, Iowa City, IA 52242, USA. david-wiemer@uiowa.edu","Department of Internal Medicine, University of Iowa, 5219 MERF, 375 Newton Road, Iowa City, IA 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Iowa, 5219 MERF, 375 Newton Road, Iowa City, IA 52242, USA. david-wiemer@uiowa.edu","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Iowa, 5219 MERF, 375 Newton Road, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112117936","display_name":"Raymond J. Hohl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268258","display_name":"Penn State Cancer Institute","ror":"https://ror.org/00bzx1854","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405268258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond J. Hohl","raw_affiliation_strings":["Penn State Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Penn State Cancer Institute","institution_ids":["https://openalex.org/I4405268258"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080031865","display_name":"David F. Wiemer","orcid":"https://orcid.org/0000-0002-4881-8544","observed_orcids":["https://orcid.org/0000-0002-4881-8544"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David F. Wiemer","raw_affiliation_strings":["Department of Chemistry, University of Iowa, 527 CB, Iowa City, IA 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Iowa, 527 CB, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.655,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.85193385,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"5","first_page":"526","last_page":"542"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.3962000012397766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.04259999841451645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isoprenoid-biosynthesis","display_name":"isoprenoid biosynthesis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/anticancer-drug-targets","display_name":"anticancer drug targets","score":0.8529999852180481},{"id":"https://openalex.org/keywords/mevalonate-kinase","display_name":"mevalonate kinase","score":0.8220000267028809},{"id":"https://openalex.org/keywords/geranylgeranyl-diphosphate-synthase","display_name":"geranylgeranyl diphosphate synthase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.765999972820282},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.5239999890327454},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.7360000014305115},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C57790582","wikidata":"https://www.wikidata.org/wiki/Q901141","display_name":"Prenylation","level":3,"score":0.653053879737854},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6092696785926819},{"id":"https://openalex.org/C2779982574","wikidata":"https://www.wikidata.org/wiki/Q14913010","display_name":"Mevalonate pathway","level":4,"score":0.578355610370636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5371829271316528},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.45960572361946106},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45295628905296326},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.42803236842155457},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.42248743772506714},{"id":"https://openalex.org/C206103511","wikidata":"https://www.wikidata.org/wiki/Q426694","display_name":"Terpenoid","level":2,"score":0.4154323637485504},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35235458612442017},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09212812781333923}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051231","descriptor_name":"Farnesyltranstransferase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051231","descriptor_name":"Farnesyltranstransferase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051231","descriptor_name":"Farnesyltranstransferase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051231","descriptor_name":"Farnesyltranstransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051231","descriptor_name":"Farnesyltranstransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051231","descriptor_name":"Farnesyltranstransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054876","descriptor_name":"Prenylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054876","descriptor_name":"Prenylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054876","descriptor_name":"Prenylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/187152009788451860","doi":"https://doi.org/10.2174/187152009788451860","is_oa":false,"landing_page_url":"https://doi.org/10.2174/187152009788451860","pdf_url":null,"source":{"id":"https://openalex.org/S159246083","display_name":"Anti-Cancer Agents in Medicinal Chemistry","issn_l":"1568-0118","issn":["1568-0118","1871-5206","1875-5968","1875-5992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Cancer Agents in Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:19519294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19519294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-cancer agents in medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306274","display_name":"Roy J. Carver Charitable Trust","ror":"https://ror.org/01ah2ch91"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2049515377","https://openalex.org/W2114210981","https://openalex.org/W1981176893","https://openalex.org/W2110763841","https://openalex.org/W2149092807","https://openalex.org/W2081770121","https://openalex.org/W2079593771","https://openalex.org/W131720133","https://openalex.org/W2101027079","https://openalex.org/W1986920855"],"abstract_inverted_index":{"Inhibitors":[0],"of":[1,20,37,89,117,143,159,185,208,220,231],"isoprenoid":[2,23,188,212],"biosynthesis":[3,24,189],"are":[4,49,54,71,99,106,200],"widely":[5],"used":[6],"to":[7,17,30,66,87,95,123],"treat":[8],"human":[9,22,58],"disease":[10],"including":[11],"statins":[12],"and":[13,34,60,77,194,225,229],"nitrogenous":[14],"bisphosphonates.":[15],"Due":[16],"the":[18,96,186,218,227],"importance":[19],"core":[21],"for":[25,73,141,157],"diverse":[26],"cellular":[27],"processes":[28],"related":[29],"cancer":[31,198,235],"cell":[32,75],"growth":[33],"metastasis,":[35],"inhibition":[36],"this":[38],"pathway":[39,213],"may":[40],"produce":[41],"beneficial":[42],"anticancer":[43],"consequences.":[44],"For":[45],"example,":[46],"ras":[47,52],"oncogenes":[48],"well":[50],"known;":[51],"proteins":[53,62,70,148],"overexpressed":[55],"in":[56,101,136,145,154,170,197,217,234],"many":[57,158],"cancers,":[59],"these":[61,118,160,209,232],"must":[63,79],"be":[64,80,128],"isoprenylated":[65,147],"function.":[67],"The":[68],"rho":[69],"important":[72],"regulating":[74],"motility,":[76],"also":[78],"isoprenylated.":[81],"This":[82,202],"has":[83],"drawn":[84],"significant":[85],"attention":[86],"inhibitors":[88],"protein":[90],"prenyl":[91],"transferases.":[92],"In":[93,178],"addition":[94],"reactions":[97],"that":[98,109,173,181],"targeted":[100],"current":[102,139,206],"clinical":[103],"applications,":[104],"there":[105,165],"other":[107],"enzymes":[108,190],"have":[110,149,166,191],"not":[111],"been":[112,150,167,192],"studied":[113],"as":[114,130],"extensively.":[115],"Inhibition":[116],"enzymes,":[119,214],"from":[120],"mevalonate":[121],"kinase":[122],"geranylgeranyl":[124],"diphosphate":[125],"synthase,":[126],"could":[127,174],"attractive":[129],"a":[131],"single":[132],"agent":[133],"therapy":[134],"or":[135],"combination":[137],"with":[138],"agents":[140],"treatment":[142],"cancers":[144],"which":[146],"implicated.":[151],"While":[152],"detailed":[153],"vivo":[155],"data":[156],"putative":[161],"targets":[162],"is":[163],"lacking,":[164],"several":[168],"breakthroughs":[169],"recent":[171],"years":[172],"facilitate":[175],"further":[176],"studies.":[177],"particular,":[179],"compounds":[180,233],"specifically":[182],"inhibit":[183],"some":[184],"downstream":[187],"developed":[193],"their":[195,221],"effects":[196,230],"models":[199],"emerging.":[201],"review":[203],"will":[204],"discuss":[205],"knowledge":[207],"lesser":[210],"known":[211],"identify":[215],"trends":[216],"development":[219],"small":[222],"molecule":[223],"inhibitors,":[224],"describe":[226],"applications":[228],"models.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-09-22T17:25:34.749102","created_date":"2025-10-10T00:00:00"}