{"id":"https://openalex.org/W2139100668","doi":"https://doi.org/10.1128/aac.45.9.2450-2454.2001","title":"Mechanism of Therapeutic Effectiveness of Cefixime against Typhoid Fever","display_name":"Mechanism of Therapeutic Effectiveness of Cefixime against Typhoid Fever","publication_year":2001,"publication_date":"2001-09-01","ids":{"openalex":"https://openalex.org/W2139100668","doi":"https://doi.org/10.1128/aac.45.9.2450-2454.2001","mag":"2139100668","pmid":"https://pubmed.ncbi.nlm.nih.gov/11502513","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/90676"},"language":"en","primary_location":{"id":"doi:10.1128/aac.45.9.2450-2454.2001","doi":"https://doi.org/10.1128/aac.45.9.2450-2454.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.45.9.2450-2454.2001","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC90676","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110345527","display_name":"Yoshimi Matsumoto","orcid":"https://orcid.org/0009-0007-1611-5696","observed_orcids":["https://orcid.org/0009-0007-1611-5696"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshimi Matsumoto","raw_affiliation_strings":["<!--label omitted: 1-->Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and","Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and","institution_ids":[]},{"raw_affiliation_string":"Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008775497","display_name":"Akiko Ikemoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akiko Ikemoto","raw_affiliation_strings":["<!--label omitted: 1-->Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and","Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and","institution_ids":[]},{"raw_affiliation_string":"Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043946994","display_name":"Yoshimi Wakai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshimi Wakai","raw_affiliation_strings":["<!--label omitted: 1-->Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and","Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and","institution_ids":[]},{"raw_affiliation_string":"Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006414517","display_name":"Fumiaki Ikeda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fumiaki Ikeda","raw_affiliation_strings":["<!--label omitted: 1-->Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and","Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and","institution_ids":[]},{"raw_affiliation_string":"Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108790171","display_name":"Shuichi Tawara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuichi Tawara","raw_affiliation_strings":["<!--label omitted: 1-->Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and","Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and","institution_ids":[]},{"raw_affiliation_string":"Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,1and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111602344","display_name":"Keiz\u014d Matsumoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keizo Matsumoto","raw_affiliation_strings":["<!--label omitted: 2-->Nagasaki University, Nagasaki,2Japan","Nagasaki University, Nagasaki,2Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 2-->Nagasaki University, Nagasaki,2Japan","institution_ids":["https://openalex.org/I43777268"]},{"raw_affiliation_string":"Nagasaki University, Nagasaki,2Japan","institution_ids":["https://openalex.org/I43777268"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.20460405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"45","issue":"9","first_page":"2450","last_page":"2454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.8012999892234802,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.8012999892234802,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.18209999799728394,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cefixime","display_name":"cefixime","score":1.0},{"id":"https://openalex.org/keywords/typhoid-fever","display_name":"typhoid fever","score":0.9990000128746033},{"id":"https://openalex.org/keywords/salmonella-typhimurium","display_name":"Salmonella typhimurium","score":0.9210000038146973},{"id":"https://openalex.org/keywords/salmonella-enterica-serovar-typhi","display_name":"Salmonella typhi","score":0.9810000061988831},{"id":"https://openalex.org/keywords/beta-lactam-antibiotics","display_name":"beta-lactam antibiotics","score":0.847000002861023},{"id":"https://openalex.org/keywords/intracellular-bacterial-growth","display_name":"intracellular bacterial growth","score":0.8009999990463257},{"id":"https://openalex.org/keywords/thp-1-cells","display_name":"THP-1 cells","score":0.7369999885559082},{"id":"https://openalex.org/keywords/mouse-model-of-infection","display_name":"mouse infection model","score":0.593999981880188},{"id":"https://openalex.org/keywords/intracellular-drug-concentration","display_name":"intracellular drug concentration","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2778243283","wikidata":"https://www.wikidata.org/wiki/Q163901","display_name":"Cefixime","level":4,"score":0.9839051365852356},{"id":"https://openalex.org/C520601542","wikidata":"https://www.wikidata.org/wiki/Q83319","display_name":"Typhoid fever","level":2,"score":0.8695601224899292},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.7904615998268127},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6501133441925049},{"id":"https://openalex.org/C2994552716","wikidata":"https://www.wikidata.org/wiki/Q21600865","display_name":"Salmonella typhi","level":4,"score":0.5586905479431152},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4843931794166565},{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.4235730767250061},{"id":"https://openalex.org/C2779607309","wikidata":"https://www.wikidata.org/wiki/Q2264864","display_name":"Salmonella enterica","level":4,"score":0.4202501177787781},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.405510812997818},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3405655026435852},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.33447927236557007},{"id":"https://openalex.org/C64778159","wikidata":"https://www.wikidata.org/wiki/Q271021","display_name":"Cephalosporin","level":3,"score":0.30804795026779175},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.15763145685195923},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.10930788516998291},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08658021688461304},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002511","descriptor_name":"Cephalosporins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012475","descriptor_name":"Salmonella","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012480","descriptor_name":"Salmonella Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012703","descriptor_name":"Serotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014435","descriptor_name":"Typhoid Fever","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020682","descriptor_name":"Cefixime","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.45.9.2450-2454.2001","doi":"https://doi.org/10.1128/aac.45.9.2450-2454.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.45.9.2450-2454.2001","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:172850","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC90676","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:90676","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/90676","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:11502513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11502513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:172850","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC90676","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W3101908","https://openalex.org/W93649015","https://openalex.org/W146036160","https://openalex.org/W1850350131","https://openalex.org/W1990373869","https://openalex.org/W2003939779","https://openalex.org/W2004125826","https://openalex.org/W2015282107","https://openalex.org/W2026165630","https://openalex.org/W2039325637","https://openalex.org/W2043305315","https://openalex.org/W2043657838","https://openalex.org/W2046478763","https://openalex.org/W2069523752","https://openalex.org/W2070864443","https://openalex.org/W2090168889","https://openalex.org/W2092831235","https://openalex.org/W2107880730","https://openalex.org/W2126550207","https://openalex.org/W2148011102","https://openalex.org/W2292993603","https://openalex.org/W2403074764","https://openalex.org/W2416072103","https://openalex.org/W4243690848","https://openalex.org/W4376860468"],"related_works":["https://openalex.org/W2039325637","https://openalex.org/W2244988934","https://openalex.org/W2008727788","https://openalex.org/W3048346584","https://openalex.org/W1897607792","https://openalex.org/W2639602435","https://openalex.org/W2097020063","https://openalex.org/W3110886267","https://openalex.org/W2029754213","https://openalex.org/W2083584892"],"abstract_inverted_index":{"beta-Lactams":[0],"have":[1],"been":[2,21],"considered":[3],"ineffective":[4],"against":[5,27,38],"organisms":[6,158],"growing":[7],"inside":[8,107,159,211],"mammalian":[9,203],"cells":[10,84,96,109,121,161,204,212],"because":[11],"of":[12,33,36,49,71,79,91,105,116,131,154,199,209],"their":[13],"poor":[14],"penetration":[15],"into":[16],"cells.":[17,77],"However,":[18],"cefixime":[19,37,106,139,200],"has":[20],"shown":[22],"to":[23,67,114,166,219],"be":[24,167],"clinically":[25],"effective":[26],"typhoid":[28,39],"fever.":[29],"The":[30,103,129],"probable":[31],"mechanism":[32],"therapeutic":[34],"effectiveness":[35],"fever":[40],"was":[41,65,85,110,140,164],"investigated":[42],"using":[43],"Salmonella":[44],"enterica":[45,51],"serovar":[46,52,72,80,92,123,156,190],"Typhimurium":[47,73,81,93,124,224],"instead":[48],"S.":[50],"Typhi":[53,157],"both":[54],"in":[55,59,82,94,126,144,177],"a":[56,60,146,196],"cellular":[57],"and":[58,181,205,225],"mouse":[61,179],"infection":[62,183],"model.":[63],"Cefixime":[64,172],"able":[66],"inhibit":[68,206],"the":[69,117,120,127,149,155,178,207,214],"growth":[70,208],"inhabiting":[74],"monocyte-derived":[75],"THP-1":[76,83,95,108],"Elongation":[78],"observed":[86,99],"microscopically.":[87],"Apparent":[88],"morphological":[89],"changes":[90],"were":[97,162],"also":[98,173],"by":[100,189],"electron":[101],"microscopy.":[102],"concentration":[104,118,147],"almost":[111],"half":[112],"(46":[113],"48%)":[115],"outside":[119],"when":[122,213],"coexisted":[125],"solution.":[128],"length":[130],"time":[132],"after":[133],"oral":[134,182],"dosing":[135],"(8":[136],"mg/kg)":[137],"that":[138,195],"present-calculated":[141],"from":[142],"levels":[143],"serum-at":[145],"above":[148],"MIC":[150],"at":[151],"which":[152],"90%":[153],"human":[160],"inhibited":[163],"presumed":[165],"more":[168],"than":[169],"12":[170],"h.":[171],"showed":[174],"excellent":[175],"activity":[176],"systemic":[180],"models":[184],"based":[185],"on":[186],"infections":[187],"caused":[188],"Typhimurium.":[191],"It":[192],"is":[193],"concluded":[194],"fair":[197],"amount":[198],"can":[201],"enter":[202],"bacteria":[210,215],"are":[216,222],"sensitive":[217],"enough":[218],"cefixime,":[220],"as":[221],"serovars":[223],"Typhi.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}