{"id":"https://openalex.org/W2139097578","doi":"https://doi.org/10.1016/s0016-5085(77)80260-6","title":"Serum \u03b1-Fetoprotein in Patients with Massive Hepatic Necrosis","display_name":"Serum \u03b1-Fetoprotein in Patients with Massive Hepatic Necrosis","publication_year":1977,"publication_date":"1977-03-01","ids":{"openalex":"https://openalex.org/W2139097578","doi":"https://doi.org/10.1016/s0016-5085(77)80260-6","mag":"2139097578","pmid":"https://pubmed.ncbi.nlm.nih.gov/64375"},"language":"en","primary_location":{"id":"doi:10.1016/s0016-5085(77)80260-6","doi":"https://doi.org/10.1016/s0016-5085(77)80260-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0016-5085(77)80260-6","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108549221","display_name":"Joseph R. Bloomer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph R. Bloomer","raw_affiliation_strings":["Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, and the Metabolism Branch and Laboratory of Cell Biology,","Howard Hughes Medical Insti-tute","National Cancer Institute, Bethesda, Maryland","ment of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, and the Metabolism Branch and Laboratory of Cell Biology,","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Howard Hughes Medical Insti-tute","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"ment of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035996420","display_name":"Thomas A. Waldmann","orcid":"https://orcid.org/0000-0003-4500-6660","observed_orcids":["https://orcid.org/0000-0003-4500-6660"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A. Waldmann","raw_affiliation_strings":["Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, and the Metabolism Branch and Laboratory of Cell Biology,","Howard Hughes Medical Insti-tute","National Cancer Institute, Bethesda, Maryland","ment of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, and the Metabolism Branch and Laboratory of Cell Biology,","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Howard Hughes Medical Insti-tute","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"ment of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111163124","display_name":"K. Robert McIntire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Robert McIntire","raw_affiliation_strings":["Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, and the Metabolism Branch and Laboratory of Cell Biology,","Howard Hughes Medical Insti-tute","National Cancer Institute, Bethesda, Maryland","ment of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, and the Metabolism Branch and Laboratory of Cell Biology,","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Howard Hughes Medical Insti-tute","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"ment of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043169110","display_name":"Gerald Klatskin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald Klatskin","raw_affiliation_strings":["Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, and the Metabolism Branch and Laboratory of Cell Biology,","Howard Hughes Medical Insti-tute","National Cancer Institute, Bethesda, Maryland","ment of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, and the Metabolism Branch and Laboratory of Cell Biology,","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Howard Hughes Medical Insti-tute","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"ment of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":null,"fwci":3.1732,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.91367265,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"72","issue":"3","first_page":"479","last_page":"482"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8047000169754028,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8047000169754028,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.13230000436306,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.9900000095367432},{"id":"https://openalex.org/keywords/fulminant-hepatitis","display_name":"fulminant hepatitis","score":0.949999988079071},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.949999988079071},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.8560000061988831},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6230000257492065},{"id":"https://openalex.org/keywords/survival-time","display_name":"survival time","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.546001136302948},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4595244526863098},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.398466557264328},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36629152297973633}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0016-5085(77)80260-6","doi":"https://doi.org/10.1016/s0016-5085(77)80260-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0016-5085(77)80260-6","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},{"id":"pmid:64375","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/64375","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8399999737739563,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W57275787","https://openalex.org/W1532896947","https://openalex.org/W1567914581","https://openalex.org/W1867279571","https://openalex.org/W1911304834","https://openalex.org/W1967036790","https://openalex.org/W1975088169","https://openalex.org/W2014222169","https://openalex.org/W2015913848","https://openalex.org/W2019518050","https://openalex.org/W2020513016","https://openalex.org/W2072167444","https://openalex.org/W2078639165","https://openalex.org/W2078769264","https://openalex.org/W2101354378","https://openalex.org/W2105394936","https://openalex.org/W2123659549","https://openalex.org/W2158562854","https://openalex.org/W2247149472","https://openalex.org/W2269604983","https://openalex.org/W2285466600","https://openalex.org/W2320619215","https://openalex.org/W2325349671","https://openalex.org/W2406742656","https://openalex.org/W2412395917","https://openalex.org/W6980078423"],"related_works":["https://openalex.org/W1805584022","https://openalex.org/W2085077316","https://openalex.org/W1911304834","https://openalex.org/W2400847315","https://openalex.org/W2031046641","https://openalex.org/W7100924635","https://openalex.org/W1970562928","https://openalex.org/W1975088169","https://openalex.org/W2414278875","https://openalex.org/W194485830"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
