{"id":"https://openalex.org/W2139096503","doi":"https://doi.org/10.1081/ncn-200026050","title":"Ribonuclease Activity of Cationic Structures Conjugated to Lipophilic Groups","display_name":"Ribonuclease Activity of Cationic Structures Conjugated to Lipophilic Groups","publication_year":2004,"publication_date":"2004-10-08","ids":{"openalex":"https://openalex.org/W2139096503","doi":"https://doi.org/10.1081/ncn-200026050","mag":"2139096503","pmid":"https://pubmed.ncbi.nlm.nih.gov/15560089"},"language":"en","primary_location":{"id":"doi:10.1081/ncn-200026050","doi":"https://doi.org/10.1081/ncn-200026050","is_oa":false,"landing_page_url":"https://doi.org/10.1081/ncn-200026050","pdf_url":null,"source":{"id":"https://openalex.org/S111464279","display_name":"Nucleosides Nucleotides & Nucleic Acids","issn_l":"1525-7770","issn":["1525-7770","1532-2335"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides, Nucleotides and Nucleic Acids","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2139096503"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085630939","display_name":"N. Koval'ov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. Koval'ov","raw_affiliation_strings":["Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia","Institute of Chemical Biology and Fundamental Medicine , Novosibirsk, 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210091979"]},{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine , Novosibirsk, 630090, Russia","institution_ids":["https://openalex.org/I4210091979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086007862","display_name":"Irina L Kuznetsova","orcid":"https://orcid.org/0000-0002-7785-734X","observed_orcids":["https://orcid.org/0000-0002-7785-734X"]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"I. Kuznetsova","raw_affiliation_strings":["Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, 630090, Russia","institution_ids":["https://openalex.org/I4210091979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060734876","display_name":"Ekaterina A. Burakova","orcid":"https://orcid.org/0000-0001-6644-5959","observed_orcids":["https://orcid.org/0000-0001-6644-5959"]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. Burakova","raw_affiliation_strings":["Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, 630090, Russia","institution_ids":["https://openalex.org/I4210091979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018232091","display_name":"Vladimir N. Silnikov","orcid":"https://orcid.org/0000-0002-7100-8953","observed_orcids":["https://orcid.org/0000-0002-7100-8953"]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V. Sil'nikov","raw_affiliation_strings":["Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, 630090, Russia","institution_ids":["https://openalex.org/I4210091979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076647301","display_name":"\u0417\u0435\u043d\u043a\u043e\u0432\u0430 \u041c\u0430\u0440\u0438\u043d\u0430 \u0410\u0440\u043a\u0430\u0434\u044c\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0003-4044-1049","observed_orcids":["https://orcid.org/0000-0003-4044-1049"]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M. Zenkova","raw_affiliation_strings":["Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, 630090, Russia","institution_ids":["https://openalex.org/I4210091979"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026239431","display_name":"Valentin V. Vlassov","orcid":"https://orcid.org/0000-0003-2845-2992","observed_orcids":["https://orcid.org/0000-0003-2845-2992"]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V. Vlassov","raw_affiliation_strings":["Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, 630090, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, 630090, Russia","institution_ids":["https://openalex.org/I4210091979"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086007862"],"corresponding_institution_ids":["https://openalex.org/I4210091979"],"apc_list":null,"apc_paid":null,"fwci":0.4812,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.52592563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"23","issue":"6-7","first_page":"977","last_page":"981"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Physical Organic Chemistry and Reaction Kinetics","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rnase-activity","display_name":"ribonuclease activity","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cationic-compounds","display_name":"cationic compounds","score":0.7730000019073486},{"id":"https://openalex.org/keywords/dabco","display_name":"DABCO","score":0.7609999775886536},{"id":"https://openalex.org/keywords/rna-cleavage","display_name":"RNA cleavage","score":0.7900000214576721},{"id":"https://openalex.org/keywords/phosphodiester-bond-cleavage","display_name":"phosphodiester bond cleavage","score":0.7870000004768372},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C183882617","wikidata":"https://www.wikidata.org/wiki/Q3046749","display_name":"Cationic polymerization","level":2,"score":0.8590880632400513},{"id":"https://openalex.org/C38441620","wikidata":"https://www.wikidata.org/wiki/Q863983","display_name":"Phosphodiester bond","level":4,"score":0.7622931003570557},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7521210312843323},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.725968599319458},{"id":"https://openalex.org/C2778976237","wikidata":"https://www.wikidata.org/wiki/Q422523","display_name":"Ribonuclease","level":4,"score":0.6910226941108704},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6460596919059753},{"id":"https://openalex.org/C2775995839","wikidata":"https://www.wikidata.org/wiki/Q423673","display_name":"DABCO","level":3,"score":0.5661895275115967},{"id":"https://openalex.org/C2776624427","wikidata":"https://www.wikidata.org/wiki/Q150681","display_name":"Octane","level":2,"score":0.5299903750419617},{"id":"https://openalex.org/C87282627","wikidata":"https://www.wikidata.org/wiki/Q3623657","display_name":"Scissile bond","level":4,"score":0.41452592611312866},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3993506133556366},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.379438579082489},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.23301109671592712},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.18425852060317993},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13017156720161438},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004951","descriptor_name":"Esterification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1081/ncn-200026050","doi":"https://doi.org/10.1081/ncn-200026050","is_oa":false,"landing_page_url":"https://doi.org/10.1081/ncn-200026050","pdf_url":null,"source":{"id":"https://openalex.org/S111464279","display_name":"Nucleosides Nucleotides & Nucleic Acids","issn_l":"1525-7770","issn":["1525-7770","1532-2335"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides, Nucleotides and Nucleic Acids","raw_type":"journal-article"},{"id":"pmid:15560089","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15560089","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides, nucleotides & nucleic acids","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W33693276","https://openalex.org/W1974618080","https://openalex.org/W1978945010","https://openalex.org/W2049170375","https://openalex.org/W2167496805"],"related_works":["https://openalex.org/W2083560916","https://openalex.org/W2950029270","https://openalex.org/W2040174282","https://openalex.org/W2032401691","https://openalex.org/W1976204061","https://openalex.org/W2950871222","https://openalex.org/W2019297937","https://openalex.org/W2035080238","https://openalex.org/W2054046480","https://openalex.org/W2394807293"],"abstract_inverted_index":{"Cationic":[0],"compounds":[1,52],"containing":[2],"benzene":[3],"ring":[4],"substituted":[5],"with":[6],"the":[7,18,26,33,37,40,60,80],"bis-quaternary":[8],"salt":[9],"of":[10,25,32,39,63,71],"diazabicyclo[2.2.2]octane":[11],"(DABCO)":[12],"bearing":[13],"a":[14,68,76],"polymethylene":[15],"fragment":[16],"at":[17],"bridge":[19],"positions":[20],"display":[21],"ribonuclease":[22],"activity.":[23],"Efficacy":[24],"catalysis":[27],"is":[28],"affected":[29],"by":[30],"geometry":[31],"cationic":[34],"structures":[35],"and":[36],"size":[38],"attached":[41],"aliphatic":[42],"fragment.":[43],"The":[44,51],"cleavage":[45,65,72],"occurs":[46],"primarily":[47],"within":[48],"CA":[49],"sequences.":[50],"do":[53],"not":[54],"possess":[55],"tradition":[56],"groups":[57],"participating":[58],"in":[59],"transesterification":[61],"step":[62],"RNA":[64,81],"reaction,":[66],"therefore":[67],"speculative":[69],"mechanism":[70],"could":[73],"be":[74],"inducing":[75],"conformational":[77],"stress":[78],"on":[79],"sugar":[82],"phosphate":[83],"backbone":[84],"providing":[85],"fragility":[86],"to":[87],"phosphodiester":[88],"bonds.":[89]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
