{"id":"https://openalex.org/W2139094825","doi":"https://doi.org/10.1038/ismej.2009.112","title":"Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice","display_name":"Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice","publication_year":2009,"publication_date":"2009-10-29","ids":{"openalex":"https://openalex.org/W2139094825","doi":"https://doi.org/10.1038/ismej.2009.112","mag":"2139094825","pmid":"https://pubmed.ncbi.nlm.nih.gov/19865183"},"language":"en","primary_location":{"id":"doi:10.1038/ismej.2009.112","doi":"https://doi.org/10.1038/ismej.2009.112","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ismej.2009.112","pdf_url":null,"source":{"id":"https://openalex.org/S149218730","display_name":"The ISME Journal","issn_l":"1751-7362","issn":["1751-7362","1751-7370"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The ISME Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005334123","display_name":"Chenhong Zhang","orcid":"https://orcid.org/0000-0002-4462-892X","observed_orcids":["https://orcid.org/0000-0002-4462-892X","https://orcid.org/0009-0009-3137-1123"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenhong Zhang","raw_affiliation_strings":["Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai , PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai , PR China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030856138","display_name":"Menghui H. Zhang","orcid":"https://orcid.org/0000-0002-9274-487X","observed_orcids":["https://orcid.org/0000-0002-9274-487X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Menghui Zhang","raw_affiliation_strings":["Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai , PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai , PR China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076180875","display_name":"Shengyue Wang","orcid":"https://orcid.org/0000-0001-9589-7719","observed_orcids":["https://orcid.org/0000-0001-9589-7719"]},"institutions":[{"id":"https://openalex.org/I4210099308","display_name":"Chinese National Human Genome Center at Shanghai","ror":"https://ror.org/017xz5989","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210099308"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengyue Wang","raw_affiliation_strings":["Chinese National Human Genome Sequencing Centre , Shanghai , PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese National Human Genome Sequencing Centre , Shanghai , PR China","institution_ids":["https://openalex.org/I4210099308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110684859","display_name":"Ruijun Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruijun Han","raw_affiliation_strings":["Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences , Shanghai , PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences , Shanghai , PR China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058408763","display_name":"Youfang Cao","orcid":"https://orcid.org/0000-0002-5880-0006","observed_orcids":["https://orcid.org/0000-0002-5880-0006"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Youfang Cao","raw_affiliation_strings":["Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai , PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai , PR China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047250113","display_name":"Weiying Hua","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiying Hua","raw_affiliation_strings":["Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai , PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai , PR China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087054470","display_name":"Yuejian Mao","orcid":"https://orcid.org/0000-0001-9036-8770","observed_orcids":["https://orcid.org/0000-0001-9036-8770"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuejian Mao","raw_affiliation_strings":["Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai , PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai , PR China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362786","display_name":"Xiaojun Zhang","orcid":"https://orcid.org/0000-0002-4559-0177","observed_orcids":["https://orcid.org/0000-0002-4559-0177"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojun Zhang","raw_affiliation_strings":["Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai , PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai , PR China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025206530","display_name":"Xiaoyan Pang","orcid":"https://orcid.org/0000-0002-1269-5466","observed_orcids":["https://orcid.org/0000-0002-1269-5466"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyan Pang","raw_affiliation_strings":["Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai , PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai , PR China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010368404","display_name":"Chaochun Wei","orcid":"https://orcid.org/0000-0002-1031-034X","observed_orcids":["https://orcid.org/0000-0002-1031-034X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaochun Wei","raw_affiliation_strings":["Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai , PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai , PR China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022141624","display_name":"Guoping Zhao","orcid":"https://orcid.org/0000-0002-7621-6620","observed_orcids":["https://orcid.org/0000-0002-7621-6620"]},"institutions":[{"id":"https://openalex.org/I4210099308","display_name":"Chinese National Human Genome Center at Shanghai","ror":"https://ror.org/017xz5989","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210099308"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoping Zhao","raw_affiliation_strings":["Chinese National Human Genome Sequencing Centre , Shanghai , PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese National Human Genome Sequencing Centre , Shanghai , PR China","institution_ids":["https://openalex.org/I4210099308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378101","display_name":"Yan Chen","orcid":"https://orcid.org/0000-0002-6630-0693","observed_orcids":["https://orcid.org/0000-0002-6630-0693","https://orcid.org/0000-0001-9158-300X"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Chen","raw_affiliation_strings":["Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences , Shanghai , PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences , Shanghai , PR China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089008822","display_name":"Liping Zhao","orcid":"https://orcid.org/0000-0001-9694-7140","observed_orcids":["https://orcid.org/0000-0001-9694-7140","https://orcid.org/0009-0009-1961-3820"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liping Zhao","raw_affiliation_strings":["Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai , PR China","Shanghai Centre for Systems Biomedicine , Shanghai , PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai , PR China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Shanghai Centre for Systems Biomedicine , Shanghai , PR China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5089008822","https://openalex.org/A5100378101"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I19820366","https://openalex.org/I4210106477"],"apc_list":{"value":3675,"currency":"EUR","value_usd":4153},"apc_paid":null,"fwci":7.24,"has_fulltext":true,"cited_by_count":1024,"citation_normalized_percentile":{"value":0.98214501,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"4","issue":"2","first_page":"232","last_page":"241"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.8169999718666077},{"id":"https://openalex.org/keywords/host-genetics","display_name":"host genetics","score":0.8569999933242798},{"id":"https://openalex.org/keywords/diet","display_name":"diet","score":0.6669999957084656},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.8880000114440918},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bifidobacterium","display_name":"Bifidobacterium","score":0.9789999723434448},{"id":"https://openalex.org/keywords/desulfovibrionaceae","display_name":"Desulfovibrionaceae","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sulfate-reducing-bacteria","display_name":"sulfate-reducing bacteria","score":0.9409999847412109},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.6690000295639038},{"id":"https://openalex.org/keywords/host-microbe-interactions","display_name":"host-microbe interactions","score":0.6589999794960022},{"id":"https://openalex.org/keywords/16s-rrna-profiling","display_name":"16S rRNA gene profiling","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9403879046440125},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.8934935331344604},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5622281432151794},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5511533617973328},{"id":"https://openalex.org/C125009961","wikidata":"https://www.wikidata.org/wiki/Q2342248","display_name":"Pyrosequencing","level":3,"score":0.5165113806724548},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.47091102600097656},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.47003835439682007},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4547306001186371},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.36503326892852783},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27080366015434265},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23191407322883606},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016632","descriptor_name":"Apolipoprotein A-I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/ismej.2009.112","doi":"https://doi.org/10.1038/ismej.2009.112","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ismej.2009.112","pdf_url":null,"source":{"id":"https://openalex.org/S149218730","display_name":"The ISME Journal","issn_l":"1751-7362","issn":["1751-7362","1751-7370"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The ISME Journal","raw_type":"journal-article"},{"id":"pmid:19865183","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19865183","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The ISME journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"},{"id":"https://metadata.un.org/sdg/2","score":0.5666999816894531,"display_name":"Zero hunger"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/10","score":0.6700000166893005,"display_name":"Reduced inequalities"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1665967996","display_name":null,"funder_award_id":"30821005","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1828425977","display_name":null,"funder_award_id":"973 Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4243412236","display_name":null,"funder_award_id":"863 Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4867292756","display_name":null,"funder_award_id":"KSCX1-YW-02","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G6098416300","display_name":null,"funder_award_id":"2008AA02Z315","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6923150021","display_name":"\u591a\u7ec4\u5b66\u7efc\u5408\u751f\u7269\u4fe1\u606f\u6316\u6398\u6280\u672f\u5728\u65b0\u53d1\u7cd6\u5c3f\u75c5\u4f8b\u7814\u7a76\u4e2d\u7684\u5e94\u7528","funder_award_id":"20875061","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7553344616","display_name":"\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u843d\u7684\u7ed3\u6784\u52a8\u529b\u5b66\u4e0e\u529f\u80fd\u89e3\u6790\u7814\u7a76","funder_award_id":"30730005","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320335773","display_name":"National High-tech Research and Development Program","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W237230946","https://openalex.org/W1569114583","https://openalex.org/W1963739832","https://openalex.org/W1985882893","https://openalex.org/W1999853225","https://openalex.org/W2013036395","https://openalex.org/W2024026026","https://openalex.org/W2030154486","https://openalex.org/W2035906320","https://openalex.org/W2038217946","https://openalex.org/W2039513204","https://openalex.org/W2042074642","https://openalex.org/W2052179757","https://openalex.org/W2056373708","https://openalex.org/W2064119981","https://openalex.org/W2069794768","https://openalex.org/W2083104012","https://openalex.org/W2086108438","https://openalex.org/W2087671769","https://openalex.org/W2088289427","https://openalex.org/W2091840905","https://openalex.org/W2097660065","https://openalex.org/W2111858111","https://openalex.org/W2122007620","https://openalex.org/W2124006710","https://openalex.org/W2124185446","https://openalex.org/W2127858899","https://openalex.org/W2128114769","https://openalex.org/W2131536322","https://openalex.org/W2133199783","https://openalex.org/W2144161775","https://openalex.org/W2144816130","https://openalex.org/W2145166062","https://openalex.org/W2148067809","https://openalex.org/W2152805980","https://openalex.org/W2153732314","https://openalex.org/W2155806125","https://openalex.org/W2156255246","https://openalex.org/W2162315106","https://openalex.org/W2164091046","https://openalex.org/W2165065263","https://openalex.org/W2165282564","https://openalex.org/W2167062509","https://openalex.org/W2169098285","https://openalex.org/W2912979477","https://openalex.org/W4210956151","https://openalex.org/W6609246937"],"related_works":["https://openalex.org/W2948737524","https://openalex.org/W2161332823","https://openalex.org/W2483463543","https://openalex.org/W2109392327","https://openalex.org/W4253128567","https://openalex.org/W2322019105","https://openalex.org/W4292478757","https://openalex.org/W2162612026","https://openalex.org/W7095585215","https://openalex.org/W2028211999"],"abstract_inverted_index":{"Both":[0],"genetic":[1,116],"variations":[2],"and":[3,23,30,52,72,86,157,203,219],"diet-disrupted":[4],"gut":[5,28,83,113,132,162,217,228],"microbiota":[6,29,84,133,218,229],"can":[7],"predispose":[8],"animals":[9,171,188,232],"to":[10,81,87,94,135,152,238],"metabolic":[11],"syndromes":[12],"(MS).":[13],"This":[14],"study":[15],"assessed":[16],"the":[17,27,42,89,108,181,194,199,204,227],"relative":[18,134],"contributions":[19],"of":[20,75,107,175,180,221,230,240],"host":[21,245],"genetics":[22],"diet":[24,60,66,210],"in":[25,34,112,154,169,186,193,215],"shaping":[26,216],"modulating":[31],"MS-relevant":[32],"phenotypes":[33],"mice.":[35],"Together":[36],"with":[37,127,149,189],"its":[38],"wild-type":[39],"(Wt)":[40],"counterpart,":[41],"Apoa-I":[43],"knockout":[44],"mouse,":[45],"which":[46,197],"has":[47,211],"impaired":[48],"glucose":[49],"tolerance":[50],"(IGT)":[51],"increased":[53],"body":[54],"fat,":[55],"was":[56],"fed":[57],"a":[58,212,234,243],"high-fat":[59],"(HFD)":[61],"or":[62],"normal":[63],"chow":[64],"(NC)":[65],"for":[67,119],"25":[68],"weeks.":[69],"DNA":[70],"fingerprinting":[71],"bar-coded":[73],"pyrosequencing":[74],"16S":[76],"rRNA":[77],"genes":[78],"were":[79,144,166,184],"used":[80],"profile":[82],"structures":[85],"identify":[88],"key":[90,147,223],"population":[91],"changes":[92,104,153,220],"relevant":[93,237],"MS":[95,158,207],"development":[96,239],"by":[97],"Partial":[98],"Least":[99],"Square":[100],"Discriminate":[101],"Analysis.":[102],"Diet":[103],"explained":[105],"57%":[106],"total":[109],"structural":[110],"variation":[111],"microbiota,":[114],"whereas":[115],"mutation":[117],"accounted":[118],"no":[120],"more":[121],"than":[122],"12%.":[123],"All":[124],"three":[125],"groups":[126],"IGT":[128],"had":[129,198],"significantly":[130,192],"different":[131],"healthy":[136],"Wt/NC-fed":[137],"animals.":[138],"In":[139],"all,":[140],"65":[141],"species-level":[142],"phylotypes":[143],"identified":[145],"as":[146],"members":[148],"differential":[150],"responses":[151],"diet,":[155],"genotype":[156],"phenotype.":[159],"Most":[160],"notably,":[161],"barrier-protecting":[163],"Bifidobacterium":[164],"spp.":[165],"nearly":[167],"absent":[168],"all":[170,187],"on":[172],"HFD,":[173],"regardless":[174],"genotype.":[176],"Sulphate-reducing,":[177],"endotoxin-producing":[178],"bacteria":[179],"family,":[182],"Desulfovibrionaceae,":[183],"enhanced":[185],"IGT,":[190],"most":[191,205],"Wt/HFD":[195],"group,":[196],"highest":[200],"calorie":[201],"intake":[202],"serious":[206],"phenotypes.":[208],"Thus,":[209],"dominating":[213],"role":[214],"some":[222],"populations":[224],"may":[225],"transform":[226],"Wt":[231],"into":[233],"pathogen-like":[235],"entity":[236],"MS,":[241],"despite":[242],"complete":[244],"genome.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":23},{"year":2025,"cited_by_count":52},{"year":2024,"cited_by_count":65},{"year":2023,"cited_by_count":76},{"year":2022,"cited_by_count":101},{"year":2021,"cited_by_count":113},{"year":2020,"cited_by_count":99},{"year":2019,"cited_by_count":81},{"year":2018,"cited_by_count":80},{"year":2017,"cited_by_count":76},{"year":2016,"cited_by_count":66},{"year":2015,"cited_by_count":56},{"year":2014,"cited_by_count":50},{"year":2013,"cited_by_count":30},{"year":2012,"cited_by_count":23}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}