{"id":"https://openalex.org/W2139094207","doi":"https://doi.org/10.1128/mbio.00027-12","title":"Identification of a Highly Transmissible Animal-Independent Staphylococcus aureus ST398 Clone with Distinct Genomic and Cell Adhesion Properties","display_name":"Identification of a Highly Transmissible Animal-Independent Staphylococcus aureus ST398 Clone with Distinct Genomic and Cell Adhesion Properties","publication_year":2012,"publication_date":"2012-02-28","ids":{"openalex":"https://openalex.org/W2139094207","doi":"https://doi.org/10.1128/mbio.00027-12","mag":"2139094207","pmid":"https://pubmed.ncbi.nlm.nih.gov/22375071","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3302565"},"language":"en","primary_location":{"id":"doi:10.1128/mbio.00027-12","doi":"https://doi.org/10.1128/mbio.00027-12","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.00027-12","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1128/mbio.00027-12","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091489538","display_name":"Anne\u2010Catrin Uhlemann","orcid":"https://orcid.org/0000-0002-9798-4768","observed_orcids":["https://orcid.org/0000-0002-9798-4768"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne-Catrin Uhlemann","raw_affiliation_strings":["Department of Medicine, Division of Infectious Diseases, College of Physicians and Surgeons, Columbia University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Infectious Diseases, College of Physicians and Surgeons, Columbia University, New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080432457","display_name":"Stephen F. Porcella","orcid":"https://orcid.org/0000-0001-5512-1553","observed_orcids":["https://orcid.org/0000-0001-5512-1553"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405287673","display_name":"Rocky Mountain Laboratories","ror":"https://ror.org/05v7g7w67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen F. Porcella","raw_affiliation_strings":["Genomics Unit, Research Technologies Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Unit, Research Technologies Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013511655","display_name":"Sheetal Trivedi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheetal Trivedi","raw_affiliation_strings":["Department of Medicine, Division of Infectious Diseases, College of Physicians and Surgeons, Columbia University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Infectious Diseases, College of Physicians and Surgeons, Columbia University, New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038455780","display_name":"Sean B. Sullivan","orcid":"https://orcid.org/0000-0002-8950-4824","observed_orcids":["https://orcid.org/0000-0002-8950-4824"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean B. Sullivan","raw_affiliation_strings":["Department of Medicine, Division of Infectious Diseases, College of Physicians and Surgeons, Columbia University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Infectious Diseases, College of Physicians and Surgeons, Columbia University, New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083324282","display_name":"Cory A. Hafer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cory Hafer","raw_affiliation_strings":["Department of Medicine, Division of Infectious Diseases, College of Physicians and Surgeons, Columbia University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Infectious Diseases, College of Physicians and Surgeons, Columbia University, New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020347433","display_name":"Adam D. Kennedy","orcid":"https://orcid.org/0000-0001-5391-9457","observed_orcids":["https://orcid.org/0000-0001-5391-9457"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405287673","display_name":"Rocky Mountain Laboratories","ror":"https://ror.org/05v7g7w67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam D. Kennedy","raw_affiliation_strings":["Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075241421","display_name":"Kent Barbian","orcid":"https://orcid.org/0000-0001-9861-6150","observed_orcids":["https://orcid.org/0000-0001-9861-6150"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405287673","display_name":"Rocky Mountain Laboratories","ror":"https://ror.org/05v7g7w67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kent D. Barbian","raw_affiliation_strings":["Genomics Unit, Research Technologies Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Unit, Research Technologies Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055004932","display_name":"Alex J. McCarthy","orcid":"https://orcid.org/0000-0002-4105-3737","observed_orcids":["https://orcid.org/0000-0002-4105-3737"]},"institutions":[{"id":"https://openalex.org/I124357947","display_name":"University of London","ror":"https://ror.org/04cw6st05","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947"]},{"id":"https://openalex.org/I165862685","display_name":"St George's, University of London","ror":"https://ror.org/040f08y74","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I165862685","https://openalex.org/I4401726869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alex J. McCarthy","raw_affiliation_strings":["Centre for Infection, Division of Clinical Sciences, St. George\u2019s, University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Infection, Division of Clinical Sciences, St. George\u2019s, University of London, London, United Kingdom","institution_ids":["https://openalex.org/I124357947","https://openalex.org/I165862685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062518186","display_name":"Craig Street","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig Street","raw_affiliation_strings":["Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089708883","display_name":"David L. Hirschberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Hirschberg","raw_affiliation_strings":["Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090343848","display_name":"Walter Ian Lipkin","orcid":"https://orcid.org/0000-0002-8768-9386","observed_orcids":["https://orcid.org/0000-0002-8768-9386"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Ian Lipkin","raw_affiliation_strings":["Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060811770","display_name":"Jodi A. Lindsay","orcid":"https://orcid.org/0000-0002-5219-1625","observed_orcids":["https://orcid.org/0000-0002-5219-1625"]},"institutions":[{"id":"https://openalex.org/I124357947","display_name":"University of London","ror":"https://ror.org/04cw6st05","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947"]},{"id":"https://openalex.org/I165862685","display_name":"St George's, University of London","ror":"https://ror.org/040f08y74","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I165862685","https://openalex.org/I4401726869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jodi A. Lindsay","raw_affiliation_strings":["Centre for Infection, Division of Clinical Sciences, St. George\u2019s, University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Infection, Division of Clinical Sciences, St. George\u2019s, University of London, London, United Kingdom","institution_ids":["https://openalex.org/I124357947","https://openalex.org/I165862685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062303919","display_name":"Frank R. DeLeo","orcid":"https://orcid.org/0000-0003-3150-2516","observed_orcids":["https://orcid.org/0000-0003-3150-2516"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405287673","display_name":"Rocky Mountain Laboratories","ror":"https://ror.org/05v7g7w67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank R. DeLeo","raw_affiliation_strings":["Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109174613","display_name":"Franklin D. Lowy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Franklin D. Lowy","raw_affiliation_strings":["Department of Medicine, Division of Infectious Diseases, College of Physicians and Surgeons, Columbia University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Infectious Diseases, College of Physicians and Surgeons, Columbia University, New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":17.6758,"has_fulltext":false,"cited_by_count":203,"citation_normalized_percentile":{"value":0.99613093,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"3","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12824","display_name":"Infections and bacterial resistance","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methicillin-susceptible-staphylococcus-aureus","display_name":"methicillin-susceptible Staphylococcus aureus","score":0.902999997138977},{"id":"https://openalex.org/keywords/livestock-associated-mrsa","display_name":"livestock-associated MRSA","score":0.8240000009536743},{"id":"https://openalex.org/keywords/human-to-human-transmission","display_name":"human-to-human transmission","score":0.718999981880188},{"id":"https://openalex.org/keywords/household-transmission","display_name":"household transmission","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mobile-genetic-elements","display_name":"mobile genetic elements","score":0.7089999914169312},{"id":"https://openalex.org/keywords/cell-adhesion-genes","display_name":"cell adhesion genes","score":0.8029999732971191},{"id":"https://openalex.org/keywords/keratinocyte-adhesion","display_name":"keratinocyte adhesion","score":0.925000011920929},{"id":"https://openalex.org/keywords/skin-colonization","display_name":"skin colonization","score":0.5379999876022339},{"id":"https://openalex.org/keywords/urban-population","display_name":"urban population","score":0.453000009059906},{"id":"https://openalex.org/keywords/northern-manhattan","display_name":"Northern Manhattan","score":0.5879999995231628},{"id":"https://openalex.org/keywords/whole-genome-sequencing","display_name":"whole genome sequencing","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C73445445","wikidata":"https://www.wikidata.org/wiki/Q1712327","display_name":"Prophage","level":5,"score":0.7425065040588379},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7025449872016907},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.679202139377594},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.6387566924095154},{"id":"https://openalex.org/C132533263","wikidata":"https://www.wikidata.org/wiki/Q2347362","display_name":"Mobile genetic elements","level":4,"score":0.5867429971694946},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.47511133551597595},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4737818241119385},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.46566036343574524},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4336293935775757},{"id":"https://openalex.org/C24527192","wikidata":"https://www.wikidata.org/wiki/Q17149729","display_name":"Human pathogen","level":3,"score":0.418215811252594},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.13202223181724548},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.06913203001022339},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.06554850935935974}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001422","descriptor_name":"Bacterial Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008712","descriptor_name":"Methicillin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009519","descriptor_name":"New York City","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020071","descriptor_name":"Interspersed Repetitive Sequences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026801","descriptor_name":"Synteny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039002","descriptor_name":"Prophages","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1128/mbio.00027-12","doi":"https://doi.org/10.1128/mbio.00027-12","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.00027-12","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3302565","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3302565","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"Text"},{"id":"pmid:22375071","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22375071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"Comparative Study"},{"id":"pmh:oai:openaccess.sgul.ac.uk:1107","doi":null,"is_oa":false,"landing_page_url":"http://openaccess.sgul.ac.uk/1107/1/mBio.00027-12.pdf","pdf_url":"http://openaccess.sgul.ac.uk/1107/1/mBio.00027-12.pdf","source":{"id":"https://openalex.org/S4306400552","display_name":"St George's Online Research Archive (St George's University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165862685","host_organization_name":"St George's, University of London","host_organization_lineage":["https://openalex.org/I165862685"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:55b901103bed415ca985ef78334e1c73","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/55b901103bed415ca985ef78334e1c73","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mBio, Vol 3, Iss 2 (2012)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9f05bdd957ab4552827546701b59b1d5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9f05bdd957ab4552827546701b59b1d5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mBio, Vol 3, Iss 2 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1128/mbio.00027-12","doi":"https://doi.org/10.1128/mbio.00027-12","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.00027-12","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G338964766","display_name":null,"funder_award_id":"AI057158","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4108419988","display_name":"Mechanisms of S. aureus transmission and persistence.","funder_award_id":"K08AI090013","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G816592571","display_name":"Modeling of S. aureus Transmission in Northern Manhattan.","funder_award_id":"R01AI077690","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8733888550","display_name":"Northeast Biodefense Center","funder_award_id":"U54AI057158","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332186","display_name":"Defense Threat Reduction Agency","ror":"https://ror.org/04tz64554"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W191677311","https://openalex.org/W1692166726","https://openalex.org/W1967056998","https://openalex.org/W1987892693","https://openalex.org/W1989787472","https://openalex.org/W1994384167","https://openalex.org/W2004538785","https://openalex.org/W2022600772","https://openalex.org/W2031021642","https://openalex.org/W2032714765","https://openalex.org/W2041998853","https://openalex.org/W2048558329","https://openalex.org/W2072550492","https://openalex.org/W2074537908","https://openalex.org/W2078335862","https://openalex.org/W2087750699","https://openalex.org/W2088542856","https://openalex.org/W2091030812","https://openalex.org/W2096607868","https://openalex.org/W2096716766","https://openalex.org/W2109922040","https://openalex.org/W2112417119","https://openalex.org/W2113996889","https://openalex.org/W2120762131","https://openalex.org/W2123787004","https://openalex.org/W2124921765","https://openalex.org/W2132013404","https://openalex.org/W2140903449","https://openalex.org/W2149731513","https://openalex.org/W2152627500","https://openalex.org/W2152878746","https://openalex.org/W2154790599","https://openalex.org/W2157079807","https://openalex.org/W2162872161","https://openalex.org/W2163438193","https://openalex.org/W2165481706","https://openalex.org/W2165557141","https://openalex.org/W2169929748","https://openalex.org/W2171610053","https://openalex.org/W2183878314","https://openalex.org/W2314649741","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2034181348","https://openalex.org/W3094732693","https://openalex.org/W3012113806","https://openalex.org/W1936686197","https://openalex.org/W2110459646","https://openalex.org/W4378907448","https://openalex.org/W2577444167","https://openalex.org/W4214584745","https://openalex.org/W2065663418","https://openalex.org/W7095868235"],"abstract_inverted_index":{"UNLABELLED:":[0],"A":[1],"methicillin-resistant":[2,258],"Staphylococcus":[3,237],"aureus":[4,37,238,253,260,278,367],"(MRSA)":[5],"clone":[6,39,118,172,215,308],"known":[7],"as":[8,12,256,280],"ST398":[9,34,62,72,99,116,141,170,199,213,257,275,293,306,322,392],"has":[10,40,52],"emerged":[11],"a":[13,74,281,295,362],"major":[14],"cause":[15,297],"of":[16,31,50,57,61,77,97,113,123,161,184,197,219,226,251,274,284,298,315,329,349,365,375,379,391],"acute":[17],"infections":[18,79,300],"in":[19,43,80,89,179,286,301,346],"individuals":[20,88],"who":[21],"have":[22,240,266],"close":[23],"contact":[24,221],"with":[25,93,193],"livestock.":[26],"More":[27],"recently,":[28],"the":[29,47,58,94,111,114,124,145,149,162,168,211,272,330,373,382,385],"emergence":[30,273],"an":[32,54,223],"animal-independent":[33],"methicillin-sensitive":[35],"S.":[36,252,259,277,366],"(MSSA)":[38,279],"been":[41,242,267],"documented":[42],"several":[44],"countries.":[45],"However,":[46,248],"limited":[48,95],"surveillance":[49,378],"MSSA":[51,78,117,142,171,200,214,299,307,323,380],"precluded":[53],"accurate":[55],"assessment":[56],"global":[59],"spread":[60,217,390],"and":[63,83,148,157,173,182,206,228,341,352,387],"its":[64],"clinical":[65],"relevance.":[66],"Here":[67,289],"we":[68,270,290],"provide":[69],"evidence":[70,383],"that":[71,110,122,210,292,320,328],"is":[73,84,119,294],"frequent":[75,296],"source":[76],"northern":[81,287],"Manhattan":[82],"readily":[85,310],"transmitted":[86,311],"between":[87,103,167],"households.":[90],"This":[91],"contrasts":[92],"transmissibility":[96],"livestock-associated":[98],"(LA-ST398)":[100],"MRSA":[101,126],"strains":[102,176,239,343],"humans.":[104,235],"Our":[105,370],"whole-genome":[106],"sequence":[107],"analysis":[108],"revealed":[109],"chromosome":[112],"human-associated":[115],"smaller":[120,326],"than":[121,327],"LA-ST398":[125,331,342],"reference":[127],"strain":[128,283,332],"S0385,":[129,174],"due":[130,334],"mainly":[131],"to":[132,202,232,244,264,335,355,357],"fewer":[133,336],"mobile":[134,337],"genetic":[135,189,338],"elements":[136],"(MGEs).":[137],"In":[138],"contrast,":[139],"human":[140,169,198,203,212,321,358],"isolates":[143,201],"harbored":[144],"prophage":[146],"\u03d53":[147],"human-specific":[150],"immune":[151],"evasion":[152],"cluster":[153],"(IEC)":[154],"genes":[155,351],"chp":[156],"scn.":[158],"While":[159],"most":[160],"core":[163],"genome":[164],"was":[165,309],"conserved":[166],"these":[175],"differed":[177,345],"substantially":[178],"their":[180,347,353],"repertoire":[181,225],"composition":[183,348],"intact":[185],"adhesion":[186,196,229,350],"genes.":[187],"These":[188],"changes":[190],"were":[191,325],"associated":[192],"significantly":[194],"enhanced":[195],"skin":[204,359],"keratinocytes":[205],"keratin.":[207],"We":[208,318],"propose":[209],"can":[216],"independent":[218,314],"animal":[220,316],"using":[222],"optimized":[224],"MGEs":[227],"molecules":[230],"adapted":[231],"transmission":[233],"among":[234],"IMPORTANCE:":[236],"generally":[241],"considered":[243],"be":[245],"species":[246],"specific.":[247],"cross-species":[249],"transfers":[250],"clones,":[254],"such":[255],"(MRSA),":[261],"from":[262],"swine":[263],"humans":[265,285],"reported.":[268],"Recently,":[269],"observed":[271],"methicillin-susceptible":[276],"colonizing":[282],"Manhattan.":[288],"report":[291],"this":[302],"urban":[303],"setting.":[304],"The":[305],"within":[312],"households,":[313],"contact.":[317],"discovered":[319],"genomes":[324],"S0385":[333],"elements.":[339],"Human":[340],"also":[344],"ability":[354],"bind":[356],"keratinocytes,":[360],"providing":[361],"potential":[363],"mechanism":[364],"host":[368],"adaptation.":[369],"findings":[371],"illustrate":[372],"importance":[374],"implementing":[376],"molecular":[377],"given":[381],"for":[384],"rapid":[386],"clinically":[388],"undetected":[389],"MSSA.":[393]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":35},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}