{"id":"https://openalex.org/W2139087557","doi":"https://doi.org/10.1271/bbb.130353","title":"Functional Analysis of the AKR4C Subfamily ofArabidopsis thaliana: Model Structures, Substrate Specificity, Acrolein Toxicity, and Responses to Light and [CO2]","display_name":"Functional Analysis of the AKR4C Subfamily ofArabidopsis thaliana: Model Structures, Substrate Specificity, Acrolein Toxicity, and Responses to Light and [CO2]","publication_year":2013,"publication_date":"2013-10-06","ids":{"openalex":"https://openalex.org/W2139087557","doi":"https://doi.org/10.1271/bbb.130353","mag":"2139087557","pmid":"https://pubmed.ncbi.nlm.nih.gov/24096666"},"language":"en","primary_location":{"id":"doi:10.1271/bbb.130353","doi":"https://doi.org/10.1271/bbb.130353","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.130353","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ryota SAITO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryota SAITO","raw_affiliation_strings":["Department of Biological and Environmental Science, Faculty of Agriculture, Graduate School of Agricultural Science, Kobe University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological and Environmental Science, Faculty of Agriculture, Graduate School of Agricultural Science, Kobe University","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005329799","display_name":"Ginga Shimakawa","orcid":"https://orcid.org/0000-0002-8557-2096","observed_orcids":["https://orcid.org/0000-0002-8557-2096"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ginga SHIMAKAWA","raw_affiliation_strings":["Department of Biological and Environmental Science, Faculty of Agriculture, Graduate School of Agricultural Science, Kobe University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological and Environmental Science, Faculty of Agriculture, Graduate School of Agricultural Science, Kobe University","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025184693","display_name":"Akiko Nishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko NISHI","raw_affiliation_strings":["Department of Biological and Environmental Science, Faculty of Agriculture, Graduate School of Agricultural Science, Kobe University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological and Environmental Science, Faculty of Agriculture, Graduate School of Agricultural Science, Kobe University","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028271577","display_name":"Tatsuya Iwamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuya IWAMOTO","raw_affiliation_strings":["Department of Biological and Environmental Science, Faculty of Agriculture, Graduate School of Agricultural Science, Kobe University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological and Environmental Science, Faculty of Agriculture, Graduate School of Agricultural Science, Kobe University","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067818323","display_name":"Katsuhiko Sakamoto","orcid":"https://orcid.org/0000-0001-7002-6685","observed_orcids":["https://orcid.org/0000-0001-7002-6685"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuhiko SAKAMOTO","raw_affiliation_strings":["Department of Biological and Environmental Science, Faculty of Agriculture, Graduate School of Agricultural Science, Kobe University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological and Environmental Science, Faculty of Agriculture, Graduate School of Agricultural Science, Kobe University","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015432645","display_name":"Hiroshi Yamamoto","orcid":"https://orcid.org/0000-0002-1739-1226","observed_orcids":["https://orcid.org/0000-0002-1739-1226"]},"institutions":[{"id":"https://openalex.org/I27650515","display_name":"Kobe Gakuin University","ror":"https://ror.org/018v0zv10","country_code":"JP","type":"education","lineage":["https://openalex.org/I27650515"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi YAMAMOTO","raw_affiliation_strings":["Faculty of Nutrition, Kobe Gakuin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Nutrition, Kobe Gakuin University","institution_ids":["https://openalex.org/I27650515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013550678","display_name":"Katsumi Amako","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsumi AMAKO","raw_affiliation_strings":["Department of Botany, Graduate School of Science, Kyoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Botany, Graduate School of Science, Kyoto University","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047408959","display_name":"Amane Makino","orcid":"https://orcid.org/0000-0003-2779-6275","observed_orcids":["https://orcid.org/0000-0003-2779-6275"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4210137396","display_name":"Centre de Recherche en \u00c9conomie et Statistique","ror":"https://ror.org/0449khs19","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I142476485","https://openalex.org/I4210108488","https://openalex.org/I4210137396","https://openalex.org/I4210145102","https://openalex.org/I4210150854","https://openalex.org/I84009706"]}],"countries":["FR","JP"],"is_corresponding":false,"raw_author_name":"Amane MAKINO","raw_affiliation_strings":["CREST, JST","Department of Agriculture, Graduate School of Agricultural Science, Tohoku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CREST, JST","institution_ids":["https://openalex.org/I4210086780","https://openalex.org/I4210137396"]},{"raw_affiliation_string":"Department of Agriculture, Graduate School of Agricultural Science, Tohoku University","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047878163","display_name":"Chikahiro Miyake","orcid":"https://orcid.org/0000-0002-2426-2377","observed_orcids":["https://orcid.org/0000-0002-2426-2377"]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4210137396","display_name":"Centre de Recherche en \u00c9conomie et Statistique","ror":"https://ror.org/0449khs19","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I142476485","https://openalex.org/I4210108488","https://openalex.org/I4210137396","https://openalex.org/I4210145102","https://openalex.org/I4210150854","https://openalex.org/I84009706"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["FR","JP"],"is_corresponding":false,"raw_author_name":"Chikahiro MIYAKE","raw_affiliation_strings":["CREST, JST","Department of Biological and Environmental Science, Faculty of Agriculture, Graduate School of Agricultural Science, Kobe University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CREST, JST","institution_ids":["https://openalex.org/I4210086780","https://openalex.org/I4210137396"]},{"raw_affiliation_string":"Department of Biological and Environmental Science, Faculty of Agriculture, Graduate School of Agricultural Science, Kobe University","institution_ids":["https://openalex.org/I65837984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3272,"currency":"USD","value_usd":3272},"apc_paid":null,"fwci":0.9849,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.70462239,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"77","issue":"10","first_page":"2038","last_page":"2045"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10014","display_name":"Plant Stress Responses and Tolerance","score":0.1851000040769577,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldo-keto-reductase","display_name":"aldo-keto reductase","score":0.9639999866485596},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.8980000019073486},{"id":"https://openalex.org/keywords/methylglyoxal","display_name":"methylglyoxal","score":0.8370000123977661},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.8920000195503235},{"id":"https://openalex.org/keywords/protein-structure-modeling","display_name":"protein structure modeling","score":0.7049999833106995},{"id":"https://openalex.org/keywords/triose-phosphate","display_name":"triose phosphate","score":0.7850000262260437},{"id":"https://openalex.org/keywords/dihydroxyacetone-phosphate","display_name":"dihydroxyacetone phosphate","score":0.972000002861023},{"id":"https://openalex.org/keywords/glyceraldehyde-3-phosphate","display_name":"glyceraldehyde-3-phosphate","score":0.9229999780654907},{"id":"https://openalex.org/keywords/light-response","display_name":"light response","score":0.7760000228881836},{"id":"https://openalex.org/keywords/photosynthate-accumulation","display_name":"photosynthate accumulation","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C2778592357","wikidata":"https://www.wikidata.org/wiki/Q903881","display_name":"Methylglyoxal","level":3,"score":0.7889108657836914},{"id":"https://openalex.org/C50929876","wikidata":"https://www.wikidata.org/wiki/Q164280","display_name":"Subfamily","level":3,"score":0.7797478437423706},{"id":"https://openalex.org/C2780866112","wikidata":"https://www.wikidata.org/wiki/Q416915","display_name":"Dihydroxyacetone phosphate","level":3,"score":0.7467461824417114},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6806771755218506},{"id":"https://openalex.org/C2775988993","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Arabidopsis thaliana","level":4,"score":0.6585431694984436},{"id":"https://openalex.org/C2779617269","wikidata":"https://www.wikidata.org/wiki/Q18015634","display_name":"DHAP","level":3,"score":0.6464135646820068},{"id":"https://openalex.org/C2778727959","wikidata":"https://www.wikidata.org/wiki/Q24777683","display_name":"Triosephosphate isomerase","level":3,"score":0.6408970355987549},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.632343590259552},{"id":"https://openalex.org/C2780422782","wikidata":"https://www.wikidata.org/wiki/Q342790","display_name":"Acrolein","level":3,"score":0.5984514951705933},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44490131735801697},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43439966440200806},{"id":"https://openalex.org/C2780535078","wikidata":"https://www.wikidata.org/wiki/Q879954","display_name":"Sugar phosphates","level":3,"score":0.4174700081348419},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.385386198759079},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28564023971557617},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000074408","descriptor_name":"Aldo-Keto Reductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000171","descriptor_name":"Acrolein","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011765","descriptor_name":"Pyruvaldehyde","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050260","descriptor_name":"Carbohydrate Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1271/bbb.130353","doi":"https://doi.org/10.1271/bbb.130353","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.130353","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},{"id":"pmid:24096666","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24096666","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, biotechnology, and biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1573729541","https://openalex.org/W1966916936","https://openalex.org/W1972954986","https://openalex.org/W1976236503","https://openalex.org/W1984253132","https://openalex.org/W1984929731","https://openalex.org/W1998790155","https://openalex.org/W1999178895","https://openalex.org/W2003589493","https://openalex.org/W2005982879","https://openalex.org/W2006292688","https://openalex.org/W2006690337","https://openalex.org/W2013053716","https://openalex.org/W2016795949","https://openalex.org/W2026546941","https://openalex.org/W2037716067","https://openalex.org/W2040852718","https://openalex.org/W2048803436","https://openalex.org/W2058233902","https://openalex.org/W2059113607","https://openalex.org/W2060742338","https://openalex.org/W2063380216","https://openalex.org/W2076183724","https://openalex.org/W2097763382","https://openalex.org/W2098518390","https://openalex.org/W2100181170","https://openalex.org/W2112692148","https://openalex.org/W2118200955","https://openalex.org/W2127662138","https://openalex.org/W2138774341","https://openalex.org/W2140795515","https://openalex.org/W2147778463","https://openalex.org/W2152301430","https://openalex.org/W2156569921","https://openalex.org/W2157186422","https://openalex.org/W2162699268"],"related_works":["https://openalex.org/W2127662138","https://openalex.org/W2084523966","https://openalex.org/W1966916936","https://openalex.org/W3020404014","https://openalex.org/W2735735061","https://openalex.org/W2157186422","https://openalex.org/W2060742338","https://openalex.org/W2031048338","https://openalex.org/W2272788573","https://openalex.org/W2480900660"],"abstract_inverted_index":{"In":[0],"Arabidopsis":[1],"thaliana,":[2],"the":[3,35,39,48,73,92,97,104,112,130,136,141],"aldo-keto":[4],"reductase":[5],"(AKR)":[6],"family":[7],"includes":[8],"four":[9,40,59,105],"enzymes":[10,106],"(The":[11],"AKR4C":[12,113,137],"subfamily:":[13],"AKR4C8,":[14],"AKR4C9,":[15],"AKR4C10,":[16],"and":[17,20,31,33,65,77,88,119,126],"AKR4C11).":[18],"AKR4C8":[19],"AKR4C9":[21,52],"might":[22],"detoxify":[23],"sugar-derived":[24,144],"reactive":[25],"carbonyls":[26],"(RCs).":[27],"We":[28],"analyzed":[29],"AKR4C10":[30,76,81],"AKR4C11,":[32],"compared":[34],"enzymatic":[36],"functions":[37],"of":[38,43,51,95,111,143],"enzymes.":[41,60],"Modeling":[42],"protein":[44],"structures":[45,62],"based":[46],"on":[47],"known":[49],"structure":[50],"found":[53],"an":[54],"(\u03b1/\u03b2)8-barrel":[55],"motif":[56],"in":[57,129,146],"all":[58,96],"Loop":[61],"(A,":[63],"B,":[64],"C)":[66],"which":[67],"determine":[68],"substrate":[69],"specificity,":[70],"differed":[71],"among":[72],"four.":[74],"Both":[75],"AKR4C11":[78],"reduced":[79,82],"methylglyoxal.":[80],"triose":[83],"phosphates,":[84],"dihydroxyacetone":[85],"phosphate":[86],"(DHAP),":[87],"glyceraldehydes":[89],"3-phosphate":[90],"(GAP),":[91],"most":[93],"efficiently":[94],"AKR4Cs.":[98],"Acrolein,":[99],"a":[100],"lipid-derived":[101],"RC,":[102],"inactivated":[103],"to":[107,140],"different":[108],"degrees.":[109],"Expression":[110],"genes":[114],"was":[115,124],"induced":[116],"under":[117],"high-[CO2]":[118],"high":[120],"light,":[121],"when":[122],"photosynthesis":[123],"enhanced":[125],"photosynthates":[127],"accumulated":[128],"cells.":[131],"These":[132],"results":[133],"suggest":[134],"that":[135],"subfamily":[138],"contributes":[139],"detoxification":[142],"RCs":[145],"plants.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
