{"id":"https://openalex.org/W2139077586","doi":"https://doi.org/10.1093/annonc/mdq358","title":"Associations of various gene polymorphisms with toxicity in colorectal cancer patients receiving oral uracil and tegafur plus leucovorin: a prospective study","display_name":"Associations of various gene polymorphisms with toxicity in colorectal cancer patients receiving oral uracil and tegafur plus leucovorin: a prospective study","publication_year":2010,"publication_date":"2010-07-21","ids":{"openalex":"https://openalex.org/W2139077586","doi":"https://doi.org/10.1093/annonc/mdq358","mag":"2139077586","pmid":"https://pubmed.ncbi.nlm.nih.gov/20647221"},"language":"en","primary_location":{"id":"doi:10.1093/annonc/mdq358","doi":"https://doi.org/10.1093/annonc/mdq358","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdq358","pdf_url":"http://www.annalsofoncology.org/article/S0923753419386600/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.annalsofoncology.org/article/S0923753419386600/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015725288","display_name":"Akira Tsunoda","orcid":"https://orcid.org/0000-0002-6211-0219","observed_orcids":["https://orcid.org/0000-0002-6211-0219","https://orcid.org/0009-0005-8963-2024"]},"institutions":[{"id":"https://openalex.org/I4210114023","display_name":"Kameda Medical Center","ror":"https://ror.org/01gf00k84","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210114023"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"A. Tsunoda","raw_affiliation_strings":["Department of Surgery, Kameda Medical Center, Chiba. a.tsunoda@kameda.jp","Department of Surgery, Kameda Medical Center, Chiba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kameda Medical Center, Chiba. a.tsunoda@kameda.jp","institution_ids":["https://openalex.org/I4210114023"]},{"raw_affiliation_string":"Department of Surgery, Kameda Medical Center, Chiba","institution_ids":["https://openalex.org/I4210114023"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021823210","display_name":"Kentaro Nakao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Nakao","raw_affiliation_strings":["Department of Gastroenterological and General Surgery, Showa University School of Medicine, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological and General Surgery, Showa University School of Medicine, Tokyo","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102009447","display_name":"Makoto Watanabe","orcid":"https://orcid.org/0000-0002-6147-7713","observed_orcids":["https://orcid.org/0000-0002-6147-7713"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Watanabe","raw_affiliation_strings":["Department of Gastroenterological and General Surgery, Showa University School of Medicine, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological and General Surgery, Showa University School of Medicine, Tokyo","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":null,"display_name":"N. Matsui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Matsui","raw_affiliation_strings":["Department of Gastroenterological and General Surgery, Showa University School of Medicine, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological and General Surgery, Showa University School of Medicine, Tokyo","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072078603","display_name":"Akio Ooyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120269","display_name":"Taiho Pharmaceutical (Japan)","ror":"https://ror.org/02v50dx14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210120269"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A. Ooyama","raw_affiliation_strings":["Taiho Pharmaceutical Co. Ltd, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taiho Pharmaceutical Co. Ltd, Tokushima, Japan","institution_ids":["https://openalex.org/I4210120269"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111759053","display_name":"Mitsuo Kusano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Kusano","raw_affiliation_strings":["Department of Gastroenterological and General Surgery, Showa University School of Medicine, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological and General Surgery, Showa University School of Medicine, Tokyo","institution_ids":["https://openalex.org/I119182057"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015725288"],"corresponding_institution_ids":["https://openalex.org/I4210114023"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":3.8706,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.92132665,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"22","issue":"2","first_page":"355","last_page":"361"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leucovorin","display_name":"leucovorin","score":0.9629999995231628},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8820000290870667},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.7630000114440918},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.921999990940094},{"id":"https://openalex.org/keywords/orotate-phosphoribosyltransferase","display_name":"orotate phosphoribosyltransferase","score":0.8679999709129333},{"id":"https://openalex.org/keywords/thymidylate-synthase","display_name":"thymidylate synthase","score":0.925000011920929},{"id":"https://openalex.org/keywords/ugt1a1","display_name":"UGT1A1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cyp2a6","display_name":"CYP2A6","score":0.8939999938011169},{"id":"https://openalex.org/keywords/5-fluorouracil-toxicity","display_name":"5-fluorouracil toxicity","score":0.878000020980835},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hyperbilirubinemia","display_name":"hyperbilirubinemia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.7590000033378601},{"id":"https://openalex.org/keywords/folate-metabolism","display_name":"folate metabolism","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2777299880","wikidata":"https://www.wikidata.org/wiki/Q413370","display_name":"Tegafur","level":3,"score":0.7750781774520874},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7432963252067566},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7159952521324158},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6900104284286499},{"id":"https://openalex.org/C2778050828","wikidata":"https://www.wikidata.org/wiki/Q1114455","display_name":"Dihydropyrimidine dehydrogenase","level":5,"score":0.6410462856292725},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5155565738677979},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.48242172598838806},{"id":"https://openalex.org/C123321153","wikidata":"https://www.wikidata.org/wiki/Q22676802","display_name":"Thymidylate synthase","level":4,"score":0.4686305522918701},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3876477777957916},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3579343557357788},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28863781690597534},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.28078967332839966}],"mesh":[{"descriptor_ui":"D000099148","descriptor_name":"UGT1A1 Enzyme","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005641","descriptor_name":"Tegafur","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014453","descriptor_name":"Glucuronosyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/annonc/mdq358","doi":"https://doi.org/10.1093/annonc/mdq358","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdq358","pdf_url":"http://www.annalsofoncology.org/article/S0923753419386600/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},{"id":"pmid:20647221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20647221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of oncology : official journal of the European Society for Medical Oncology","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:annonc:mdq358v1","doi":null,"is_oa":false,"landing_page_url":"http://annonc.oxfordjournals.org/cgi/content/short/mdq358v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/annonc/mdq358","doi":"https://doi.org/10.1093/annonc/mdq358","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdq358","pdf_url":"http://www.annalsofoncology.org/article/S0923753419386600/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139077586.pdf","grobid_xml":"https://content.openalex.org/works/W2139077586.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1831535185","https://openalex.org/W1864484242","https://openalex.org/W1893512222","https://openalex.org/W1970089074","https://openalex.org/W1974957356","https://openalex.org/W1982728538","https://openalex.org/W1992094340","https://openalex.org/W2001337137","https://openalex.org/W2001446629","https://openalex.org/W2004441139","https://openalex.org/W2009388286","https://openalex.org/W2022932998","https://openalex.org/W2030108537","https://openalex.org/W2031304873","https://openalex.org/W2031340221","https://openalex.org/W2044170424","https://openalex.org/W2048391139","https://openalex.org/W2049439467","https://openalex.org/W2053371603","https://openalex.org/W2055307705","https://openalex.org/W2065580295","https://openalex.org/W2065876196","https://openalex.org/W2068907962","https://openalex.org/W2069305509","https://openalex.org/W2097117460","https://openalex.org/W2100021150","https://openalex.org/W2105763971","https://openalex.org/W2118385151","https://openalex.org/W2121058342","https://openalex.org/W2122226579","https://openalex.org/W2147062206","https://openalex.org/W2147520342","https://openalex.org/W2148708125","https://openalex.org/W2154767509","https://openalex.org/W2155639923","https://openalex.org/W2157377073","https://openalex.org/W2162998038","https://openalex.org/W2168284699","https://openalex.org/W2168600267","https://openalex.org/W2229928428","https://openalex.org/W2322536880","https://openalex.org/W2339778209","https://openalex.org/W2408948947","https://openalex.org/W4236891330","https://openalex.org/W6639441487","https://openalex.org/W6677924696","https://openalex.org/W6703781524"],"related_works":["https://openalex.org/W1999338183","https://openalex.org/W2162998038","https://openalex.org/W2604516796","https://openalex.org/W2031083378","https://openalex.org/W2223009350","https://openalex.org/W751606657","https://openalex.org/W2154548748","https://openalex.org/W6939363042","https://openalex.org/W2795899174","https://openalex.org/W2116181319"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}