{"id":"https://openalex.org/W2139070096","doi":"https://doi.org/10.1186/1476-4598-9-28","title":"An evolved ribosome-inactivating protein targets and kills human melanoma cells in vitro and in vivo","display_name":"An evolved ribosome-inactivating protein targets and kills human melanoma cells in vitro and in vivo","publication_year":2010,"publication_date":"2010-02-03","ids":{"openalex":"https://openalex.org/W2139070096","doi":"https://doi.org/10.1186/1476-4598-9-28","mag":"2139070096","pmid":"https://pubmed.ncbi.nlm.nih.gov/20128926","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2828990"},"language":"en","primary_location":{"id":"doi:10.1186/1476-4598-9-28","doi":"https://doi.org/10.1186/1476-4598-9-28","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1476-4598-9-28","pdf_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/1476-4598-9-28","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/1476-4598-9-28","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Melissa C Cheung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Melissa C Cheung","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Toronto, 144 College Street, Toronto, ON, M5S 3 M2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Toronto, 144 College Street, Toronto, ON, M5S 3 M2, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052009051","display_name":"Leigh Revers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Leigh Revers","raw_affiliation_strings":["Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2 M9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2 M9, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031003571","display_name":"Subodini Perampalam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Subodini Perampalam","raw_affiliation_strings":["Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2 M9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2 M9, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025619970","display_name":"Xin Wei","orcid":"https://orcid.org/0000-0001-9363-0455","observed_orcids":["https://orcid.org/0000-0001-9363-0455"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Xin Wei","raw_affiliation_strings":["Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2 M9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2 M9, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086399826","display_name":"Reza Kiarash","orcid":"https://orcid.org/0000-0001-7079-4772","observed_orcids":["https://orcid.org/0000-0001-7079-4772"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Reza Kiarash","raw_affiliation_strings":["Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2 M9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2 M9, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David E Green","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David E Green","raw_affiliation_strings":["Department of Radiation Physics, Radiation Medicine Program, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, ON, M5G 2 M9, Canada","STTARR Innovation Centre, Radiation Medicine Program, Princess Margaret Hospital, University Health Network, 101 College Street, Toronto, ON, M5G 1L7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Physics, Radiation Medicine Program, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, ON, M5G 2 M9, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"raw_affiliation_string":"STTARR Innovation Centre, Radiation Medicine Program, Princess Margaret Hospital, University Health Network, 101 College Street, Toronto, ON, M5G 1L7, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019394462","display_name":"Aws Abdul\u2010Wahid","orcid":"https://orcid.org/0000-0002-0334-4699","observed_orcids":["https://orcid.org/0000-0002-0334-4699"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Aws Abdul-Wahid","raw_affiliation_strings":["Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2 M9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2 M9, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006919436","display_name":"Jean Gari\u00e9py","orcid":"https://orcid.org/0000-0003-2217-2981","observed_orcids":["https://orcid.org/0000-0003-2217-2981"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Jean Gari\u00e9py","raw_affiliation_strings":["Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2 M9, Canada","Department of Pharmaceutical Sciences, University of Toronto, 144 College Street, Toronto, ON, M5S 3 M2, Canada","Imaging Research, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON, M4N 3 M5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2 M9, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Toronto, 144 College Street, Toronto, ON, M5S 3 M2, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Imaging Research, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON, M4N 3 M5, Canada","institution_ids":["https://openalex.org/I4391768120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5006919436"],"corresponding_institution_ids":["https://openalex.org/I185261750","https://openalex.org/I4391768120"],"apc_list":{"value":5090,"currency":"USD","value_usd":5090},"apc_paid":{"value":5090,"currency":"USD","value_usd":5090},"fwci":1.4137,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.80514498,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"9","issue":"1","first_page":"28","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribosome-inactivating-proteins","display_name":"ribosome-inactivating proteins","score":0.9409999847412109},{"id":"https://openalex.org/keywords/shiga-like-toxin-1","display_name":"Shiga-like toxin 1","score":0.8820000290870667},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7059999704360962},{"id":"https://openalex.org/keywords/peptide-insertion","display_name":"peptide insertion","score":0.6259999871253967},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.6980000138282776},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.7289999723434448},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.8180000185966492},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5630000233650208},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.8109999895095825},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.5490000247955322},{"id":"https://openalex.org/keywords/toxin-evolution","display_name":"toxin evolution","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.7919265627861023},{"id":"https://openalex.org/C2780964509","wikidata":"https://www.wikidata.org/wiki/Q416975","display_name":"Dacarbazine","level":3,"score":0.6898741126060486},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6654918789863586},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6025698184967041},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5922560095787048},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5751909613609314},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5142068862915039},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.48568853735923767},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4413708448410034},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3784579932689667},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16728070378303528},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022622","descriptor_name":"Shiga Toxin 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D022622","descriptor_name":"Shiga Toxin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022622","descriptor_name":"Shiga Toxin 1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054788","descriptor_name":"Ribosome Inactivating Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1476-4598-9-28","doi":"https://doi.org/10.1186/1476-4598-9-28","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1476-4598-9-28","pdf_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/1476-4598-9-28","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2828990","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2828990","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cancer","raw_type":"Text"},{"id":"pmid:20128926","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20128926","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer","raw_type":"Journal Article"},{"id":"pmh:oai:utoronto.scholaris.ca:1807/84804","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/84804","pdf_url":"https://utoronto.scholaris.ca/bitstreams/033dda27-bd97-494e-bdf1-ec8a1714511d/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.356.6620","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.356.6620","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/95/29/Mol_Cancer_2010_Feb_3_9_28.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:28769672b8fe4d82957857a52bcc60c6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/28769672b8fe4d82957857a52bcc60c6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Cancer, Vol 9, Iss 1, p 28 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1476-4598-9-28","doi":"https://doi.org/10.1186/1476-4598-9-28","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1476-4598-9-28","pdf_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/1476-4598-9-28","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334576","display_name":"Canadian Cancer Society Research Institute","ror":"https://ror.org/017343w90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139070096.pdf","grobid_xml":"https://content.openalex.org/works/W2139070096.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W7092856","https://openalex.org/W27573832","https://openalex.org/W1534382357","https://openalex.org/W1534849470","https://openalex.org/W1841065486","https://openalex.org/W1978473225","https://openalex.org/W1978908299","https://openalex.org/W1985585224","https://openalex.org/W1988849896","https://openalex.org/W1997919830","https://openalex.org/W2003935158","https://openalex.org/W2004738840","https://openalex.org/W2005230990","https://openalex.org/W2009013652","https://openalex.org/W2009642161","https://openalex.org/W2012316489","https://openalex.org/W2027286738","https://openalex.org/W2030044360","https://openalex.org/W2034500754","https://openalex.org/W2037523875","https://openalex.org/W2041759339","https://openalex.org/W2042760441","https://openalex.org/W2043103956","https://openalex.org/W2057520802","https://openalex.org/W2057626554","https://openalex.org/W2062219794","https://openalex.org/W2071609648","https://openalex.org/W2073119578","https://openalex.org/W2073643139","https://openalex.org/W2077599419","https://openalex.org/W2083380905","https://openalex.org/W2090216135","https://openalex.org/W2098684046","https://openalex.org/W2106723663","https://openalex.org/W2109689528","https://openalex.org/W2114005632","https://openalex.org/W2116508133","https://openalex.org/W2121058401","https://openalex.org/W2129781700","https://openalex.org/W2132851603","https://openalex.org/W2134603265","https://openalex.org/W2140409748","https://openalex.org/W2141023706","https://openalex.org/W2154654760","https://openalex.org/W2157769714","https://openalex.org/W2160272971","https://openalex.org/W2318605753","https://openalex.org/W4256331572"],"related_works":["https://openalex.org/W2319160127","https://openalex.org/W2754738768","https://openalex.org/W7097519935","https://openalex.org/W2197053323","https://openalex.org/W2409690073","https://openalex.org/W2016146782","https://openalex.org/W7071442084","https://openalex.org/W2053268382","https://openalex.org/W4388087099","https://openalex.org/W2170479207"],"abstract_inverted_index":{"BACKGROUND:":[0],"Few":[1],"treatment":[2,213],"options":[3],"exist":[4],"for":[5,61],"patients":[6],"with":[7,29,40,133,191],"metastatic":[8],"melanoma,":[9],"resulting":[10,140],"in":[11,141,149,194,201,206,233,240,247,272,284,287],"poor":[12],"prognosis.":[13],"One":[14],"standard":[15],"treatment,":[16],"dacarbazine":[17],"(DTIC),":[18],"shows":[19],"low":[20],"response":[21],"rates":[22],"ranging":[23],"from":[24,81],"15":[25],"to":[26,103,116,128,182,208,263],"25":[27],"percent":[28],"an":[30],"8-month":[31],"median":[32,217],"survival":[33,200,218],"time.":[34],"The":[35],"development":[36],"of":[37,43,73,86,119,137,144,156,188,257,266,275],"targeted":[38],"therapeutics":[39],"novel":[41,267],"mechanisms":[42],"action":[44],"may":[45],"improve":[46],"patient":[47],"outcome.":[48],"Ribosome-inactivating":[49],"proteins":[50],"(RIPs)":[51],"such":[52,150],"as":[53,180],"Shiga-like":[54],"Toxin":[55],"1":[56],"(SLT-1)":[57],"represent":[58],"powerful":[59],"scaffolds":[60],"developing":[62],"selective":[63],"anticancer":[64],"agents.":[65],"Here":[66],"we":[67],"report":[68],"the":[69,82,90,100,142,177,186,255,264,273],"discovery":[70,265],"and":[71,106,147,153,197,221,235,271,286],"properties":[72],"a":[74,134,166,258],"single":[75],"chain":[76],"ribosome-inactivating":[77],"protein":[78,145],"(scRIP)":[79],"derived":[80],"cytotoxic":[83],"A":[84],"subunit":[85],"SLT-1":[87],"(SLT-1A),":[88],"harboring":[89],"7-amino":[91],"acid":[92],"peptide":[93],"insertion":[94],"IYSNKLM":[95,113,159,190,212,230,277],"(termed":[96],"SLT-1A":[97,112,158,189,211,229,276],"IYSNKLM)":[98],"allowing":[99],"toxin":[101],"variant":[102],"selectively":[104],"target":[105],"kill":[107,117,280],"human":[108,121,130,167,281],"melanoma":[109,122,131,168,282],"cells.":[110,151],"RESULTS:":[111],"was":[114],"able":[115],"7":[118],"8":[120],"cell":[123],"lines.":[124],"This":[125],"scRIP":[126,259],"binds":[127],"518-A2":[129],"cells":[132,283],"dissociation":[135],"constant":[136],"18":[138],"nM,":[139],"blockage":[143],"synthesis":[146],"apoptosis":[148],"Biodistribution":[152],"imaging":[154],"studies":[155],"radiolabeled":[157],"administered":[160],"intravenously":[161],"into":[162],"SCID":[163],"mice":[164],"bearing":[165],"xenograft":[169,204],"indicate":[170],"that":[171,254],"SLT-1AI":[172],"YSNKLM":[173],"readily":[174],"accumulates":[175],"at":[176],"tumor":[178,195],"site":[179],"opposed":[181],"non-target":[183],"tissues.":[184],"Furthermore,":[185],"co-administration":[187],"DTIC":[192,209],"resulted":[193,239],"regression":[196],"greatly":[198],"increased":[199],"this":[202],"mouse":[203],"model":[205],"comparison":[207],"or":[210],"alone":[214],"(115":[215],"day":[216],"versus":[219],"46":[220],"47":[222],"days":[223],"respectively;":[224],"P":[225],"values":[226],"<":[227],"0.001).":[228],"is":[231],"stable":[232],"serum":[234],"its":[236],"intravenous":[237],"administration":[238],"modest":[241],"immune":[242],"responses":[243],"following":[244],"repeated":[245],"injections":[246],"CD1":[248],"mice.":[249],"CONCLUSIONS:":[250],"These":[251],"results":[252],"demonstrate":[253],"evolution":[256],"template":[260],"can":[261,278],"lead":[262],"cancer":[268],"cell-targeted":[269],"compounds":[270],"case":[274],"specifically":[279],"vitro":[285],"vivo.":[288]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
