{"id":"https://openalex.org/W2139056458","doi":null,"title":"Interactions between glucocorticoid metabolism and inflammation in obesity and insulin resistance.","display_name":"Interactions between glucocorticoid metabolism and inflammation in obesity and insulin resistance.","publication_year":2011,"publication_date":"2011-07-05","ids":{"openalex":"https://openalex.org/W2139056458","mag":"2139056458"},"language":"en","primary_location":{"id":"pmh:oai:era.ed.ac.uk:1842/5593","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1842/5593","pdf_url":"http://hdl.handle.net/1842/5593","source":{"id":"https://openalex.org/S7407055182","display_name":"ERA","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1842/5593","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033187618","display_name":"Mark Nixon","orcid":"https://orcid.org/0000-0001-5437-3724","observed_orcids":["https://orcid.org/0000-0001-5437-3724"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mark Nixon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5437-3724","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033187618"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoid-metabolism","display_name":"glucocorticoid metabolism","score":0.9089999794960022},{"id":"https://openalex.org/keywords/11beta-hydroxysteroid-dehydrogenase-type-1","display_name":"11\u03b2-hydroxysteroid dehydrogenase type 1","score":0.9490000009536743},{"id":"https://openalex.org/keywords/5alpha-reductase-type-1","display_name":"5\u03b1-reductase type 1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6919999718666077},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.7599999904632568},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.7300000190734863},{"id":"https://openalex.org/keywords/salicylates","display_name":"salicylates","score":0.7020000219345093},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.640999972820282},{"id":"https://openalex.org/keywords/visceral-adipose-tissue","display_name":"visceral adipose tissue","score":0.703000009059906},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.8309999704360962},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8320746421813965},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.6921002268791199},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6257162094116211},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6139838099479675},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4421490728855133},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4234955310821533},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39296066761016846},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3508339524269104},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32991689443588257}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:era.ed.ac.uk:1842/5593","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1842/5593","pdf_url":"http://hdl.handle.net/1842/5593","source":{"id":"https://openalex.org/S7407055182","display_name":"ERA","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},{"id":"pmh:hdl:10068/999334","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/999334","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:2139056458","doi":null,"is_oa":false,"landing_page_url":"https://www.era.lib.ed.ac.uk/bitstream/handle/1842/5593/Nixon2011.pdf;sequence=2","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:era.ed.ac.uk:1842/5593","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1842/5593","pdf_url":"http://hdl.handle.net/1842/5593","source":{"id":"https://openalex.org/S7407055182","display_name":"ERA","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139056458.pdf","grobid_xml":"https://content.openalex.org/works/W2139056458.grobid-xml"},"referenced_works_count":272,"referenced_works":["https://openalex.org/W3952446","https://openalex.org/W76165172","https://openalex.org/W97158386","https://openalex.org/W1482831570","https://openalex.org/W1489635597","https://openalex.org/W1513790829","https://openalex.org/W1521173359","https://openalex.org/W1534360145","https://openalex.org/W1546304862","https://openalex.org/W1558393737","https://openalex.org/W1569578194","https://openalex.org/W1576975040","https://openalex.org/W1578893636","https://openalex.org/W1585751449","https://openalex.org/W1596357625","https://openalex.org/W1633895660","https://openalex.org/W1647312149","https://openalex.org/W1745264954","https://openalex.org/W1756428141","https://openalex.org/W1764140709","https://openalex.org/W1798196211","https://openalex.org/W1803730350","https://openalex.org/W1823480916","https://openalex.org/W1835200336","https://openalex.org/W1835342283","https://openalex.org/W1906626576","https://openalex.org/W1913377531","https://openalex.org/W1923917571","https://openalex.org/W1963545612","https://openalex.org/W1965284228","https://openalex.org/W1970381949","https://openalex.org/W1971473415","https://openalex.org/W1973416470","https://openalex.org/W1973619189","https://openalex.org/W1974033843","https://openalex.org/W1974092523","https://openalex.org/W1975045088","https://openalex.org/W1975801129","https://openalex.org/W1975898092","https://openalex.org/W1976844022","https://openalex.org/W1978262109","https://openalex.org/W1978690375","https://openalex.org/W1978718098","https://openalex.org/W1978996572","https://openalex.org/W1979181245","https://openalex.org/W1980675454","https://openalex.org/W1981261500","https://openalex.org/W1981318616","https://openalex.org/W1981399070","https://openalex.org/W1981586422","https://openalex.org/W1984180526","https://openalex.org/W1987093243","https://openalex.org/W1987212025","https://openalex.org/W1988297612","https://openalex.org/W1988507837","https://openalex.org/W1990051527","https://openalex.org/W1990586585","https://openalex.org/W1991401793","https://openalex.org/W1993418845","https://openalex.org/W1994651737","https://openalex.org/W1995377650","https://openalex.org/W1997103341","https://openalex.org/W1997510672","https://openalex.org/W1998086294","https://openalex.org/W1998238499","https://openalex.org/W2000054651","https://openalex.org/W2003578638","https://openalex.org/W2004391265","https://openalex.org/W2005508784","https://openalex.org/W2007078899","https://openalex.org/W2008494093","https://openalex.org/W2008869160","https://openalex.org/W2009971000","https://openalex.org/W2010237936","https://openalex.org/W2010911569","https://openalex.org/W2011210301","https://openalex.org/W2013895711","https://openalex.org/W2015141911","https://openalex.org/W2016125985","https://openalex.org/W2017547545","https://openalex.org/W2018053019","https://openalex.org/W2020961215","https://openalex.org/W2021943148","https://openalex.org/W2022065845","https://openalex.org/W2022207302","https://openalex.org/W2022505753","https://openalex.org/W2024682491","https://openalex.org/W2025202132","https://openalex.org/W2025383646","https://openalex.org/W2025976180","https://openalex.org/W2027749435","https://openalex.org/W2029778331","https://openalex.org/W2030097812","https://openalex.org/W2031084334","https://openalex.org/W2031637294","https://openalex.org/W2033474018","https://openalex.org/W2036130822","https://openalex.org/W2036303156","https://openalex.org/W2038018821","https://openalex.org/W2038099088","https://openalex.org/W2038665356","https://openalex.org/W2038725731","https://openalex.org/W2042443117","https://openalex.org/W2043106623","https://openalex.org/W2045389096","https://openalex.org/W2045534080","https://openalex.org/W2046188044","https://openalex.org/W2046387295","https://openalex.org/W2046444626","https://openalex.org/W2048921445","https://openalex.org/W2049403597","https://openalex.org/W2049905679","https://openalex.org/W2049965571","https://openalex.org/W2051051060","https://openalex.org/W2051734063","https://openalex.org/W2053125671","https://openalex.org/W2054415546","https://openalex.org/W2054714819","https://openalex.org/W2056430739","https://openalex.org/W2056879548","https://openalex.org/W2057702283","https://openalex.org/W2058294329","https://openalex.org/W2058387263","https://openalex.org/W2058409230","https://openalex.org/W2059652342","https://openalex.org/W2060630008","https://openalex.org/W2060862416","https://openalex.org/W2060990402","https://openalex.org/W2061331723","https://openalex.org/W2064626225","https://openalex.org/W2065746841","https://openalex.org/W2066069709","https://openalex.org/W2066225075","https://openalex.org/W2067359474","https://openalex.org/W2067870508","https://openalex.org/W2071882444","https://openalex.org/W2072546876","https://openalex.org/W2072973204","https://openalex.org/W2073983790","https://openalex.org/W2074545234","https://openalex.org/W2074696400","https://openalex.org/W2074809456","https://openalex.org/W2076153232","https://openalex.org/W2076179697","https://openalex.org/W2076310317","https://openalex.org/W2076366151","https://openalex.org/W2077405556","https://openalex.org/W2078156067","https://openalex.org/W2079067885","https://openalex.org/W2079548019","https://openalex.org/W2084253425","https://openalex.org/W2084542824","https://openalex.org/W2085217115","https://openalex.org/W2085634170","https://openalex.org/W2085944780","https://openalex.org/W2086635975","https://openalex.org/W2087433514","https://openalex.org/W2087588579","https://openalex.org/W2088431330","https://openalex.org/W2089354656","https://openalex.org/W2090056328","https://openalex.org/W2092020543","https://openalex.org/W2092404686","https://openalex.org/W2092463003","https://openalex.org/W2092900546","https://openalex.org/W2093083083","https://openalex.org/W2093165805","https://openalex.org/W2094498915","https://openalex.org/W2094628847","https://openalex.org/W2094863064","https://openalex.org/W2095060581","https://openalex.org/W2096774529","https://openalex.org/W2097775881","https://openalex.org/W2097794068","https://openalex.org/W2097838137","https://openalex.org/W2098217678","https://openalex.org/W2099324598","https://openalex.org/W2100196548","https://openalex.org/W2101273148","https://openalex.org/W2101328621","https://openalex.org/W2102133185","https://openalex.org/W2102170193","https://openalex.org/W2102177965","https://openalex.org/W2102683312","https://openalex.org/W2103521664","https://openalex.org/W2104181407","https://openalex.org/W2105412616","https://openalex.org/W2106471110","https://openalex.org/W2107550410","https://openalex.org/W2107732097","https://openalex.org/W2109018676","https://openalex.org/W2109918049","https://openalex.org/W2110114520","https://openalex.org/W2111262533","https://openalex.org/W2111305451","https://openalex.org/W2112004869","https://openalex.org/W2113184924","https://openalex.org/W2113745992","https://openalex.org/W2114269326","https://openalex.org/W2114328961","https://openalex.org/W2115274616","https://openalex.org/W2117268230","https://openalex.org/W2118020419","https://openalex.org/W2119251936","https://openalex.org/W2119519672","https://openalex.org/W2119963782","https://openalex.org/W2120071870","https://openalex.org/W2121082844","https://openalex.org/W2123662065","https://openalex.org/W2126618865","https://openalex.org/W2127187614","https://openalex.org/W2127808488","https://openalex.org/W2129316761","https://openalex.org/W2131059659","https://openalex.org/W2134055375","https://openalex.org/W2134133526","https://openalex.org/W2135268524","https://openalex.org/W2136024338","https://openalex.org/W2137408083","https://openalex.org/W2138673784","https://openalex.org/W2139666950","https://openalex.org/W2139833921","https://openalex.org/W2140298451","https://openalex.org/W2140471892","https://openalex.org/W2141189887","https://openalex.org/W2141277427","https://openalex.org/W2141463840","https://openalex.org/W2141472493","https://openalex.org/W2141956031","https://openalex.org/W2143092625","https://openalex.org/W2143199040","https://openalex.org/W2144032315","https://openalex.org/W2145248244","https://openalex.org/W2145855378","https://openalex.org/W2145906341","https://openalex.org/W2148022513","https://openalex.org/W2149858760","https://openalex.org/W2150252938","https://openalex.org/W2150304467","https://openalex.org/W2150925908","https://openalex.org/W2151672809","https://openalex.org/W2152199891","https://openalex.org/W2153747896","https://openalex.org/W2153965794","https://openalex.org/W2154442601","https://openalex.org/W2154753838","https://openalex.org/W2154972651","https://openalex.org/W2155506878","https://openalex.org/W2156597872","https://openalex.org/W2157456005","https://openalex.org/W2157906581","https://openalex.org/W2158050028","https://openalex.org/W2158852128","https://openalex.org/W2159379486","https://openalex.org/W2159798354","https://openalex.org/W2159865859","https://openalex.org/W2160112616","https://openalex.org/W2161961353","https://openalex.org/W2161966681","https://openalex.org/W2165085430","https://openalex.org/W2165202791","https://openalex.org/W2165787609","https://openalex.org/W2165792408","https://openalex.org/W2167940070","https://openalex.org/W2171151613","https://openalex.org/W2191143683","https://openalex.org/W2288839881","https://openalex.org/W2322243000","https://openalex.org/W2792659630","https://openalex.org/W2999510508","https://openalex.org/W3144570277","https://openalex.org/W3148892838"],"related_works":["https://openalex.org/W2006108107","https://openalex.org/W2091817461","https://openalex.org/W2065831905","https://openalex.org/W1973619189","https://openalex.org/W7099216001","https://openalex.org/W2036586168","https://openalex.org/W2145230775","https://openalex.org/W2165019512","https://openalex.org/W647503899","https://openalex.org/W2086309596"],"abstract_inverted_index":{"Inflammation":[0],"plays":[1],"a":[2,239,255,312,377,435,466,492],"key":[3],"role":[4,184,257],"in":[5,22,36,100,109,149,155,160,187,194,196,217,232,261,281,284,423,438,462],"the":[6,43,62,67,117,124,128,150,175,179,188,200,245,263,273,407,429,451,456,471,478,482],"underlying":[7],"pathogenesis":[8],"of":[9,19,33,42,55,64,71,106,127,140,178,185,190,249,267,276,328,349,354,382,388,396,411,444,460,475],"obesity":[10,463],"and":[11,25,51,69,169,214,230,283,298,306,323,341,371],"its":[12,133],"associated":[13],"health":[14],"risks,":[15],"with":[16,38,199,360],"increased":[17,39,52,104,138,386],"markers":[18,96],"inflammation":[20,148,162,186,422],"evident":[21],"both":[23,290,321],"liver":[24,180],"adipose":[26,40,164,219,233],"tissue.":[27],"In":[28,89,206,286,398],"parallel,":[29],"there":[30,79],"is":[31,80],"dysregulation":[32,75],"glucocorticoid":[34,73,118,165,172,292,402,416,488,498],"metabolism":[35,74,166,173,417],"obesity,":[37,161],"levels":[41,54,459],"glucocorticoid-regenerating":[44],"enzyme":[45,108,433],"11\u03b2-hydroxysteroid":[46],"dehydrogenase":[47],"type":[48,57],"1":[49,58],"(11\u03b2HSD1)":[50],"hepatic":[53,141,171,458],"5\u03b1-reductase":[56,461],"(5\u03b1R1),":[59],"which":[60],"catalyses":[61],"reduction":[63],"glucocorticoids.":[65],"Both":[66],"mechanisms":[68,271],"consequences":[70],"this":[72,107,156,432],"remain":[76],"unclear,":[77],"however,":[78],"evidence":[81],"that":[82,94,116,137,159,170,364,381,414,431,455],"it":[83],"may":[84,143,418,464,490],"be":[85,465],"related":[86],"to":[87,145,244,311,319,376,380,450,469],"inflammation.":[88],"vitro":[90,282],"studies":[91],"have":[92,446],"demonstrated":[93,115],"pro-inflammatory":[95,390],"upregulate":[97],"11\u03b2HSD1":[98,191,212,259,405],"expression":[99,105,139,213,348],"adipocytes,":[101],"potentially":[102],"explaining":[103],"obesity.":[110,424],"Previous":[111],"work":[112],"has":[113],"also":[114],"metabolites":[119,293,443,489],"produced":[120],"by":[121,404],"5\u03b1R1":[122,142],"lack":[123],"metabolic":[125,440,473],"effects":[126,248,395,410,474],"parent":[129,452],"glucocorticoid,":[130,453],"but":[131,480],"retain":[132],"anti-inflammatory":[134,201,268,274,448,484],"properties,":[135],"indicating":[136,393,454],"serve":[144],"dampen":[146],"down":[147],"liver.":[151],"The":[152,183,270],"hypotheses":[153],"addressed":[154],"thesis":[157],"are":[158],"regulates":[163,174],"through":[167,181],"11\u03b2HSD1,":[168],"inflammatory":[176,330,502],"state":[177],"5\u03b1R1.":[182],"regulation":[189],"was":[192],"assessed":[193],"vivo":[195],"mice":[197,237],"treated":[198],"compound":[202],"sodium":[203],"salicylate":[204,210,250],"(salicylate).":[205],"diet-induced":[207],"obese":[208],"mice,":[209],"downregulated":[211],"activity":[215],"selectively":[216],"visceral":[218],"tissue,":[220],"alongside":[221],"improved":[222],"glucose":[223],"tolerance,":[224],"reduced":[225,400],"plasma":[226],"non-esterified":[227],"fatty":[228],"acids,":[229],"changes":[231],"lipid":[234],"metabolism.":[235],"11\u03b2HSD1-deficient":[236],"fed":[238],"high-fat":[240],"diet":[241],"were":[242,279],"resistant":[243],"insulin":[246,264,408],"sensitising":[247,265,409],"treatment.":[251,269],"These":[252,486],"results":[253],"indicate":[254],"novel":[256],"for":[258,501],"down-regulation":[260],"mediating":[262],"effect":[266],"underpinning":[272],"properties":[275,449],"5\u03b1-reduced":[277,291,442,487],"glucocorticoids":[278,445,476],"explored":[280],"vivo.":[285],"lipopolysaccharide-stimulated":[287],"murine":[288],"macrophages,":[289],"tested,":[294],"namely":[295],"5\u03b1-dihydrocorticosterone":[296],"(5\u03b1DHB)":[297],"5\u03b1-tetrahydrocorticosterone":[299],"(5\u03b1THB),":[300],"suppressed":[301,326,366],"tumor":[302],"necrosis":[303],"factor-\u03b1":[304],"(TNF\u03b1)":[305],"interleukin-6":[307],"(IL-6)":[308],"release,":[309],"although":[310],"lesser":[313],"extent":[314,379],"than":[315],"corticosterone":[316],"(B).":[317],"Similar":[318],"B,":[320,383],"5\u03b1DHB":[322,365],"5\u03b1":[324],"THB":[325],"phosphorylation":[327],"intra-cellular":[329],"signalling":[331],"mitogen-activated":[332],"protein":[333,347],"kinases":[334],"(MAPK)":[335],"proteins":[336],"c-Jun":[337],"N-terminal":[338],"kinase":[339],"(JNK)":[340],"p38,":[342],"as":[343,345,496],"well":[344],"increasing":[346],"MAPK":[350],"phosphatase-1":[351],"(MKP-1).":[352],"Treatment":[353],"phorbol":[355],"ester-stimulated":[356],"HEK293":[357],"kidney":[358],"cells":[359],"these":[361,389,426],"5\u03b1-metabolites":[362],"revealed":[363],"nuclear":[367],"factor":[368],"\u03baB":[369],"(NF\u03baB)":[370],"activator":[372],"protein-1":[373],"(AP-1)":[374],"activation":[375,387],"similar":[378,447],"whilst":[384],"5\u03b1THB":[385],"transcription":[391],"factors,":[392],"cell-specific":[394],"5\u03b1THB.":[397],"conclusion,":[399],"intra-adipose":[401,421],"regeneration":[403],"mediates":[406],"salicylate,":[412],"suggesting":[413],"altered":[415,420],"reflect":[419],"Furthermore,":[425],"data":[427],"support":[428],"concept":[430],"provides":[434],"therapeutic":[436,494],"target":[437],"obesity-related":[439],"disorders.":[441],"elevated":[457],"protective":[467],"mechanism":[468],"limit":[470],"adverse":[472],"upon":[477],"liver,":[479],"maintain":[481],"beneficial":[483],"properties.":[485],"provide":[491],"potential":[493],"treatment":[495],"selective":[497],"receptor":[499],"modulators":[500],"conditions.":[503]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}