{"id":"https://openalex.org/W2139050120","doi":"https://doi.org/10.1186/1129-2377-15-14","title":"Activation of CB2 receptors as a potential therapeutic target for migraine: evaluation in an animal model","display_name":"Activation of CB2 receptors as a potential therapeutic target for migraine: evaluation in an animal model","publication_year":2014,"publication_date":"2014-03-17","ids":{"openalex":"https://openalex.org/W2139050120","doi":"https://doi.org/10.1186/1129-2377-15-14","mag":"2139050120","pmid":"https://pubmed.ncbi.nlm.nih.gov/24636539","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3995520"},"language":"en","primary_location":{"id":"doi:10.1186/1129-2377-15-14","doi":"https://doi.org/10.1186/1129-2377-15-14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1129-2377-15-14","pdf_url":"https://thejournalofheadacheandpain.biomedcentral.com/counter/pdf/10.1186/1129-2377-15-14","source":{"id":"https://openalex.org/S143427143","display_name":"The Journal of Headache and Pain","issn_l":"1129-2369","issn":["1129-2369","1129-2377"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Headache and Pain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://thejournalofheadacheandpain.biomedcentral.com/counter/pdf/10.1186/1129-2377-15-14","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059884450","display_name":"Rosaria Greco","orcid":"https://orcid.org/0000-0001-6577-0629","observed_orcids":["https://orcid.org/0000-0001-6577-0629"]},"institutions":[{"id":"https://openalex.org/I4210095701","display_name":"Fondazione Istituto Neurologico Nazionale Casimiro Mondino","ror":"https://ror.org/009h0v784","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210095701","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosaria Greco","raw_affiliation_strings":["Laboratory of Neurophysiology of Integrative Autonomic Systems, Headache Science Centre, \u201cC. Mondino\u201d National Neurological Institute, 27100, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurophysiology of Integrative Autonomic Systems, Headache Science Centre, \u201cC. Mondino\u201d National Neurological Institute, 27100, Pavia, Italy","institution_ids":["https://openalex.org/I4210095701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053470889","display_name":"Antonina Stefania Mangione","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095701","display_name":"Fondazione Istituto Neurologico Nazionale Casimiro Mondino","ror":"https://ror.org/009h0v784","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210095701","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonina Stefania Mangione","raw_affiliation_strings":["Laboratory of Neurophysiology of Integrative Autonomic Systems, Headache Science Centre, \u201cC. Mondino\u201d National Neurological Institute, 27100, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurophysiology of Integrative Autonomic Systems, Headache Science Centre, \u201cC. Mondino\u201d National Neurological Institute, 27100, Pavia, Italy","institution_ids":["https://openalex.org/I4210095701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083338647","display_name":"Giorgio Sandrini","orcid":"https://orcid.org/0000-0001-6234-6777","observed_orcids":["https://orcid.org/0000-0001-6234-6777"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I4210095701","display_name":"Fondazione Istituto Neurologico Nazionale Casimiro Mondino","ror":"https://ror.org/009h0v784","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210095701","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Sandrini","raw_affiliation_strings":["Department of Brain and Behaviour, University of Pavia, 27100, Pavia, Italy","Laboratory of Neurophysiology of Integrative Autonomic Systems, Headache Science Centre, \u201cC. Mondino\u201d National Neurological Institute, 27100, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Brain and Behaviour, University of Pavia, 27100, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"Laboratory of Neurophysiology of Integrative Autonomic Systems, Headache Science Centre, \u201cC. Mondino\u201d National Neurological Institute, 27100, Pavia, Italy","institution_ids":["https://openalex.org/I4210095701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033117643","display_name":"Giuseppe Nappi","orcid":"https://orcid.org/0000-0003-4274-5281","observed_orcids":["https://orcid.org/0000-0003-4274-5281"]},"institutions":[{"id":"https://openalex.org/I4210095701","display_name":"Fondazione Istituto Neurologico Nazionale Casimiro Mondino","ror":"https://ror.org/009h0v784","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210095701","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Nappi","raw_affiliation_strings":["Laboratory of Neurophysiology of Integrative Autonomic Systems, Headache Science Centre, \u201cC. Mondino\u201d National Neurological Institute, 27100, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurophysiology of Integrative Autonomic Systems, Headache Science Centre, \u201cC. Mondino\u201d National Neurological Institute, 27100, Pavia, Italy","institution_ids":["https://openalex.org/I4210095701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053749762","display_name":"Cristina Tassorelli","orcid":"https://orcid.org/0000-0003-1513-2113","observed_orcids":["https://orcid.org/0000-0003-1513-2113"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I4210095701","display_name":"Fondazione Istituto Neurologico Nazionale Casimiro Mondino","ror":"https://ror.org/009h0v784","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210095701","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Cristina Tassorelli","raw_affiliation_strings":["Laboratory of Neurophysiology of Integrative Autonomic Systems, Headache Science Centre, \"C, Mondino\" National Neurological Institute, 27100 Pavia, Italy. cristina.tassorelli@mondino.it","Department of Brain and Behaviour, University of Pavia, 27100, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurophysiology of Integrative Autonomic Systems, Headache Science Centre, \"C, Mondino\" National Neurological Institute, 27100 Pavia, Italy. cristina.tassorelli@mondino.it","institution_ids":["https://openalex.org/I4210095701"]},{"raw_affiliation_string":"Department of Brain and Behaviour, University of Pavia, 27100, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5053749762"],"corresponding_institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210095701"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":{"value":3990,"currency":"USD","value_usd":3990},"fwci":4.6455,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.95290218,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"14","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.7954000234603882,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.7954000234603882,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.18400000035762787,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cb2-receptor","display_name":"CB2 receptor","score":0.8209999799728394},{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.9300000071525574},{"id":"https://openalex.org/keywords/endocannabinoid-system","display_name":"endocannabinoid system","score":0.9070000052452087},{"id":"https://openalex.org/keywords/am1241","display_name":"AM1241","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cannabinoid-receptor-agonists","display_name":"cannabinoid receptor agonists","score":0.7820000052452087},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tail-flick-test","display_name":"tail-flick test","score":0.7860000133514404},{"id":"https://openalex.org/keywords/formalin-test","display_name":"formalin test","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pain-perception","display_name":"pain perception","score":0.5289999842643738},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7897185683250427},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.7072558403015137},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.6736025810241699},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.6584829092025757},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6098028421401978},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.6077641248703003},{"id":"https://openalex.org/C93248783","wikidata":"https://www.wikidata.org/wiki/Q21150595","display_name":"Cannabinoid receptor type 2","level":5,"score":0.5689898133277893},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5491953492164612},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5301631093025208},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.508040189743042},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.4631212651729584},{"id":"https://openalex.org/C52396799","wikidata":"https://www.wikidata.org/wiki/Q7676069","display_name":"Tail flick test","level":4,"score":0.4101925194263458},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.38865020871162415},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30649706721305847},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002186","descriptor_name":"Cannabinoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043885","descriptor_name":"Receptor, Cannabinoid, CB2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043885","descriptor_name":"Receptor, Cannabinoid, CB2","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1129-2377-15-14","doi":"https://doi.org/10.1186/1129-2377-15-14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1129-2377-15-14","pdf_url":"https://thejournalofheadacheandpain.biomedcentral.com/counter/pdf/10.1186/1129-2377-15-14","source":{"id":"https://openalex.org/S143427143","display_name":"The Journal of Headache and Pain","issn_l":"1129-2369","issn":["1129-2369","1129-2377"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Headache and Pain","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2985982","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3995520","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3995520","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3995520","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Headache Pain","raw_type":"Text"},{"id":"pmid:24636539","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24636539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of headache and pain","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/1129-2377-15-14","doi":"https://doi.org/10.1186/1129-2377-15-14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1129-2377-15-14","pdf_url":"https://thejournalofheadacheandpain.biomedcentral.com/counter/pdf/10.1186/1129-2377-15-14","source":{"id":"https://openalex.org/S143427143","display_name":"The Journal of Headache and Pain","issn_l":"1129-2369","issn":["1129-2369","1129-2377"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Headache and Pain","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139050120.pdf","grobid_xml":"https://content.openalex.org/works/W2139050120.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W17520955","https://openalex.org/W46438429","https://openalex.org/W1542528083","https://openalex.org/W1578820780","https://openalex.org/W1593293708","https://openalex.org/W1594786713","https://openalex.org/W1907919347","https://openalex.org/W1963842138","https://openalex.org/W1967131555","https://openalex.org/W1974178115","https://openalex.org/W1974876331","https://openalex.org/W1980780117","https://openalex.org/W1989155012","https://openalex.org/W1994720073","https://openalex.org/W1998472195","https://openalex.org/W1998941878","https://openalex.org/W1998953911","https://openalex.org/W2006605504","https://openalex.org/W2009345240","https://openalex.org/W2009738204","https://openalex.org/W2011142394","https://openalex.org/W2018078088","https://openalex.org/W2020043315","https://openalex.org/W2021408853","https://openalex.org/W2023670383","https://openalex.org/W2024009202","https://openalex.org/W2029637645","https://openalex.org/W2033931579","https://openalex.org/W2036912145","https://openalex.org/W2040299229","https://openalex.org/W2048626163","https://openalex.org/W2049395687","https://openalex.org/W2053892531","https://openalex.org/W2054563583","https://openalex.org/W2055746391","https://openalex.org/W2056188558","https://openalex.org/W2058816780","https://openalex.org/W2060752724","https://openalex.org/W2065201875","https://openalex.org/W2070226133","https://openalex.org/W2070535004","https://openalex.org/W2072463279","https://openalex.org/W2076257628","https://openalex.org/W2084872420","https://openalex.org/W2087454739","https://openalex.org/W2088568499","https://openalex.org/W2089694370","https://openalex.org/W2093129801","https://openalex.org/W2093570206","https://openalex.org/W2098443650","https://openalex.org/W2106607972","https://openalex.org/W2112924959","https://openalex.org/W2121432742","https://openalex.org/W2124248227","https://openalex.org/W2144513536","https://openalex.org/W2144693103","https://openalex.org/W2149250228","https://openalex.org/W2150954514","https://openalex.org/W2165518874","https://openalex.org/W2165551982"],"related_works":["https://openalex.org/W2093129801","https://openalex.org/W2964104564","https://openalex.org/W1578820780","https://openalex.org/W7097157465","https://openalex.org/W2084872420","https://openalex.org/W3040739497","https://openalex.org/W2033931579","https://openalex.org/W2253641688","https://openalex.org/W2046550691","https://openalex.org/W1594786713"],"abstract_inverted_index":{"BACKGROUND:":[0],"Experimental":[1],"animal":[2,102],"models":[3,103],"of":[4,10,55,59,77,83,97,104,196,201,212,225],"migraine":[5],"have":[6],"suggested":[7],"the":[8,13,28,45,53,70,81,95,112,117,147,158,163,193,202,209,213,223],"existence":[9],"interactions":[11],"between":[12],"endocannabinoid":[14],"system":[15],"and":[16,116,144,162],"pain":[17,105],"mediation":[18],"in":[19,32,52,67,69,87,100,129,173,176],"migraine.":[20,226],"Extensive":[21],"evidence":[22],"has":[23],"demonstrated":[24],"a":[25,50,75,169,218],"role":[26,51,96],"for":[27,110,222],"cannabinoid-1":[29],"(CB1)":[30],"receptor":[31,215],"antinociception.":[33],"However,":[34],"recent":[35],"research":[36],"suggests":[37],"that":[38,106,208],"also":[39],"CB2":[40,98,148,214],"receptors,":[41],"especially":[42],"located":[43],"outside":[44],"central":[46],"nervous":[47],"system,":[48],"play":[49],"perception":[54],"pain.":[56],"Systemic":[57],"administration":[58],"nitroglycerin":[60],"(NTG)":[61],"consistently":[62],"induces":[63,74],"spontaneous-like":[64],"headache":[65],"attacks":[66],"migraneurs;":[68],"rat,":[71],"systemic":[72],"NTG":[73,135,185],"condition":[76],"hyperalgesia,":[78],"probably":[79],"through":[80],"activation":[82],"cerebral/spinal":[84],"structures":[85],"involved":[86],"nociceptive":[88],"transmission.":[89],"In":[90],"this":[91],"study":[92,126],"we":[93],"evaluated":[94],"receptors":[99],"two":[101],"may":[107,216],"be":[108],"relevant":[109],"migraine:":[111],"tail":[113,159],"flick":[114,160],"test":[115,119,161],"formalin":[118,164],"performed":[120,128],"during":[121,198],"NTG-induced":[122],"hyperalgesia.":[123],"METHODS:":[124],"The":[125],"was":[127],"male":[130],"Sprague-Dawley":[131],"rats":[132],"pre-treated":[133],"with":[134,146],"(10":[136],"mg/kg,":[137],"i.p.)":[138],"or":[139],"vehicle":[140],"(4":[141],"hours":[142,183],"before)":[143],"treated":[145],"agonist":[149],"AM1241":[150,167,187],"o":[151],"dimethylsulfoxide":[152],"(DMSO)":[153],"60":[154],"minutes":[155],"before":[156],"both":[157,177,189],"test.":[165,203],"RESULTS:":[166],"showed":[168],"significant":[170],"analgesic":[171],"effect":[172],"baseline":[174],"conditions":[175],"tests.":[178],"Furthermore,":[179],"when":[180],"administered":[181],"3":[182],"after":[184],"administration,":[186],"at":[188],"doses":[190],"significantly":[191],"reduced":[192],"total":[194],"number":[195],"flinches/shakes":[197],"phase":[199],"II":[200],"CONCLUSION:":[204],"These":[205],"findings":[206],"suggest":[207],"pharmacological":[210],"manipulation":[211],"represent":[217],"potential":[219],"therapeutic":[220],"tool":[221],"treatment":[224]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
