{"id":"https://openalex.org/W2139018389","doi":"https://doi.org/10.5455/jeim.060611.rw.003","title":"Epigenetic mechanisms in human physiology and diseases","display_name":"Epigenetic mechanisms in human physiology and diseases","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2139018389","doi":"https://doi.org/10.5455/jeim.060611.rw.003","mag":"2139018389"},"language":"en","primary_location":{"id":"doi:10.5455/jeim.060611.rw.003","doi":"https://doi.org/10.5455/jeim.060611.rw.003","is_oa":false,"landing_page_url":"https://doi.org/10.5455/jeim.060611.rw.003","pdf_url":null,"source":{"id":"https://openalex.org/S2764854715","display_name":"Journal of Experimental and Integrative Medicine","issn_l":"1309-4572","issn":["1309-4572","2146-3298"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental and Integrative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040718202","display_name":"Ahmet Korkmaz","orcid":"https://orcid.org/0000-0002-3886-5953","observed_orcids":["https://orcid.org/0000-0002-3886-5953"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahmet Korkmaz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111679007","display_name":"Lucien C. Manchester","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucien Manchester","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063229459","display_name":"Turgut Topal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Turgut Topal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108335411","display_name":"Shuran Ma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuran Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Dun Tan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dun Tan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063159500","display_name":"Russel Joseph Reiter","orcid":"https://orcid.org/0000-0001-6763-4225","observed_orcids":["https://orcid.org/0000-0001-6763-4225"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Russel Reiter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3883,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.60840996,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"1","issue":"3","first_page":"139","last_page":"139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.9779999852180481},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.9800000190734863},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.9980000257492065},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.8009999990463257},{"id":"https://openalex.org/keywords/human-physiology","display_name":"human physiology","score":0.6140000224113464},{"id":"https://openalex.org/keywords/human-disease","display_name":"human disease","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5507711172103882},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4848250150680542},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40609031915664673},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32539933919906616},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3212432861328125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2899605631828308},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0799151360988617},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5455/jeim.060611.rw.003","doi":"https://doi.org/10.5455/jeim.060611.rw.003","is_oa":false,"landing_page_url":"https://doi.org/10.5455/jeim.060611.rw.003","pdf_url":null,"source":{"id":"https://openalex.org/S2764854715","display_name":"Journal of Experimental and Integrative Medicine","issn_l":"1309-4572","issn":["1309-4572","2146-3298"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental and Integrative Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W1529905521","https://openalex.org/W1549705622","https://openalex.org/W1648301895","https://openalex.org/W1831033366","https://openalex.org/W1967222077","https://openalex.org/W1974277276","https://openalex.org/W1974387660","https://openalex.org/W1977200537","https://openalex.org/W1984151107","https://openalex.org/W1985444222","https://openalex.org/W1987489036","https://openalex.org/W1989288106","https://openalex.org/W1989573122","https://openalex.org/W1995049218","https://openalex.org/W2002698073","https://openalex.org/W2003363961","https://openalex.org/W2006290358","https://openalex.org/W2008953417","https://openalex.org/W2011880080","https://openalex.org/W2012508649","https://openalex.org/W2013186220","https://openalex.org/W2013195055","https://openalex.org/W2019129277","https://openalex.org/W2020951058","https://openalex.org/W2021527895","https://openalex.org/W2024277839","https://openalex.org/W2024504116","https://openalex.org/W2026383040","https://openalex.org/W2027650876","https://openalex.org/W2030047242","https://openalex.org/W2032733245","https://openalex.org/W2040149948","https://openalex.org/W2044303805","https://openalex.org/W2046241907","https://openalex.org/W2046398111","https://openalex.org/W2050150552","https://openalex.org/W2050159754","https://openalex.org/W2054020882","https://openalex.org/W2056147363","https://openalex.org/W2062262581","https://openalex.org/W2065583248","https://openalex.org/W2066636897","https://openalex.org/W2068078666","https://openalex.org/W2070541344","https://openalex.org/W2075329854","https://openalex.org/W2077861623","https://openalex.org/W2083605403","https://openalex.org/W2085592081","https://openalex.org/W2093419517","https://openalex.org/W2095231192","https://openalex.org/W2098103685","https://openalex.org/W2099952513","https://openalex.org/W2100827807","https://openalex.org/W2101182085","https://openalex.org/W2102161750","https://openalex.org/W2105004481","https://openalex.org/W2110666579","https://openalex.org/W2112856354","https://openalex.org/W2113008059","https://openalex.org/W2117996813","https://openalex.org/W2118540634","https://openalex.org/W2119259865","https://openalex.org/W2128676090","https://openalex.org/W2139118960","https://openalex.org/W2141991853","https://openalex.org/W2142352901","https://openalex.org/W2143658931","https://openalex.org/W2144851362","https://openalex.org/W2145021085","https://openalex.org/W2145247262","https://openalex.org/W2145484725","https://openalex.org/W2145571228","https://openalex.org/W2148660548","https://openalex.org/W2149099455","https://openalex.org/W2149291473","https://openalex.org/W2149386327","https://openalex.org/W2152155904","https://openalex.org/W2156443907","https://openalex.org/W2157830796","https://openalex.org/W2159164310","https://openalex.org/W2159630189","https://openalex.org/W2170493345","https://openalex.org/W2409321758","https://openalex.org/W2486820350","https://openalex.org/W4251934001","https://openalex.org/W4322702681"],"related_works":["https://openalex.org/W7091611298","https://openalex.org/W4389212324","https://openalex.org/W4409315293","https://openalex.org/W4286563968","https://openalex.org/W3166373905","https://openalex.org/W7220074740","https://openalex.org/W6967072605","https://openalex.org/W2149576129","https://openalex.org/W2554317521","https://openalex.org/W2029094731"],"abstract_inverted_index":{"Although":[0],"the":[1,11,29,33,46,84,92,108,119,126],"sequence":[2],"of":[3,10,86,104,110],"human":[4,40,69],"genome":[5,47],"is":[6,19,37],"known,":[7],"our":[8],"understanding":[9],"complicated":[12],"network":[13],"that":[14,116,122],"takes":[15],"place":[16],"inside":[17],"cells":[18],"far":[20],"from":[21],"complete.":[22],"Many":[23],"questions":[24,97],"still":[25],"remain":[26],"unanswered":[27],"with":[28],"regard":[30],"to":[31,49,95],"how":[32,44],"complex":[34],"genomic":[35],"information":[36],"used":[38],"by":[39,149],"cells.":[41],"For":[42],"example,":[43],"does":[45],"work":[48],"orchestrate":[50],"changes":[51],"in":[52,63,67,78,101,118,135],"gene":[53,162],"expression":[54],"during":[55],"development":[56],"and":[57,147,158],"differentiation?":[58],"Are":[59],"all":[60,68],"genes":[61,73],"expressed":[62],"every":[64],"cell":[65],"type":[66],"tissues?":[70],"How":[71],"many":[72,93],"are":[74,83,114,138],"coding":[75],"or":[76],"non-coding":[77,87,150],"a":[79,102],"particular":[80],"cell?":[81],"What":[82],"functions":[85],"genes?":[88],"It":[89],"seems":[90],"clear":[91],"answers":[94],"these":[96],"will":[98],"be":[99],"found":[100],"field":[103],"growing":[105],"interest,":[106],"i.e.":[107],"study":[109],"epigenetics.":[111],"\r\nEpigenetic":[112],"mechanisms":[113,157],"modifications":[115,134],"occur":[117],"genetic":[120],"material":[121],"do":[123],"not":[124],"change":[125],"nucleotide":[127],"sequence,":[128],"but":[129],"instead":[130],"may":[131],"cause":[132],"conformational":[133],"DNA.":[136],"There":[137],"basically":[139],"three":[140],"epigenetic":[141,155],"modifications;":[142],"DNA":[143],"methylation,":[144],"histone":[145],"modification":[146],"regulation":[148],"RNA.":[151],"This":[152],"paper":[153],"summarizes":[154],"regulatory":[156],"their":[159],"effects":[160],"on":[161],"transcription.":[163]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
