{"id":"https://openalex.org/W2139017777","doi":"https://doi.org/10.1126/scisignal.2002979","title":"Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock","display_name":"Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock","publication_year":2012,"publication_date":"2012-05-29","ids":{"openalex":"https://openalex.org/W2139017777","doi":"https://doi.org/10.1126/scisignal.2002979","mag":"2139017777","pmid":"https://pubmed.ncbi.nlm.nih.gov/22649097"},"language":"en","primary_location":{"id":"doi:10.1126/scisignal.2002979","doi":"https://doi.org/10.1126/scisignal.2002979","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scisignal.2002979","pdf_url":null,"source":{"id":"https://openalex.org/S155937366","display_name":"Science Signaling","issn_l":"1937-9145","issn":["1937-9145","1945-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Signaling","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047305204","display_name":"Chao Xu","orcid":"https://orcid.org/0000-0003-0444-7080","observed_orcids":["https://orcid.org/0000-0003-0444-7080"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2803004491","display_name":"Structural Genomics Consortium","ror":"https://ror.org/04jzps455","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I2803004491"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Chao Xu","raw_affiliation_strings":["Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2803004491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100449370","display_name":"Jing Jin","orcid":"https://orcid.org/0000-0001-7023-5305","observed_orcids":["https://orcid.org/0000-0001-7023-5305"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Jing Jin","raw_affiliation_strings":["Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102250336","display_name":"Chuanbing Bian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2803004491","display_name":"Structural Genomics Consortium","ror":"https://ror.org/04jzps455","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I2803004491"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Chuanbing Bian","raw_affiliation_strings":["Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2803004491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102943179","display_name":"Robert Lam","orcid":"https://orcid.org/0000-0002-9658-9299","observed_orcids":["https://orcid.org/0000-0002-9658-9299"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2803004491","display_name":"Structural Genomics Consortium","ror":"https://ror.org/04jzps455","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I2803004491"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Robert Lam","raw_affiliation_strings":["Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2803004491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069877503","display_name":"Ruijun Tian","orcid":"https://orcid.org/0000-0001-9521-5124","observed_orcids":["https://orcid.org/0000-0001-9521-5124"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ruijun Tian","raw_affiliation_strings":["Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041982408","display_name":"Ryan Weist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405260784","display_name":"Institut du cancer Rosalind & Morris Goodman","ror":"https://ror.org/0494tzz73","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405260784","https://openalex.org/I5023651"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ryan Weist","raw_affiliation_strings":["Department of Medicine, McGill University Health Center, Montr\u00e9al, Qu\u00e9bec H3A 1A3, Canada","Rosalind and Morris Goodman Cancer Research Center and Department of Biochemistry, McGill University, Montr\u00e9al, Qu\u00e9bec H3A 1A3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, McGill University Health Center, Montr\u00e9al, Qu\u00e9bec H3A 1A3, Canada","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Rosalind and Morris Goodman Cancer Research Center and Department of Biochemistry, McGill University, Montr\u00e9al, Qu\u00e9bec H3A 1A3, Canada","institution_ids":["https://openalex.org/I4405260784","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044692352","display_name":"Linya You","orcid":"https://orcid.org/0000-0002-2569-0269","observed_orcids":["https://orcid.org/0000-0002-2569-0269"]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405260784","display_name":"Institut du cancer Rosalind & Morris Goodman","ror":"https://ror.org/0494tzz73","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405260784","https://openalex.org/I5023651"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Linya You","raw_affiliation_strings":["Department of Medicine, McGill University Health Center, Montr\u00e9al, Qu\u00e9bec H3A 1A3, Canada","Rosalind and Morris Goodman Cancer Research Center and Department of Biochemistry, McGill University, Montr\u00e9al, Qu\u00e9bec H3A 1A3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, McGill University Health Center, Montr\u00e9al, Qu\u00e9bec H3A 1A3, Canada","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Rosalind and Morris Goodman Cancer Research Center and Department of Biochemistry, McGill University, Montr\u00e9al, Qu\u00e9bec H3A 1A3, Canada","institution_ids":["https://openalex.org/I4405260784","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jianyun Nie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]},{"id":"https://openalex.org/I4405260784","display_name":"Institut du cancer Rosalind & Morris Goodman","ror":"https://ror.org/0494tzz73","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405260784","https://openalex.org/I5023651"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA","CN"],"is_corresponding":false,"raw_author_name":"Jianyun Nie","raw_affiliation_strings":["Rosalind and Morris Goodman Cancer Research Center and Department of Biochemistry, McGill University, Montr\u00e9al, Qu\u00e9bec H3A 1A3, Canada","The Third Affiliated Hospital, Kunming Medical College, Yunnan 650031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosalind and Morris Goodman Cancer Research Center and Department of Biochemistry, McGill University, Montr\u00e9al, Qu\u00e9bec H3A 1A3, Canada","institution_ids":["https://openalex.org/I4405260784","https://openalex.org/I5023651"]},{"raw_affiliation_string":"The Third Affiliated Hospital, Kunming Medical College, Yunnan 650031, China","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103428526","display_name":"Alexey V. Bochkarev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2803004491","display_name":"Structural Genomics Consortium","ror":"https://ror.org/04jzps455","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I2803004491"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alexey Bochkarev","raw_affiliation_strings":["Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2803004491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074238831","display_name":"W. Tempel","orcid":"https://orcid.org/0000-0003-3680-0678","observed_orcids":["https://orcid.org/0000-0003-3680-0678"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2803004491","display_name":"Structural Genomics Consortium","ror":"https://ror.org/04jzps455","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I2803004491"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Wolfram Tempel","raw_affiliation_strings":["Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2803004491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051693291","display_name":"Chris Soon Heng Tan","orcid":"https://orcid.org/0000-0002-8172-5235","observed_orcids":["https://orcid.org/0000-0002-8172-5235","https://orcid.org/0000-0003-2929-8966"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Chris S. Tan","raw_affiliation_strings":["Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009882486","display_name":"Gregory A. Wasney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2803004491","display_name":"Structural Genomics Consortium","ror":"https://ror.org/04jzps455","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I2803004491"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gregory A. Wasney","raw_affiliation_strings":["Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2803004491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035700215","display_name":"Masoud Vedadi","orcid":"https://orcid.org/0000-0002-0574-0169","observed_orcids":["https://orcid.org/0000-0002-0574-0169"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2803004491","display_name":"Structural Genomics Consortium","ror":"https://ror.org/04jzps455","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I2803004491"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Masoud Vedadi","raw_affiliation_strings":["Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2803004491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089044952","display_name":"Gerald\u00a0D. Gish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gerald D. Gish","raw_affiliation_strings":["Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012117525","display_name":"C.H. Arrowsmith","orcid":"https://orcid.org/0000-0002-4971-3250","observed_orcids":["https://orcid.org/0000-0002-4971-3250"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2803004491","display_name":"Structural Genomics Consortium","ror":"https://ror.org/04jzps455","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I2803004491"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Cheryl H. Arrowsmith","raw_affiliation_strings":["Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada","Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2803004491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109102479","display_name":"Tony J. Pawson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tony Pawson","raw_affiliation_strings":["Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada","Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046514658","display_name":"Xiang\u2010Jiao Yang","orcid":"https://orcid.org/0000-0003-0598-120X","observed_orcids":["https://orcid.org/0000-0003-0598-120X"]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405260784","display_name":"Institut du cancer Rosalind & Morris Goodman","ror":"https://ror.org/0494tzz73","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405260784","https://openalex.org/I5023651"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Xiang-Jiao Yang","raw_affiliation_strings":["Department of Medicine, McGill University Health Center, Montr\u00e9al, Qu\u00e9bec H3A 1A3, Canada","Rosalind and Morris Goodman Cancer Research Center and Department of Biochemistry, McGill University, Montr\u00e9al, Qu\u00e9bec H3A 1A3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, McGill University Health Center, Montr\u00e9al, Qu\u00e9bec H3A 1A3, Canada","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Rosalind and Morris Goodman Cancer Research Center and Department of Biochemistry, McGill University, Montr\u00e9al, Qu\u00e9bec H3A 1A3, Canada","institution_ids":["https://openalex.org/I4405260784","https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017127830","display_name":"Jinrong Min","orcid":"https://orcid.org/0000-0001-5210-3130","observed_orcids":["https://orcid.org/0000-0001-5210-3130"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2803004491","display_name":"Structural Genomics Consortium","ror":"https://ror.org/04jzps455","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I2803004491"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Jinrong Min","raw_affiliation_strings":["Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2803004491"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5017127830","https://openalex.org/A5047305204","https://openalex.org/A5100449370","https://openalex.org/A5102943179"],"corresponding_institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I185261750","https://openalex.org/I210557978","https://openalex.org/I2803004491"],"apc_list":null,"apc_paid":null,"fwci":1.2599,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.78107339,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"5","issue":"226","first_page":"ra39","last_page":"ra39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.4672999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.4672999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.3043999969959259,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13526","display_name":"14-3-3 protein interactions","score":0.11460000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ankyrin-repeat-domain","display_name":"ankyrin repeat domain","score":0.8740000128746033},{"id":"https://openalex.org/keywords/rfxank","display_name":"RFXANK","score":0.8519999980926514},{"id":"https://openalex.org/keywords/hdac4","display_name":"HDAC4","score":0.7400000095367432},{"id":"https://openalex.org/keywords/hdac5","display_name":"HDAC5","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hdac9","display_name":"HDAC9","score":0.9350000023841858},{"id":"https://openalex.org/keywords/megalin","display_name":"megalin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/rfx5","display_name":"RFX5","score":0.9769999980926514},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.6269999742507935},{"id":"https://openalex.org/keywords/phosphorylation-dependent-binding","display_name":"phosphorylation-dependent binding","score":0.7310000061988831},{"id":"https://openalex.org/keywords/14-3-3-proteins","display_name":"14-3-3 proteins","score":0.9700000286102295},{"id":"https://openalex.org/keywords/pathogenic-variants","display_name":"pathogenic variants","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C32276052","wikidata":"https://www.wikidata.org/wiki/Q908349","display_name":"Motif (music)","level":2,"score":0.8018596172332764},{"id":"https://openalex.org/C113241181","wikidata":"https://www.wikidata.org/wiki/Q24784174","display_name":"Ankyrin repeat","level":3,"score":0.7791879177093506},{"id":"https://openalex.org/C182800266","wikidata":"https://www.wikidata.org/wiki/Q414971","display_name":"Ankyrin","level":3,"score":0.6393992900848389},{"id":"https://openalex.org/C117745874","wikidata":"https://www.wikidata.org/wiki/Q901612","display_name":"Sequence motif","level":3,"score":0.47537198662757874},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.43206876516342163},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3939163088798523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3897762894630432},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3753099739551544},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3410780131816864},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29942959547042847},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2632800042629242},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16058290004730225},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.1345495581626892},{"id":"https://openalex.org/C107038049","wikidata":"https://www.wikidata.org/wiki/Q35986","display_name":"Aesthetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071701","descriptor_name":"Regulatory Factor X Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017089","descriptor_name":"Ankyrin Repeat","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017487","descriptor_name":"Ankyrins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017487","descriptor_name":"Ankyrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017487","descriptor_name":"Ankyrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D048948","descriptor_name":"14-3-3 Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048948","descriptor_name":"14-3-3 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048948","descriptor_name":"14-3-3 Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/scisignal.2002979","doi":"https://doi.org/10.1126/scisignal.2002979","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scisignal.2002979","pdf_url":null,"source":{"id":"https://openalex.org/S155937366","display_name":"Science Signaling","issn_l":"1937-9145","issn":["1937-9145","1945-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Signaling","raw_type":"journal-article"},{"id":"pmid:22649097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22649097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science signaling","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1525531613","https://openalex.org/W1600029913","https://openalex.org/W1886386345","https://openalex.org/W1900565974","https://openalex.org/W1920211008","https://openalex.org/W1970083434","https://openalex.org/W1971727526","https://openalex.org/W1976728998","https://openalex.org/W1978719931","https://openalex.org/W1991443411","https://openalex.org/W1995972219","https://openalex.org/W1998173729","https://openalex.org/W2002507728","https://openalex.org/W2004333515","https://openalex.org/W2014885180","https://openalex.org/W2028004837","https://openalex.org/W2028691831","https://openalex.org/W2032384795","https://openalex.org/W2034391603","https://openalex.org/W2037374227","https://openalex.org/W2047918322","https://openalex.org/W2049118388","https://openalex.org/W2056455937","https://openalex.org/W2057805290","https://openalex.org/W2063284451","https://openalex.org/W2064767087","https://openalex.org/W2065155413","https://openalex.org/W2072387160","https://openalex.org/W2076547904","https://openalex.org/W2077895194","https://openalex.org/W2080577208","https://openalex.org/W2083582836","https://openalex.org/W2089623038","https://openalex.org/W2089847155","https://openalex.org/W2090701628","https://openalex.org/W2091709805","https://openalex.org/W2099405868","https://openalex.org/W2108116956","https://openalex.org/W2114618946","https://openalex.org/W2121652706","https://openalex.org/W2122995034","https://openalex.org/W2133446638","https://openalex.org/W2139044529","https://openalex.org/W2142194813","https://openalex.org/W2150271494","https://openalex.org/W2151833757","https://openalex.org/W2154572495","https://openalex.org/W2158133029","https://openalex.org/W2162404348","https://openalex.org/W2162480928","https://openalex.org/W2168448928","https://openalex.org/W2169359398","https://openalex.org/W2171072225","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2100156364","https://openalex.org/W2996614702","https://openalex.org/W1995972219","https://openalex.org/W2081489336","https://openalex.org/W2065155413","https://openalex.org/W1991443411","https://openalex.org/W2127143932","https://openalex.org/W2153724411","https://openalex.org/W1526649778","https://openalex.org/W1516730417"],"abstract_inverted_index":{"Ankyrin":[0],"repeat":[1,28,67],"family":[2],"A":[3],"protein":[4,40,227],"2":[5],"(ANKRA2)":[6],"interacts":[7],"with":[8,73,100],"the":[9,15,26,65,81,92,104,107,113,159,165,185,188,192],"plasma":[10],"membrane":[11],"receptor":[12],"megalin":[13],"and":[14,21,32,56,106,219],"class":[16],"IIa":[17],"histone":[18],"deacetylases":[19],"HDAC4":[20],"HDAC5.":[22],"We":[23],"report":[24],"that":[25,78,118,126,201],"ankyrin":[27,66,84],"domains":[29],"of":[30,64,69,80,86,139,142,152,162,167,191],"ANKRA2":[31,70,87,101,168],"its":[33,74],"close":[34],"paralog":[35],"regulatory":[36,57],"factor":[37,58],"X-associated":[38],"ankyrin-containing":[39],"(RFXANK)":[41],"recognize":[42],"a":[43,89,96,136,146,155,171,202,215,225],"PxLPxI/L":[44,93,160,193],"motif":[45,94,110,161,194],"found":[46],"in":[47,71,95,122,184,208],"diverse":[48],"binding":[49,75,98,109,130,166,189],"proteins,":[50,177],"including":[51],"HDAC4,":[52,163],"HDAC5,":[53],"HDAC9,":[54],"megalin,":[55],"X,":[59],"5":[60],"(RFX5).":[61],"Crystal":[62],"structures":[63],"domain":[68],"complex":[72],"peptides":[76],"revealed":[77],"each":[79],"middle":[82],"three":[83,119],"repeats":[85],"recognizes":[88],"residue":[90,156],"from":[91],"tumbler-lock":[97],"mode,":[99],"acting":[102],"as":[103,112],"lock":[105],"linear":[108,143],"serving":[111],"key.":[114],"Structural":[115],"analysis":[116],"showed":[117],"disease-causing":[120],"mutations":[121],"RFXANK":[123],"affect":[124],"residues":[125],"are":[127],"critical":[128],"for":[129,175,224],"to":[131],"RFX5.":[132],"These":[133],"results":[134],"suggest":[135],"fundamental":[137],"principle":[138],"longitudinal":[140],"recognition":[141,222],"sequences":[144],"by":[145],"repeat-type":[147,226],"domain.":[148,228],"In":[149],"addition,":[150],"phosphorylation":[151],"serine":[153],"350,":[154],"embedded":[157],"within":[158],"impaired":[164],"but":[169],"generated":[170],"high-affinity":[172],"docking":[173],"site":[174],"14-3-3":[176],"which":[178],"may":[179,206],"help":[180],"sequester":[181],"this":[182],"HDAC":[183],"cytoplasm.":[186],"Thus,":[187],"preference":[190],"is":[195],"signal-dependent.":[196],"Furthermore,":[197],"proteome-wide":[198],"screening":[199],"suggested":[200],"similar":[203],"phosphorylation-dependent":[204],"switch":[205],"operate":[207],"other":[209],"pathways.":[210],"Together,":[211],"our":[212],"findings":[213],"uncover":[214],"previously":[216],"uncharacterized":[217],"sequence-":[218],"signal-dependent":[220],"peptide":[221],"mode":[223]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}