{"id":"https://openalex.org/W2139013223","doi":"https://doi.org/10.1093/jac/dkt457","title":"An immunomodulatory activity of micafungin in preclinical aspergillosis","display_name":"An immunomodulatory activity of micafungin in preclinical aspergillosis","publication_year":2013,"publication_date":"2013-11-20","ids":{"openalex":"https://openalex.org/W2139013223","doi":"https://doi.org/10.1093/jac/dkt457","mag":"2139013223","pmid":"https://pubmed.ncbi.nlm.nih.gov/24265229"},"language":"en","primary_location":{"id":"doi:10.1093/jac/dkt457","doi":"https://doi.org/10.1093/jac/dkt457","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/dkt457","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009727581","display_name":"Silvia Moretti","orcid":"https://orcid.org/0000-0002-8177-7254","observed_orcids":["https://orcid.org/0000-0002-8177-7254"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Moretti","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Science, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132 Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Science, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132 Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012163897","display_name":"Silvia Bozza","orcid":"https://orcid.org/0000-0002-8163-2936","observed_orcids":["https://orcid.org/0000-0002-8163-2936"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Bozza","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Science, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132 Perugia, Italy","1Department of Experimental Medicine and Biochemical Science, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132 Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Science, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132 Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"1Department of Experimental Medicine and Biochemical Science, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132 Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027442852","display_name":"Cristina Massi-Benedetti","orcid":"https://orcid.org/0000-0003-0120-9992","observed_orcids":["https://orcid.org/0000-0003-0120-9992"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Massi-Benedetti","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Science, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132 Perugia, Italy","1Department of Experimental Medicine and Biochemical Science, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132 Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Science, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132 Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"1Department of Experimental Medicine and Biochemical Science, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132 Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070776998","display_name":"Lucia Prezioso","orcid":"https://orcid.org/0000-0003-1660-4960","observed_orcids":["https://orcid.org/0000-0003-1660-4960"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Prezioso","raw_affiliation_strings":["Hematology and Bone Marrow Transplant Unit, University of Parma, Ospedale Maggiore, via Gramsci 14, 43100 Parma, Italy","2Hematology and Bone Marrow Transplant Unit, University of Parma, Ospedale Maggiore, via Gramsci 14, 43100 Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Bone Marrow Transplant Unit, University of Parma, Ospedale Maggiore, via Gramsci 14, 43100 Parma, Italy","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"2Hematology and Bone Marrow Transplant Unit, University of Parma, Ospedale Maggiore, via Gramsci 14, 43100 Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041577362","display_name":"Elena Rossetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Rossetti","raw_affiliation_strings":["Hematology and Bone Marrow Transplant Unit, University of Parma, Ospedale Maggiore, via Gramsci 14, 43100 Parma, Italy","2Hematology and Bone Marrow Transplant Unit, University of Parma, Ospedale Maggiore, via Gramsci 14, 43100 Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Bone Marrow Transplant Unit, University of Parma, Ospedale Maggiore, via Gramsci 14, 43100 Parma, Italy","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"2Hematology and Bone Marrow Transplant Unit, University of Parma, Ospedale Maggiore, via Gramsci 14, 43100 Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087834518","display_name":"Luigina R. Romani","orcid":"https://orcid.org/0000-0002-1356-525X","observed_orcids":["https://orcid.org/0000-0002-1356-525X"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Romani","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Science, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132 Perugia, Italy","1Department of Experimental Medicine and Biochemical Science, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132 Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Science, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132 Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"1Department of Experimental Medicine and Biochemical Science, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132 Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021123903","display_name":"Franco Aversa","orcid":"https://orcid.org/0000-0002-8871-6817","observed_orcids":["https://orcid.org/0000-0002-8871-6817","https://orcid.org/0000-0003-0689-1572"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Aversa","raw_affiliation_strings":["Hematology and Bone Marrow Transplant Unit, University of Parma, Ospedale Maggiore, via Gramsci 14, 43100 Parma, Italy","2Hematology and Bone Marrow Transplant Unit, University of Parma, Ospedale Maggiore, via Gramsci 14, 43100 Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Bone Marrow Transplant Unit, University of Parma, Ospedale Maggiore, via Gramsci 14, 43100 Parma, Italy","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"2Hematology and Bone Marrow Transplant Unit, University of Parma, Ospedale Maggiore, via Gramsci 14, 43100 Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079900713","display_name":"Lucia Pitzurra","orcid":"https://orcid.org/0000-0002-6866-7982","observed_orcids":["https://orcid.org/0000-0002-6866-7982"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"L. Pitzurra","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Science, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132 Perugia, Italy","1Department of Experimental Medicine and Biochemical Science, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132 Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Science, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132 Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"1Department of Experimental Medicine and Biochemical Science, University of Perugia, Polo Unico Sant'Andrea delle Fratte, 06132 Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079900713"],"corresponding_institution_ids":["https://openalex.org/I27483092"],"apc_list":{"value":2869,"currency":"GBP","value_usd":3784},"apc_paid":null,"fwci":1.73,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.82799741,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"69","issue":"4","first_page":"1065","last_page":"1074"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/micafungin","display_name":"micafungin","score":1.0},{"id":"https://openalex.org/keywords/invasive-aspergillosis","display_name":"invasive aspergillosis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/aspergillus-fumigatus","display_name":"Aspergillus fumigatus","score":0.8859999775886536},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9679999947547913},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.777999997138977},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.7179999947547913},{"id":"https://openalex.org/keywords/dectin-1","display_name":"Dectin-1","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tlr3","display_name":"TLR3","score":0.9860000014305115},{"id":"https://openalex.org/keywords/trif","display_name":"TRIF","score":0.9850000143051147},{"id":"https://openalex.org/keywords/innate-immune-receptors","display_name":"innate immune receptors","score":0.8849999904632568},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7889999747276306},{"id":"https://openalex.org/keywords/dose-dependent-efficacy","display_name":"dose-dependent efficacy","score":0.609000027179718},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C2779020398","wikidata":"https://www.wikidata.org/wiki/Q6827850","display_name":"Micafungin","level":4,"score":0.993375301361084},{"id":"https://openalex.org/C2776391196","wikidata":"https://www.wikidata.org/wiki/Q259626","display_name":"Aspergillosis","level":2,"score":0.7407258749008179},{"id":"https://openalex.org/C2910751997","wikidata":"https://www.wikidata.org/wiki/Q3718510","display_name":"Echinocandins","level":5,"score":0.6617029905319214},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5150506496429443},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4647720456123352},{"id":"https://openalex.org/C2779320740","wikidata":"https://www.wikidata.org/wiki/Q3718510","display_name":"Echinocandin","level":4,"score":0.44948726892471313},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40704312920570374},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.3963259756565094},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32308679819107056},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3203161358833313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2893836498260498},{"id":"https://openalex.org/C2779629538","wikidata":"https://www.wikidata.org/wiki/Q412223","display_name":"Amphotericin B","level":3,"score":0.14403802156448364},{"id":"https://openalex.org/C2780402444","wikidata":"https://www.wikidata.org/wiki/Q420875","display_name":"Caspofungin","level":4,"score":0.13181331753730774},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077551","descriptor_name":"Micafungin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001228","descriptor_name":"Aspergillosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001228","descriptor_name":"Aspergillosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D001232","descriptor_name":"Aspergillus fumigatus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054714","descriptor_name":"Echinocandins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054714","descriptor_name":"Echinocandins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D055666","descriptor_name":"Lipopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D055666","descriptor_name":"Lipopeptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D058491","descriptor_name":"Bacterial Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/jac/dkt457","doi":"https://doi.org/10.1093/jac/dkt457","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/dkt457","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},{"id":"pmid:24265229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24265229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antimicrobial chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:jac:dkt457v1","doi":null,"is_oa":false,"landing_page_url":"http://jac.oxfordjournals.org/cgi/content/short/dkt457v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1482128986","https://openalex.org/W1553804017","https://openalex.org/W1572283658","https://openalex.org/W1887296783","https://openalex.org/W1993519123","https://openalex.org/W2001583229","https://openalex.org/W2002612766","https://openalex.org/W2002836781","https://openalex.org/W2023900788","https://openalex.org/W2033784922","https://openalex.org/W2034599708","https://openalex.org/W2073237203","https://openalex.org/W2084509745","https://openalex.org/W2096277540","https://openalex.org/W2096722233","https://openalex.org/W2099551805","https://openalex.org/W2101233099","https://openalex.org/W2111094455","https://openalex.org/W2122278166","https://openalex.org/W2130778407","https://openalex.org/W2131077875","https://openalex.org/W2137694267","https://openalex.org/W2139029972","https://openalex.org/W2139814397","https://openalex.org/W2143014057","https://openalex.org/W2144246402","https://openalex.org/W2146545211","https://openalex.org/W2147217394","https://openalex.org/W2156556397","https://openalex.org/W2166822160","https://openalex.org/W2166875045","https://openalex.org/W2170595857","https://openalex.org/W2171152958","https://openalex.org/W2316477856"],"related_works":["https://openalex.org/W2584305331","https://openalex.org/W1990709959","https://openalex.org/W1706252591","https://openalex.org/W2964625774","https://openalex.org/W1539406292","https://openalex.org/W2171152958","https://openalex.org/W1913848463","https://openalex.org/W4220918721","https://openalex.org/W2080468965","https://openalex.org/W4302138042"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Micafungin":[1,79],"inhibits":[2],"1,3-\u03b2-D-glucan":[3],"synthase":[4],"and":[5,53,60,99,136,143],"interferes":[6],"with":[7,115,125],"fungal":[8,25],"cell":[9],"wall":[10],"synthesis.":[11],"Clinically,":[12],"micafungin":[13,36,50,111,133,156],"has":[14],"been":[15],"shown":[16],"to":[17,82,87],"be":[18],"efficacious":[19],"for":[20,73],"the":[21,32,43,93,107,116,121,141,152,162,169],"treatment":[22],"of":[23,35,46,49,67,95,102,110,132,155,164],"invasive":[24,68],"infections.":[26,39],"However,":[27],"little":[28],"is":[29,159],"known":[30],"about":[31],"immunomodulatory":[33,44],"activity":[34,45,118,131],"in":[37,51,58,61,63,157],"these":[38,148],"METHODS:":[40],"We":[41],"evaluated":[42],"escalating":[47],"doses":[48],"murine":[52],"human":[54],"polymorphonuclear":[55],"neutrophils":[56],"(PMNs)":[57],"vitro":[59],"vivo":[62],"different":[64],"preclinical":[65],"models":[66],"aspergillosis,":[69],"including":[70],"mice":[71],"deficient":[72],"selected":[74],"innate":[75,165],"immune":[76,166],"receptors.":[77],"RESULTS:":[78],"was":[80,112],"able":[81],"regulate":[83],"PMN":[84],"cytokine":[85],"response":[86],"Aspergillus":[88],"fumigatus":[89],"conidia":[90],"by":[91,161],"decreasing":[92],"expression":[94],"tumour":[96],"necrosis":[97],"factor-\u03b1":[98],"increasing":[100],"that":[101,151],"interleukin-10":[103],"(IL-10).":[104],"In":[105],"vivo,":[106],"therapeutic":[108,153],"efficacy":[109,154],"strictly":[113],"dose-dependent,":[114],"maximum":[117],"observed":[119],"at":[120],"highest":[122],"dose,":[123],"concomitant":[124],"reduced":[126],"inflammatory":[127],"pathology.":[128],"The":[129],"anti-inflammatory":[130],"required":[134],"IL-10":[135],"occurred":[137],"through":[138],"signalling":[139],"via":[140],"TLR2/dectin-1":[142],"TLR3/TRIF":[144],"pathways.":[145],"CONCLUSION:":[146],"Together,":[147],"findings":[149],"suggest":[150],"aspergillosis":[158],"orchestrated":[160],"activation":[163],"receptors":[167],"affecting":[168],"inflammatory/anti-inflammatory":[170],"balance":[171],"during":[172],"infection.":[173]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}