{"id":"https://openalex.org/W2138964355","doi":"https://doi.org/10.1038/nsmb.1377","title":"Crystal structure of the multifunctional G\u03b25\u2013RGS9 complex","display_name":"Crystal structure of the multifunctional G\u03b25\u2013RGS9 complex","publication_year":2008,"publication_date":"2008-01-20","ids":{"openalex":"https://openalex.org/W2138964355","doi":"https://doi.org/10.1038/nsmb.1377","mag":"2138964355","pmid":"https://pubmed.ncbi.nlm.nih.gov/18204463"},"language":"en","primary_location":{"id":"doi:10.1038/nsmb.1377","doi":"https://doi.org/10.1038/nsmb.1377","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nsmb.1377","pdf_url":null,"source":{"id":"https://openalex.org/S139253143","display_name":"Nature Structural & Molecular Biology","issn_l":"1545-9985","issn":["1545-9985","1545-9993"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Structural & Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.17615/y9kb-4m80","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021818612","display_name":"Matthew L. Cheever","orcid":"https://orcid.org/0000-0001-5353-4880","observed_orcids":["https://orcid.org/0000-0001-5353-4880"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew L Cheever","raw_affiliation_strings":["Department of Pharmacology, University of North Carolina School of Medicine, Campus Box 7365, Chapel Hill, North Carolina 27599-7365, USA","Department of Pharmacology, University of North Carolina School of Medicine, Campus Box 7365, Chapel Hill, 27599-7365, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina School of Medicine, Campus Box 7365, Chapel Hill, North Carolina 27599-7365, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina School of Medicine, Campus Box 7365, Chapel Hill, 27599-7365, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084453658","display_name":"Jason T. Snyder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason T Snyder","raw_affiliation_strings":["Department of Pharmacology, University of North Carolina School of Medicine, Campus Box 7365, Chapel Hill, 27599-7365, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina School of Medicine, Campus Box 7365, Chapel Hill, 27599-7365, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055668062","display_name":"Svetlana Gershburg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Svetlana Gershburg","raw_affiliation_strings":["Department of Pharmacology, University of North Carolina School of Medicine, Campus Box 7365, Chapel Hill, 27599-7365, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina School of Medicine, Campus Box 7365, Chapel Hill, 27599-7365, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075879139","display_name":"David Peter Siderovski","orcid":"https://orcid.org/0000-0002-0688-8210","observed_orcids":["https://orcid.org/0000-0002-0688-8210"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David P Siderovski","raw_affiliation_strings":["Department of Pharmacology, University of North Carolina School of Medicine, Campus Box 7365, Chapel Hill, 27599-7365, North Carolina, USA","Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Campus Box 7295, Chapel Hill, 27599-7295, North Carolina, USA","UNC Neuroscience Center, University of North Carolina School of Medicine, Campus Box 7250, Chapel Hill, 27599-7250, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina School of Medicine, Campus Box 7365, Chapel Hill, 27599-7365, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Campus Box 7295, Chapel Hill, 27599-7295, North Carolina, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]},{"raw_affiliation_string":"UNC Neuroscience Center, University of North Carolina School of Medicine, Campus Box 7250, Chapel Hill, 27599-7250, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108821664","display_name":"T. Kendall Harden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Kendall Harden","raw_affiliation_strings":["Department of Pharmacology, University of North Carolina School of Medicine, Campus Box 7365, Chapel Hill, 27599-7365, North Carolina, USA","Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Campus Box 7295, Chapel Hill, 27599-7295, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina School of Medicine, Campus Box 7365, Chapel Hill, 27599-7365, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Campus Box 7295, Chapel Hill, 27599-7295, North Carolina, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002265218","display_name":"John Sondek","orcid":"https://orcid.org/0000-0002-1127-8310","observed_orcids":["https://orcid.org/0000-0002-1127-8310"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John Sondek","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Campus Box 7260, Chapel Hill, 27599-7260, North Carolina, USA","Department of Pharmacology, University of North Carolina School of Medicine, Campus Box 7365, Chapel Hill, 27599-7365, North Carolina, USA","Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Campus Box 7295, Chapel Hill, 27599-7295, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Campus Box 7260, Chapel Hill, 27599-7260, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina School of Medicine, Campus Box 7365, Chapel Hill, 27599-7365, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Campus Box 7295, Chapel Hill, 27599-7295, North Carolina, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002265218"],"corresponding_institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":5.2119,"has_fulltext":true,"cited_by_count":102,"citation_normalized_percentile":{"value":0.9665653,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"15","issue":"2","first_page":"155","last_page":"162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gbeta5","display_name":"G\u03b25","score":0.7089999914169312},{"id":"https://openalex.org/keywords/rgs9","display_name":"RGS9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/regulators-of-g-protein-signaling","display_name":"regulator of G protein signaling","score":0.9319999814033508},{"id":"https://openalex.org/keywords/g-protein-beta-subunit","display_name":"G protein beta subunit","score":0.675000011920929},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.746999979019165},{"id":"https://openalex.org/keywords/g-protein-activation","display_name":"G protein activation","score":0.6499999761581421},{"id":"https://openalex.org/keywords/g-protein-deactivation","display_name":"G protein deactivation","score":0.878000020980835},{"id":"https://openalex.org/keywords/phototransduction","display_name":"phototransduction","score":0.7950000166893005},{"id":"https://openalex.org/keywords/neuronal-signal-transduction","display_name":"neuronal transduction","score":0.8939999938011169},{"id":"https://openalex.org/keywords/protein-complex-structure","display_name":"protein complex structure","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.7512377500534058},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.7240983247756958},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.6932436227798462},{"id":"https://openalex.org/C163181125","wikidata":"https://www.wikidata.org/wiki/Q408592","display_name":"GTPase-activating protein","level":4,"score":0.6507869958877563},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6295290589332581},{"id":"https://openalex.org/C2777993845","wikidata":"https://www.wikidata.org/wiki/Q6592084","display_name":"Regulator of G protein signaling","level":5,"score":0.5983424186706543},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.5594794750213623},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4858643412590027},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.457481324672699},{"id":"https://openalex.org/C66135807","wikidata":"https://www.wikidata.org/wiki/Q24726231","display_name":"Gq alpha subunit","level":4,"score":0.42357444763183594},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40434253215789795},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29201608896255493},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08705171942710876}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020710","descriptor_name":"RGS Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020710","descriptor_name":"RGS Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020710","descriptor_name":"RGS Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020710","descriptor_name":"RGS Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044387","descriptor_name":"GTP-Binding Protein beta Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044387","descriptor_name":"GTP-Binding Protein beta Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044387","descriptor_name":"GTP-Binding Protein beta Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044387","descriptor_name":"GTP-Binding Protein beta Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/nsmb.1377","doi":"https://doi.org/10.1038/nsmb.1377","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nsmb.1377","pdf_url":null,"source":{"id":"https://openalex.org/S139253143","display_name":"Nature Structural & Molecular Biology","issn_l":"1545-9985","issn":["1545-9985","1545-9993"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Structural & Molecular Biology","raw_type":"journal-article"},{"id":"pmid:18204463","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18204463","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature structural & molecular biology","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:d791sq297","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/y9kb-4m80","pdf_url":"https://doi.org/10.17615/y9kb-4m80","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Structural Biology, 15(2)","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2702320","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2702320","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nat Struct Mol Biol","raw_type":"Text"},{"id":"doi:10.17615/y9kb-4m80","doi":"https://doi.org/10.17615/y9kb-4m80","is_oa":true,"landing_page_url":"https://doi.org/10.17615/y9kb-4m80","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:cdr.lib.unc.edu:d791sq297","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/y9kb-4m80","pdf_url":"https://doi.org/10.17615/y9kb-4m80","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Structural Biology, 15(2)","raw_type":"Article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1502057101","display_name":null,"funder_award_id":"P01 GM065533","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3611480971","display_name":null,"funder_award_id":"P01 GM65533","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3658761489","display_name":null,"funder_award_id":"R01 GM081881","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000297221","display_name":null,"funder_award_id":"GM65533","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000913976","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016086","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337480","display_name":"Basic Energy Sciences","ror":"https://ror.org/05mg91w61"},{"id":"https://openalex.org/F4320338284","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2138964355.pdf","grobid_xml":"https://content.openalex.org/works/W2138964355.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1487123743","https://openalex.org/W1520928812","https://openalex.org/W1539796472","https://openalex.org/W1953109900","https://openalex.org/W1965819474","https://openalex.org/W1970205026","https://openalex.org/W1980926257","https://openalex.org/W1993404146","https://openalex.org/W1994286350","https://openalex.org/W1994342014","https://openalex.org/W1997328693","https://openalex.org/W1997907891","https://openalex.org/W2004360551","https://openalex.org/W2004581292","https://openalex.org/W2016221462","https://openalex.org/W2016923687","https://openalex.org/W2018483093","https://openalex.org/W2022058405","https://openalex.org/W2025671442","https://openalex.org/W2027542864","https://openalex.org/W2030185192","https://openalex.org/W2031016015","https://openalex.org/W2033111233","https://openalex.org/W2038840577","https://openalex.org/W2043647387","https://openalex.org/W2050307742","https://openalex.org/W2052280808","https://openalex.org/W2059400954","https://openalex.org/W2062243309","https://openalex.org/W2063715433","https://openalex.org/W2064464664","https://openalex.org/W2069629128","https://openalex.org/W2071242185","https://openalex.org/W2095143153","https://openalex.org/W2095769092","https://openalex.org/W2097382368","https://openalex.org/W2098936754","https://openalex.org/W2109310563","https://openalex.org/W2115921407","https://openalex.org/W2125216942","https://openalex.org/W2133321625","https://openalex.org/W2137588110","https://openalex.org/W2144081223","https://openalex.org/W2148882351","https://openalex.org/W2149063573","https://openalex.org/W2152616334","https://openalex.org/W2159432682","https://openalex.org/W2162842869","https://openalex.org/W2187773005","https://openalex.org/W2331959327","https://openalex.org/W2428440012","https://openalex.org/W2915537949"],"related_works":["https://openalex.org/W1571901884","https://openalex.org/W1984910438","https://openalex.org/W3101723335","https://openalex.org/W2739518502","https://openalex.org/W338648647","https://openalex.org/W1985624168","https://openalex.org/W2147198454","https://openalex.org/W1977493444","https://openalex.org/W2184031881","https://openalex.org/W180308560"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2016-06-24T00:00:00"}