{"id":"https://openalex.org/W2138956059","doi":"https://doi.org/10.1002/glia.10190","title":"Recovery from lactacidosis\u2010induced glial cell swelling with the aid of exogenous anion channels","display_name":"Recovery from lactacidosis\u2010induced glial cell swelling with the aid of exogenous anion channels","publication_year":2003,"publication_date":"2003-01-08","ids":{"openalex":"https://openalex.org/W2138956059","doi":"https://doi.org/10.1002/glia.10190","mag":"2138956059","pmid":"https://pubmed.ncbi.nlm.nih.gov/12528180"},"language":"en","primary_location":{"id":"doi:10.1002/glia.10190","doi":"https://doi.org/10.1002/glia.10190","is_oa":false,"landing_page_url":"https://doi.org/10.1002/glia.10190","pdf_url":null,"source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056346763","display_name":"Takashi Nabekura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]},{"id":"https://openalex.org/I4210145863","display_name":"National Institute for Physiological Sciences","ror":"https://ror.org/048v13307","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922","https://openalex.org/I4210145863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Nabekura","raw_affiliation_strings":["Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Japan","Department of Otolaryngology, Miyazaki Medical College, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Japan","institution_ids":["https://openalex.org/I4210145863"]},{"raw_affiliation_string":"Department of Otolaryngology, Miyazaki Medical College, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090563200","display_name":"Shigeru Morishima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145863","display_name":"National Institute for Physiological Sciences","ror":"https://ror.org/048v13307","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922","https://openalex.org/I4210145863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Morishima","raw_affiliation_strings":["CREST of Japan Science and Technology Corporation, Okazaki, Japan","Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CREST of Japan Science and Technology Corporation, Okazaki, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Japan","institution_ids":["https://openalex.org/I4210145863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017198868","display_name":"Timothy L. Cover","orcid":"https://orcid.org/0000-0001-8503-002X","observed_orcids":["https://orcid.org/0000-0001-8503-002X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy L. Cover","raw_affiliation_strings":["Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109235228","display_name":"Shin\u2010Ichiro Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145863","display_name":"National Institute for Physiological Sciences","ror":"https://ror.org/048v13307","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922","https://openalex.org/I4210145863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin\u2010Ichiro Mori","raw_affiliation_strings":["CREST of Japan Science and Technology Corporation, Okazaki, Japan","Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CREST of Japan Science and Technology Corporation, Okazaki, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Japan","institution_ids":["https://openalex.org/I4210145863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108435892","display_name":"Hiroshi Kannan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Kannan","raw_affiliation_strings":["Department of Physiology, Miyazaki Medical College, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Miyazaki Medical College, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030342167","display_name":"Shizuo Komune","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shizuo Komune","raw_affiliation_strings":["Department of Otolaryngology, Miyazaki Medical College, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Miyazaki Medical College, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027563984","display_name":"Yasunobu Okada","orcid":"https://orcid.org/0000-0003-0899-1665","observed_orcids":["https://orcid.org/0000-0003-0899-1665"]},"institutions":[{"id":"https://openalex.org/I4210145863","display_name":"National Institute for Physiological Sciences","ror":"https://ror.org/048v13307","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922","https://openalex.org/I4210145863"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yasunobu Okada","raw_affiliation_strings":["CREST of Japan Science and Technology Corporation, Okazaki, Japan","Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CREST of Japan Science and Technology Corporation, Okazaki, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Japan","institution_ids":["https://openalex.org/I4210145863"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5027563984"],"corresponding_institution_ids":["https://openalex.org/I4210145863"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":0.943,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.7050829,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"41","issue":"3","first_page":"247","last_page":"259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lactic-acidosis","display_name":"lactic acidosis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9259999990463257},{"id":"https://openalex.org/keywords/volume-regulation","display_name":"volume regulation","score":0.6019999980926514},{"id":"https://openalex.org/keywords/regulatory-volume-decrease","display_name":"regulatory volume decrease","score":0.9819999933242798},{"id":"https://openalex.org/keywords/vaca","display_name":"VacA","score":0.859000027179718},{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hypotonic-stress","display_name":"hypotonic stress","score":0.8149999976158142},{"id":"https://openalex.org/keywords/c6-glioma-cells","display_name":"C6 glioma cells","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.7730000019073486},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.711895227432251},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.49872517585754395},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48717278242111206},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3498077392578125},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08246532082557678},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.042118340730667114}],"mesh":[{"descriptor_ui":"D000140","descriptor_name":"Acidosis, Lactic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000838","descriptor_name":"Anions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007038","descriptor_name":"Hypotonic Solutions","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/glia.10190","doi":"https://doi.org/10.1002/glia.10190","is_oa":false,"landing_page_url":"https://doi.org/10.1002/glia.10190","pdf_url":null,"source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},{"id":"pmid:12528180","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12528180","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W98200862","https://openalex.org/W110310975","https://openalex.org/W120090531","https://openalex.org/W310193716","https://openalex.org/W643256415","https://openalex.org/W952145762","https://openalex.org/W1029099544","https://openalex.org/W1500891430","https://openalex.org/W1509313163","https://openalex.org/W1543868776","https://openalex.org/W1563482856","https://openalex.org/W1745204207","https://openalex.org/W1859174804","https://openalex.org/W1864129699","https://openalex.org/W1963785325","https://openalex.org/W1964119066","https://openalex.org/W1965216782","https://openalex.org/W1967210581","https://openalex.org/W1968226779","https://openalex.org/W1977213966","https://openalex.org/W1984256619","https://openalex.org/W1988517559","https://openalex.org/W1988606081","https://openalex.org/W1990918868","https://openalex.org/W1992089296","https://openalex.org/W1995531989","https://openalex.org/W1998976350","https://openalex.org/W2000702715","https://openalex.org/W2034153873","https://openalex.org/W2036136248","https://openalex.org/W2036511400","https://openalex.org/W2036742792","https://openalex.org/W2040740610","https://openalex.org/W2043161274","https://openalex.org/W2048788380","https://openalex.org/W2050293532","https://openalex.org/W2052638490","https://openalex.org/W2058506832","https://openalex.org/W2062238583","https://openalex.org/W2062474757","https://openalex.org/W2063444914","https://openalex.org/W2063455081","https://openalex.org/W2064272270","https://openalex.org/W2075147562","https://openalex.org/W2076707026","https://openalex.org/W2080124127","https://openalex.org/W2085165592","https://openalex.org/W2102604237","https://openalex.org/W2113175699","https://openalex.org/W2113607189","https://openalex.org/W2114131838","https://openalex.org/W2122062921","https://openalex.org/W2129692557","https://openalex.org/W2130076730","https://openalex.org/W2132087327","https://openalex.org/W2132905706","https://openalex.org/W2136598957","https://openalex.org/W2138812532","https://openalex.org/W2140880538","https://openalex.org/W2141989775","https://openalex.org/W2142809718","https://openalex.org/W2157422268","https://openalex.org/W2160440316","https://openalex.org/W2161569989","https://openalex.org/W2164659357","https://openalex.org/W2165365321","https://openalex.org/W2167582289","https://openalex.org/W2205329504","https://openalex.org/W2247602706","https://openalex.org/W2277562581","https://openalex.org/W2290010678","https://openalex.org/W2291887555","https://openalex.org/W2316634253","https://openalex.org/W2340712601","https://openalex.org/W2400918729","https://openalex.org/W2402698977","https://openalex.org/W2406075271","https://openalex.org/W2406414528","https://openalex.org/W2443018828"],"related_works":["https://openalex.org/W2089162294","https://openalex.org/W2052638490","https://openalex.org/W2066549001","https://openalex.org/W207129670","https://openalex.org/W1968226779","https://openalex.org/W7071164197","https://openalex.org/W938784933","https://openalex.org/W1984256619","https://openalex.org/W6986865447","https://openalex.org/W67940738"],"abstract_inverted_index":{"Hypotonic":[0],"challenge":[1],"induces":[2,23],"transient":[3,158],"swelling":[4,26,159,193],"in":[5,27,49,84,129,197,222],"glial":[6,198,206],"cells,":[7,113],"which":[8,42,217],"is":[9,218],"typically":[10],"followed":[11,160],"by":[12,41,143,161,195],"a":[13,61,64,167,186,210],"regulatory":[14],"volume":[15,47],"decrease":[16],"(RVD).":[17],"In":[18,33,163],"contrast,":[19,164],"lactic":[20],"acidosis":[21],"(lactacidosis)":[22],"persistent":[24,175,192],"cell":[25,176],"astrocytes":[28],"without":[29],"an":[30,100,114],"accompanying":[31],"RVD.":[32,162],"the":[34,39,130,134,137],"present":[35],"study,":[36],"we":[37,181],"studied":[38],"mechanisms":[40],"lactacidosis":[43,144,196,221],"interferes":[44],"with":[45,72,99,149,220],"normal":[46],"regulation":[48],"rat":[50],"astrocytic":[51],"glioma":[52],"C6":[53,58,91,112],"cells.":[54,199],"Following":[55],"exposure":[56],"of":[57,74,136,166,185,201],"cells":[59,92,207],"to":[60,83,88,94,96,111,125,154,172,191],"hypotonic":[62,97],"challenge,":[63],"current":[65],"was":[66,123,140],"detected":[67],"that":[68,183],"exhibited":[69],"properties":[70],"consistent":[71],"those":[73],"volume-sensitive":[75,187],"outwardly":[76],"rectifying":[77],"(VSOR)":[78],"anion":[79,104,115,188,202],"channels.":[80],"When":[81,109],"exposed":[82,153],"vitro":[85],"conditions":[86,156],"designed":[87],"simulate":[89],"lactacidosis,":[90],"failed":[93,171],"respond":[95],"stress":[98],"RVD,":[101],"and":[102,133,151],"VSOR":[103],"currents":[105],"were":[106],"not":[107,141],"activated.":[108],"added":[110],"channel-forming":[116],"protein":[117],"purified":[118],"from":[119],"Helicobacter":[120],"pylori,":[121],"VacA,":[122],"found":[124],"form":[126],"anion-selective":[127],"channels":[128],"plasma":[131],"membrane,":[132],"activity":[135,204],"VacA":[138,150],"channel":[139,189,203],"affected":[142],"(pH":[145],"6.2).":[146],"Cells":[147],"preincubated":[148],"then":[152],"lactacidotic":[155],"underwent":[157],"application":[165],"cation":[168],"ionophore,":[169],"gramicidin,":[170],"inhibit":[173],"lactacidosis-induced":[174],"swelling.":[177],"From":[178],"these":[179],"results,":[180],"conclude":[182],"inhibition":[184],"contributes":[190],"induced":[194],"Introduction":[200],"into":[205],"might":[208],"provide":[209],"novel":[211],"approach":[212],"for":[213],"treating":[214],"cerebral":[215,223],"edema,":[216],"associated":[219],"ischemia":[224],"or":[225],"head":[226],"injury.":[227]},"counts_by_year":[{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}