{"id":"https://openalex.org/W2138908243","doi":"https://doi.org/10.1161/01.hyp.0000103160.35395.9e","title":"Sympathetic Augmentation in Hypertension","display_name":"Sympathetic Augmentation in Hypertension","publication_year":2003,"publication_date":"2003-11-11","ids":{"openalex":"https://openalex.org/W2138908243","doi":"https://doi.org/10.1161/01.hyp.0000103160.35395.9e","mag":"2138908243","pmid":"https://pubmed.ncbi.nlm.nih.gov/14610101"},"language":"en","primary_location":{"id":"doi:10.1161/01.hyp.0000103160.35395.9e","doi":"https://doi.org/10.1161/01.hyp.0000103160.35395.9e","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.hyp.0000103160.35395.9e","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.HYP.0000103160.35395.9E","source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.HYP.0000103160.35395.9E","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047370873","display_name":"Markus Peter Schlaich","orcid":"https://orcid.org/0000-0002-1765-0195","observed_orcids":["https://orcid.org/0000-0002-1765-0195"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]}],"countries":["AU","DE"],"is_corresponding":false,"raw_author_name":"Markus P. Schlaich","raw_affiliation_strings":["From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany; and Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital (E.L., D.M.K., Z.K., G.L., J.H., A.A., M.D.E.), and St Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne (D.J.C.), Melbourne, Australia","Markus P. Schlaich From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany; and Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital (E.L., D.M.K., Z.K., G.L., J.H., A.A., M.D.E.), and St Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne (D.J.C.), Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I181369854","https://openalex.org/I2801993434","https://openalex.org/I77826658"]},{"raw_affiliation_string":"Markus P. Schlaich From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014744580","display_name":"\u00c9lisabeth Lambert","orcid":"https://orcid.org/0000-0002-2232-9048","observed_orcids":["https://orcid.org/0000-0002-2232-9048"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]}],"countries":["AU","DE"],"is_corresponding":false,"raw_author_name":"Elisabeth Lambert","raw_affiliation_strings":["From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany; and Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital (E.L., D.M.K., Z.K., G.L., J.H., A.A., M.D.E.), and St Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne (D.J.C.), Melbourne, Australia","Elisabeth Lambert From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany; and Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital (E.L., D.M.K., Z.K., G.L., J.H., A.A., M.D.E.), and St Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne (D.J.C.), Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I181369854","https://openalex.org/I2801993434","https://openalex.org/I77826658"]},{"raw_affiliation_string":"Elisabeth Lambert From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003988683","display_name":"David M. Kaye","orcid":"https://orcid.org/0000-0003-4058-0372","observed_orcids":["https://orcid.org/0000-0003-4058-0372"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]}],"countries":["AU","DE"],"is_corresponding":false,"raw_author_name":"David M. Kaye","raw_affiliation_strings":["From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany; and Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital (E.L., D.M.K., Z.K., G.L., J.H., A.A., M.D.E.), and St Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne (D.J.C.), Melbourne, Australia","David M. Kaye From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany; and Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital (E.L., D.M.K., Z.K., G.L., J.H., A.A., M.D.E.), and St Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne (D.J.C.), Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I181369854","https://openalex.org/I2801993434","https://openalex.org/I77826658"]},{"raw_affiliation_string":"David M. Kaye From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051067965","display_name":"Zygmunt S. Krozowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]}],"countries":["AU","DE"],"is_corresponding":false,"raw_author_name":"Zygmunt Krozowski","raw_affiliation_strings":["From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany; and Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital (E.L., D.M.K., Z.K., G.L., J.H., A.A., M.D.E.), and St Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne (D.J.C.), Melbourne, Australia","Zygmunt Krozowski From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany; and Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital (E.L., D.M.K., Z.K., G.L., J.H., A.A., M.D.E.), and St Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne (D.J.C.), Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I181369854","https://openalex.org/I2801993434","https://openalex.org/I77826658"]},{"raw_affiliation_string":"Zygmunt Krozowski From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022682140","display_name":"Duncan John Campbell","orcid":"https://orcid.org/0000-0002-6896-7571","observed_orcids":["https://orcid.org/0000-0002-6896-7571"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]}],"countries":["AU","DE"],"is_corresponding":false,"raw_author_name":"Duncan J. Campbell","raw_affiliation_strings":["From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany; and Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital (E.L., D.M.K., Z.K., G.L., J.H., A.A., M.D.E.), and St Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne (D.J.C.), Melbourne, Australia","Duncan J. Campbell From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany; and Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital (E.L., D.M.K., Z.K., G.L., J.H., A.A., M.D.E.), and St Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne (D.J.C.), Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I181369854","https://openalex.org/I2801993434","https://openalex.org/I77826658"]},{"raw_affiliation_string":"Duncan J. Campbell From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086606783","display_name":"Gavin William Lambert","orcid":"https://orcid.org/0000-0003-0315-645X","observed_orcids":["https://orcid.org/0000-0003-0315-645X"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]}],"countries":["AU","DE"],"is_corresponding":false,"raw_author_name":"Gavin Lambert","raw_affiliation_strings":["From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany; and Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital (E.L., D.M.K., Z.K., G.L., J.H., A.A., M.D.E.), and St Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne (D.J.C.), Melbourne, Australia","Gavin Lambert From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany; and Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital (E.L., D.M.K., Z.K., G.L., J.H., A.A., M.D.E.), and St Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne (D.J.C.), Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I181369854","https://openalex.org/I2801993434","https://openalex.org/I77826658"]},{"raw_affiliation_string":"Gavin Lambert From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040269799","display_name":"Jacqui Hastings","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]}],"countries":["AU","DE"],"is_corresponding":false,"raw_author_name":"Jacqui Hastings","raw_affiliation_strings":["From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany; and Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital (E.L., D.M.K., Z.K., G.L., J.H., A.A., M.D.E.), and St Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne (D.J.C.), Melbourne, Australia","Jacqui Hastings From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany; and Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital (E.L., D.M.K., Z.K., G.L., J.H., A.A., M.D.E.), and St Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne (D.J.C.), Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I181369854","https://openalex.org/I2801993434","https://openalex.org/I77826658"]},{"raw_affiliation_string":"Jacqui Hastings From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101595814","display_name":"Anuradha Aggarwal","orcid":"https://orcid.org/0000-0003-2698-1823","observed_orcids":["https://orcid.org/0000-0003-2698-1823"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]}],"countries":["AU","DE"],"is_corresponding":false,"raw_author_name":"Anuradha Aggarwal","raw_affiliation_strings":["From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany; and Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital (E.L., D.M.K., Z.K., G.L., J.H., A.A., M.D.E.), and St Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne (D.J.C.), Melbourne, Australia","Anuradha Aggarwal From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany; and Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital (E.L., D.M.K., Z.K., G.L., J.H., A.A., M.D.E.), and St Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne (D.J.C.), Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I181369854","https://openalex.org/I2801993434","https://openalex.org/I77826658"]},{"raw_affiliation_string":"Anuradha Aggarwal From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011375886","display_name":"Murray Esler","orcid":"https://orcid.org/0000-0002-8755-7658","observed_orcids":["https://orcid.org/0000-0002-8755-7658"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]}],"countries":["AU","DE"],"is_corresponding":false,"raw_author_name":"Murray D. Esler","raw_affiliation_strings":["From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany; and Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital (E.L., D.M.K., Z.K., G.L., J.H., A.A., M.D.E.), and St Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne (D.J.C.), Melbourne, Australia","Murray D. Esler From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany; and Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital (E.L., D.M.K., Z.K., G.L., J.H., A.A., M.D.E.), and St Vincent\u2019s Institute of Medical Research and Department of Medicine, University of Melbourne (D.J.C.), Melbourne, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I181369854","https://openalex.org/I2801993434","https://openalex.org/I77826658"]},{"raw_affiliation_string":"Murray D. Esler From the Department of Medicine IV, University of Erlangen-Nuernberg (M.P.S.), Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.5932,"has_fulltext":true,"cited_by_count":512,"citation_normalized_percentile":{"value":0.97139773,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"43","issue":"2","first_page":"169","last_page":"175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.1005999967455864,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.9909999966621399},{"id":"https://openalex.org/keywords/sympathetic-hyperactivity","display_name":"sympathetic hyperactivity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/neurogenic-hypertension","display_name":"neurogenic hypertension","score":0.7829999923706055},{"id":"https://openalex.org/keywords/norepinephrine-uptake","display_name":"norepinephrine uptake","score":0.8429999947547913},{"id":"https://openalex.org/keywords/desipramine","display_name":"desipramine","score":0.7929999828338623},{"id":"https://openalex.org/keywords/norepinephrine-spillover","display_name":"norepinephrine spillover","score":0.7979999780654907},{"id":"https://openalex.org/keywords/cardiac-sympathetic-nerve-activity","display_name":"cardiac sympathetic activity","score":0.6380000114440918},{"id":"https://openalex.org/keywords/baroreflex","display_name":"baroreflex","score":0.6549999713897705},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9750000238418579},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"neuromodulation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/sympathetic-nerve-activity","display_name":"sympathetic activity","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C191237925","wikidata":"https://www.wikidata.org/wiki/Q808725","display_name":"Baroreflex","level":4,"score":0.7589782476425171},{"id":"https://openalex.org/C2775898464","wikidata":"https://www.wikidata.org/wiki/Q3312240","display_name":"Microneurography","level":5,"score":0.7329367399215698},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7024730443954468},{"id":"https://openalex.org/C2776533406","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic nervous system","level":3,"score":0.6563758850097656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6527865529060364},{"id":"https://openalex.org/C99631742","wikidata":"https://www.wikidata.org/wiki/Q22290476","display_name":"Reuptake","level":4,"score":0.6063491106033325},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5351771712303162},{"id":"https://openalex.org/C2780250439","wikidata":"https://www.wikidata.org/wiki/Q423288","display_name":"Desipramine","level":4,"score":0.5256696343421936},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4748292863368988},{"id":"https://openalex.org/C176233148","wikidata":"https://www.wikidata.org/wiki/Q14874257","display_name":"Norepinephrine transporter","level":4,"score":0.4542927145957947},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.44561058282852173},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.34234243631362915},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.3320508599281311},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.10191306471824646},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.059526145458221436},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003891","descriptor_name":"Desipramine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018759","descriptor_name":"Adrenergic Uptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.hyp.0000103160.35395.9e","doi":"https://doi.org/10.1161/01.hyp.0000103160.35395.9e","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.hyp.0000103160.35395.9e","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.HYP.0000103160.35395.9E","source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},{"id":"pmid:14610101","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14610101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension (Dallas, Tex. : 1979)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1161/01.hyp.0000103160.35395.9e","doi":"https://doi.org/10.1161/01.hyp.0000103160.35395.9e","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.hyp.0000103160.35395.9e","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.HYP.0000103160.35395.9E","source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8100000023841858}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320442","display_name":"National Heart Foundation of Australia","ror":"https://ror.org/039d9wr27"},{"id":"https://openalex.org/F4320320570","display_name":"Heart Research Institute","ror":"https://ror.org/046fa4y88"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2138908243.pdf","grobid_xml":"https://content.openalex.org/works/W2138908243.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1907985808","https://openalex.org/W1915438004","https://openalex.org/W2004988120","https://openalex.org/W2010889362","https://openalex.org/W2022233089","https://openalex.org/W2040564940","https://openalex.org/W2049957143","https://openalex.org/W2052590473","https://openalex.org/W2072069204","https://openalex.org/W2072294014","https://openalex.org/W2074413125","https://openalex.org/W2119938390","https://openalex.org/W2121069700","https://openalex.org/W2128791637","https://openalex.org/W2129125192","https://openalex.org/W2137335941","https://openalex.org/W2140595638","https://openalex.org/W2150759625","https://openalex.org/W2164012016","https://openalex.org/W2314802508","https://openalex.org/W2413054326","https://openalex.org/W2415138340","https://openalex.org/W3080346889"],"related_works":["https://openalex.org/W1971546596","https://openalex.org/W60266478","https://openalex.org/W1994158938","https://openalex.org/W2088749476","https://openalex.org/W1909773925","https://openalex.org/W2044862663","https://openalex.org/W2023629143","https://openalex.org/W4250753802","https://openalex.org/W6339482","https://openalex.org/W3037600626"],"abstract_inverted_index":{"There":[0],"is":[1,7,11],"growing":[2],"evidence":[3],"that":[4,174],"essential":[5],"hypertension":[6],"commonly":[8],"neurogenic":[9],"and":[10,13,40,53,66,99,120,125,150,203,218,242],"initiated":[12],"sustained":[14],"by":[15,43],"sympathetic":[16,25,37,41,60,93,108,117,185,210,215,226,239],"nervous":[17],"system":[18],"overactivity.":[19],"Potential":[20],"mechanisms":[21],"include":[22],"increased":[23,115],"central":[24],"outflow,":[26],"altered":[27],"norepinephrine":[28],"(NE)":[29],"neuronal":[30,86,130,220],"reuptake,":[31],"diminished":[32,190],"arterial":[33,98,235],"baroreflex":[34,182,236],"dampening":[35],"of":[36,84,97,104,145,166,184,209,214,247],"nerve":[38,118,186,216,240],"traffic,":[39],"neuromodulation":[42],"angiotensin":[44,92,105,248],"II.":[45],"To":[46,89],"address":[47],"this":[48],"issue,":[49],"we":[50],"used":[51],"microneurography":[52],"radiotracer":[54],"dilution":[55],"methodology":[56],"to":[57,78,107,140,207,225,251],"measure":[58],"regional":[59],"activity":[61,109,119],"in":[62,135,153,160,191,200,228],"22":[63],"hypertensive":[64,136,161,192],"patients":[65,113],"11":[67],"normotensive":[68],"control":[69,183],"subjects.":[70,137,193],"The":[71],"NE":[72,87,127,131,155,168,221],"transport":[73],"inhibitor":[74],"desipramine":[75],"was":[76,110,133,188],"infused":[77],"directly":[79],"assess":[80],"the":[81,95,143,151,167],"potential":[82],"role":[83,232],"impaired":[85],"reuptake.":[88],"evaluate":[90],"possible":[91],"neuromodulation,":[94],"relation":[96],"coronary":[100],"sinus":[101],"plasma":[102,196],"concentrations":[103,197],"II":[106,195,249],"investigated.":[111],"Hypertensive":[112],"displayed":[114],"muscle":[116],"elevated":[121],"total":[122],"systemic,":[123],"cardiac,":[124],"renal":[126],"spillover.":[128],"Cardiac":[129],"reuptake":[132,222],"decreased":[134],"In":[138],"response":[139],"desipramine,":[141],"both":[142,201,223],"reduction":[144],"fractional":[146],"transcardiac":[147],"3[H]NE":[148],"extraction":[149],"increase":[152],"cardiac":[154],"spillover":[156],"were":[157,198,204],"less":[158],"pronounced":[159],"patients.":[162],"DNA":[163],"sequencing":[164],"analysis":[165],"transporter":[169,179],"gene":[170],"revealed":[171],"no":[172],"mutations":[173],"could":[175],"account":[176],"for":[177,233],"reduced":[178,219],"activity.":[180],"Arterial":[181],"traffic":[187,241],"not":[189,205],"Angiotensin":[194],"similar":[199],"groups":[202],"related":[206],"indexes":[208],"activation.":[211],"Increased":[212],"rates":[213],"firing":[217],"contribute":[224],"activation":[227],"hypertension,":[229],"whereas":[230],"a":[231,243],"dampened":[234],"restraint":[237],"on":[238],"peripheral":[244],"neuromodulating":[245],"influence":[246],"appear":[250],"be":[252],"excluded.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":31},{"year":2016,"cited_by_count":33},{"year":2015,"cited_by_count":26},{"year":2014,"cited_by_count":41},{"year":2013,"cited_by_count":46},{"year":2012,"cited_by_count":39}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}