{"id":"https://openalex.org/W2138876346","doi":"https://doi.org/10.1186/1753-6561-3-s7-s115","title":"A multilevel linear mixed model of the association between candidate genes and weight and body mass index using the Framingham longitudinal family data","display_name":"A multilevel linear mixed model of the association between candidate genes and weight and body mass index using the Framingham longitudinal family data","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W2138876346","doi":"https://doi.org/10.1186/1753-6561-3-s7-s115","mag":"2138876346","pmid":"https://pubmed.ncbi.nlm.nih.gov/20017980","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2795887"},"language":"en","primary_location":{"id":"doi:10.1186/1753-6561-3-s7-s115","doi":"https://doi.org/10.1186/1753-6561-3-s7-s115","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1753-6561-3-s7-s115","pdf_url":"https://bmcproc.biomedcentral.com/counter/pdf/10.1186/1753-6561-3-S7-S115","source":{"id":"https://openalex.org/S49206733","display_name":"BMC Proceedings","issn_l":"1753-6561","issn":["1753-6561"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Proceedings","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcproc.biomedcentral.com/counter/pdf/10.1186/1753-6561-3-S7-S115","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027538163","display_name":"Jian\u2019an Luan","orcid":"https://orcid.org/0000-0003-3137-6337","observed_orcids":["https://orcid.org/0000-0003-3137-6337"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I4210158597","display_name":"MRC Epidemiology Unit","ror":"https://ror.org/052578691","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210158597","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jian'an Luan","raw_affiliation_strings":["Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK","Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK","institution_ids":["https://openalex.org/I4210156194","https://openalex.org/I4210158597","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194","https://openalex.org/I4210158597","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076909146","display_name":"Berit Kerner","orcid":"https://orcid.org/0000-0002-7873-1116","observed_orcids":["https://orcid.org/0000-0002-7873-1116"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Berit Kerner","raw_affiliation_strings":["Center for Neurobehavioral Genetics, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, 695 South Charles E Young Drive, Los Angeles, California 90095, USA","Center for Neurobehavioral Genetics, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurobehavioral Genetics, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, 695 South Charles E Young Drive, Los Angeles, California 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Center for Neurobehavioral Genetics, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101521779","display_name":"Jinghua Zhao","orcid":"https://orcid.org/0000-0001-6408-2314","observed_orcids":["https://orcid.org/0000-0001-6408-2314"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I4210158597","display_name":"MRC Epidemiology Unit","ror":"https://ror.org/052578691","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210158597","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jing-Hua Zhao","raw_affiliation_strings":["Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK","Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK","institution_ids":["https://openalex.org/I4210156194","https://openalex.org/I4210158597","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194","https://openalex.org/I4210158597","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016233543","display_name":"Ruth J. F. Loos","orcid":"https://orcid.org/0000-0002-8532-5087","observed_orcids":["https://orcid.org/0000-0002-8532-5087","https://orcid.org/0000-0002-2713-686X","https://orcid.org/0000-0002-9275-4189"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I4210158597","display_name":"MRC Epidemiology Unit","ror":"https://ror.org/052578691","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210158597","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ruth JF Loos","raw_affiliation_strings":["Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK","Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK","institution_ids":["https://openalex.org/I4210156194","https://openalex.org/I4210158597","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194","https://openalex.org/I4210158597","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052443670","display_name":"Stephen J. Sharp","orcid":"https://orcid.org/0000-0003-2375-1440","observed_orcids":["https://orcid.org/0000-0003-2375-1440"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I4210158597","display_name":"MRC Epidemiology Unit","ror":"https://ror.org/052578691","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210158597","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen J Sharp","raw_affiliation_strings":["Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK","Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK","institution_ids":["https://openalex.org/I4210156194","https://openalex.org/I4210158597","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194","https://openalex.org/I4210158597","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010588180","display_name":"Bengt Muth\u00e9n","orcid":"https://orcid.org/0000-0001-9308-6525","observed_orcids":["https://orcid.org/0000-0001-9308-6525"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bengt O Muth\u00e9n","raw_affiliation_strings":["Department of Education, 2005 East Moore Hall, University of California at Los Angeles, California 90095, USA","Department of Education, University of California at Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Education, 2005 East Moore Hall, University of California at Los Angeles, California 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Education, University of California at Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100717719","display_name":"Nicholas J. Wareham","orcid":"https://orcid.org/0000-0003-1422-2993","observed_orcids":["https://orcid.org/0000-0003-1422-2993","https://orcid.org/0000-0003-4963-0815"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I4210158597","display_name":"MRC Epidemiology Unit","ror":"https://ror.org/052578691","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210158597","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas J Wareham","raw_affiliation_strings":["Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK","Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK","institution_ids":["https://openalex.org/I4210156194","https://openalex.org/I4210158597","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194","https://openalex.org/I4210158597","https://openalex.org/I90344618"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5027538163"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194","https://openalex.org/I4210158597","https://openalex.org/I90344618"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":1.3488,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.80843408,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"S7","first_page":"S115","last_page":"S115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8769999742507935},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9390000104904175},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.7039999961853027},{"id":"https://openalex.org/keywords/fto-gene","display_name":"FTO","score":0.9649999737739563},{"id":"https://openalex.org/keywords/mc4r-gene","display_name":"MC4R gene","score":0.9330000281333923},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.984000027179718},{"id":"https://openalex.org/keywords/candidate-genes","display_name":"candidate genes","score":0.7369999885559082},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.8519999980926514},{"id":"https://openalex.org/keywords/haplotype-association","display_name":"haplotype association","score":0.7770000100135803},{"id":"https://openalex.org/keywords/framingham-heart-study","display_name":"Framingham Heart Study","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C157410074","wikidata":"https://www.wikidata.org/wiki/Q6869145","display_name":"Minor allele frequency","level":5,"score":0.7914363145828247},{"id":"https://openalex.org/C111815664","wikidata":"https://www.wikidata.org/wiki/Q1440693","display_name":"Framingham Heart Study","level":4,"score":0.7571845054626465},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7463275194168091},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.6935941576957703},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5928829908370972},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5772684812545776},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.525679886341095},{"id":"https://openalex.org/C2780428817","wikidata":"https://www.wikidata.org/wiki/Q14912501","display_name":"FTO gene","level":5,"score":0.4870951175689697},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4739282727241516},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.45062074065208435},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.4495564103126526},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40392065048217773},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37434321641921997},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.3534330129623413},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2633686661720276},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.260728657245636},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24789747595787048},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23070409893989563},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.18603095412254333},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13312485814094543}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1186/1753-6561-3-s7-s115","doi":"https://doi.org/10.1186/1753-6561-3-s7-s115","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1753-6561-3-s7-s115","pdf_url":"https://bmcproc.biomedcentral.com/counter/pdf/10.1186/1753-6561-3-S7-S115","source":{"id":"https://openalex.org/S49206733","display_name":"BMC Proceedings","issn_l":"1753-6561","issn":["1753-6561"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Proceedings","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2048417","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2795887","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2795887","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2795887","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Proc","raw_type":"Text"},{"id":"pmid:20017980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20017980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC proceedings","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.355.9949","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.355.9949","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/95/33/BMC_Proc_2009_Dec_15_3(Suppl_7)_S115.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1186/1753-6561-3-s7-s115","doi":"https://doi.org/10.1186/1753-6561-3-s7-s115","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1753-6561-3-s7-s115","pdf_url":"https://bmcproc.biomedcentral.com/counter/pdf/10.1186/1753-6561-3-S7-S115","source":{"id":"https://openalex.org/S49206733","display_name":"BMC Proceedings","issn_l":"1753-6561","issn":["1753-6561"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Proceedings","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6544469227","display_name":"Symptom Dimensions in Psychosis","funder_award_id":"K08MH074057","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G715637723","display_name":"Parsing of Bipolar Disorders and Schizophrenia: A Latent Class Approach","funder_award_id":"R01MH085744","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G736005061","display_name":"Genetic Analysis of Common Diseases: An Evaluation","funder_award_id":"R01GM031575","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2138876346.pdf","grobid_xml":"https://content.openalex.org/works/W2138876346.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W1985765463","https://openalex.org/W2055160461","https://openalex.org/W2066874799","https://openalex.org/W2097660065","https://openalex.org/W2098161436","https://openalex.org/W2110678911"],"related_works":["https://openalex.org/W7096262762","https://openalex.org/W2133122361","https://openalex.org/W2105653570","https://openalex.org/W2467839379","https://openalex.org/W4317751980","https://openalex.org/W2170423840","https://openalex.org/W2110678911","https://openalex.org/W4280609697","https://openalex.org/W2521520524","https://openalex.org/W2078843839"],"abstract_inverted_index":{"Obesity":[0],"has":[1],"become":[2],"an":[3,113],"epidemic":[4],"in":[5,142,204,256],"many":[6],"countries":[7],"and":[8,27,38,50,70,110,160,170,177,206,216],"is":[9],"one":[10],"of":[11,138,151],"the":[12,53,60,92,126,133,139,143,148,152,193,196,200,209,219,226],"major":[13],"risk":[14],"conditions":[15],"for":[16,73,122,132,189,195],"disease":[17],"including":[18,67],"type":[19],"2":[20],"diabetes,":[21],"coronary":[22],"heart":[23],"disease,":[24],"stroke,":[25],"dyslipidemia,":[26],"hypertension.":[28],"Recent":[29],"genome-wide":[30,129],"association":[31],"studies":[32],"have":[33],"identified":[34],"two":[35,227,251],"genes":[36],"(FTO":[37],"near":[39,104,253],"MC4R)":[40],"that":[41,147],"were":[42,64,155,167,255],"unequivocally":[43],"associated":[44,156,244],"with":[45,81,108,157,245],"body":[46],"mass":[47],"index":[48],"(BMI)":[49],"obesity.":[51],"For":[52],"Genetic":[54],"Analysis":[55],"Workshop":[56],"16,":[57],"data":[58,83,131],"from":[59],"Framingham":[61],"Heart":[62],"Study":[63],"made":[65],"available,":[66],"longitudinal":[68],"anthropometric":[69],"metabolic":[71],"traits":[72],"7130":[74],"Caucasian":[75],"individuals":[76],"over":[77],"three":[78],"generations,":[79],"each":[80],"follow-up":[82,220],"at":[84,191],"up":[85],"to":[86],"four":[87,95,134,153],"time":[88],"points.":[89],"We":[90,116],"explored":[91],"associations":[93,166],"between":[94,168,225],"single-nucleotide":[96],"polymorphisms":[97],"(SNPs)":[98],"on":[99],"FTO":[100,228],"(rs1121980,":[101],"rs9939609)":[102],"or":[103,248],"MC4R":[105,254],"(rs17782313,":[106],"rs17700633)":[107],"weight":[109,159,171,205,215,247],"BMI":[111,178,217],"under":[112],"additive":[114],"model.":[115],"applied":[117],"multilevel":[118,140],"linear":[119],"mixed":[120],"model":[121],"continuous":[123],"outcomes,":[124],"using":[125],"Affymetrix":[127],"500k":[128],"genotype":[130],"SNPs.":[135],"The":[136,163,184,250],"results":[137,185],"modeling":[141],"entire":[144],"sample":[145],"indicated":[146],"minor":[149,197],"alleles":[150],"SNPs":[154,190,229,252],"higher":[158,161],"BMI.":[162,249],"most":[164,201],"significant":[165],"rs9939609":[169],"(p":[172,179],"=":[173,180,233,236,260,263],"4.7":[174],"x":[175,182],"10-6)":[176],"8.9":[181],"10-8).":[183],"also":[186],"showed":[187],"that,":[188],"FTO,":[192],"homozygotes":[194,212],"allele":[198,211],"had":[199],"pronounced":[202],"increase":[203],"BMI,":[207],"while":[208],"common":[210],"gained":[213],"less":[214],"during":[218],"period.":[221],"Linkage":[222],"disequilibrium":[223],"(LD)":[224],"was":[230,241],"strong":[231],"(D'":[232,259],"0.997,":[234],"r2":[235,262],"0.875)":[237],"but":[238],"their":[239],"haplotype":[240],"not":[242],"significantly":[243],"either":[246],"weak":[257],"LD":[258],"0.487,":[261],"0.166).":[264]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}