{"id":"https://openalex.org/W2138780853","doi":"https://doi.org/10.1161/01.atv.12.9.1008","title":"Role of the extracellular matrix in age-related modifications of the rat aorta. Ultrastructural, morphometric, and enzymatic evaluations.","display_name":"Role of the extracellular matrix in age-related modifications of the rat aorta. Ultrastructural, morphometric, and enzymatic evaluations.","publication_year":1992,"publication_date":"1992-09-01","ids":{"openalex":"https://openalex.org/W2138780853","doi":"https://doi.org/10.1161/01.atv.12.9.1008","mag":"2138780853","pmid":"https://pubmed.ncbi.nlm.nih.gov/1356019"},"language":"en","primary_location":{"id":"doi:10.1161/01.atv.12.9.1008","doi":"https://doi.org/10.1161/01.atv.12.9.1008","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.atv.12.9.1008","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.12.9.1008","source":{"id":"https://openalex.org/S4210240347","display_name":"Arteriosclerosis and Thrombosis A Journal of Vascular Biology","issn_l":"1049-8834","issn":["1049-8834","2330-9199"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis and Thrombosis: A Journal of Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.12.9.1008","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009458029","display_name":"Claudio Fornieri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Fornieri","raw_affiliation_strings":["Institute of General Pathology, University of Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of General Pathology, University of Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063163622","display_name":"Daniela Quaglino","orcid":"https://orcid.org/0000-0002-4302-5078","observed_orcids":["https://orcid.org/0000-0002-4302-5078"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D Quaglino","raw_affiliation_strings":["Institute of General Pathology, University of Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of General Pathology, University of Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020298043","display_name":"Giuseppe Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Mori","raw_affiliation_strings":["Institute of General Pathology, University of Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of General Pathology, University of Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I122346577"],"apc_list":null,"apc_paid":null,"fwci":1.7501,"has_fulltext":true,"cited_by_count":94,"citation_normalized_percentile":{"value":0.85915054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"9","first_page":"1008","last_page":"1016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.6309000253677368,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.6309000253677368,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.16300000250339508,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.05570000037550926,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9819999933242798},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.7549999952316284},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8040000200271606},{"id":"https://openalex.org/keywords/vascular-aging","display_name":"vascular aging","score":0.8069999814033508},{"id":"https://openalex.org/keywords/lysyl-oxidase","display_name":"lysyl oxidase","score":0.9169999957084656},{"id":"https://openalex.org/keywords/elastin","display_name":"elastin","score":0.6190000176429749},{"id":"https://openalex.org/keywords/extracellular-matrix-fibrosis","display_name":"extracellular matrix fibrosis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/arterial-stiffness","display_name":"arterial stiffness","score":0.7689999938011169},{"id":"https://openalex.org/keywords/aortic-remodeling","display_name":"aortic remodeling","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C193143273","wikidata":"https://www.wikidata.org/wiki/Q419389","display_name":"Lysyl oxidase","level":3,"score":0.9209187030792236},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.8876166343688965},{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.8717496395111084},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.7384597063064575},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6644830703735352},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.6064982414245605},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5306951999664307},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5287891030311584},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.5152371525764465},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.5150535106658936},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4158513844013214},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36903613805770874},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3464089334011078},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23235705494880676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21092769503593445},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11403796076774597}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004549","descriptor_name":"Elastin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008249","descriptor_name":"Protein-Lysine 6-Oxidase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/01.atv.12.9.1008","doi":"https://doi.org/10.1161/01.atv.12.9.1008","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.atv.12.9.1008","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.12.9.1008","source":{"id":"https://openalex.org/S4210240347","display_name":"Arteriosclerosis and Thrombosis A Journal of Vascular Biology","issn_l":"1049-8834","issn":["1049-8834","2330-9199"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis and Thrombosis: A Journal of Vascular Biology","raw_type":"journal-article"},{"id":"pmid:1356019","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1356019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis and thrombosis : a journal of vascular biology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unimore.it:11380/11477","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/11477","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:3140292702","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/atv91.12.9.1356019?related-urls=yes&legid=atvbaha%3B12%2F9%2F1008&cited-by=yesl12%2F9%2F1008","pdf_url":null,"source":{"id":"https://openalex.org/S4210240347","display_name":"Arteriosclerosis and Thrombosis A Journal of Vascular Biology","issn_l":"1049-8834","issn":["1049-8834","2330-9199"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Arteriosclerosis and Thrombosis: A Journal of Vascular Biology","raw_type":null}],"best_oa_location":{"id":"doi:10.1161/01.atv.12.9.1008","doi":"https://doi.org/10.1161/01.atv.12.9.1008","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.atv.12.9.1008","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.12.9.1008","source":{"id":"https://openalex.org/S4210240347","display_name":"Arteriosclerosis and Thrombosis A Journal of Vascular Biology","issn_l":"1049-8834","issn":["1049-8834","2330-9199"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis and Thrombosis: A Journal of Vascular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2138780853.pdf","grobid_xml":"https://content.openalex.org/works/W2138780853.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W17874309","https://openalex.org/W25497486","https://openalex.org/W56942247","https://openalex.org/W576862899","https://openalex.org/W1518756578","https://openalex.org/W1555431976","https://openalex.org/W1595809126","https://openalex.org/W1601367732","https://openalex.org/W1961726212","https://openalex.org/W1971189227","https://openalex.org/W1977930195","https://openalex.org/W1985867932","https://openalex.org/W1988665275","https://openalex.org/W1992412033","https://openalex.org/W1992505667","https://openalex.org/W2006794852","https://openalex.org/W2014480079","https://openalex.org/W2018088453","https://openalex.org/W2018855982","https://openalex.org/W2028524496","https://openalex.org/W2031573687","https://openalex.org/W2033393629","https://openalex.org/W2034771809","https://openalex.org/W2037483544","https://openalex.org/W2037903109","https://openalex.org/W2040209245","https://openalex.org/W2048485019","https://openalex.org/W2051283670","https://openalex.org/W2052199973","https://openalex.org/W2056075470","https://openalex.org/W2058345849","https://openalex.org/W2061629338","https://openalex.org/W2063883194","https://openalex.org/W2065425329","https://openalex.org/W2080103533","https://openalex.org/W2083697402","https://openalex.org/W2091143849","https://openalex.org/W2093465672","https://openalex.org/W2106007994","https://openalex.org/W2129120732","https://openalex.org/W2152172603","https://openalex.org/W2161065289","https://openalex.org/W2166987121","https://openalex.org/W2238391935","https://openalex.org/W2341771454","https://openalex.org/W2406196401","https://openalex.org/W2412251935","https://openalex.org/W2417831017","https://openalex.org/W2426412139","https://openalex.org/W2489164411","https://openalex.org/W2562408361","https://openalex.org/W2623951256"],"related_works":["https://openalex.org/W2031170353","https://openalex.org/W4213015984","https://openalex.org/W2042207127","https://openalex.org/W2423011847","https://openalex.org/W1984738546","https://openalex.org/W2650476068","https://openalex.org/W2421183504","https://openalex.org/W2061627185","https://openalex.org/W3118917764","https://openalex.org/W7099047325"],"abstract_inverted_index":{"Connective":[0],"tissues":[1],"such":[2],"as":[3],"blood":[4],"vessels":[5],"are":[6],"known":[7],"to":[8,22,51,75,147],"be":[9,99],"greatly":[10,133],"affected":[11],"by":[12,53,61],"age":[13],"because":[14],"of":[15,27,34,55,63,78,89,108,117,124,138,150],"impaired":[16],"functional":[17,136],"properties":[18,137],"and":[19,57,60,82,121,129],"increased":[20,106],"susceptibility":[21],"diseases.":[23],"With":[24],"the":[25,32,35,43,46,70,79,95,105,109,118,122,125,135,139,148],"aim":[26],"providing":[28],"further":[29],"information":[30],"on":[31,69,83],"role":[33],"extracellular":[36,80,111,130],"matrix":[37,81],"in":[38,45,94,142],"age-related":[39,115,153],"modifications,":[40],"we":[41],"investigated":[42],"aorta":[44],"rat":[47],"model":[48],"from":[49],"birth":[50],"senescence":[52],"means":[54],"morphological":[56],"morphometric":[58],"observations":[59],"evaluation":[62],"lysyl":[64,90],"oxidase":[65,91],"activity.":[66],"Results":[67],"focused":[68],"dramatic":[71],"vascular":[72,154],"rearrangements":[73],"due":[74],"progressive":[76],"fibrosis":[77],"prominent":[84],"elastin":[85],"modifications.":[86],"The":[87,113],"presence":[88],"activity,":[92],"even":[93],"oldest":[96],"animals,":[97],"might":[98,132],"at":[100,144],"least":[101,145],"partly":[102],"responsible":[103],"for":[104],"stiffness":[107],"aging":[110],"matrix.":[112],"striking":[114],"remodeling":[116],"aortic":[119],"architecture":[120],"alterations":[123],"interactions":[126],"between":[127],"cellular":[128],"compartments":[131],"influence":[134],"arterial":[140],"wall":[141],"senescence,":[143],"contributing":[146],"consequences":[149],"some":[151],"apparently":[152],"disorders.":[155]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}