{"id":"https://openalex.org/W2138670853","doi":"https://doi.org/10.2215/cjn.09720913","title":"Incorporation of Biomarkers with the Renal Angina Index for Prediction of Severe AKI in Critically Ill Children","display_name":"Incorporation of Biomarkers with the Renal Angina Index for Prediction of Severe AKI in Critically Ill Children","publication_year":2014,"publication_date":"2014-03-28","ids":{"openalex":"https://openalex.org/W2138670853","doi":"https://doi.org/10.2215/cjn.09720913","mag":"2138670853","pmid":"https://pubmed.ncbi.nlm.nih.gov/24677554","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3974366"},"language":"en","primary_location":{"id":"doi:10.2215/cjn.09720913","doi":"https://doi.org/10.2215/cjn.09720913","is_oa":false,"landing_page_url":"https://doi.org/10.2215/cjn.09720913","pdf_url":null,"source":{"id":"https://openalex.org/S184267533","display_name":"Clinical Journal of the American Society of Nephrology","issn_l":"1555-9041","issn":["1555-9041","1555-905X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3974366","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039986643","display_name":"Rajit K. Basu","orcid":"https://orcid.org/0000-0002-3184-341X","observed_orcids":["https://orcid.org/0000-0002-3184-341X"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rajit K. Basu","raw_affiliation_strings":["Center for Acute Care Nephrology,, Divisions of \u2021Critical Care and, \u00a7Biostatistics and Epidemiology, and, \u00b6The Heart Institute, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio;, \u2020Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, \u2016Division of Anesthesiology and Critical Care Medicine, George Washington University, Washington, DC","Biostatistics and Epidemiology, and","Center for Acute Care Nephrology","Critical Care and","Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio","Dr. Rajit K. Basu, Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 2005, Cincinnati OH, 45229. Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Acute Care Nephrology,, Divisions of \u2021Critical Care and, \u00a7Biostatistics and Epidemiology, and, \u00b6The Heart Institute, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio;, \u2020Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, \u2016Division of Anesthesiology and Critical Care Medicine, George Washington University, Washington, DC","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I193531525","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Biostatistics and Epidemiology, and","institution_ids":[]},{"raw_affiliation_string":"Center for Acute Care Nephrology","institution_ids":[]},{"raw_affiliation_string":"Critical Care and","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]},{"raw_affiliation_string":"Dr. Rajit K. Basu, Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 2005, Cincinnati OH, 45229. Email: [email\u00a0protected]","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100445351","display_name":"Yu Wang","orcid":"https://orcid.org/0000-0003-2265-3742","observed_orcids":["https://orcid.org/0000-0003-2265-3742","https://orcid.org/0009-0005-3396-9437"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Wang","raw_affiliation_strings":["Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; and","Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; and","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020609229","display_name":"Hector R. Wong","orcid":"https://orcid.org/0000-0001-7989-1173","observed_orcids":["https://orcid.org/0000-0001-7989-1173"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hector R. Wong","raw_affiliation_strings":["Critical Care and","Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; and","Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care and","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; and","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089235509","display_name":"Lakhmir S. Chawla","orcid":"https://orcid.org/0000-0001-5987-8318","observed_orcids":["https://orcid.org/0000-0001-5987-8318"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lakhmir S. Chawla","raw_affiliation_strings":["Division of Anesthesiology and Critical Care Medicine, George Washington University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Anesthesiology and Critical Care Medicine, George Washington University, Washington, DC","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017807208","display_name":"Derek S. Wheeler","orcid":"https://orcid.org/0000-0002-9902-2730","observed_orcids":["https://orcid.org/0000-0002-9902-2730"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Derek S. Wheeler","raw_affiliation_strings":["Center for Acute Care Nephrology","Critical Care and","Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; and","Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Acute Care Nephrology","institution_ids":[]},{"raw_affiliation_string":"Critical Care and","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; and","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012594790","display_name":"Stuart L. Goldstein","orcid":"https://orcid.org/0000-0003-3711-8785","observed_orcids":["https://orcid.org/0000-0003-3711-8785"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stuart L. Goldstein","raw_affiliation_strings":["Center for Acute Care Nephrology","Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; and","The Heart Institute, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio","Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Acute Care Nephrology","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; and","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"The Heart Institute, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5012594790","https://openalex.org/A5017807208","https://openalex.org/A5039986643"],"corresponding_institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I193531525","https://openalex.org/I63135867","https://openalex.org/I92156820"],"apc_list":null,"apc_paid":null,"fwci":11.6725,"has_fulltext":false,"cited_by_count":148,"citation_normalized_percentile":{"value":0.99087878,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"9","issue":"4","first_page":"654","last_page":"662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9110000133514404},{"id":"https://openalex.org/keywords/renal-angina-index","display_name":"renal angina index","score":0.9739999771118164},{"id":"https://openalex.org/keywords/kidney-injury-biomarkers","display_name":"kidney injury biomarkers","score":0.921999990940094},{"id":"https://openalex.org/keywords/neutrophil-gelatinase-associated-lipocalin","display_name":"neutrophil gelatinase-associated lipocalin","score":0.9539999961853027},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-8","display_name":"matrix metalloproteinase-8","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pediatric-intensive-care","display_name":"pediatric intensive care","score":0.6430000066757202},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.8230000138282776},{"id":"https://openalex.org/keywords/aki-prediction","display_name":"AKI prediction","score":0.6959999799728394},{"id":"https://openalex.org/keywords/net-reclassification-improvement","display_name":"net reclassification improvement","score":0.7559999823570251},{"id":"https://openalex.org/keywords/integrated-discrimination-improvement","display_name":"integrated discrimination improvement","score":0.9869999885559082},{"id":"https://openalex.org/keywords/critically-ill-children","display_name":"critically ill children","score":0.7160000205039978},{"id":"https://openalex.org/keywords/neutrophilic-inflammation","display_name":"neutrophilic inflammation","score":0.5220000147819519},{"id":"https://openalex.org/keywords/acute-tubular-necrosis","display_name":"acute tubular necrosis","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9568798542022705},{"id":"https://openalex.org/C2991859549","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critically ill","level":2,"score":0.8446288108825684},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5343016982078552},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.4994962215423584},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.455716609954834},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4453662931919098},{"id":"https://openalex.org/C2778425758","wikidata":"https://www.wikidata.org/wiki/Q180762","display_name":"Angina","level":3,"score":0.4263516962528229},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.09040120244026184}],"mesh":[{"descriptor_ui":"D000071068","descriptor_name":"Lipocalin-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000209","descriptor_name":"Acute-Phase Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004796","descriptor_name":"Clinical Enzyme Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015278","descriptor_name":"Intensive Care Units, Pediatric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016002","descriptor_name":"Discriminant Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D019272","descriptor_name":"Leukocyte Elastase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020784","descriptor_name":"Matrix Metalloproteinase 8","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054834","descriptor_name":"Lipocalins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2215/cjn.09720913","doi":"https://doi.org/10.2215/cjn.09720913","is_oa":false,"landing_page_url":"https://doi.org/10.2215/cjn.09720913","pdf_url":null,"source":{"id":"https://openalex.org/S184267533","display_name":"Clinical Journal of the American Society of Nephrology","issn_l":"1555-9041","issn":["1555-9041","1555-905X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Journal of the American Society of Nephrology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3351613","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3974366","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3974366","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3974366","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin J Am Soc Nephrol","raw_type":"Text"},{"id":"pmid:24677554","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24677554","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical journal of the American Society of Nephrology : CJASN","raw_type":"Comparative Study"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3351613","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3974366","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1729943678","display_name":"Genomic analysis of pediatric SIRS and septic shock","funder_award_id":"R01GM064619","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4169322547","display_name":null,"funder_award_id":"RC1-HL100474","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4649632379","display_name":"Stratification of pediatric septic shock","funder_award_id":"R01GM099773","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4773855036","display_name":"THE PEDIATRIC SEPSIS BIOMARKER RISK MODEL","funder_award_id":"5rc1hl100474-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W64255601","https://openalex.org/W1579301857","https://openalex.org/W1973242726","https://openalex.org/W1973477505","https://openalex.org/W1973914566","https://openalex.org/W1977108608","https://openalex.org/W1982875844","https://openalex.org/W1987226507","https://openalex.org/W1991240049","https://openalex.org/W1992455819","https://openalex.org/W2007813089","https://openalex.org/W2011970190","https://openalex.org/W2018916823","https://openalex.org/W2024433016","https://openalex.org/W2026086741","https://openalex.org/W2026274122","https://openalex.org/W2026477188","https://openalex.org/W2028804710","https://openalex.org/W2043574891","https://openalex.org/W2061669280","https://openalex.org/W2068742405","https://openalex.org/W2078237412","https://openalex.org/W2079911401","https://openalex.org/W2102265071","https://openalex.org/W2106421416","https://openalex.org/W2112316706","https://openalex.org/W2124770381","https://openalex.org/W2129351461","https://openalex.org/W2134208843","https://openalex.org/W2152073293","https://openalex.org/W2162801113","https://openalex.org/W2165163860","https://openalex.org/W2165209366","https://openalex.org/W2170947595","https://openalex.org/W2328176404","https://openalex.org/W2414803544","https://openalex.org/W2952762910","https://openalex.org/W4234830388","https://openalex.org/W4254245747","https://openalex.org/W4321429623"],"related_works":["https://openalex.org/W2310717279","https://openalex.org/W4281483716","https://openalex.org/W2952950268","https://openalex.org/W2314071996","https://openalex.org/W4206022441","https://openalex.org/W4403831706","https://openalex.org/W4400318369","https://openalex.org/W2766757911","https://openalex.org/W4416293193","https://openalex.org/W3096688886"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"OBJECTIVES:":[2],"Novel":[3],"AKI":[4,12,32,43,82,93,174,207,271,287],"biomarkers":[5,33,94,168,272,288],"carry":[6],"variable":[7],"performance":[8],"for":[9,64,152,172,214,230,241,278],"prediction":[10,55,102,187,208],"of":[11,27,41,59,92,103,116,130,192,197,218,245,255,261,270,286],"in":[13,22,95,147,289],"patients":[14,25,96,118],"with":[15,126,149,221,250],"heterogeneous":[16],"illness.":[17],"Until":[18],"utility":[19,285],"is":[20],"demonstrated":[21,169,224,252],"critically":[23,292],"ill":[24,293],"outside":[26],"the":[28,57,77,88,101,121,128,150,189,193,203,222,274,284],"cardiopulmonary":[29],"bypass":[30],"population,":[31],"are":[34],"unlikely":[35],"to":[36,53,75,80,120,186,202,211],"gain":[37],"widespread":[38],"implementation.":[39],"Operationalization":[40],"an":[42,253,259],"risk":[44],"stratification":[45],"methodology,":[46],"termed":[47],"renal":[48,69,98,204],"angina,":[49],"was":[50,73],"recently":[51],"reported":[52],"enhance":[54],"at":[56],"time":[58],"intensive":[60,123],"care":[61,124],"unit":[62,125],"admission":[63],"persistent":[65,104],"severe":[66,105,153,173,279],"AKI.":[67,106,154,280],"The":[68,216,243,281],"angina":[70,99,205],"index":[71],"(RAI)":[72],"developed":[74],"provide":[76],"clinical":[78,190],"context":[79],"direct":[81],"biomarker":[83,199,220],"testing.":[84],"This":[85,265],"study":[86,115,266],"tested":[87],"hypothesis":[89],"that":[90,268],"incorporation":[91,269],"fulfilling":[97],"improves":[100,276],"DESIGN,":[107],"SETTING,":[108],"PARTICIPANTS,":[109],"&":[110],"MEASUREMENTS:":[111],"In":[112],"a":[113,290],"multicenter":[114],"214":[117],"admitted":[119],"pediatric":[122],"sepsis,":[127],"discrimination":[129,161,171,277],"plasma":[131],"neutrophil":[132,140],"gelatinase-associated":[133],"lipocalin":[134],"(NGAL),":[135],"matrix":[136],"metalloproteinase-8":[137],"(MMP-8),":[138],"and":[139,146,159,228,233,238,248,258],"elastase-2":[141],"(Ela-2)":[142],"were":[143,164],"determined":[144],"individually":[145],"combination":[148],"RAI":[151,194,223,251,275,282],"Net":[155],"reclassification":[156],"improvement":[157,162],"(NRI)":[158],"integrated":[160],"(IDI)":[163],"calculated.":[165],"RESULTS:":[166],"Individual":[167],"marginal":[170],"(area":[175],"under":[176],"curve":[177],"[AUC]:":[178],"NGAL,":[179,231],"0.72;":[180],"MMP-8,":[181,232],"0.68;":[182],"Ela-2,":[183,234],"0.72),":[184],"inferior":[185],"by":[188],"model":[191,206],"(AUC=0.80).":[195],"Incorporation":[196],"each":[198,219],"significantly":[200],"added":[201],"(AUC=0.80,":[209],"increased":[210],"0.84-0.88;":[212],"P<0.05":[213],"each).":[215],"inclusion":[217,244],"NRI":[225,254],"(0.512,":[226],"0.428,":[227],"0.545":[229],"respectively;":[235],"all":[236],"P<0.03)":[237],"IDI":[239,260],"(0.075":[240],"Ela-2).":[242],"both":[246],"Ela-2":[247],"NGAL":[249],"0.871":[256],"(P<0.001)":[257],"0.1":[262],"(P=0.01).":[263],"CONCLUSIONS:":[264],"shows":[267],"into":[273],"optimizes":[283],"heterogeneous,":[291],"patient":[294],"population.":[295]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
