{"id":"https://openalex.org/W2138657517","doi":null,"title":"Therapeutic efficacy of long duration-low temperature whole body hyperthermia when combined with tumor necrosis factor and carboplatin in rats.","display_name":"Therapeutic efficacy of long duration-low temperature whole body hyperthermia when combined with tumor necrosis factor and carboplatin in rats.","publication_year":1994,"publication_date":"1994-04-15","ids":{"openalex":"https://openalex.org/W2138657517","mag":"2138657517","pmid":"https://pubmed.ncbi.nlm.nih.gov/8174130"},"language":"en","primary_location":{"id":"pmid:8174130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8174130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077509484","display_name":"Yuri Sakaguchi","orcid":"https://orcid.org/0000-0002-5818-1110","observed_orcids":["https://orcid.org/0000-0002-5818-1110"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Sakaguchi","raw_affiliation_strings":["Department of Internal Medicine, University of Texas Medical School, Houston 77225"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Medical School, Houston 77225","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Makino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Makino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Kaneko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Kaneko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103563066","display_name":"L. Clifton Stephens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L C Stephens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111444055","display_name":"Frederick R. Strebel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F R Strebel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022505437","display_name":"L Danhauser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L L Danhauser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113872567","display_name":"G. N. Jenkins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G N Jenkins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113646944","display_name":"J. M. C. Bull","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Bull","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4816,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.77768313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"54","issue":"8","first_page":"2223","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/whole-body-hyperthermia","display_name":"whole-body hyperthermia","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9120000004768372},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":1.0},{"id":"https://openalex.org/keywords/fibrosarcoma","display_name":"fibrosarcoma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7630000114440918},{"id":"https://openalex.org/keywords/normal-tissue-toxicity","display_name":"normal tissue toxicity","score":0.8529999852180481},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.8510000109672546},{"id":"https://openalex.org/keywords/combination-cancer-therapy","display_name":"combination cancer therapy","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.7142363786697388},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.7118027210235596},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.7053473591804504},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6600189208984375},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.5376155972480774},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4113613963127136},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40201812982559204},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36805760860443115},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.2052762806415558}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005354","descriptor_name":"Fibrosarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005354","descriptor_name":"Fibrosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005354","descriptor_name":"Fibrosarcoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:8174130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8174130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2138657517","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8174130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:2342373383","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/80007550109","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1504331874","display_name":"THERAPEUTIC INDEX OF ONCOLYTIC ISOMERIC PLATINUM DRUGS","funder_award_id":"R01CA041581","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5531742113","display_name":"OPTIMIZING CANCER CHEMOTHERAPY","funder_award_id":"R01CA043090","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W408225","https://openalex.org/W121366921","https://openalex.org/W1571316982","https://openalex.org/W1974296722","https://openalex.org/W1998742541","https://openalex.org/W2002755677","https://openalex.org/W2030586706","https://openalex.org/W2061520241","https://openalex.org/W2072167849","https://openalex.org/W2093171374","https://openalex.org/W2095974308","https://openalex.org/W2104199731","https://openalex.org/W2133509588","https://openalex.org/W2162265492","https://openalex.org/W2275523420","https://openalex.org/W2428625291"],"related_works":["https://openalex.org/W2342373383","https://openalex.org/W2146140449","https://openalex.org/W153669188","https://openalex.org/W2109151898","https://openalex.org/W1966997252","https://openalex.org/W2013783311","https://openalex.org/W1986521037","https://openalex.org/W2036002347","https://openalex.org/W2104199731","https://openalex.org/W2370553050"],"abstract_inverted_index":{"This":[0],"study":[1],"examines":[2],"the":[3,112,126,183],"effects":[4],"of":[5,10,109,114,121],"a":[6,34,117,214],"combined":[7,100],"modality":[8],"regimen":[9],"long":[11],"duration-low":[12],"temperature":[13,48],"whole":[14,49],"body":[15,50,154],"hyperthermia":[16,51],"(6":[17],"h":[18,53],"at":[19,54],"40.0":[20],"degrees":[21],"C;":[22],"LL-WBH),":[23],"recombinant":[24],"human":[25],"tumor":[26,65],"necrosis":[27],"factor-alpha":[28],"(TNF)":[29],"and":[30,76,92,141,160,188,211],"carboplatin":[31],"(CBDCA)":[32],"on":[33,64],"transplantable":[35],"fibrosarcoma":[36],"as":[37,39],"well":[38],"normal":[40,149],"tissue.":[41],"We":[42,191],"compare":[43],"LL-WBH":[44,58,142,206],"with":[45,71,78,101,145,168,200,209],"short":[46],"duration-high":[47],"(2":[52],"41.5":[55],"degrees;":[56],"SH-WBH).":[57],"alone":[59,73,80],"had":[60],"no":[61,135],"significant":[62],"effect":[63],"growth.":[66],"Tumor":[67],"growth":[68],"delay":[69],"(TGD)":[70],"TNF":[72,210],"(0.1":[74],"days)":[75,82],"that":[77,177,205],"CBDCA":[79,212],"(1.3":[81],"were":[83,162],"significantly":[84,118,163],"increased":[85,107],"to":[86,125,171,182],"2.6":[87],"days":[88,94],"(P":[89,95,130],"<":[90,96,131],"0.05)":[91],"2.8":[93],"0.05),":[97],"respectively,":[98],"when":[99],"LL-WBH.":[102],"Although":[103],"TNF+CBDCA":[104],"produced":[105,116],"minimally":[106],"TGD":[108,120],"1.9":[110],"days,":[111,123],"combination":[113,144,208],"LL-WBH+TNF+CBDCA":[115],"greater":[119,164,215],"5.6":[122],"compared":[124,170],"other":[127],"dual":[128],"combinations":[129],"0.01).":[132],"There":[133],"was":[134],"difference":[136],"between":[137],"TGDs":[138],"for":[139],"SH-WBH":[140],"in":[143,165,197,207],"TNF+CBDCA.":[146],"Trimodality":[147],"treatment-induced":[148],"tissue":[150],"toxicities,":[151],"characterized":[152],"by":[153],"weight":[155],"loss,":[156],"diarrhea,":[157],"foot":[158],"edema,":[159],"myelosuppression,":[161],"rats":[166,198],"treated":[167,199],"SH-WBH+TNF+CBDCA,":[169],"LL-WBH+TNF+CBDCA.":[172,201],"Histopathological":[173],"examination":[174],"also":[175],"demonstrated":[176],"SH-WBH+TNF+CBDCA":[178],"caused":[179],"severe":[180],"damage":[181],"lymphoid":[184],"tissues,":[185],"intestinal":[186],"tract,":[187],"peripheral":[189],"microvasulature.":[190],"observed":[192,196],"minimal":[193],"histopathological":[194],"changes":[195],"These":[202],"data":[203],"suggest":[204],"has":[213],"therapeutic":[216],"efficacy":[217],"than":[218],"SH-WBH.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
