{"id":"https://openalex.org/W2138625528","doi":"https://doi.org/10.1183/09031936.01.00064101","title":"The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4+ T-cells in asthma","display_name":"The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4+ T-cells in asthma","publication_year":2001,"publication_date":"2001-07-01","ids":{"openalex":"https://openalex.org/W2138625528","doi":"https://doi.org/10.1183/09031936.01.00064101","mag":"2138625528","pmid":"https://pubmed.ncbi.nlm.nih.gov/11510804"},"language":"en","primary_location":{"id":"doi:10.1183/09031936.01.00064101","doi":"https://doi.org/10.1183/09031936.01.00064101","is_oa":true,"landing_page_url":"https://doi.org/10.1183/09031936.01.00064101","pdf_url":"https://erj.ersjournals.com/content/erj/18/1/45.full.pdf","source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://erj.ersjournals.com/content/erj/18/1/45.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003397190","display_name":"Onn Min Kon","orcid":"https://orcid.org/0000-0003-2647-4688","observed_orcids":["https://orcid.org/0000-0003-2647-4688"]},"institutions":[{"id":"https://openalex.org/I2802918412","display_name":"London Chest Hospital","ror":"https://ror.org/03zhk7994","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2802918412"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"O.M. Kon","raw_affiliation_strings":["Department of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, UK","Dept of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, SmithKline Beecham Pharmaceuticals, Harlow, Essex, The London Chest Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Dept of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, SmithKline Beecham Pharmaceuticals, Harlow, Essex, The London Chest Hospital, London, UK","institution_ids":["https://openalex.org/I2802918412","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005970340","display_name":"B.S. Sihra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802918412","display_name":"London Chest Hospital","ror":"https://ror.org/03zhk7994","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2802918412"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B.S. Sihra","raw_affiliation_strings":["Dept of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, SmithKline Beecham Pharmaceuticals, Harlow, Essex, The London Chest Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, SmithKline Beecham Pharmaceuticals, Harlow, Essex, The London Chest Hospital, London, UK","institution_ids":["https://openalex.org/I2802918412","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022775015","display_name":"Li\u2010Cher Loh","orcid":"https://orcid.org/0000-0003-1257-8603","observed_orcids":["https://orcid.org/0000-0003-1257-8603"]},"institutions":[{"id":"https://openalex.org/I2802918412","display_name":"London Chest Hospital","ror":"https://ror.org/03zhk7994","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2802918412"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L.C. Loh","raw_affiliation_strings":["Dept of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, SmithKline Beecham Pharmaceuticals, Harlow, Essex, The London Chest Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, SmithKline Beecham Pharmaceuticals, Harlow, Essex, The London Chest Hospital, London, UK","institution_ids":["https://openalex.org/I2802918412","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004428649","display_name":"Julia R. Barkans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802918412","display_name":"London Chest Hospital","ror":"https://ror.org/03zhk7994","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2802918412"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Barkans","raw_affiliation_strings":["Dept of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, SmithKline Beecham Pharmaceuticals, Harlow, Essex, The London Chest Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, SmithKline Beecham Pharmaceuticals, Harlow, Essex, The London Chest Hospital, London, UK","institution_ids":["https://openalex.org/I2802918412","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103564506","display_name":"Christopher H. Compton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802918412","display_name":"London Chest Hospital","ror":"https://ror.org/03zhk7994","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2802918412"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C.H. Compton","raw_affiliation_strings":["Dept of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, SmithKline Beecham Pharmaceuticals, Harlow, Essex, The London Chest Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, SmithKline Beecham Pharmaceuticals, Harlow, Essex, The London Chest Hospital, London, UK","institution_ids":["https://openalex.org/I2802918412","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051386979","display_name":"Noah Barnes","orcid":"https://orcid.org/0000-0002-3948-2049","observed_orcids":["https://orcid.org/0000-0002-3948-2049"]},"institutions":[{"id":"https://openalex.org/I2802918412","display_name":"London Chest Hospital","ror":"https://ror.org/03zhk7994","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2802918412"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N.C. Barnes","raw_affiliation_strings":["Dept of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, SmithKline Beecham Pharmaceuticals, Harlow, Essex, The London Chest Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, SmithKline Beecham Pharmaceuticals, Harlow, Essex, The London Chest Hospital, London, UK","institution_ids":["https://openalex.org/I2802918412","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077280281","display_name":"Mark Larch\u00e9","orcid":"https://orcid.org/0000-0002-1439-7593","observed_orcids":["https://orcid.org/0000-0002-1439-7593"]},"institutions":[{"id":"https://openalex.org/I2802918412","display_name":"London Chest Hospital","ror":"https://ror.org/03zhk7994","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2802918412"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. Larch\u00e9","raw_affiliation_strings":["Dept of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, SmithKline Beecham Pharmaceuticals, Harlow, Essex, The London Chest Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, SmithKline Beecham Pharmaceuticals, Harlow, Essex, The London Chest Hospital, London, UK","institution_ids":["https://openalex.org/I2802918412","https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113998589","display_name":"A. Barry Kay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802918412","display_name":"London Chest Hospital","ror":"https://ror.org/03zhk7994","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2802918412"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A.B. Kay","raw_affiliation_strings":["Dept of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, SmithKline Beecham Pharmaceuticals, Harlow, Essex, The London Chest Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, SmithKline Beecham Pharmaceuticals, Harlow, Essex, The London Chest Hospital, London, UK","institution_ids":["https://openalex.org/I2802918412","https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3903,"has_fulltext":true,"cited_by_count":67,"citation_normalized_percentile":{"value":0.88121709,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"18","issue":"1","first_page":"45","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-cd4-monoclonal-antibody","display_name":"anti-CD4 monoclonal antibody","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.7990000247955322},{"id":"https://openalex.org/keywords/corticosteroid-dependent-asthma","display_name":"corticosteroid-dependent asthma","score":0.949999988079071},{"id":"https://openalex.org/keywords/cd25","display_name":"CD25","score":0.6299999952316284},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cd45ro","display_name":"CD45RO","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cd45ra","display_name":"CD45RA","score":0.9909999966621399},{"id":"https://openalex.org/keywords/t-cell-receptor-expression","display_name":"T cell receptor expression","score":0.6320000290870667},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8809999823570251},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9739999771118164},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":1.0},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.6882314682006836},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5867747068405151},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5802263617515564},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.573805034160614},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5727932453155518},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.5477088093757629},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5412418842315674},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41340315341949463},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.38550522923469543},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35025057196617126},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3401593267917633},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3381345570087433},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3334023356437683},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2701566815376282},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2668493688106537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2133634090423584},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012130","descriptor_name":"Respiratory Hypersensitivity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012130","descriptor_name":"Respiratory Hypersensitivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1183/09031936.01.00064101","doi":"https://doi.org/10.1183/09031936.01.00064101","is_oa":true,"landing_page_url":"https://doi.org/10.1183/09031936.01.00064101","pdf_url":"https://erj.ersjournals.com/content/erj/18/1/45.full.pdf","source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},{"id":"pmid:11510804","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11510804","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European respiratory journal","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1183/09031936.01.00064101","doi":"https://doi.org/10.1183/09031936.01.00064101","is_oa":true,"landing_page_url":"https://doi.org/10.1183/09031936.01.00064101","pdf_url":"https://erj.ersjournals.com/content/erj/18/1/45.full.pdf","source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2138625528.pdf","grobid_xml":"https://content.openalex.org/works/W2138625528.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W102717324","https://openalex.org/W142500424","https://openalex.org/W1480813099","https://openalex.org/W1494218680","https://openalex.org/W1591113877","https://openalex.org/W1973375820","https://openalex.org/W1979825377","https://openalex.org/W1992553838","https://openalex.org/W2023256966","https://openalex.org/W2026925338","https://openalex.org/W2039000918","https://openalex.org/W2047129941","https://openalex.org/W2047202466","https://openalex.org/W2050030598","https://openalex.org/W2056764108","https://openalex.org/W2060107852","https://openalex.org/W2077115276","https://openalex.org/W2079931256","https://openalex.org/W2080420848","https://openalex.org/W2084585806","https://openalex.org/W2094082235","https://openalex.org/W2102930433","https://openalex.org/W2115209627","https://openalex.org/W2116313488","https://openalex.org/W2139255736","https://openalex.org/W2148370330","https://openalex.org/W2312870247","https://openalex.org/W2788950036","https://openalex.org/W2895812704"],"related_works":["https://openalex.org/W2115209627","https://openalex.org/W2077015041","https://openalex.org/W2355199416","https://openalex.org/W2356417170","https://openalex.org/W2005594152","https://openalex.org/W2371990708","https://openalex.org/W2337825704","https://openalex.org/W2358087620","https://openalex.org/W2015211352","https://openalex.org/W2437245467"],"abstract_inverted_index":{"CD4+":[0,34,109,121,218,256,261,278],"T-cells":[1,35,257],"are":[2],"likely":[3],"to":[4,236,248,286],"be":[5,272],"involved":[6],"as":[7,234,242],"a":[8,52,65,143,228,237,249,275,287],"source":[9],"of":[10,20,23,41,55,182,194,206,221,255,260,269],"pro-inflammatory":[11],"cytokines":[12],"in":[13,36,80,120,124,135,146,153,159,190,203,217,231,252,264,277,284,289],"asthma.":[14],"This":[15],"study":[16],"assessed":[17],"the":[18,154,168,191,204,253],"effects":[19,126,268],"an":[21,27,243],"infusion":[22,54,158],"keliximab":[24,270],"(IDEC":[25],"CE9.1),":[26],"anti-CD4+":[28],"monoclonal":[29,239,245],"antibody,":[30,246],"on":[31,108,127],"peripheral":[32,81,129],"blood":[33,130],"corticosteroid-dependent":[37],"asthmatics.":[38,266],"Three":[39],"cohorts":[40],"patients":[42],"(termed":[43],"C0.5:":[44],"n=6,":[45],"C1.5:":[46],"n=5,":[47],"and":[48,71,84,92,95,105,111,117,162,197,210,258,281],"C3.0:":[49],"n=5)":[50],"received":[51],"single":[53],"0.5,":[56],"1.5":[57],"or":[58,224],"3.0":[59],"mg":[60],"x":[61],"kg(-1),":[62],"respectively,":[63],"with":[64],"fourth":[66],"receiving":[67],"placebo":[68],"(Cpl:":[69],"n=6),":[70],"were":[72,138,187,200,214],"followed-up":[73],"for":[74],"4":[75],"weeks.":[76],"By":[77],"flow":[78,151],"cytometry":[79],"blood,":[82],"pre-":[83],"postinfusion":[85],"assessment":[86],"was":[87,142,174,179],"made":[88],"of:":[89],"a)":[90],"CD4":[91],"CD8":[93,172],"counts":[94],"mean":[96,192],"fluorescence;":[97],"b)":[98],"CD25,":[99,207],"human":[100],"leukocyte":[101],"antigen-DR":[102],"(HLA-DR),":[103],"CD45RO":[104,209],"CD45RA":[106],"expression":[107,119,220,263,280],"T-cells;":[110],"c)":[112],"interferon":[113],"(IFN)-gamma,":[114],"interleukin":[115],"(IL)-4":[116],"IL-5":[118],"T-cells.":[122],"Keliximab's":[123],"vitro":[125],"allergen-specific":[128],"mononuclear":[131],"cells":[132],"(PBMC)":[133],"proliferation":[134,233],"atopic":[136],"asthmatics":[137],"also":[139],"evaluated.":[140],"There":[141,213],"significant":[144,188,201,229],"increase":[145],"lung":[147],"function":[148],"(peak":[149],"expiratory":[150],"rate)":[152],"C3.0":[155,163],"group.":[156],"Following":[157],"C0.5,":[160],"C1.5":[161],"but":[164,170],"not":[165,171],"Cpl:":[166],"1)":[167],"CD4,":[169],"count":[173],"significantly":[175],"decreased;":[176],"2)":[177],"there":[178,186,199],"total":[180],"loss":[181],"Leu3a":[183],"staining;":[184],"3)":[185],"reductions":[189,202],"fluorescence":[193],"OKT4":[195],"binding;":[196],"4)":[198],"numbers":[205],"HLA-DR,":[208],"CD45RA/CD4+":[211],"cells.":[212],"no":[215],"changes":[216],"cell":[219],"IFN-gamma,":[222],"IL-4":[223],"IL-5.":[225],"Keliximab":[226],"caused":[227],"reduction":[230,251,288],"T-cell":[232],"compared":[235],"control":[238],"antibody.":[240],"Keliximab,":[241],"anti-CD4":[244],"leads":[247],"transient":[250],"number":[254],"modulation":[259],"receptor":[262],"severe":[265],"The":[267],"may":[271],"mediated":[273],"through":[274],"decrease":[276],"surface":[279],"T-lymphocyte":[282],"numbers,":[283],"addition":[285],"allergen-induced":[290],"proliferation.":[291]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}