{"id":"https://openalex.org/W2138551940","doi":"https://doi.org/10.1152/physiolgenomics.00031.2012","title":"Role of sepsis in the development of limb muscle weakness in a porcine intensive care unit model","display_name":"Role of sepsis in the development of limb muscle weakness in a porcine intensive care unit model","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W2138551940","doi":"https://doi.org/10.1152/physiolgenomics.00031.2012","mag":"2138551940","pmid":"https://pubmed.ncbi.nlm.nih.gov/22851759"},"language":"en","primary_location":{"id":"doi:10.1152/physiolgenomics.00031.2012","doi":"https://doi.org/10.1152/physiolgenomics.00031.2012","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiolgenomics.00031.2012","pdf_url":null,"source":{"id":"https://openalex.org/S57123121","display_name":"Physiological Genomics","issn_l":"1094-8341","issn":["1094-8341","1531-2267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological Genomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072043518","display_name":"Sudhakar Aare","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sudhakar Aare","raw_affiliation_strings":["Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden;","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079467700","display_name":"Peter J. Radell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Peter Radell","raw_affiliation_strings":["Department of Anesthesiology, Karolinska Institute, Stockholm, Sweden;","2Department of Anesthesiology, Karolinska Institute, Stockholm, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Karolinska Institute, Stockholm, Sweden;","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"2Department of Anesthesiology, Karolinska Institute, Stockholm, Sweden;","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109205473","display_name":"Lars I. Eriksson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lars I. Eriksson","raw_affiliation_strings":["Department of Anesthesiology, Karolinska Institute, Stockholm, Sweden;","2Department of Anesthesiology, Karolinska Institute, Stockholm, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Karolinska Institute, Stockholm, Sweden;","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"2Department of Anesthesiology, Karolinska Institute, Stockholm, Sweden;","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100439338","display_name":"Yi-Wen Chen","orcid":"https://orcid.org/0000-0003-1635-4586","observed_orcids":["https://orcid.org/0000-0003-1635-4586"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi-Wen Chen","raw_affiliation_strings":["Department of Pediatrics, The George Washington University Medical Center, Washington, District of Columbia; and","Research Center for Genetic Medicine, Children's National Medical Center, Washington, District of Columbia;","3Research Center for Genetic Medicine, Children's National Medical Center, Washington, District of Columbia;","4Department of Pediatrics, The George Washington University Medical Center, Washington, District of Columbia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The George Washington University Medical Center, Washington, District of Columbia; and","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"Research Center for Genetic Medicine, Children's National Medical Center, Washington, District of Columbia;","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"3Research Center for Genetic Medicine, Children's National Medical Center, Washington, District of Columbia;","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"4Department of Pediatrics, The George Washington University Medical Center, Washington, District of Columbia; and","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086088688","display_name":"Eric P. Hoffman","orcid":"https://orcid.org/0000-0001-6470-5139","observed_orcids":["https://orcid.org/0000-0001-6470-5139","https://orcid.org/0000-0002-7172-6592"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric P. Hoffman","raw_affiliation_strings":["Department of Pediatrics, The George Washington University Medical Center, Washington, District of Columbia; and","Research Center for Genetic Medicine, Children's National Medical Center, Washington, District of Columbia;","3Research Center for Genetic Medicine, Children's National Medical Center, Washington, District of Columbia;","4Department of Pediatrics, The George Washington University Medical Center, Washington, District of Columbia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The George Washington University Medical Center, Washington, District of Columbia; and","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"Research Center for Genetic Medicine, Children's National Medical Center, Washington, District of Columbia;","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"3Research Center for Genetic Medicine, Children's National Medical Center, Washington, District of Columbia;","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"4Department of Pediatrics, The George Washington University Medical Center, Washington, District of Columbia; and","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059674225","display_name":"Lars Larsson","orcid":"https://orcid.org/0000-0003-3722-035X","observed_orcids":["https://orcid.org/0000-0003-3722-035X"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["SE","US"],"is_corresponding":true,"raw_author_name":"Lars Larsson","raw_affiliation_strings":["Department of Biobehavioral Health, The Pennsylvania State University, University Park, Pennsylvania","Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden;","1Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden;","5Department of Biobehavioral Health, The Pennsylvania State University, University Park, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biobehavioral Health, The Pennsylvania State University, University Park, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden;","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"1Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden;","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"5Department of Biobehavioral Health, The Pennsylvania State University, University Park, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5059674225"],"corresponding_institution_ids":["https://openalex.org/I123387679","https://openalex.org/I130769515"],"apc_list":null,"apc_paid":null,"fwci":1.4585,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.83887238,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"44","issue":"18","first_page":"865","last_page":"877"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.22579999268054962,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.02500000037252903,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/limb-muscle-weakness","display_name":"limb muscle weakness","score":0.8339999914169312},{"id":"https://openalex.org/keywords/critical-illness-myopathy","display_name":"critical illness myopathy","score":0.703000009059906},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.6480000019073486},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/immobilization","display_name":"immobilization","score":0.8799999952316284},{"id":"https://openalex.org/keywords/biceps-femoris","display_name":"biceps femoris","score":0.8299999833106995},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7179999947547913},{"id":"https://openalex.org/keywords/specific-force","display_name":"specific force","score":0.6830000281333923},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6740000247955322},{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.9750000238418579},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.9570000171661377},{"id":"https://openalex.org/keywords/intensive-care-unit","display_name":"intensive care unit","score":0.5139999985694885},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.3100000023841858}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.8464174866676331},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.5795528292655945},{"id":"https://openalex.org/C2779764123","wikidata":"https://www.wikidata.org/wiki/Q7972881","display_name":"Wasting","level":2,"score":0.5379911065101624},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.5372568964958191},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46280330419540405},{"id":"https://openalex.org/C2777488582","wikidata":"https://www.wikidata.org/wiki/Q29630","display_name":"Myostatin","level":3,"score":0.4294697940349579},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.41233718395233154},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.3758460581302643},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34760308265686035},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.33899903297424316}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018908","descriptor_name":"Muscle Weakness","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/physiolgenomics.00031.2012","doi":"https://doi.org/10.1152/physiolgenomics.00031.2012","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiolgenomics.00031.2012","pdf_url":null,"source":{"id":"https://openalex.org/S57123121","display_name":"Physiological Genomics","issn_l":"1094-8341","issn":["1094-8341","1531-2267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological Genomics","raw_type":"journal-article"},{"id":"pmid:22851759","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22851759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiological genomics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W79015887","https://openalex.org/W1515782410","https://openalex.org/W1539535784","https://openalex.org/W1863429598","https://openalex.org/W1970549359","https://openalex.org/W1979141370","https://openalex.org/W1980606567","https://openalex.org/W1988151686","https://openalex.org/W1992358357","https://openalex.org/W1996382011","https://openalex.org/W1998342895","https://openalex.org/W2000923252","https://openalex.org/W2010855976","https://openalex.org/W2012125922","https://openalex.org/W2014897682","https://openalex.org/W2020165890","https://openalex.org/W2023542439","https://openalex.org/W2025942837","https://openalex.org/W2033693969","https://openalex.org/W2035775942","https://openalex.org/W2038437697","https://openalex.org/W2043323238","https://openalex.org/W2048462672","https://openalex.org/W2057224156","https://openalex.org/W2057643731","https://openalex.org/W2063415882","https://openalex.org/W2071165824","https://openalex.org/W2075255092","https://openalex.org/W2081098333","https://openalex.org/W2081978814","https://openalex.org/W2089748634","https://openalex.org/W2097489686","https://openalex.org/W2097689258","https://openalex.org/W2097795961","https://openalex.org/W2099704543","https://openalex.org/W2103650142","https://openalex.org/W2105389477","https://openalex.org/W2111144454","https://openalex.org/W2119507154","https://openalex.org/W2128693866","https://openalex.org/W2130788082","https://openalex.org/W2135554379","https://openalex.org/W2144063416","https://openalex.org/W2144354629","https://openalex.org/W2148435252","https://openalex.org/W2158354899","https://openalex.org/W2162187216","https://openalex.org/W2167183423","https://openalex.org/W2170984819","https://openalex.org/W2170989872"],"related_works":["https://openalex.org/W2132081425","https://openalex.org/W1976550535","https://openalex.org/W4392281673","https://openalex.org/W1979942493","https://openalex.org/W4400737974","https://openalex.org/W2346739881","https://openalex.org/W1987773785","https://openalex.org/W7137460256","https://openalex.org/W4411878475","https://openalex.org/W4318670889"],"abstract_inverted_index":{"Severe":[0],"muscle":[1,6,69,74,117,221,246],"wasting":[2,247],"and":[3,25,43,66,88,180,193,195,228,231],"loss":[4],"of":[5,154,163,172,188],"function":[7,222],"in":[8,50,79,92,110,129,175,185,223,243],"critically":[9,224],"ill":[10,225],"mechanically":[11],"ventilated":[12],"intensive":[13],"care":[14],"unit":[15],"(ICU)":[16],"patients":[17],"have":[18,103],"significant":[19,125,217],"negative":[20,218],"consequences":[21],"on":[22,120,200,220],"their":[23,31],"recovery":[24],"rehabilitation":[26],"that":[27,105],"persist":[28],"long":[29],"after":[30],"hospital":[32],"discharge;":[33],"moreover,":[34],"the":[35,145,152,157,186,189,201,210],"underlying":[36],"mechanisms":[37],"are":[38,236],"unclear.":[39],"Mechanical":[40],"ventilation":[41],"(MV)":[42],"immobilization-induced":[44],"modifications":[45],"play":[46,239],"an":[47,169,240],"important":[48],"role":[49,242],"these":[51],"consequences,":[52],"including":[53],"endotoxin-induced":[54],"sepsis.":[55],"The":[56],"present":[57],"study":[58],"aims":[59],"to":[60,82,135,144,149,156,209,238],"investigate":[61],"how":[62],"sepsis":[63,113,141,155,206,214],"aggravates":[64],"ventilator":[65],"immobilization-related":[67],"limb":[68],"dysfunction.":[70],"Hence,":[71],"biceps":[72],"femoris":[73],"gene":[75],"expression":[76,171],"was":[77,127,142,207],"investigated":[78],"pigs":[80],"exposed":[81],"ICU":[83,106,146,158,211,226],"intervention,":[84],"i.e.,":[85],"immobilization,":[86],"sedation,":[87],"MV,":[89],"alone":[90,108],"or":[91,109],"combination":[93,111],"with":[94,112],"sepsis,":[95],"for":[96],"5":[97],"days.":[98],"In":[99],"previous":[100],"studies,":[101],"we":[102],"shown":[104],"intervention":[107,159],"did":[114],"not":[115],"affect":[116],"fiber":[118,131],"size":[119],"day":[121],"5,":[122],"but":[123],"a":[124,161,216],"decrease":[126],"observed":[128],"single":[130],"maximal":[132],"force":[133],"normalized":[134],"cross-sectional":[136],"area":[137],"(specific":[138],"force)":[139],"when":[140,205],"added":[143,208],"intervention.":[147,212],"According":[148],"microarray":[150],"data,":[151],"addition":[153],"induced":[160],"deregulation":[162],">":[164],"500":[165],"genes,":[166],"such":[167],"as":[168],"increased":[170],"genes":[173,235],"involved":[174,184],"chemokine":[176,229],"activity,":[177,179],"kinase":[178],"transcriptional":[181],"regulation.":[182],"Genes":[183],"regulation":[187],"oxidative":[190],"stress":[191],"response":[192],"cytoskeletal/sarcomeric":[194],"heat":[196,232],"shock":[197,233],"proteins":[198],"were":[199],"other":[202],"hand":[203],"downregulated":[204],"Thus,":[213],"has":[215],"effect":[219],"patients,":[227],"activity":[230],"protein":[234],"forwarded":[237],"instrumental":[241],"this":[244],"specific":[245],"condition.":[248]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
