{"id":"https://openalex.org/W2138497006","doi":"https://doi.org/10.1021/ja9021717","title":"Live Cell Cytotoxicity Studies: Documentation of the Interactions of Antitumor Active Dirhodium Compounds with Nuclear DNA","display_name":"Live Cell Cytotoxicity Studies: Documentation of the Interactions of Antitumor Active Dirhodium Compounds with Nuclear DNA","publication_year":2009,"publication_date":"2009-07-22","ids":{"openalex":"https://openalex.org/W2138497006","doi":"https://doi.org/10.1021/ja9021717","mag":"2138497006","pmid":"https://pubmed.ncbi.nlm.nih.gov/19624128"},"language":"en","primary_location":{"id":"doi:10.1021/ja9021717","doi":"https://doi.org/10.1021/ja9021717","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja9021717","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014517639","display_name":"J. Dafhne Aguirre","orcid":"https://orcid.org/0000-0001-7056-9719","observed_orcids":["https://orcid.org/0000-0001-7056-9719"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Dafhne Aguirre","raw_affiliation_strings":["Department of Chemistry and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, and Department of Chemistry, The Ohio State University, Columbus, Ohio 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, and Department of Chemistry, The Ohio State University, Columbus, Ohio 43210","institution_ids":["https://openalex.org/I52357470","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000146662","display_name":"Alfredo Milton Angeles-Boza","orcid":"https://orcid.org/0000-0002-5560-4405","observed_orcids":["https://orcid.org/0000-0002-5560-4405"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfredo M. Angeles-Boza","raw_affiliation_strings":["Department of Chemistry and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, and Department of Chemistry, The Ohio State University, Columbus, Ohio 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, and Department of Chemistry, The Ohio State University, Columbus, Ohio 43210","institution_ids":["https://openalex.org/I52357470","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049066751","display_name":"Abdellatif Chouai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdellatif Chouai","raw_affiliation_strings":["Department of Chemistry and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, and Department of Chemistry, The Ohio State University, Columbus, Ohio 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, and Department of Chemistry, The Ohio State University, Columbus, Ohio 43210","institution_ids":["https://openalex.org/I52357470","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031224601","display_name":"Jean\u2010Philippe Pellois","orcid":"https://orcid.org/0000-0001-8528-4652","observed_orcids":["https://orcid.org/0000-0001-8528-4652"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean-Philippe Pellois","raw_affiliation_strings":["Department of Chemistry and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, and Department of Chemistry, The Ohio State University, Columbus, Ohio 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, and Department of Chemistry, The Ohio State University, Columbus, Ohio 43210","institution_ids":["https://openalex.org/I52357470","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038676358","display_name":"Claudia Turr\u00f3","orcid":"https://orcid.org/0000-0003-3202-5870","observed_orcids":["https://orcid.org/0000-0003-3202-5870"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudia Turro","raw_affiliation_strings":["Department of Chemistry and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, and Department of Chemistry, The Ohio State University, Columbus, Ohio 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, and Department of Chemistry, The Ohio State University, Columbus, Ohio 43210","institution_ids":["https://openalex.org/I52357470","https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056201103","display_name":"Kim R. Dunbar","orcid":"https://orcid.org/0000-0001-5728-7805","observed_orcids":["https://orcid.org/0000-0001-5728-7805"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kim R. Dunbar","raw_affiliation_strings":["Department of Chemistry and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, and Department of Chemistry, The Ohio State University, Columbus, Ohio 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, and Department of Chemistry, The Ohio State University, Columbus, Ohio 43210","institution_ids":["https://openalex.org/I52357470","https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056201103"],"corresponding_institution_ids":["https://openalex.org/I52357470","https://openalex.org/I91045830"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.6571,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.95547138,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"131","issue":"32","first_page":"11353","last_page":"11360"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dirhodium-complexes","display_name":"dirhodium complexes","score":0.9259999990463257},{"id":"https://openalex.org/keywords/dirhodium-ii-complexes","display_name":"dirhodium(II) complexes","score":0.7419999837875366},{"id":"https://openalex.org/keywords/anticancer-metal-complexes","display_name":"anticancer metal complexes","score":0.7630000114440918},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.8130000233650208},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.7070000171661377},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8740000128746033},{"id":"https://openalex.org/keywords/dppz","display_name":"dppz","score":0.8659999966621399},{"id":"https://openalex.org/keywords/dipyrido-3-2-a-2-3-c-phenazine","display_name":"dipyrido[3,2-a:2',3'-c]phenazine","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hydrophobicity","display_name":"hydrophobicity","score":0.722000002861023},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8930000066757202},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8930000066757202},{"id":"https://openalex.org/keywords/l-buthionine-sulfoximine","display_name":"L-buthionine sulfoximine","score":0.9330000281333923},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.3089999854564667}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9344018697738647},{"id":"https://openalex.org/C2778370995","wikidata":"https://www.wikidata.org/wiki/Q419781","display_name":"Phenazine","level":2,"score":0.6917985677719116},{"id":"https://openalex.org/C2780362310","wikidata":"https://www.wikidata.org/wiki/Q419930","display_name":"Quinoxaline","level":2,"score":0.6561973094940186},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.6465689539909363},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.6361356973648071},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6280015707015991},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5634638071060181},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.537208080291748},{"id":"https://openalex.org/C2777660389","wikidata":"https://www.wikidata.org/wiki/Q416005","display_name":"Phenanthroline","level":2,"score":0.4857049882411957},{"id":"https://openalex.org/C2780358455","wikidata":"https://www.wikidata.org/wiki/Q903780","display_name":"Comet assay","level":4,"score":0.46415624022483826},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4431539475917816},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3096641004085541},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.22246778011322021},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15222561359405518},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.11234903335571289},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09760332107543945},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07651159167289734}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004587","descriptor_name":"Electrophoresis, Agar Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009691","descriptor_name":"Nucleic Acid Denaturation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012238","descriptor_name":"Rhodium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012238","descriptor_name":"Rhodium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014783","descriptor_name":"Viscosity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020552","descriptor_name":"Comet Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ja9021717","doi":"https://doi.org/10.1021/ja9021717","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja9021717","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:19624128","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19624128","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W210395626","https://openalex.org/W1487427081","https://openalex.org/W1507562524","https://openalex.org/W1528887896","https://openalex.org/W1535524422","https://openalex.org/W1569113399","https://openalex.org/W1826381055","https://openalex.org/W1965272410","https://openalex.org/W1971380388","https://openalex.org/W1980411311","https://openalex.org/W1981540750","https://openalex.org/W1984808665","https://openalex.org/W1984848080","https://openalex.org/W1988129027","https://openalex.org/W1999243253","https://openalex.org/W2000951435","https://openalex.org/W2001174028","https://openalex.org/W2004326614","https://openalex.org/W2009180778","https://openalex.org/W2012682560","https://openalex.org/W2017030176","https://openalex.org/W2019913425","https://openalex.org/W2030993908","https://openalex.org/W2032442944","https://openalex.org/W2034412778","https://openalex.org/W2041459118","https://openalex.org/W2041486892","https://openalex.org/W2043610941","https://openalex.org/W2044918757","https://openalex.org/W2045083595","https://openalex.org/W2051054249","https://openalex.org/W2051941062","https://openalex.org/W2052173156","https://openalex.org/W2053726603","https://openalex.org/W2053987411","https://openalex.org/W2062546205","https://openalex.org/W2064769568","https://openalex.org/W2064885067","https://openalex.org/W2068975001","https://openalex.org/W2072754176","https://openalex.org/W2083484180","https://openalex.org/W2089570339","https://openalex.org/W2089731664","https://openalex.org/W2092759233","https://openalex.org/W2095935525","https://openalex.org/W2117277757","https://openalex.org/W2118345116","https://openalex.org/W2120066726","https://openalex.org/W2121773722","https://openalex.org/W2123950781","https://openalex.org/W2126902508","https://openalex.org/W2144486308","https://openalex.org/W2150136645","https://openalex.org/W2151185811","https://openalex.org/W2165810890","https://openalex.org/W2333667115","https://openalex.org/W2414129550","https://openalex.org/W2462792603","https://openalex.org/W2885978694","https://openalex.org/W3105783285","https://openalex.org/W4245957869"],"related_works":["https://openalex.org/W2036948290","https://openalex.org/W2019913425","https://openalex.org/W7021137563","https://openalex.org/W2141405104","https://openalex.org/W2948432995","https://openalex.org/W2003032213","https://openalex.org/W2123950781","https://openalex.org/W1977006394","https://openalex.org/W2338518842","https://openalex.org/W4409901268"],"abstract_inverted_index":{"The":[0,137],"promising":[1],"antitumor":[2],"activity":[3,24,36,185],"of":[4,20,22,40,45,129,140,146,169,186,205],"dirhodium":[5,189,207],"complexes":[6,44],"has":[7],"been":[8],"known":[9],"for":[10],"over":[11],"30":[12],"years.":[13],"There":[14],"remains,":[15],"however,":[16,119],"a":[17],"general":[18,46],"lack":[19],"understanding":[21],"their":[23],"in":[25,37,154,178,202],"cellulo.":[26],"In":[27],"this":[28],"study,":[29],"we":[30],"report":[31],"the":[32,93,102,113,122,130,150,155,184,198,203],"DNA":[33,71,106],"interactions":[34,72],"and":[35,67,81,135,173],"living":[38],"cells":[39,133],"six":[41],"monosubstituted":[42],"dirhodium(II,II)":[43],"formula":[47],"[Rh(2)(mu-O(2)CCH(3))(2)(eta(1)-O(2)CCH(3))(L)(CH(3)OH)](+),":[48],"where":[49],"L":[50],"=":[51],"bpy":[52],"(2,2'-bipyridine)":[53],"(1),":[54],"phen":[55],"(1,10-phenanthroline)":[56],"(2),":[57],"dpq":[58],"(dipyrido[3,2-f:2',3'-h]quinoxaline)":[59],"(3),":[60],"dppz":[61],"(dipyrido[3,2-a:2',3'-c]phenazine)":[62],"(4),":[63],"dppn":[64],"(benzo[i]dipyrido[3,2-a:2',3'-c]phenazine)":[65],"(5),":[66],"dap":[68],"(4,7-dihydrodibenzo[de,gh][1,10]phenanthroline)":[69],"(6).":[70],"were":[73],"investigated":[74],"by":[75,112],"UV/visible":[76],"spectroscopy,":[77],"relative":[78],"viscosity":[79],"measurements,":[80],"electrophoretic":[82],"mobility":[83],"shift":[84],"assay.":[85,116],"These":[86,191],"measurements":[87],"indicate":[88,175],"that":[89,145,176,194],"compound":[90,153],"5":[91,99,141],"exhibits":[92],"strongest":[94],"interaction":[95],"with":[96],"DNA.":[97],"Compound":[98,117],"also":[100],"causes":[101],"most":[103,123,151],"damage":[104],"to":[105,144,160],"after":[107],"cellular":[108,163],"internalization,":[109],"as":[110,142],"evaluated":[111],"alkaline":[114],"comet":[115],"5,":[118],"is":[120,149,196],"not":[121,182,197],"effective":[124,152],"at":[125],"inhibiting":[126],"cell":[127],"viability":[128],"human":[131],"cancer":[132],"HeLa":[134],"COLO-316.":[136],"greater":[138],"hydrophobicity":[139],"compared":[143],"4,":[147],"which":[148],"series,":[156],"hinders":[157],"its":[158,162],"ability":[159],"reach":[161],"target(s).":[164],"Data":[165],"from":[166],"modulation":[167],"studies":[168],"glutathione":[170,179,195],"using":[171],"N-acetylcysteine":[172],"L-buthionine-sulfoximine":[174],"changes":[177],"levels":[180],"do":[181],"affect":[183],"these":[187,206],"particular":[188],"complexes.":[190,208],"results":[192],"suggest":[193],"only":[199],"agent":[200],"involved":[201],"deactivation":[204]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}