{"id":"https://openalex.org/W2138489088","doi":"https://doi.org/10.1093/emboj/20.4.914","title":"A role for p53 in base excision repair","display_name":"A role for p53 in base excision repair","publication_year":2001,"publication_date":"2001-02-15","ids":{"openalex":"https://openalex.org/W2138489088","doi":"https://doi.org/10.1093/emboj/20.4.914","mag":"2138489088","pmid":"https://pubmed.ncbi.nlm.nih.gov/11179235","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/145418"},"language":"en","primary_location":{"id":"doi:10.1093/emboj/20.4.914","doi":"https://doi.org/10.1093/emboj/20.4.914","is_oa":true,"landing_page_url":"https://doi.org/10.1093/emboj/20.4.914","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/emboj/20.4.914","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/emboj/20.4.914","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009220759","display_name":"Jian\u2010Min Zhou","orcid":"https://orcid.org/0000-0002-9943-2975","observed_orcids":["https://orcid.org/0000-0002-9943-2975"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianmin Zhou","raw_affiliation_strings":["Department of Biological Sciences, Columbia University, New York, NY 10025, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, NY 10025, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jinwoo Ahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinwoo Ahn","raw_affiliation_strings":["Department of Biological Sciences, Columbia UniversityNew YorkNY10025USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia UniversityNew YorkNY10025USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Samuel H. Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel H. Wilson","raw_affiliation_strings":["Laboratory of Structural Biology, NIEHS, National Institute of Health, Research Triangle ParkNC27709USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Biology, NIEHS, National Institute of Health, Research Triangle ParkNC27709USA","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":null,"display_name":"Carol Prives","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carol Prives","raw_affiliation_strings":["Department of Biological Sciences, Columbia UniversityNew YorkNY10025USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia UniversityNew YorkNY10025USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":null,"fwci":9.8096,"has_fulltext":true,"cited_by_count":341,"citation_normalized_percentile":{"value":0.99258878,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"20","issue":"4","first_page":"914","last_page":"923"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.03889999911189079,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":1.0},{"id":"https://openalex.org/keywords/base-excision-repair","display_name":"base excision repair","score":1.0},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8169999718666077},{"id":"https://openalex.org/keywords/abasic-dna","display_name":"abasic DNA","score":0.7419999837875366},{"id":"https://openalex.org/keywords/dna-polymerase-beta","display_name":"DNA polymerase beta","score":0.9169999957084656},{"id":"https://openalex.org/keywords/ap-endonuclease","display_name":"AP endonuclease","score":0.9319999814033508},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7459999918937683},{"id":"https://openalex.org/keywords/transactivation-domain","display_name":"transactivation domain","score":0.6819999814033508},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9070227146148682},{"id":"https://openalex.org/C187206112","wikidata":"https://www.wikidata.org/wiki/Q3113091","display_name":"Base excision repair","level":4,"score":0.8778712749481201},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.7809592485427856},{"id":"https://openalex.org/C150777479","wikidata":"https://www.wikidata.org/wiki/Q176783","display_name":"AP site","level":4,"score":0.6693850755691528},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.6653007864952087},{"id":"https://openalex.org/C1009745","wikidata":"https://www.wikidata.org/wiki/Q4653506","display_name":"AP endonuclease","level":5,"score":0.6638296246528625},{"id":"https://openalex.org/C2777028655","wikidata":"https://www.wikidata.org/wiki/Q415601","display_name":"Endonuclease","level":3,"score":0.5393151640892029},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5249752402305603},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5139686465263367},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4868692457675934},{"id":"https://openalex.org/C2778462844","wikidata":"https://www.wikidata.org/wiki/Q18030641","display_name":"DNA polymerase beta","level":5,"score":0.4369899034500122},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.43315938115119934},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3580242395401001},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2638036608695984},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15408790111541748},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.13034868240356445}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019951","descriptor_name":"DNA Polymerase beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/emboj/20.4.914","doi":"https://doi.org/10.1093/emboj/20.4.914","is_oa":true,"landing_page_url":"https://doi.org/10.1093/emboj/20.4.914","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/emboj/20.4.914","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"pmid:11179235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11179235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:145418","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC145418/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/emboj/20.4.914","doi":"https://doi.org/10.1093/emboj/20.4.914","is_oa":true,"landing_page_url":"https://doi.org/10.1093/emboj/20.4.914","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/emboj/20.4.914","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1329990932","display_name":"Regulation of the p53 tumore suppressor protein","funder_award_id":"R37CA058316","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7602737170","display_name":"Regulation of the p53 tumor suppressor protein","funder_award_id":"R01CA058316","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G78353511","display_name":null,"funder_award_id":"CA 58316","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000281898","display_name":null,"funder_award_id":"CA58316","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2138489088.pdf","grobid_xml":"https://content.openalex.org/works/W2138489088.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W12339002","https://openalex.org/W136200863","https://openalex.org/W175540666","https://openalex.org/W1491876634","https://openalex.org/W1545021361","https://openalex.org/W1547619885","https://openalex.org/W1548972556","https://openalex.org/W1590831713","https://openalex.org/W1600706591","https://openalex.org/W1815879748","https://openalex.org/W1824120105","https://openalex.org/W1918570764","https://openalex.org/W1929053900","https://openalex.org/W1932728046","https://openalex.org/W1949973946","https://openalex.org/W1956055380","https://openalex.org/W1965912307","https://openalex.org/W1969995067","https://openalex.org/W1971602039","https://openalex.org/W1972241251","https://openalex.org/W1978518304","https://openalex.org/W1986444835","https://openalex.org/W1992514146","https://openalex.org/W1993114600","https://openalex.org/W1993831923","https://openalex.org/W1994163195","https://openalex.org/W1994552302","https://openalex.org/W1997388033","https://openalex.org/W1999320089","https://openalex.org/W2000479074","https://openalex.org/W2000605935","https://openalex.org/W2003567663","https://openalex.org/W2006607764","https://openalex.org/W2009115701","https://openalex.org/W2012053348","https://openalex.org/W2012291005","https://openalex.org/W2014170738","https://openalex.org/W2014644281","https://openalex.org/W2020517175","https://openalex.org/W2024894759","https://openalex.org/W2025823631","https://openalex.org/W2028025897","https://openalex.org/W2034723609","https://openalex.org/W2040825860","https://openalex.org/W2042316019","https://openalex.org/W2042699531","https://openalex.org/W2051444751","https://openalex.org/W2054549064","https://openalex.org/W2061596601","https://openalex.org/W2063573579","https://openalex.org/W2064477710","https://openalex.org/W2064538331","https://openalex.org/W2064795157","https://openalex.org/W2072763798","https://openalex.org/W2074964515","https://openalex.org/W2075371890","https://openalex.org/W2081446097","https://openalex.org/W2089574530","https://openalex.org/W2096079439","https://openalex.org/W2113724086","https://openalex.org/W2114539716","https://openalex.org/W2120921507","https://openalex.org/W2126401395","https://openalex.org/W2129905922","https://openalex.org/W2131833681","https://openalex.org/W2134259738","https://openalex.org/W2136979107","https://openalex.org/W2140118545","https://openalex.org/W2144232168","https://openalex.org/W2149922717","https://openalex.org/W2150710841","https://openalex.org/W2152863070","https://openalex.org/W2155740016","https://openalex.org/W2156299289","https://openalex.org/W2157559194","https://openalex.org/W2159099751","https://openalex.org/W2218833219","https://openalex.org/W2324975577","https://openalex.org/W2424215327","https://openalex.org/W2604409822","https://openalex.org/W4212962560","https://openalex.org/W4229664794","https://openalex.org/W4232126293","https://openalex.org/W4234787291","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2014644281","https://openalex.org/W2329991259","https://openalex.org/W1999119036","https://openalex.org/W2325787473","https://openalex.org/W2126784037","https://openalex.org/W2085689485","https://openalex.org/W2164821454","https://openalex.org/W3172902909","https://openalex.org/W2238336822","https://openalex.org/W2022957486"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}