{"id":"https://openalex.org/W2138482000","doi":"https://doi.org/10.1109/iembs.2002.1136925","title":"Effects of tissue stretching or cell shrinkage on penetration depth of macromolecules in a rat fibrosarcoma","display_name":"Effects of tissue stretching or cell shrinkage on penetration depth of macromolecules in a rat fibrosarcoma","publication_year":2003,"publication_date":"2003-06-26","ids":{"openalex":"https://openalex.org/W2138482000","doi":"https://doi.org/10.1109/iembs.2002.1136925","mag":"2138482000"},"language":"en","primary_location":{"id":"doi:10.1109/iembs.2002.1136925","doi":"https://doi.org/10.1109/iembs.2002.1136925","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2002.1136925","pdf_url":null,"source":{"id":"https://openalex.org/S4363608786","display_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","issn_l":"2375-7477","issn":["2375-7477"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["doyens","jufo-1","ki-jl-1","medline","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017416702","display_name":"Sarah McGuire","orcid":"https://orcid.org/0000-0003-4020-0536","observed_orcids":["https://orcid.org/0000-0003-4020-0536"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.M. McGuire","raw_affiliation_strings":["Department of Biomedical Engineering, Duke University, Durham, NC, USA","[Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"[Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA]","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033255876","display_name":"Fan Yuan","orcid":"https://orcid.org/0000-0002-0687-6607","observed_orcids":["https://orcid.org/0000-0002-0687-6607"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fan Yuan","raw_affiliation_strings":["Department of Biomedical Engineering, Duke University, Durham, NC, USA","[Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"[Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA]","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17914439,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":null,"first_page":"516","last_page":"517"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.3767000138759613,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.3767000138759613,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.12020000070333481,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.08810000121593475,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-stretching","display_name":"tissue stretching","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cell-shrinkage","display_name":"cell shrinkage","score":0.9850000143051147},{"id":"https://openalex.org/keywords/fibrosarcoma","display_name":"fibrosarcoma","score":0.8759999871253967},{"id":"https://openalex.org/keywords/dextran","display_name":"dextran","score":0.8899999856948853},{"id":"https://openalex.org/keywords/molecular-size","display_name":"molecular size","score":0.6600000262260437},{"id":"https://openalex.org/keywords/mannitol","display_name":"mannitol","score":0.7059999704360962},{"id":"https://openalex.org/keywords/interstitial-space","display_name":"interstitial space","score":0.796999990940094},{"id":"https://openalex.org/keywords/tumor-drug-delivery","display_name":"tumor drug delivery","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C204389451","wikidata":"https://www.wikidata.org/wiki/Q178593","display_name":"Macromolecule","level":2,"score":0.8827559947967529},{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.8389096856117249},{"id":"https://openalex.org/C2777339698","wikidata":"https://www.wikidata.org/wiki/Q423123","display_name":"Dextran","level":2,"score":0.8341379165649414},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5708304643630981},{"id":"https://openalex.org/C2778445172","wikidata":"https://www.wikidata.org/wiki/Q407646","display_name":"Mannitol","level":2,"score":0.5703268647193909},{"id":"https://openalex.org/C2776495794","wikidata":"https://www.wikidata.org/wiki/Q1362453","display_name":"Fibrosarcoma","level":2,"score":0.5595793724060059},{"id":"https://openalex.org/C150489694","wikidata":"https://www.wikidata.org/wiki/Q6057172","display_name":"Interstitial space","level":2,"score":0.557384192943573},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4861468970775604},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.476113885641098},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3909700810909271},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.23732298612594604},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2138366401195526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10989943146705627},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/iembs.2002.1136925","doi":"https://doi.org/10.1109/iembs.2002.1136925","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iembs.2002.1136925","pdf_url":null,"source":{"id":"https://openalex.org/S4363608786","display_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","issn_l":"2375-7477","issn":["2375-7477"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["doyens","jufo-1","ki-jl-1","medline","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7599999904632568}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W1993050497","https://openalex.org/W2148639396"],"related_works":["https://openalex.org/W2085210434","https://openalex.org/W1965001670","https://openalex.org/W2171227711","https://openalex.org/W2148639396","https://openalex.org/W1523918944","https://openalex.org/W2088602142","https://openalex.org/W2084175641","https://openalex.org/W2135500620","https://openalex.org/W1993050497","https://openalex.org/W1545928943"],"abstract_inverted_index":{"Interstitial":[0],"penetration":[1,14,111],"is":[2],"critical":[3],"for":[4,87,95],"drug":[5],"delivery":[6],"in":[7,34,104,114,134],"tumor":[8],"tissues.":[9,115,135],"To":[10],"experimentally":[11],"determine":[12,61],"the":[13,19,82,92,110],"depth":[15],"of":[16,36,41,69,102,112],"macromolecules":[17,113],"at":[18],"steady":[20],"state,":[21],"rat":[22],"fibrosarcoma":[23],"tissues":[24,103],"were":[25,56],"sectioned":[26],"into":[27],"600":[28],"/spl":[29,53],"mu/m":[30,54],"slices":[31],"and":[32,46,58,91],"incubated":[33],"solutions":[35],"dextrans":[37],"with":[38],"molecular":[39,70],"weights":[40],"10":[42,52,72],"kDa,":[43,45,48],"70":[44,88],"2000":[47,96],"respectively.":[49],"After":[50],"incubation,":[51],"cross-sections":[55],"taken":[57],"imaged":[59],"to":[60],"normalized":[62],"steady-state":[63],"concentration":[64,79,83],"profiles":[65],"as":[66],"a":[67,76],"function":[68],"size.":[71],"kDa":[73,89,97],"dextran":[74,90],"had":[75],"relatively":[77],"uniform":[78,94],"distribution.":[80],"However,":[81],"profile":[84],"was":[85],"nonuniform":[86],"least":[93],"dextran.":[98],"Stretching":[99],"or":[100,127],"incubation":[101],"1":[105],"M":[106],"mannitol":[107],"solution":[108],"improved":[109],"These":[116],"results":[117],"indicate":[118],"that":[119],"creating":[120],"more":[121],"interstitial":[122],"space":[123],"by":[124],"either":[125],"stretching":[126],"reducing":[128],"cell":[129],"size":[130],"improves":[131],"macromolecule":[132],"distribution":[133]},"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2016-06-24T00:00:00"}
