{"id":"https://openalex.org/W2138460040","doi":"https://doi.org/10.1006/mthe.2000.0233","title":"Immunomodulation by Electrically Enhanced Delivery of Plasmid DNA Encoding IL-12 to Murine Skeletal Muscle","display_name":"Immunomodulation by Electrically Enhanced Delivery of Plasmid DNA Encoding IL-12 to Murine Skeletal Muscle","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2138460040","doi":"https://doi.org/10.1006/mthe.2000.0233","mag":"2138460040","pmid":"https://pubmed.ncbi.nlm.nih.gov/11162310"},"language":"en","primary_location":{"id":"doi:10.1006/mthe.2000.0233","doi":"https://doi.org/10.1006/mthe.2000.0233","is_oa":true,"landing_page_url":"https://doi.org/10.1006/mthe.2000.0233","pdf_url":"http://www.cell.com/article/S1525001600902338/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S1525001600902338/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M.Lee Lucas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.Lee Lucas","raw_affiliation_strings":["Department of Medical Microbiology and Immunology/Institute for Biomolecular Science, University of South Florida, Tampa, Florida 33612, USA","Department of Medical Microbiology and Immunology/Institute for Biomolecular Science, University of South Florida, Tampa, Florida, 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Immunology/Institute for Biomolecular Science, University of South Florida, Tampa, Florida 33612, USA","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Department of Medical Microbiology and Immunology/Institute for Biomolecular Science, University of South Florida, Tampa, Florida, 33612","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057362562","display_name":"Richard F. Heller","orcid":"https://orcid.org/0000-0003-1899-3859","observed_orcids":["https://orcid.org/0000-0003-1899-3859"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard Heller","raw_affiliation_strings":["Center for Molecular Delivery, University of South Florida, Tampa, Florida, 33612","Department of Medical Microbiology and Immunology/Institute for Biomolecular Science, University of South Florida, Tampa, Florida, 33612","Department of Surgery, University of South Florida, Tampa, Florida, 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Delivery, University of South Florida, Tampa, Florida, 33612","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Department of Medical Microbiology and Immunology/Institute for Biomolecular Science, University of South Florida, Tampa, Florida, 33612","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Department of Surgery, University of South Florida, Tampa, Florida, 33612","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5057362562"],"corresponding_institution_ids":["https://openalex.org/I2613432"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":5.7527,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.97621593,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"3","issue":"1","first_page":"47","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-vivo-electroporation","display_name":"in vivo electroporation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/plasmid-dna-delivery","display_name":"plasmid DNA delivery","score":0.9700000286102295},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.8299999833106995},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.7390000224113464},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/field-strength","display_name":"field strength","score":0.6600000262260437},{"id":"https://openalex.org/keywords/pulse-duration","display_name":"pulse duration","score":0.8880000114440918},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8809999823570251},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C186852380","wikidata":"https://www.wikidata.org/wiki/Q1142521","display_name":"Electroporation","level":3,"score":0.9555729627609253},{"id":"https://openalex.org/C34742353","wikidata":"https://www.wikidata.org/wiki/Q842015","display_name":"Microsecond","level":2,"score":0.8325163125991821},{"id":"https://openalex.org/C60327585","wikidata":"https://www.wikidata.org/wiki/Q723733","display_name":"Millisecond","level":2,"score":0.8052062392234802},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.7033764123916626},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6745634078979492},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5364124774932861},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.48086315393447876},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.464901328086853},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.42543017864227295},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4148252308368683},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40162891149520874},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37121766805648804},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31504350900650024},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3029331564903259},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16613474488258362},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15709340572357178},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11829352378845215},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.117828369140625},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.08173558115959167},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07720118761062622},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/mthe.2000.0233","doi":"https://doi.org/10.1006/mthe.2000.0233","is_oa":true,"landing_page_url":"https://doi.org/10.1006/mthe.2000.0233","pdf_url":"http://www.cell.com/article/S1525001600902338/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},{"id":"pmid:11162310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11162310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy : the journal of the American Society of Gene Therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1006/mthe.2000.0233","doi":"https://doi.org/10.1006/mthe.2000.0233","is_oa":true,"landing_page_url":"https://doi.org/10.1006/mthe.2000.0233","pdf_url":"http://www.cell.com/article/S1525001600902338/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2138460040.pdf"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1622592612","https://openalex.org/W1894015978","https://openalex.org/W1917630072","https://openalex.org/W1979908488","https://openalex.org/W1980446245","https://openalex.org/W1995340682","https://openalex.org/W2006178861","https://openalex.org/W2009644962","https://openalex.org/W2014495927","https://openalex.org/W2018744718","https://openalex.org/W2031145204","https://openalex.org/W2034688094","https://openalex.org/W2039942347","https://openalex.org/W2054457322","https://openalex.org/W2074353166","https://openalex.org/W2084123085","https://openalex.org/W2170381415","https://openalex.org/W2327204353","https://openalex.org/W3024831056","https://openalex.org/W6639763190"],"related_works":["https://openalex.org/W1999031183","https://openalex.org/W2315841028","https://openalex.org/W2104724445","https://openalex.org/W3024831056","https://openalex.org/W3030505123","https://openalex.org/W2093096884","https://openalex.org/W2793221955","https://openalex.org/W2316005366","https://openalex.org/W1998740008","https://openalex.org/W2003371146"],"abstract_inverted_index":{"Recent":[0],"reports":[1,21],"have":[2,22],"shown":[3],"the":[4,34,53,70,100,142,178],"successful":[5],"delivery":[6,179],"of":[7,19,33,36,45,52,55,99,136,145,156,180],"plasmid":[8,157,181],"DNA":[9,158],"to":[10,40,47,80],"skeletal":[11],"muscle":[12],"by":[13],"in":[14,152,170,186],"vivo":[15,171],"electroporation.":[16],"However,":[17],"most":[18],"these":[20],"used":[23],"what":[24],"has":[25],"been":[26],"characterized":[27],"as":[28,124,126],"low-voltage,":[29,148],"millisecond":[30,67,149],"pulses.":[31,140,162],"One":[32],"purposes":[35],"this":[37,93,165],"study":[38],"was":[39,92,105],"examine":[41],"a":[42,49,82],"wide":[43],"range":[44],"parameters":[46,135,146],"establish":[48],"better":[50],"understanding":[51],"effects":[54],"field":[56],"strength":[57],"and":[58,69,122,183],"pulse":[59],"length.":[60],"Two":[61],"electroporation":[62,172],"conditions,":[63],"one":[64,98],"utilizing":[65],"low-voltage":[66],"pulses":[68,150],"other":[71],"high-voltage":[72],"microsecond":[73,161],"pulses,":[74],"were":[75],"compared":[76],"for":[77,177],"their":[78],"ability":[79],"deliver":[81],"molecule":[83,94],"that":[84,169],"can":[85],"be":[86,190],"measured":[87,107],"systemically,":[88,108],"IL-12.":[89],"Not":[90],"only":[91],"efficiently":[95],"delivered,":[96],"but":[97],"molecules":[101],"it":[102],"induces":[103],"(IFN-gamma)":[104],"also":[106],"with":[109],"expression":[110,155],"peaking":[111],"at":[112],"greater":[113],"than":[114,159],"200":[115],"pg/ml":[116,128],"serum":[117],"levels":[118],"on":[119,129],"day":[120,130],"7":[121],"still":[123],"high":[125],"40":[127],"21":[131],"when":[132],"using":[133],"electrical":[134],"100":[137],"V/cm,":[138],"20-ms":[139],"Of":[141],"two":[143],"types":[144],"tested,":[147],"resulted":[151],"higher,":[153],"prolonged":[154],"high-voltage,":[160],"In":[163],"summary,":[164],"report":[166],"provides":[167],"evidence":[168],"is":[173],"an":[174],"efficient":[175],"method":[176],"DNA,":[182],"its":[184],"use":[185],"immunotherapy":[187],"protocols":[188],"should":[189],"furthered":[191],"examined.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
