{"id":"https://openalex.org/W2138397971","doi":null,"title":"Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer.","display_name":"Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer.","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W2138397971","mag":"2138397971","pmid":"https://pubmed.ncbi.nlm.nih.gov/11705852"},"language":"en","primary_location":{"id":"pmid:11705852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11705852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002570387","display_name":"Richard J. Bing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129567078","display_name":"Huntington Medical Research Institutes","ror":"https://ror.org/05p1phv38","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I129567078"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R J Bing","raw_affiliation_strings":["Department of Experimental Cardiology, Huntington Medical Research Institutes, Pasadena, CA 91101, USA. cardio@hmri.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Cardiology, Huntington Medical Research Institutes, Pasadena, CA 91101, USA. cardio@hmri.org","institution_ids":["https://openalex.org/I129567078"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Miyataka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Miyataka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103695858","display_name":"Kathryn A. Rich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K A Rich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"N Hanson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Hanson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100322864","display_name":"Lingling Wang","orcid":"https://orcid.org/0000-0002-2399-7646","observed_orcids":["https://orcid.org/0000-0002-2399-7646"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010091312","display_name":"H D Slosser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H D Slosser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102081828","display_name":"S-R Shi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S R Shi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.8294,"has_fulltext":false,"cited_by_count":116,"citation_normalized_percentile":{"value":0.96319278,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"7","issue":"11","first_page":"3385","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8610000014305115},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.875},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/prostanoids","display_name":"prostanoids","score":0.8759999871253967},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/thromboxane","display_name":"thromboxane","score":0.8930000066757202},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.8209999799728394},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":1.0},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.984000027179718},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.640999972820282},{"id":"https://openalex.org/keywords/inflammatory-changes","display_name":"inflammatory changes","score":0.41600000858306885},{"id":"https://openalex.org/keywords/metastatic-potential","display_name":"metastatic potential","score":0.7419999837875366},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7657321691513062},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.6852112412452698},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6503811478614807},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6410316228866577},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.6118051409721375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6057332158088684},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5046008825302124},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.448355495929718},{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.43836510181427},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4336729645729065},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.4293172359466553},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41233140230178833},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4116725027561188},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3879079222679138},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27518966794013977},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.23042526841163635},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1142263114452362}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013929","descriptor_name":"Thromboxane B2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015121","descriptor_name":"6-Ketoprostaglandin F1 alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11705852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11705852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2138397971","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11705852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W203004974","https://openalex.org/W1482218984","https://openalex.org/W1488833292","https://openalex.org/W1505955094","https://openalex.org/W1557123095","https://openalex.org/W1575045356","https://openalex.org/W1648593433","https://openalex.org/W1869980306","https://openalex.org/W1962449772","https://openalex.org/W1965647807","https://openalex.org/W1976887945","https://openalex.org/W1985056444","https://openalex.org/W2016443777","https://openalex.org/W2020638356","https://openalex.org/W2020911016","https://openalex.org/W2026732117","https://openalex.org/W2027507048","https://openalex.org/W2043500156","https://openalex.org/W2051031104","https://openalex.org/W2051686420","https://openalex.org/W2052712275","https://openalex.org/W2052942682","https://openalex.org/W2055354965","https://openalex.org/W2056574134","https://openalex.org/W2064999451","https://openalex.org/W2066395665","https://openalex.org/W2067290049","https://openalex.org/W2089747387","https://openalex.org/W2090106927","https://openalex.org/W2090241785","https://openalex.org/W2090902301","https://openalex.org/W2094090874","https://openalex.org/W2097997344","https://openalex.org/W2107665428","https://openalex.org/W2115522061","https://openalex.org/W2120404354","https://openalex.org/W2127558096","https://openalex.org/W2131916468","https://openalex.org/W2135938816","https://openalex.org/W2138533953","https://openalex.org/W2141415623","https://openalex.org/W2148122132","https://openalex.org/W2148907720","https://openalex.org/W2150966393","https://openalex.org/W2156470937","https://openalex.org/W2163462883","https://openalex.org/W2165663767","https://openalex.org/W2324677651","https://openalex.org/W2336169581","https://openalex.org/W2464674916"],"related_works":["https://openalex.org/W2092460829","https://openalex.org/W2150966393","https://openalex.org/W2010973568","https://openalex.org/W2113435266","https://openalex.org/W2403146421","https://openalex.org/W1981788357","https://openalex.org/W7098840183","https://openalex.org/W1565012681","https://openalex.org/W2369827474","https://openalex.org/W2360208376"],"abstract_inverted_index":{"PURPOSE:":[0],"Several":[1],"studies":[2],"have":[3],"shown":[4],"an":[5,85,141],"overexpression":[6,183],"of":[7,13,29,32,45,65,90,97,122,144,159,163,176,184,223,230],"cyclooxygenase-2":[8],"(COX-2)":[9],"and":[10,16,38,42,50,62,69,102,130,135,153,161,187,227],"elevated":[11],"levels":[12],"prostacyclin":[14],"(PGI(2))":[15],"thromboxane":[17],"(TXA(2))":[18],"in":[19,40,60,67,127,146,165,171,179,190,202,207,220],"colon":[20,49,68,134,147,166,180],"cancer.":[21,71,181,231],"In":[22],"this":[23,177,203],"report,":[24],"we":[25,57],"determined":[26],"the":[27,82,95,150,169,174,193,208,211,221,228],"distribution":[28],"inducible":[30],"form":[31],"nitric":[33,188],"oxide":[34,189],"synthase":[35],"(iNOS),":[36],"PGI(2),":[37,129],"TXA(2)":[39,103,131],"cancerous":[41],"adjoining":[43,192,210],"areas":[44,191],"specimens":[46],"from":[47,84],"human":[48],"breast":[51,70,136],"cancer":[52,137,167,212],"obtained":[53,76],"during":[54,77],"surgery.":[55],"Additionally,":[56],"investigated":[58],"differences":[59,126],"expression":[61,121,143,158],"histological":[63],"localization":[64],"COX-2":[66,145,217],"EXPERIMENTAL":[72],"DESIGN:":[73],"Specimens":[74],"were":[75,104,138],"surgery,":[78],"one":[79],"centrally":[80],"located,":[81],"second":[83],"adjacent,":[86],"cancer-free":[87],"area.":[88,204],"Activity":[89],"iNOS":[91,160],"was":[92,117],"determined,":[93],"using":[94,110],"conversion":[96],"L-[(14)C]arginine":[98],"to":[99],"L-[(14)C]citrulline.":[100],"PGI(2)":[101],"measured":[105],"as":[106],"their":[107],"stable":[108],"metabolites,":[109],"enzyme":[111,178],"immunoassay.":[112],"A":[113],"standard":[114],"immunoperoxidase":[115],"method":[116],"used":[118],"for":[119,199],"immunohistochemical":[120],"COX-2.":[123],"RESULTS:":[124],"Significant":[125],"iNOS,":[128],"expressions":[132],"between":[133],"noted,":[139],"with":[140],"enhanced":[142],"cancer,":[148],"including":[149],"cancerous,":[151],"adjoining,":[152],"stromatous":[154],"fields.":[155],"CONCLUSIONS:":[156],"Increased":[157],"production":[162],"prostanoids":[164],"parallels":[168],"increase":[170],"COX-2,":[172,185],"confirming":[173],"importance":[175],"The":[182],"prostanoids,":[186],"tumor":[194],"indicates":[195],"increased":[196],"metastatic":[197],"potential":[198],"neoplastic":[200],"cells":[201],"Inflammatory":[205],"changes":[206],"tissue":[209],"may":[213,218],"play":[214],"a":[215],"role.":[216],"result":[219],"formation":[222],"new":[224],"blood":[225],"vessels":[226],"spread":[229]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}